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Autoimmunity Volume 47, 2014 - Issue 8
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Research Articles

The defective bone marrow-derived mesenchymal stem cells in patients with chronic immune thrombocytopenia

Donglei ZhangState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College TianjinChina
,
Huiyuan LiState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College TianjinChina
,
Li MaState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College TianjinChina
,
Xian ZhangState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College TianjinChina
,
Feng XueState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College TianjinChina
,
Zeping ZhouState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College TianjinChina;Department of Hematology, The Second Affiliated Hospital of Kunming Medical University KunmingChina
,
Ying ChiState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College TianjinChina
,
Xiaofan LiuState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College TianjinChina
,
Yueting HuangState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College TianjinChina
,
Yanhui YangState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College TianjinChina;Key Laboratory of Hormones and Development (Ministry of Health), 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics TianjinChina
&
Renchi YangState Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College TianjinChinaCorrespondence[email protected]
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Pages 519-529 | Received 22 Sep 2013, Accepted 22 Jun 2014, Published online: 14 Jul 2014

Citations (20)

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Read on this site (2)

Jun-Ying Wang, Shuang Ye & Hua Zhong. (2017) The role of bone marrow microenvironment in platelet production and their implications for the treatment of thrombocytopenic diseases. Hematology 22:10, pages 630-639.
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Xian Zhang, Donglei Zhang, Wenjie Liu, Huiyuan Li, Rongfeng Fu, Xiaofan Liu, Feng Xue & Renchi Yang. (2016) Abnormal lipid rafts related ganglioside expression and signaling in T lymphocytes in immune thrombocytopenia patients. Autoimmunity 49:1, pages 58-68.
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Articles from other publishers (18)

