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Autoimmunity Volume 25, 1997 - Issue 2
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Original Article

High Circulating IL-6 Level in Graves' Ophthalmopathy

Ildikó Molnár 3rd Department of Internal Medicine, Kenézy County Teaching Hospital, H-4043 Debrecen, Bartók B.u. 2-26., Hungary
&
Csaba Balazs 3rd Department of Internal Medicine, Kenézy County Teaching Hospital, H-4043 Debrecen, Bartók B.u. 2-26., Hungary
Pages 91-96 | Received 12 Dec 1995, Accepted 03 Aug 1996, Published online: 07 Jul 2009

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Oliver Dorado Cortez, Damien Grivet, Nicolas Perrillat, Philippe Gain & Gilles Thuret. (2023) Treatment of corticosteroid-resistant Graves’ orbitopathy with tocilizumab: a single-centre prospective study. Orbit 42:4, pages 411-417.
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Mariya Asenova Stoynova, Alexander Dimitrov Shinkov, Georgi Kirilov Georgiev & Roussanka Dimitrova Kovatcheva. (2021) Association between Clinical Activity Score and Serum Interleukin-6, Interleukin-8 and Interleukin-10 during Systemic Glucocorticoid Treatment for Active Moderate-to-Severe Graves’ Orbitopathy. Current Eye Research 46:10, pages 1503-1508.
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Fatemeh Rajaii, Allison N McCoy & Terry J Smith. (2014) Cytokines as villains and potential therapeutic targets in thyroid-associated ophthalmopathy: from bench to bedside. Expert Review of Ophthalmology 9:3, pages 227-234.
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Katarzyna Lacka, Ewa Manuszewska, Izabela Korczowska & Jan K. Lacki. (2007) The Effect of Methylprednisolone Pulse Treatment on Cytokine Network in Graves Ophthalmopathy. Current Eye Research 32:3, pages 291-297.
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Tomasz Bednarczuk, Alina Kuryłowicz, Yuji Hiromatsu, Jacek Kiljański, Anna Telichowska & Janusz Nauman. (2004) Association of G-174C Polymorphism of the Interleukin-6 Gene Promoter with Graves' Ophthalmopathy. Autoimmunity 37:3, pages 223-226.
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R.A. Ajjan & A.P. Weetman. (2003) Cytokines in Thyroid Autoimmunity. Autoimmunity 36:6-7, pages 351-359.
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Articles from other publishers (36)

Bita Mohammadi, Kamal Dua, Mohammadreza Saghafi, Sachin Kumar Singh, Zahra Heydarifard & Milad Zandi. (2023) COVID‐19‐induced autoimmune thyroiditis: Exploring molecular mechanisms. Journal of Medical Virology 95:8.
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Pengbo Zhang & Huang Zhu. (2022) Cytokines in Thyroid-Associated Ophthalmopathy. Journal of Immunology Research 2022, pages 1-12.
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Hans Olav Ueland, Grethe Åstrøm Ueland, Kristian Løvås, Lars Ertesvåg Breivk, Alexander Stanley Thrane, Ann-Elin Meling Stokland, Eyvind Rødahl & Eystein Sverre Husebye. (2022) Novel inflammatory biomarkers in thyroid eye disease. European Journal of Endocrinology 187:2, pages 293-300.
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Niranjan Karthik Senthil Kumar, Senthamarai G & Samarapuri A. (2022) Correlation of clinical parameters and objective assessment tools in active thyroid eye disease – Prospective analytical study. IP International Journal of Ocular Oncology and Oculoplasty 8:1, pages 31-36.
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E. J. Neag & T. J. Smith. (2021) 2021 update on thyroid-associated ophthalmopathy. Journal of Endocrinological Investigation 45:2, pages 235-259.
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Tiago Borges, Arsénio Barbosa & Sérgio Silva. 2022. Translational Autoimmunity. Translational Autoimmunity 83 114 .
Ildikó Molnár. 2021. Graves' Disease. Graves' Disease.
Nicholas R. Mahoney & Fatemeh Rajaii. (2021) Current Management of Thyroid Eye Disease. Current Treatment Options in Neurology 23:7.
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Charlene Y. C. Chau, Kendrick C. Shih, Loraine L. W. Chow & Victor H. F. Lee. (2020) Considerations for Use of Immune Checkpoint Inhibitors in Cancer Therapy for Patients with Co-Existing Thyroid Eye Disease. Ophthalmology and Therapy 10:1, pages 5-12.
