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Research Article

Garlic Extracts Stimulate Proliferation of Rat Lymphocytes in Vitro by Increasing IL-2 and IL-4 Production

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Pages 163-181 | Published online: 27 Sep 2008

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Gauri Desai, Michelle Schelske-Santos, Cruz M. Nazario, Rosa V. Rosario-Rosado, Imar Mansilla-Rivera, Farah Ramírez-Marrero, Jing Nie, Ajay A. Myneni, Zuo-Feng Zhang, Jo L. Freudenheim & Lina Mu. (2020) Onion and Garlic Intake and Breast Cancer, a Case-Control Study in Puerto Rico. Nutrition and Cancer 72:5, pages 791-800.
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Dinçer Altınel, Merdan Serin, Havva Erdem, Burcu Biltekin, Mert Celikten, Sevgi Kurt Yazar, Gaye Toplu & Eymen Oruc. (2019) The beneficial effects of subcutaneous Allium cepa injection on random flap survival in rats. Journal of Plastic Surgery and Hand Surgery 53:5, pages 260-264.
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Alireza Zamani, Mohammad Hoseinipanah, Hasan Madadi & Mehdi Arjipour. (2011) Effect of garlic consumption on the argyrophilic nucleolar organiser regions (AgNORs) in splenocytes and thymocytes of rats. Food and Agricultural Immunology 22:4, pages 345-353.
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Masood Sadiq Butt, Muhammad Tauseef Sultan, MehmoodS. Butt & Javaid Iqbal. (2009) Garlic: Nature's Protection Against Physiological Threats. Critical Reviews in Food Science and Nutrition 49:6, pages 538-551.
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Jiyeon Kim, Dae Han Lee, Bazarragchaa Badamtsetseg, Sangwoo Lee & Soon Ae Kim. (2020) Anti-Proliferative Effect of Allium senescens L. Extract in Human T-Cell Acute Lymphocytic Leukemia Cells. Molecules 26:1, pages 35.
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Kivanc Seref, Kaan Sonmez, Merve Altin Gulburun, Ozgur Ekinci, Ceren Bilkan Oge, Ozlem Gulbahar, Burak Arslan, Hasan Dagli, Ramazan Karabulut & Zafer Turkyilmaz. (2020) Protective Effects of Contractubex® on Stricture Formation after Experimental Corrosive Esophageal Burns in Rats. Archives of Medical Research 51:7, pages 664-669.
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Ning Zhao, Min-Jie Guan, Ming-Jun Li & Tao Zeng. (2018) Effects of garlic-derived lipid soluble organosulfur compounds on hematological parameters in mice. Journal of Functional Foods 46, pages 85-89.
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Mouna Moutia, Norddine Habti & Abdallah Badou. (2018) In Vitro and In Vivo Immunomodulator Activities of Allium sativum L. . Evidence-Based Complementary and Alternative Medicine 2018, pages 1-10.
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Yeldur P. Venkatesh. 2018. Immunology. Immunology 203 224 .
Wamidh H. Talib. (2017) Consumption of garlic and lemon aqueous extracts combination reduces tumor burden by angiogenesis inhibition, apoptosis induction, and immune system modulation. Nutrition 43-44, pages 89-97.
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Mouna Moutia, Fouad Seghrouchni, Omar Abouelazz, Anass Elouaddari, Abdellah Al Jahid, Abdelhalim Elhou, Sellama Nadifi, Jamal Jamal Eddine, Norddine Habti & Abdallah Badou. (2016) Allium sativum L. regulates in vitro IL-17 gene expression in human peripheral blood mononuclear cells. BMC Complementary and Alternative Medicine 16:1.
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C.N. Horita, A.M. Farías-Campomanes, T.S. Barbosa, E.A. Esmerino, A. Gomes da Cruz, H.M.A. Bolini, M.A.A. Meireles & M.A.R. Pollonio. (2016) The antimicrobial, antioxidant and sensory properties of garlic and its derivatives in Brazilian low-sodium frankfurters along shelf-life. Food Research International 84, pages 1-8.
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Holly L. Nicastro, Sharon A. Ross & John A. Milner. (2015) Garlic and Onions: Their Cancer Prevention Properties. Cancer Prevention Research 8:3, pages 181-189.
