248
Views
63
CrossRef citations to date
0
Altmetric
Research Article

ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset

, , , , , , , , , , & show all
Pages 598-606 | Received 12 Oct 2009, Accepted 14 Dec 2009, Published online: 19 Mar 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Lijuan Luan, Rong Xue, Chao Lu, Anfeng Cui, Yanqiang Hou, Jing Quan, Meng Xiang, Xinhong Wang, Wenjun Yuan, Ning Sun, Dan Meng & Sifeng Chen. (2016) Anti-serum with anti-autoantibody activity decreases autoantibody-positive B lymphocytes and type 1 diabetes of female NOD mice. Autoimmunity 49:1, pages 21-30.
Read now
Mette K. Andersen, Taina Härkönen, Carol Forsblom, Per-Henrik Groop, Mikael Knip & Tiinamaija Tuomi. (2013) Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes. Autoimmunity 46:4, pages 251-258.
Read now
Elin Pettersen Sørgjerd, Frank Skorpen, Kirsti Kvaløy, Kristian Midthjell & Valdemar Grill. (2013) Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes. Results from the HUNT study, Norway. Autoimmunity 46:1, pages 74-79.
Read now
Sofie Ingemansson, Fariba Vaziri-Sani, Ulf Lindblad, Soffia Gudbjornsdottir & Carina Törn. (2013) Long-term sustained autoimmune response to beta cell specific zinc transporter (ZnT8, W, R, Q) in young adult patients with preserved beta cell function at diagnosis of diabetes. Autoimmunity 46:1, pages 50-61.
Read now
Lotte B. Nielsen, Fariba Vaziri-Sani, Sven Pörksen, Marie-Louise M. Andersen, Jannet Svensson, Regine Bergholdt, Flemming Pociot, Philip Hougaard, Carine de Beaufort, Luis Castaño, Henrik B. Mortensen, Åke Lernmark & Lars Hansen. (2011) Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes. Autoimmunity 44:8, pages 616-623.
Read now
Jennifer Kjellerås, Fariba Vaziri-Sani & Daniel Agardh. (2011) Improved efficacy by using the pTnT-rhtTG plasmid for the detection of celiac disease specific tissue transglutaminase autoantibodies in radioligand binding assays. Scandinavian Journal of Clinical and Laboratory Investigation 71:8, pages 701-704.
Read now
C. Andersson, K. Larsson, F. Vaziri-Sani, K. Lynch, A. Carlsson, E. Cedervall, B. Jönsson, J. Neiderud, M. Månsson, A. Nilsson, Å. Lernmark, H. Elding Larsson & S.-A. Ivarsson. (2011) The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes. Autoimmunity 44:5, pages 394-405.
Read now

Articles from other publishers (56)

Dudu Erkoc-Kaya, Hilal Arikoglu, Kazim Muslu Korez, Suleyman Hilmi Ipekci & Suleyman Baldane. (2023) Protective effect of the rare variant rs13266634C/T of the SLC30A8 gene in the genetic background of the development of type 2 diabetes in Turkish population. International Journal of Diabetes in Developing Countries 43:6, pages 1052-1060.
Crossref
Siddhartha Sharma, Xuqian Tan, Josh Boyer, Don Clarke, Anne Costanzo, Brian Abe, Lisa Kain, Marie Holt, Adrienne ArmstrongMarynette Rihanek, Andrew Su, Cate Speake, Peter Gottlieb, Michael GottschalkJeremy Pettus & Luc Teyton. (2023) Measuring anti-islet autoimmunity in mouse and human by profiling peripheral blood antigen-specific CD4 T cells. Science Translational Medicine 15:703.
Crossref
Deborah Morrison, Robyn Evans, Rahat Maitland & Greg Jones. (2023) Idiopathic remitting type 1 diabetes: a case report. Practical Diabetes 40:3, pages 33.
Crossref
Xuejiao Zhang, Ying Dong, Dianyuan Liu, Liu Yang, Jiayi Xu & Qing Wang. (2022) Antigen-specific immunotherapies in type 1 diabetes. Journal of Trace Elements in Medicine and Biology 73, pages 127040.
Crossref
Sureka Bhola, Eleanor M Cave, Sindeep Bhana, Nigel J Crowther & Carolyn J Padoa. (2021) Zinc transporter 8 (ZnT8) autoantibody prevalence in black South African participants with type 1 diabetes. BMC Endocrine Disorders 21:1.