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Yi-Hsuan Wei, Shu-Lang Liao, Chia-Chun Wang, Sen-Hsu Wang, Wan-Chun Tang & Chang-Hao Yang. (2021) Simvastatin Inhibits CYR61 Expression in Orbital Fibroblasts in Graves’ Ophthalmopathy through the Regulation of FoxO3a Signaling. Mediators of Inflammation 2021, pages 1-12.
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Pui S. Chan, Qingqing Li, Bowen Zhang, Kenneth K.W. To & Sharon S.Y. Leung. (2020) In vivo biocompatibility and efficacy of dexamethasone-loaded PLGA-PEG-PLGA thermogel in an alkali-burn induced corneal neovascularization disease model. European Journal of Pharmaceutics and Biopharmaceutics 155, pages 190-198.
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John Y. Lee, Ryan A. Gallo, Paul J. Ledon, Wensi Tao, David T. Tse, Daniel Pelaez & Sara T. Wester. (2020) Integrating Differential Gene Expression Analysis with Perturbagen-Response Signatures May Identify Novel Therapies for Thyroid-Associated Orbitopathy. Translational Vision Science & Technology 9:9, pages 39.
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Ildikó Molnár. (2020) Interactions among thyroid hormone (FT4), chemokine (MCP-1) and neurotrophin (NGF-β) levels studied in Hungarian postmenopausal and obese women. Cytokine 127, pages 154948.
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Alan Chun Hong Lee & George J. Kahaly. (2020) Novel Approaches for Immunosuppression in Graves’ Hyperthyroidism and Associated Orbitopathy. European Thyroid Journal 9:Suppl. 1, pages 17-30.
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Ildikó Molnár, József A. Szentmiklósi, Rudolf Gesztelyi & Éva Somogyiné-Vári. (2019) Effect of antithyroid drugs on the occurrence of antibodies against type 2 deiodinase (DIO2), which are involved in hyperthyroid Graves’ disease influencing the therapeutic efficacy. Clinical and Experimental Medicine 19:2, pages 245-254.
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Safikur Rahman, Ayyagari Archana, Arif Tasleem Jan, Durgashree Dutta, Abhishek Shankar, Jihoe Kim & Rinki Minakshi. (2019) Molecular Insights Into the Relationship Between Autoimmune Thyroid Diseases and Breast Cancer: A Critical Perspective on Autoimmunity and ER Stress. Frontiers in Immunology 10.
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Edina Kishazi, Marianne Dor, Simone Eperon, Aurélie Oberic, Natacha Turck & Mehrad Hamedani. (2018) Differential profiling of lacrimal cytokines in patients suffering from thyroid-associated orbitopathy. Scientific Reports 8:1.
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Utta Berchner-Pfannschmidt, Sajad Moshkelgosha, Salvador Diaz-Cano, Bärbel Edelmann, Gina-Eva Görtz, Mareike Horstmann, Alistair Noble, Wiebke Hansen, Anja Eckstein & J. Paul Banga. (2016) Comparative Assessment of Female Mouse Model of Graves' Orbitopathy Under Different Environments, Accompanied by Proinflammatory Cytokine and T-Cell Responses to Thyrotropin Hormone Receptor Antigen. Endocrinology 157:4, pages 1673-1682.
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Yunhai Tu, Yilong Wang, Luna Ding, Jiao Zhang & Wencan Wu. (2016) Development of a Novel Thyroid Function Fluctuated Animal Model for Thyroid-Associated Ophthalmopathy. PLOS ONE 11:2, pages e0148595.
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Kah Hie Wong, Shi Song Rong, Kelvin K. L. Chong, Alvin L. Young, Chi Pui Pang & Li Jia Chen. (2015) Genetic Associations of Interleukin-related Genes with Graves’ Ophthalmopathy: a Systematic Review and Meta-analysis. Scientific Reports 5:1.
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Nupur Raychaudhuri, Roshini Fernando & Terry J. Smith. (2013) Thyrotropin Regulates IL-6 Expression in CD34+ Fibrocytes: Clear Delineation of Its cAMP-Independent Actions. PLoS ONE 8:9, pages e75100.