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J. Oh, A.N. Hristov, C. Lee, T. Cassidy, K. Heyler, G.A. Varga, J. Pate, S. Walusimbi, E. Brzezicka, K. Toyokawa, J. Werner, S.S. Donkin, R. Elias, S. Dowd & D. Bravo. (2013) Immune and production responses of dairy cows to postruminal supplementation with phytonutrients. Journal of Dairy Science 96:12, pages 7830-7843.
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S.G. Santhosha, Prakash Jamuna & S.N. Prabhavathi. (2013) Bioactive components of garlic and their physiological role in health maintenance: A review. Food Bioscience 3, pages 59-74.
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Fatima Clement, Siddanakoppalu N. Pramod & Yeldur P. Venkatesh. (2010) Identity of the immunomodulatory proteins from garlic (Allium sativum) with the major garlic lectins or agglutinins. International Immunopharmacology 10:3, pages 316-324.
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P.M. Chandrashekar & Y.P. Venkatesh. (2009) Identification of the protein components displaying immunomodulatory activity in aged garlic extract. Journal of Ethnopharmacology 124:3, pages 384-390.
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Alireza Zamani, Aliasghar Vahidinia & Masoud Sabouri Ghannad. (2008) The effect of garlic consumption on Th1/Th2 cytokines in phytohemagglutinin (PHA) activated rat spleen lymphocytes. Phytotherapy Research 23:4, pages 579-581.
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J.M. Burke, A. Wells, P. Casey & J.E. Miller. (2009) Garlic and papaya lack control over gastrointestinal nematodes in goats and lambs. Veterinary Parasitology 159:2, pages 171-174.
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M. R. Gamboa-León, I. Aranda-González, M. Mut-Martín, M. R. García-Miss & E. Dumonteil. (2007) In vivo and In vitro Control of Leishmania mexicana due to Garlic-induced NO Production. Scandinavian Journal of Immunology 66:5, pages 508-514.
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A. M. Massadeh, S. A. Al-Safi, I. F. Momani, A. A. Alomary, Q. M. Jaradat & A. S. AlKofahi. (2007) Garlic (Allium sativum L.) as a Potential Antidote for Cadmium and Lead Intoxication: Cadmium and Lead Distribution and Analysis in Different Mice Organs. Biological Trace Element Research 120:1-3, pages 227-234.
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Mau BhattacharyyaG.V. GirishSoumendra K. KarmohapatraS.A. SamadAsru K. Sinha. (2007) Systemic Production of IFN- α by Garlic ( Allium Sativum ) in Humans . Journal of Interferon & Cytokine Research 27:5, pages 377-382.
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Nada Kovačević, Miodrag Čolić, Aleksandar Backović & Zvezdana Došlov-Kokoruš. (2006) Immunomodulatory effects of the methanolic extract of Epimedium alpinum in vitro. Fitoterapia 77:7-8, pages 561-567.
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John Milner & Sharon Ross. 2006. Handbook of Nutraceuticals and Functional Foods, Second Edition. Handbook of Nutraceuticals and Functional Foods, Second Edition 73 99 .
A. Dorhoi, V. Dobrean, M. Zăhan & P. Virag. (2006) Modulatory effects of several herbal extracts on avian peripheral blood cell immune responses. Phytotherapy Research 20:5, pages 352-358.
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M. Čolić, D. Vučević, V. Kilibarda, N. Radičević & M. Savić. (2002) Modulatory effects of garlic extracts on proliferation of T-lymphocytes in vitro stimulated with concanavalin A. Phytomedicine 9:2, pages 117-124.
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Chih-Chung WuLee-Yan SheenHaw-Wen ChenWei-Wen KuoShun-Jen TsaiChong-Kuei Lii. (2001) Differential Effects of Garlic Oil and Its Three Major Organosulfur Components on the Hepatic Detoxification System in Rats. Journal of Agricultural and Food Chemistry 50:2, pages 378-383.
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