Feifeng Wu, Zhou She, Cuifang Li, Jueyi Mao, Senlin Luo, Xiaoyu Chen, Jidong Tian & Chuan Wen. (2023) Therapeutic potential of MSCs and MSC-derived extracellular vesicles in immune thrombocytopenia. Stem Cell Research & Therapy 14:1.
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Yue Lv, Huiping Shi, Hong Liu & Lu Zhou. (2022) Current therapeutic strategies and perspectives in refractory ITP: What have we learned recently?. Frontiers in Immunology 13.
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Alessandra Di Paola, Giuseppe Palumbo, Chiara Tortora, Maura Argenziano, Marialuigia Catanoso, Caterina Di Leva, Giulia Ceglie, Silverio Perrotta, Franco Locatelli & Francesca Rossi. (2021) Eltrombopag in paediatric immune thrombocytopenia: Iron metabolism modulation in mesenchymal stromal cells. British Journal of Haematology 197:1, pages 110-119.
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Sandra Muntión, Silvia Preciado, Elena Sánchez-Luis, Luis Corchete, María Díez-Campelo, Lika Osugui, Gerardo-Javier Martí-Chillón, María-Belén Vidriales, Almudena Navarro-Bailón, Javier De Las Rivas & Fermín Sánchez-Guijo. (2022) Eltrombopag increases the hematopoietic supporting ability of mesenchymal stem/stromal cells. Therapeutic Advances in Hematology 13, pages 204062072211421.
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Yue He, Dexiang Ji, Wei Lu & Guoan Chen. (2022) The Mechanistic Effects and Clinical Applications of Various Derived Mesenchymal Stem Cells in Immune Thrombocytopenia. Acta Haematologica 145:1, pages 9-17.
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Tian-shu YuHao-yi WangYa-jing ZhaoYa-fei Yu, Yu Hou, Shuang LiuPan-pan HanXiao-fei NiXue-bin JiJun Peng, Xin-guang LiuMing Hou. (2021) Abnormalities of bone marrow B cells and plasma cells in primary immune thrombocytopenia. Blood Advances 5:20, pages 4087-4101.
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José Carlos Jaime-Pérez, Eugenia M. Ramos-Dávila, Jesús D. Meléndez-Flores, Andrés Gómez-De León & David Gómez-Almaguer. (2021) Insights on chronic immune thrombocytopenia pathogenesis: A bench to bedside update. Blood Reviews 49, pages 100827.
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Huiyuan Li, Yue Guan, Boyang Sun, Xueqing Dou, Xiaofan Liu, Feng Xue, Rongfeng Fu, Lei Zhang & Renchi Yang. (2020) Role of bone marrow‐derived mesenchymal stem cell defects in CD8 + CD28 – suppressor T‐lymphocyte induction in patients with immune thrombocytopenia and associated mechanisms . British Journal of Haematology 191:5, pages 852-862.
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Yanan Wang, Jiamin Zhang, Yan Su, Chencong Wang, Gaochao Zhang, Xiao Liu, Qi Chen, Meng Lv, Yingjun Chang, Jun Peng, Ming Hou, Xiaojun Huang & Xiaohui Zhang. (2020) miRNA-98-5p Targeting IGF2BP1 Induces Mesenchymal Stem Cell Apoptosis by Modulating PI3K/Akt and p53 in Immune Thrombocytopenia. Molecular Therapy - Nucleic Acids 20, pages 764-776.
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Fataneh Tavasolian, Ahmad Z. Hosseini, Ali Mirzaei, Elham Abdollahi, Pouria Jandaghi, Sara Soudi, Mahmood Naderi, Ehsan Saburi, Amir Abbas Momtazi‐Borojeni, Thomas P. Johnston & Amirhossein Sahebkar. (2019) Unfolded protein response‐mediated modulation of mesenchymal stem cells. IUBMB Life 72:2, pages 187-197.
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Jia-Min Zhang, Xiao-Lu Zhu, Jing Xue, Xiao Liu, X. Long Zheng, Ying-Jun Chang, Kai-Yan Liu, Xiao-Jun Huang & Xiao-Hui Zhang. (2018) Integrated mRNA and miRNA profiling revealed deregulation of cellular stress response in bone marrow mesenchymal stem cells derived from patients with immune thrombocytopenia. Functional & Integrative Genomics 18:3, pages 287-299.
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Yun He, Lin-Lin Xu, Fei-Er Feng, Qian-Ming Wang, Xiao-Lu Zhu, Chen-Cong Wang, Jia-Min Zhang, Hai-Xia Fu, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang & Xiao-Hui Zhang. (2018) Mesenchymal stem cell deficiency influences megakaryocytopoiesis through the TNFAIP3/NF-κB/SMAD pathway in patients with immune thrombocytopenia. British Journal of Haematology 180:3, pages 395-411.
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Lin-lin XuHai-xia FuJia-min ZhangFei-er FengQian-ming WangXiao-lu ZhuJing XueChen-cong WangQi ChenXiao LiuYa-zhe WangYa-zhen QinYuan KongYing-Jun ChangLan-ping XuKai-yan LiuXiao-jun HuangXiao-hui Zhang. (2017) Impaired Function of Bone Marrow Mesenchymal Stem Cells from Immune Thrombocytopenia Patients in Inducing Regulatory Dendritic Cell Differentiation Through the Notch-1/Jagged-1 Signaling Pathway. Stem Cells and Development 26:22, pages 1648-1661.
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Huiyuan Li, Yating Hao, Donglei Zhang, Wenjie Liu, Yang Li, Mingen Lyu, Rongfeng Fu, Feng Xue, Xiaofan Liu & Renchi Yang. (2017) Numerical and functional defects in CD8 + CD28 − T-suppressor lymphocytes from patients with primary immune thrombocytopenia . British Journal of Haematology 178:2, pages 292-301.
Crossref
Anne Zufferey, Rick Kapur & John Semple. (2017) Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP). Journal of Clinical Medicine 6:2, pages 16.
Crossref
Vito Pistoia & Lizzia Raffaghello. (2017) Mesenchymal stromal cells and autoimmunity. International Immunology 29:2, pages 49-58.
Crossref
Jia-min Zhang, Fei-er Feng, Qian-ming Wang, Xiao-lu Zhu, Hai-xia Fu, Lan-ping Xu, Kai-yan Liu, Xiao-jun Huang & Xiao-hui Zhang. (2016) Platelet-Derived Growth Factor-BB Protects Mesenchymal Stem Cells (MSCs) Derived From Immune Thrombocytopenia Patients Against Apoptosis and Senescence and Maintains MSC-Mediated Immunosuppression. Stem Cells Translational Medicine 5:12, pages 1631-1643.
Crossref
Elaheh Khodadi, Ali Amin Asnafi, Saeid Shahrabi, Mohammad Shahjahani & Najmaldin Saki. (2016) Bone marrow niche in immune thrombocytopenia: a focus on megakaryopoiesis. Annals of Hematology 95:11, pages 1765-1776.
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