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Original Article

Oral Mercaptopurine in Childhood Leukemia: Influence of Food Intake on Bioavailability

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Pages 105-112 | Received 19 May 1988, Accepted 14 Oct 1988, Published online: 09 Jul 2009

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Read on this site (2)

Aikaterini Sofianou-Katsoulis, Gulamabbas Khakoo & Richard Kaczmarski. (2006) REDUCTION IN BIOAVAILABILITY OF 6-MERCAPTOPURINE ON SIMULTANEOUS ADMINISTRATION WITH COW'S MILK. Pediatric Hematology and Oncology 23:6, pages 485-487.
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Salvatore P. Dibenedetto, Vincenzo Guardabasso, Rosalia Ragusa, Andrea Di Cataldo, Vito Miraglia, Salvatore D'Arnico & Anna M. Ippolito. (1994) 6-Mercaptopurine Cumulative Dose: A Critical Factor of Maintenance Therapy in Average Risk Childhood Acute Lymphoblastic Leukemia. Pediatric Hematology and Oncology 11:3, pages 251-258.
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Articles from other publishers (18)

Malinda Salim, Thomas Eason & Ben J. Boyd. (2022) Opportunities for milk and milk-related systems as ‘new’ low-cost excipient drug delivery materials. Advanced Drug Delivery Reviews 183, pages 114139.
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Claire Amaris Hobson, Stéphane Bonacorsi, Didier Hocquet, André Baruchel, Mony Fahd, Thomas Storme, Raksamy Tang, Catherine Doit, Olivier Tenaillon & André Birgy. (2020) Impact of anticancer chemotherapy on the extension of beta-lactamase spectrum: an example with KPC-type carbapenemase activity towards ceftazidime-avibactam. Scientific Reports 10:1.
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Yogesh C. Yadav, Kamla Pathak & Devender Pathak. (2020) Review on Preclinical and Clinical Evidence of Food (Beverages, Fruits and Vegetables) and Drug Interactions: Mechanism and Safety. Current Drug Therapy 15:1, pages 12-27.
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Marina Statelova, Konstantinos Goumas, Nikoletta Fotaki, René Holm, Mira Symillides, Christos Reppas & Maria Vertzoni. (2019) On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants: an Exploratory Study Highlighting the Importance of Infant Food. The AAPS Journal 22:1.
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Mariana Guimarães, Marina Statelova, René Holm, Christos Reppas, Moira Symilllides, Maria Vertzoni & Nikoletta Fotaki. (2019) Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products – a PEARRL review. Journal of Pharmacy and Pharmacology 71:4, pages 603-642.
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Wendy LandierLindsey HagemanYanjun ChenNancy KornegayWilliam E. EvansBruce C. BostromJacqueline CasillasDavid S. DickensAnne L. AngiolilloGlen LewKelly W. MaloneyLeo MascarenhasA. Kim RitcheyAmanda M. TermuhlenWilliam L. CarrollMary V. RellingF. Lennie WongSmita Bhatia. (2017) Mercaptopurine Ingestion Habits, Red Cell Thioguanine Nucleotide Levels, and Relapse Risk in Children With Acute Lymphoblastic Leukemia: A Report From the Children’s Oncology Group Study AALL03N1. Journal of Clinical Oncology 35:15, pages 1730-1736.
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Hannah Batchelor. (2015) Influence of Food on Paediatric Gastrointestinal Drug Absorption Following Oral Administration: A Review. Children 2:2, pages 244-271.
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Kjeld Schmiegelow, Stine N. Nielsen, Thomas L. Frandsen & Jacob Nersting. (2014) Mercaptopurine/Methotrexate Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia. Journal of Pediatric Hematology/Oncology 36:7, pages 503-517.
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Kim K.B. Clemmensen, Regitse H. Christensen, Diana N. Shabaneh, Arja Harila-Saari, Mats Heyman, Olafur G. Jonsson, Finn Wesenberg, Susanne Rosthøj & Kjeld Schmiegelow. (2014) The circadian schedule for childhood acute lymphoblastic leukemia maintenance therapy does not influence event-free survival in the NOPHO ALL92 protocol. Pediatric Blood & Cancer 61:4, pages 653-658.
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Sarah L. Noble, Eric Sherer, Robert E. Hannemann, Doraiswami Ramkrishna, Terry Vik & Ann E. Rundell. (2010) Using adaptive model predictive control to customize maintenance therapy chemotherapeutic dosing for childhood acute lymphoblastic leukemia. Journal of Theoretical Biology 264:3, pages 990-1002.
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Mário L. de Lemos, Linda Hamata, Sarah Jennings & Tanya Leduc. (2016) Interaction between mercaptopurine and milk. Journal of Oncology Pharmacy Practice 13:4, pages 237-240.
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Charity D. Scripture & William D. Figg. (2006) Drug interactions in cancer therapy. Nature Reviews Cancer 6:7, pages 546-558.
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Brahma N. Singh. (2005) A quantitative approach to probe the dependence and correlation of food-effect with aqueous solubility, dose/solubility ratio, and partition coefficient (LogP) for orally active drugs administered as immediate-release formulations. Drug Development Research 65:2, pages 55-75.
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Brahma N Singh & Bimal K Malhotra. (2004) Effects of Food on the Clinical Pharmacokinetics of Anticancer Agents. Clinical Pharmacokinetics 43:15, pages 1127-1156.
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Lars E. Schmidt & Kim Dalhoff. (2002) Food-Drug Interactions. Drugs 62:10, pages 1481-1502.
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D. L. Lancaster, N. Patel, L. Lennard & J. S. Lilleyman. (2002) 6‐Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6‐thioguanine nucleotide concentrations. British Journal of Clinical Pharmacology 51:6, pages 531-539.
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Kjeld Schmiegelow, Anders Glomstein, Jon Kristinsson, Toivo Salmi, Henrik Schrøder & Olle Björk. (1997) Impact of Morning Versus Evening Schedule for Oral Methotrexate and 6-Mercaptopurine on Relapse Risk for Children with Acute Lymphoblastic Leukemia. Journal of Pediatric Hematology/Oncology 19:2, pages 102-109.
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P. Lafolie, S. Hayder, O. Björk & C. Peterson. (1991) Intraindividual variation in 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute lymphoblastic leukaemia. European Journal of Clinical Pharmacology 40:6, pages 599-601.
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