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Original Article

Interleukin-1β Increases the Biosynthesis of the Heat Shock Protein hsp70 and Selectively Decreases the Biosynthesis of five Proteins in rat Pancreatic Islets

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Pages 33-40 | Received 31 Jul 1990, Accepted 19 Oct 1990, Published online: 07 Jul 2009

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Read on this site (6)

Thomas Sparre, Regine Bergholdt, Jørn Nerup & Flemming Pociot. (2003) Application of genomics and proteomics in Type 1 diabetes pathogenesis research. Expert Review of Molecular Diagnostics 3:6, pages 743-757.
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U. Bjerre Christensen, P. Mose Larsen, S. J. Fey, H. Ullits Andersen, A. Nawrocki, T. Sparre, T. Mandrup-Poulsen & J. Nerup. (2000) Islet Protein Expression Changes during Diabetes Development in Islet Syngrafts in BB-DP Rats and during Rejection of BB-DP Islet Allografts. Autoimmunity 32:1, pages 1-15.
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Stellan Sandler$suffix/text()$suffix/text(), Annika K. Andersson, Andreea Barbu, Claes Hellerström, Maria Holstad, Ella Karlsson, Jan-Olov Sandberg, Eva Strandell, Johan Saldeen, Johnny Sternesjö, Linda Tillmar, Decio L. Eizirik, Malin Flodström & Nils Welsh. (2000) Novel Experimental Strategies to Prevent the Development of Type 1 Diabetes Mellitus. Upsala Journal of Medical Sciences 105:2, pages 17-34.
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Wei Hao & Jerry P. Palmer. (1995) The Effect of Cytokines on Expression of Glutamic Acid Decarboxylase-65 in Cultured Islets. Autoimmunity 22:4, pages 209-218.
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Stellan Sandler, Décio L. Eizirik, Carina Svensson, Eva Strandell, Michael Welsh & Nils Welsh. (1991) Biochemical and Molecular Actions of Interleukin-1 on Pancreatic β-Cells. Autoimmunity 10:3, pages 241-253.
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Claes Hellerström, Décio L. Eizirik, Nils Welsh, Åke Sjöholm, Leif Jansson, Carina Svensson, Eva Strandell, Olle Korsgren, Zuo-Qiang Li, Arne Andersson & Stellan Sandler. (1991) New Perspectives on the Structure and Function of the Normal and Diabetic β-cell. Upsala Journal of Medical Sciences 96:1, pages 1-16.
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Articles from other publishers (19)