Crossref
Sian Louise Grace, Angela Cooper, Angus G Jones & Timothy James McDonald. (2021) Zinc transporter 8 autoantibody testing requires age-related cut-offs. BMJ Open Diabetes Research & Care 9:1, pages e002296.
Crossref
K. Baumann, K. Kesselring, V. Lampasona, U. Walschus, W. Kerner, R. Wassmuth & M. Schlosser. (2020) Autoantibodies against zinc transporter 8 further stratify the autoantibody‐defined risk for type 1 diabetes in a general population of schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes: results from the Karlsburg Type 1 Diabetes Risk Study. Diabetic Medicine 38:2.
Crossref
Anatoly V. Skalny, Michael Aschner & Alexey A. Tinkov. 2021. The Latest Research and Development of Minerals in Human Nutrition. The Latest Research and Development of Minerals in Human Nutrition 251 310 .
Nevena Chakarova, Rumyana Dimova, Mina Serdarova, Greta Grozeva, Maria Kuncheva, Lubomir Kamenov & Tsvetalina Tankova. (2020) Islet, thyroid and transglutaminase antibodies in adult Bulgarian patients with type 1 diabetes. Endocrine 70:2, pages 299-306.
Crossref
Nur Rochmah, Muhammad Faizi & Siti Wahyu Windarti. (2020) Zinc transporter 8 autoantibody in the diagnosis of type 1 diabetes in children. Clinical and Experimental Pediatrics 63:10, pages 402-405.
Crossref
Eiji Kawasaki, Yoichi Oikawa, Akira Okada, Norio Kanatsuna, Tomoyuki Kawamura, Tadashi Kikuchi, Jungo Terasaki, Junnosuke Miura, Yoshihisa Ito & Toshiaki Hanafusa. (2020) Zinc transporter 8 autoantibodies complement glutamic acid decarboxylase and insulinoma‐associated antigen‐2 autoantibodies in the identification and characterization of Japanese type 1 diabetes. Journal of Diabetes Investigation 11:5, pages 1181-1187.
Crossref
Omaima M. Sabek, Maria J. Redondo, Duc T. Nguyen, Christine A. Beamish, Daniel W. Fraga, Christiane S. Hampe, Surya N. Mulukutla, Edward A. Graviss & A. Osama Gaber. (2019) Serum C‐peptide and osteocalcin levels in children with recently diagnosed diabetes. Endocrinology, Diabetes & Metabolism 3:1.
Crossref
H. Yaghootkar, F. Abbasi, N. Ghaemi, A. Rabbani, M. N. Wakeling, P. Eshraghi, S. Enayati, S. Vakili, S. Heidari, K. Patel, F. Sayarifard, S. Borhan‐Dayani, T. J. McDonald, S. Ellard, A. T. Hattersley, M. M. Amoli, R. Vakili & K. Colclough. (2019) Type 1 diabetes genetic risk score discriminates between monogenic and Type 1 diabetes in children diagnosed at the age of <5 years in the Iranian population. Diabetic Medicine 36:12, pages 1694-1702.
Crossref
Sugumar Shruthi, Viswanathan Mohan, Muralidhara Rao Maradana & Vivekanandhan Aravindhan. (2019) In silico identification and wet lab validation of novel cryptic B cell epitopes in ZnT8 zinc transporter autoantigen. International Journal of Biological Macromolecules 127, pages 657-664.
Crossref
Petr Heneberg, Daniela Šimčíková, Marie Čecháková, Blanka Rypáčková, Petr Kučera & Michal Anděl. (2019) Autoantibodies against ZnT8 are rare in Central-European LADA patients and absent in MODY patients, including those positive for other autoantibodies. Journal of Diabetes and its Complications 33:1, pages 46-52.
Crossref
Xuan Qiu, Cuili Ning, Lin Xiao, Jianmin Jing, Zhenyun Mu & Kuanzhi Liu. (2018) Zinc transporter 8 autoantibody (ZnT8A) by ELISA for diagnosing type 1 diabetes among Chinese people. International Journal of Diabetes in Developing Countries 39:1, pages 47-52.
Crossref
Nasim Samandari, Aashiq Mirza, Simranjeet Kaur, Philip Hougaard, Lotte Nielsen, Siri Fredheim, Henrik Mortensen & Flemming Pociot. (2018) Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes. Non-Coding RNA 4:4, pages 35.
