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Autoimmunity Volume 46, 2013 - Issue 1
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Selective pharmacological inhibition of phosphoinositide 3-kinase p110delta opposes the progression of autoimmune diabetes in non-obese diabetic (NOD) mice

Caylib A. DurandDepartment of Microbiology and Immunology, Infection, Inflammation, and Immunity (I3) Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
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Martin J. RicherDepartment of Microbiology and Immunology, Infection, Inflammation, and Immunity (I3) Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
,
Kathrin BrenkerDepartment of Microbiology and Immunology, Infection, Inflammation, and Immunity (I3) Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
,
Marcia GravesDepartment of Microbiology and Immunology, Infection, Inflammation, and Immunity (I3) Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
,
Iryna ShaninaDepartment of Microbiology and Immunology, Infection, Inflammation, and Immunity (I3) Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
,
Kate ChoiDepartment of Microbiology and Immunology, Infection, Inflammation, and Immunity (I3) Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
,
Marc S. HorwitzDepartment of Microbiology and Immunology, Infection, Inflammation, and Immunity (I3) Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
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Kamal D. PuriGilead Sciences Inc., Seattle, Washington 98102, USA
&
Michael R. GoldDepartment of Microbiology and Immunology, Infection, Inflammation, and Immunity (I3) Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3Correspondence[email protected]
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Pages 62-73 | Received 01 Feb 2012, Accepted 15 Sep 2012, Published online: 08 Oct 2012

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Kamal D. Puri, Julie A. Di Paolo & Michael R. Gold. (2013) B-Cell Receptor Signaling Inhibitors for Treatment of Autoimmune Inflammatory Diseases and B-Cell Malignancies. International Reviews of Immunology 32:4, pages 397-427.
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Articles from other publishers (15)

Gaia Mancuso, Camillo Bechi Genzano, Alessandra Fierabracci & Georgia Fousteri. (2023) Type 1 diabetes and inborn errors of immunity: Complete strangers or 2 sides of the same coin?. Journal of Allergy and Clinical Immunology 151:6, pages 1429-1447.
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Priyanka Rajan, Premkumar Natraj, Sachithra S. Ranaweera, Lakshi A. Dayarathne, Young Jae Lee & Chang-Hoon Han. (2022) Anti-diabetic effect of hesperidin on palmitate (PA)-treated HepG2 cells and high fat diet-induced obese mice. Food Research International 162, pages 112059.
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Stephen G. Ward. 2022. PI3K and AKT Isoforms in Immunity. PI3K and AKT Isoforms in Immunity 337 347 .
Hong Sun, Cunyu Li, Shufa Li, Xunhua Li, Jinguang Wang, Zhongqi Zhou & Mingtao Shao. (2018) Gene silencing of ZnT8 attenuates inflammation and protects pancreatic tissue injury in T1D. Immunology Letters 198, pages 1-6.
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Montse Erra, Joan Taltavull, Angelique Gréco, Francisco Javier Bernal, Juan Francisco Caturla, Jordi Gràcia, María Domínguez, Mar Sabaté, Stéphane Paris, Salomé Soria, Begoña Hernández, Clara Armengol, Judit Cabedo, Mónica Bravo, Elena Calama, Montserrat Miralpeix & Martin D. Lehner. (2016) Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases. ACS Medicinal Chemistry Letters 8:1, pages 118-123.
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Klemens Hoegenauer, Nicolas Soldermann, Christina Hebach, Gregory J. Hollingworth, Ian Lewis, Anette von Matt, Alexander B. Smith, Romain M. Wolf, Rainer Wilcken, Dorothea Haasen, Christoph Burkhart & Frédéric Zécri. (2016) Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties. Bioorganic & Medicinal Chemistry Letters 26:23, pages 5657-5662.
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Klemens Hoegenauer, Nicolas Soldermann, Frédéric Stauffer, Pascal Furet, Nadege Graveleau, Alexander B. Smith, Christina Hebach, Gregory J. Hollingworth, Ian Lewis, Sascha Gutmann, Gabriele Rummel, Mark Knapp, Romain M. Wolf, Joachim Blanz, Roland Feifel, Christoph Burkhart & Frédéric Zécri. (2016) Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors. ACS Medicinal Chemistry Letters 7:8, pages 762-767.
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Ariana Barbera Betancourt, Juliet L. Emery, Asha Recino, F. Susan Wong, Anne Cooke, Klaus Okkenhaug & Maja Wallberg. (2016) Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production. PLOS ONE 11:1, pages e0146516.
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Anne-Katrien Stark, Srividya Sriskantharajah, Edith M Hessel & Klaus Okkenhaug. (2015) PI3K inhibitors in inflammation, autoimmunity and cancer. Current Opinion in Pharmacology 23, pages 82-91.
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Qiming Duan, Namrata D. Madan, Jian Wu, Jennifer Kalisz, Krunal Y. Doshi, Saptarsi M. Haldar, Lijun Liu & Sandrine V. Pierre. (2015) Role of phosphoinositide 3-kinase IA (PI3K-IA) activation in cardioprotection induced by ouabain preconditioning. Journal of Molecular and Cellular Cardiology 80, pages 114-125.
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Borja Quiroga, David Arroyo & Gabriel de Arriba. (2015) Present and Future in the Treatment of Diabetic Kidney Disease. Journal of Diabetes Research 2015, pages 1-13.
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Jennifer Ball, Sophie Archer & Stephen Ward. (2014) PI3K inhibitors as potential therapeutics for autoimmune disease. Drug Discovery Today 19:8, pages 1195-1199.
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Beatriz Fernandez-Fernandez, Alberto Ortiz, Carmen Gomez-Guerrero & Jesus Egido. (2014) Therapeutic approaches to diabetic nephropathy—beyond the RAS. Nature Reviews Nephrology 10:6, pages 325-346.
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Yanxia Wang, Lei Zhang, Ping Wei, Huailiang Zhang & Cuijie Liu. (2014) Inhibition of PI3Kδ Improves Systemic Lupus in Mice. Inflammation 37:3, pages 978-983.
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Massimo Gadina. (2014) Advances in kinase inhibition. Current Opinion in Rheumatology 26:2, pages 237-243.
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