Amanda Almeida de Oliveira, Valentina Ochoa Mendoza, Swasti Rastogi & Kenia Pedrosa Nunes. (2022) New insights into the role and therapeutic potential of HSP70 in diabetes. Pharmacological Research 178, pages 106173.
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Mauricio Krause, Patricia Martins Bock, Hilton Kenji Takahashi, Paulo Ivo Homem De BittencourtJrJr & Philip Newsholme. (2015) The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes. Clinical Science 128:11, pages 789-803.
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N. L. Millar, G. A. C. Murrell & I. B. McInnes. (2013) Alarmins in tendinopathy: unravelling new mechanisms in a common disease. Rheumatology 52:5, pages 769-779.
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Dariush MokhtariAndreea BarbuIlir Mehmeti, Chantal Vercamer & Nils Welsh. (2009) Overexpression of the nuclear factor-κB subunit c-Rel protects against human islet cell death in vitro. American Journal of Physiology-Endocrinology and Metabolism 297:5, pages E1067-E1077.
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P. Bergsten. (2009) Islet protein profiling. Diabetes, Obesity and Metabolism 11, pages 97-117.
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Dariush Mokhtari, Björn Åkerblom, Ilir Mehmeti, Xuan Wang, Nina S. Funa, Johan Olerud, Sigurd Lenzen, Nils Welsh & Michael Welsh. (2009) Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice. Biochemical and Biophysical Research Communications 387:3, pages 553-557.
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P. Mose Larsen, S.J. Fey, M.R. Larsen, A. Nawrocki, H.U. Andersen, H. Kähler, C. Heilmann, M.C. Voss, P. Roepstorff, F. Pociot, A.E. Karlsen & J. Nerup. (2001) Proteome Analysis of Interleukin-1β–Induced Changes in Protein Expression in Rat Islets of Langerhans. Diabetes 50:5, pages 1056-1063.
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Daniel Brandhorst, Hans-Peter Hammes, Heide Brandhorst, Anke Zwolinski, Fariborz Nahidi, Alexandra Alt & Reinhard G. Bretzel. (2017) Pretransplant Induction of HSP-70 in Isolated Adult Pig Islets Decreases Early Islet Xenograft Survival. Cell Transplantation 9:3, pages 423-430.
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M.J. Rewinski, M. Krastins, R.T. Schweizer & G.A. Perdrizet. (1997) Acute stress impairs lymphocyte function but spares pancreatic endocrine function. Transplantation Proceedings 29:4, pages 2047-2049.
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Henrik U. Andersen, Stephen J. Fey, Peter Mose Larsen, Arkadiusz Nawrocki, Kim R. Hejnæs, Thomas Mandrup-Poulsen & Jørn Nerup. (1997) Interleukin-1β induced changes in the protein expression of rat islets: A computerized database. Electrophoresis 18:11, pages 2091-2103.
Crossref
D. L. Eizirik, M. Flodström, A. E. Karlsen & N. Welsh. (1996) The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia 39:8, pages 875-890.
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John A. Corbett & Michael L. McDaniel. 1996. Nitric Oxide. Nitric Oxide 177 217 .
W. HAO & J.P. PALMER. (1995) Recombinant Human Transforming Growth Factor β Does Not Inhibit the Effects of Interleukin-1β on Pancreatic Islet Cells. Journal of Interferon & Cytokine Research 15:12, pages 1075-1081.
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Eva Strandell, Karsten Buschard, Johan Saldeen & Nils Welsh. (1995) Interleukin-1β induces the expression of HSP70, heme oxygenase and Mn-SOD in FACS-purified rat islet β-cells, but not in α-cells. Immunology Letters 48:2, pages 145-148.
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A. Dunger, D. Schröder, P. Augstein, T. Witstruck, G. Wachlin, L. Vogt, B. Ziegler & S. Schmidt. (1995) Impact of metabolic activity of beta cells on cytokine-induced damage and recovery of rat pancreatic islets. Acta Diabetologica 32:4, pages 217-224.
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Nils Welsh, Boris Margulis, L. A. Håkan Borg, Helena Jernberg Wiklund, Johan Saldeen, Malin Flodström, Maria Alice Mello, Arne Andersson, Daniel G. Pipeleers, Claes Hellerström & Decio L. Eizirik. (1995) Differences in the Expression of Heat-Shock Proteins and Antioxidant Enzymes between Human and Rodent Pancreatic Islets: Implications for the Pathogenesis of Insulin-Dependent Diabetes Mellitus. Molecular Medicine 1:7, pages 806-820.
Crossref
N. Welsh & S. Sandler. (1994) Protective action by hemin against interleukin-1β induced inhibition of rat pancreatic islet function. Molecular and Cellular Endocrinology 103:1-2, pages 109-114.
Crossref
P. Arkhammar, L. Juntti-Berggren, O. Larsson, M. Welsh, E. Nånberg, A. Sjöholm, M. Köhler & P.O. Berggren. (1994) Protein kinase C modulates the insulin secretory process by maintaining a proper function of the beta-cell voltage-activated Ca2+ channels.. Journal of Biological Chemistry 269:4, pages 2743-2749.
Crossref
E. Strandell, S. Sandler, C. Boitard & D. L. Eizirik. (1992) Role of infiltrating T cells for impaired glucose metabolism in pancreatic islets isolated from non-obese diabetic mice. Diabetologia 35:10, pages 924-931.
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