Crossref
A. Lounici Boudiaf, D. Bouziane, M. Smara, Y. Meddour, E.M. Haffaf, B. Oudjit, S. Chaib Mamouzi & S. Aouichat Bouguerra. (2018) Could ZnT8 antibodies replace ICA, GAD, IA2 and insulin antibodies in the diagnosis of type 1 diabetes?. Current Research in Translational Medicine 66:1, pages 1-7.
Crossref
James Luke Godwin, Shuchie Jaggi, Imali Sirisena, Pankaj Sharda, Ajay D. Rao, Ranee Mehra & Colleen Veloski. (2017) Nivolumab-induced autoimmune diabetes mellitus presenting as diabetic ketoacidosis in a patient with metastatic lung cancer. Journal for ImmunoTherapy of Cancer 5:1.
Crossref
Natalia I. Faccinetti, Luciano L. Guerra, Adriana V. Sabljic, Silvina S. Bombicino, Bruno D. Rovitto, Ruben F. Iacono, Edgardo Poskus, Aldana Trabucchi & Silvina N. Valdez. (2017) Prokaryotic expression and characterization of the heterodimeric construction of ZnT8 and its application for autoantibodies detection in diabetes mellitus. Microbial Cell Factories 16:1.
Crossref
Maria J Redondo, Beverly A Shirkey, Daniel W Fraga, A. Osama Gaber & Omaima M Sabek. (2017) Serum undercarboxylated osteocalcin correlates with hemoglobin A1c in children with recently diagnosed pediatric diabetes. Pediatric Diabetes 18:8, pages 869-873.
Crossref
Fariba Vaziri-Sani, Charlotte Brundin & Daniel Agardh. (2017) Osteoprotegerin autoantibodies do not predict low bone mineral density in middle-aged women. Bone Reports 7, pages 132-136.
Crossref
Inga Wessels, Martina Maywald & Lothar Rink. (2017) Zinc as a Gatekeeper of Immune Function. Nutrients 9:12, pages 1286.
Crossref
N. Bansal, C. S. Hampe, L. Rodriguez, E. O'Brian Smith, J. Kushner, A. Balasubramanyam & M. J. Redondo. (2017) DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes. Diabetic Medicine 34:5, pages 641-646.
Crossref
Karla Fabiana Brasil Gomes, Cintia Semzezem, Rodolfo Batista, Rosa Tsuneshiro Fukui, Aritania Sousa Santos, Márcia Regina Correia, Maria Rita Passos-Bueno & Maria Elizabeth Rossi da Silva. (2017) Importance of Zinc Transporter 8 Autoantibody in the Diagnosis of Type 1 Diabetes in Latin Americans. Scientific Reports 7:1.
Crossref
Marta Fichna, Anita Rogowicz-Frontczak, Magdalena Żurawek, Piotr Fichna, Maria Gryczyńska, Dorota Zozulińska-Ziółkiewicz & Marek Ruchała. (2016) Positive autoantibodies to ZnT8 indicate elevated risk for additional autoimmune conditions in patients with Addison’s disease. Endocrine 53:1, pages 249-257.
Crossref
D.B. Araujo de Pina Cabral, J.R. Dantas, H. Skärstrand, B. Barone, F. Carvalho, R. Tortora, A. Milech, F. Vaziri-Sani, J.E. P. Oliveira, L. Zajdenverg & M. Rodacki. (2015) Prospective evaluation of glutamine and phospholipids levels in first degree relatives of patients with Type 1 Diabetes from a multiethnic population. Diabetology & Metabolic Syndrome 7:1.
Crossref
Muhammad Ahmad Mujtaba, Jonathan Fridell, Benita Book, Sara Faiz, Asif Sharfuddin, Eric Wiebke, Mark Rigby & Tim Taber. (2015) Re-exposure to beta cell autoantigens in pancreatic allograft recipients with preexisting beta cell autoantibodies. Clinical Transplantation 29:11, pages 991-996.
Crossref
Janet M. Wenzlau, Lisa M. Frisch, John C. Hutton, Pamela R. Fain & Howard W. Davidson. (2015) Changes in Zinc Transporter 8 Autoantibodies Following Type 1 Diabetes Onset: The Type 1 Diabetes Genetics Consortium Autoantibody Workshop. Diabetes Care 38:Supplement_2, pages S14-S20.