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Dana Butnaru, José V. Pérez-Moreiras & Silvia Sánchez-Ramón. (2013) Anti-IL-6R therapy on Graves' ophthalmopathy. Clinical Immunology 147:2, pages 120-121.
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Nupur Raychaudhuri, Raymond S. Douglas & Terry J. Smith. (2010) PGE2 Induces IL-6 in Orbital Fibroblasts through EP2 Receptors and Increased Gene Promoter Activity: Implications to Thyroid-Associated Ophthalmopathy. PLoS ONE 5:12, pages e15296.
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Seema KumarReagan SchieferMichael J. CoenenRebecca S. Bahn. (2010) A Stimulatory Thyrotropin Receptor Antibody (M22) and Thyrotropin Increase Interleukin-6 Expression and Secretion in Graves' Orbital Preadipocyte Fibroblasts. Thyroid 20:1, pages 59-65.
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Terry J. SmithChieh Chih TsaiMei-Ju ShihShanli TsuiBeiling ChenRui HanVibha NaikChris S. KingChris PressShweta KamatRobert A. GoldbergRichard P. PhippsRaymond S. DouglasAndrew G. Gianoukakis. (2008) Unique Attributes of Orbital Fibroblasts and Global Alterations in IGF-1 Receptor Signaling Could Explain Thyroid-Associated Ophthalmopathy. Thyroid 18:9, pages 983-988.
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Roy Moncayo & Helga Moncayo. (2007) A musculoskeletal model of low grade connective tissue inflammation in patients with thyroid associated ophthalmopathy (TAO): the WOMED concept of lateral tension and its general implications in disease. BMC Musculoskeletal Disorders 8:1.
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Beiling Chen, Shanli Tsui & Terry J. Smith. (2005) IL-1β Induces IL-6 Expression in Human Orbital Fibroblasts: Identification of an Anatomic-Site Specific Phenotypic Attribute Relevant to Thyroid-Associated Ophthalmopathy. The Journal of Immunology 175:2, pages 1310-1319.
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R. A. Ajjan & A. P. Weetman. (2014) New understanding of the role of cytokines in the pathogenesis of Graves’ ophthalmopathy. Journal of Endocrinological Investigation 27:3, pages 237-245.
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Seema Kumar & Rebecca S. Bahn. (2003) Relative Overexpression of Macrophage-Derived Cytokines in Orbital Adipose Tissue from Patients with Graves’ Ophthalmopathy. The Journal of Clinical Endocrinology & Metabolism 88:9, pages 4246-4250.
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Yuji HiromatsuHiroo KakuIkuyo MiyakeShiro MurayamaEri Soejima. (2002) Role of Cytokines in the Pathogenesis of Thyroid-Associated Ophthalmopathy. Thyroid 12:3, pages 217-221.
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Rebecca S. Bahn. (2002) Thyrotropin Receptor Expression in Orbital Adipose/Connective Tissues from Patients with Thyroid-Associated Ophthalmopathy. Thyroid 12:3, pages 193-195.
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Soma C. JyonouchiRosanee W. ValyaseviDebra A. HarteneckCharyl M. DuttonRebecca S. Bahn. (2001) Interleukin-6 Stimulates Thyrotropin Receptor Expression in Human Orbital Preadipocyte Fibroblasts from Patients with Graves' Ophthalmopathy. Thyroid 11:10, pages 929-934.
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Yuji Hiromatsu & Tomasz Bednarczukt. 2001. Thyroid Eye Disease. Thyroid Eye Disease 45 65 .
Yuji Hiromatsu, Dame Yang, Tomasz Bednarczuk, Ikuyo Miyake, Kyohei Nonaka & Yoichi Inoue. (2000) Cytokine Profiles in Eye Muscle Tissue and Orbital Fat Tissue from Patients with Thyroid-Associated Ophthalmopathy*. The Journal of Clinical Endocrinology & Metabolism 85:3, pages 1194-1199.
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A. Siddiqi, J. P. Monson, D. F. Wood, G. M. Besser & J. M. Burrin. (1999) Serum Cytokines in Thyrotoxicosis1. The Journal of Clinical Endocrinology & Metabolism 84:2, pages 435-439.
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Gregor Förster & George Kahaly. (1998) Endokrine Orbitopathie 1998Graves’ Ophthalmopathy 1998. Medizinische Klinik 93:6, pages 365-373.
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