Crossref
Bo Yi, Gan Huang & Zhi-Guang Zhou. (2015) Current and Future Clinical Applications of Zinc Transporter-8 in Type 1 Diabetes Mellitus. Chinese Medical Journal 128:17, pages 2387-2394.
Crossref
Walter P. Maksymowych, Gilles Boire, Dirkjan van Schaardenburg, Stephanie Wichuk, Samina Turk, Maarten Boers, Katherine A. Siminovitch, Vivian Bykerk, Ed Keystone, Paul Peter Tak, Arno W. van Kuijk, Robert Landewé, Desiree van der Heijde, Mairead Murphy & Anthony Marotta. (2015) 14-3-3η Autoantibodies: Diagnostic Use in Early Rheumatoid Arthritis. The Journal of Rheumatology 42:9, pages 1587-1594.
Crossref
Gareth Dunseath, Rossitza Ananieva-Jordanova, Rebecca Coles, Michael Powell, Marie Amoroso, Jadwiga Furmaniak, Bernard Rees Smith, Colin Dayan & Stephen Luzio. (2015) Bridging-type enzyme-linked immunoassay for zinc transporter 8 autoantibody measurements in adult patients with diabetes mellitus. Clinica Chimica Acta 447, pages 90-95.
Crossref
H Skärstrand, E Krupinska, T J K Haataja, F Vaziri-Sani, J O Lagerstedt & Å Lernmark. (2015) Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody-positive type 1 diabetes patients. Clinical and Experimental Immunology 179:2, pages 220-229.
Crossref
Åke Lernmark & Daria LaTorre. 2015. Islets of Langerhans. Islets of Langerhans 1047 1080 .
Débora Batista Araujo, Hanna Skärstrand, Bianca Barone, Joana Rodrigues Dantas, Rosane Kupfer, Lenita Zajdenverg, Adolpho Milech, Fariba Vaziri-Sani, José Egídio Paulo de Oliveira & Melanie Rodacki. (2014) Zinc transporter 8 autoantibodies in patients with type 1 diabetes from a multiethnic population and their first degree relatives. Arquivos Brasileiros de Endocrinologia & Metabologia 58:7, pages 737-743.
Crossref
Nicole Fabien. (2014) Les anticorps anti-ZnT8. Revue Francophone des Laboratoires 2014:464, pages 45-47.
Crossref
L. M. Shulman, C. S. Hampe, A. Ben-Haroush, Y. Perepliotchikov, F. Vaziri-Sani, S. Israel, K. Miller, H. Bin, B. Kaplan & Z. Laron. (2014) Antibodies to islet cell autoantigens, rotaviruses and/or enteroviruses in cord blood and healthy mothers in relation to the 2010-2011 winter viral seasons in Israel: a pilot study. Diabetic Medicine 31:6, pages 681-685.
Crossref
Li LiDavid J. RuauChirag J. PatelSusan C. WeberRong ChenNicholas P. TatonettiJoel T. DudleyAtul J. Butte. (2014) Disease Risk Factors Identified Through Shared Genetic Architecture and Electronic Medical Records. Science Translational Medicine 6:234.
Crossref
Maria J Redondo, Jesse Muniz, Luisa M Rodriguez, Dinakar Iyer, Fariba Vaziri-Sani, Morey W Haymond, Christiane S Hampe, Michael L Metzker, Struan F A Grant & Ashok Balasubramanyam. (2014) Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes . BMJ Open Diabetes Research & Care 2:1, pages e000008.
Crossref
L. Petruzelkova, R. Ananieva-Jordanova, J. Vcelakova, Z. Vesely, K. Stechova, J. Lebl, P. Dusatkova, Z. Sumnik, R. Coles, M. Powell, J. Furmaniak, B. Rees Smith & S. Kolouskova. (2014) The dynamic changes of zinc transporter 8 autoantibodies in Czech children from the onset of Type 1 diabetes mellitus. Diabetic Medicine 31:2, pages 165-171.
Crossref
Åke Lernmark & Daria LaTorre. 2013. Islets of Langerhans, 2. ed.. Islets of Langerhans, 2. ed. 1 31 .
Barbara M. Brooks-Worrell, Dinakar Iyer, Ivonne Coraza, Christiane S. Hampe, Ramaswami Nalini, Kerem Ozer, Radhika Narla, Jerry P. Palmer & Ashok Balasubramanyam. (2013) Islet-Specific T-Cell Responses and Proinflammatory Monocytes Define Subtypes of Autoantibody-Negative Ketosis-Prone Diabetes. Diabetes Care 36:12, pages 4098-4103.
Crossref
Hanna Skärstrand, L.B. Dahlin, Å. Lernmark & F. Vaziri-Sani. (2013) Neuropeptide Y autoantibodies in patients with long-term type 1 and type 2 diabetes and neuropathy. Journal of Diabetes and its Complications 27:6, pages 609-617.
Crossref
K. M. Salonen, S. Ryhänen, T. Härkönen, J. Ilonen & M. Knip. (2013) Autoantibodies against zinc transporter 8 are related to age, metabolic state and HLA DR genotype in children with newly diagnosed type 1 diabetes. Diabetes/Metabolism Research and Reviews 29:8, pages 646-654.
Crossref
Francesca Capasso, Novella Rapini, Gigliola Di Matteo, Manuela Testi, Susanna Arcano, Roberta Lidano, Arianna Petrelli, Paolo Rossi, Simona Piccinini, Maria Luisa Manca Bitti & Federica Angelini. (2013) A variable degree of autoimmunity in the pedigree of a patient with type 1 diabetes homozygous for the PTPN 22 1858T variant . Pediatric Diabetes 14:4, pages 304-310.
Crossref
Fabrice Chimienti. (2013) Zinc, pancreatic islet cell function and diabetes: new insights into an old story. Nutrition Research Reviews 26:1, pages 1-11.
Crossref
H. Skärstrand, Å. Lernmark & F. Vaziri‐Sani. (2012) Antigenicity and Epitope Specificity of ZnT8 Autoantibodies in Type 1 Diabetes. Scandinavian Journal of Immunology 77:1, pages 21-29.
Crossref
Daria La Torre. 2013. Diabetes. Diabetes 194 218 .
Marie Louise M Andersen, Fariba Vaziri-Sani, Ahmed Delli, Sven Pörksen, Emma Jacobssen, Jane Thomsen, Jannet Svensson, Jacob Steen Petersen, Lars Hansen, Åke Lernmark, Henrik B Mortensen & Lotte B Nielsen. (2012) Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes. Pediatric Diabetes 13:6, pages 454-462.
Crossref
J. M. M. Howson, S. Krause, H. Stevens, D. J. Smyth, J. M. Wenzlau, E. Bonifacio, J. Hutton, A. G. Ziegler, J. A. Todd & P. Achenbach. (2012) Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases. Diabetologia 55:7, pages 1978-1984.
Crossref
J.S. Sorensen, F. Vaziri-Sani, M. Maziarz, K. Kristensen, A. Ellerman, N. Breslow, Å. Lernmark, F. Pociot, C. Brorsson & N.H. Birkebaek. (2012) Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3–6 years. Diabetes Research and Clinical Practice 96:2, pages 204-210.
Crossref
Beate Karges, Thomas Meissner, Andrea Icks, Thomas Kapellen & Reinhard W. Holl. (2011) Management of diabetes mellitus in infants. Nature Reviews Endocrinology 8:4, pages 201-211.
Crossref
Carlo Selmi. (2011) Autoimmunity in 2010. Autoimmunity Reviews 10:12, pages 725-732.
Crossref
Ilse Vermeulen, Ilse Weets, Milca Asanghanwa, Johannes Ruige, Luc Van Gaal, Chantal Mathieu, Bart Keymeulen, Vito Lampasona, Janet M. Wenzlau, John C. Hutton, Daniel G. Pipeleers & Frans K. Gorus. (2011) Contribution of Antibodies Against IA-2β and Zinc Transporter 8 to Classification of Diabetes Diagnosed Under 40 Years of Age. Diabetes Care 34:8, pages 1760-1765.
Crossref
Fariba Vaziri-Sani, Ahmed J. Delli, Helena Elding-Larsson, Bengt Lindblad, Annelie Carlsson, Gun Forsander, Sten A. Ivarsson, Johnny Ludvigsson, Claude Marcus & Åke Lernmark. (2011) A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes. Journal of Immunological Methods 371:1-2, pages 25-37.
Crossref
William E Winter & Desmond A Schatz. (2011) Autoimmune Markers in Diabetes. Clinical Chemistry 57:2, pages 168-175.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.