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Research Article

Omeprazole Inhibits Phagocytosis and Acidification of Phagolysosomes of Normal Human Neutrophils In Vitro

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Pages 357-372 | Published online: 27 Sep 2008

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Christopher D. Conrady, Cagri G. Besirli, Caroline R. Baumal, Jaclyn L. Kovach, Justin D. Etzel, Jonathan C. Tsui, Susan G. Elner & Mark W. Johnson. (2022) Ocular Toxoplasmosis after Exposure to Wild Game. Ocular Immunology and Inflammation 30:3, pages 527-532.
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Maarten M Bruin, Ruud L M Deijkers, Roos Bazuin, Erika P M Elzakker & Bart G Pijls. (2021) Proton-pump inhibitors are associated with increased risk of prosthetic joint infection in patients with total hip arthroplasty: a case-cohort study. Acta Orthopaedica 92:4, pages 431-435.
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Shu-Juan Zhou, Si-Qian Wang, Yong-Yong Ma, Li-Yuan Tang, Yi-Fen Shi, Bin Liang, Yi Chen & Kang Yu. (2016) Association of proton pump inhibitors with the occurrence of gut-derived bacteraemia in patients with haematological malignancy after chemotherapy. Hematology 21:6, pages 332-337.
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Angela Vassallo, Mai-Chi N Tran & Ellie JC Goldstein. (2014) Clostridium difficile: improving the prevention paradigm in healthcare settings. Expert Review of Anti-infective Therapy 12:9, pages 1087-1102.
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Prabath G. Biju, Igor Gubrij, Sarita Garg, Prem K. Gupta, Martin Hauer-Jensen & Alexander F. Burnett. (2014) Radiation lethality potentiation in total body irradiated mice by a commonly prescribed proton pump inhibitor, Pantoprazole sodium. International Journal of Radiation Biology 90:7, pages 554-559.
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Bikash Medhi & Ajay Prakash. (2008) Effects of a one-week treatment with acid gastric inhibitors on Helicobacter pylori-infected mice. Scandinavian Journal of Gastroenterology 43:8, pages 1022-1023.
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Marta Maróstica, Demetrius Paiva Arçari, Waldemar Bartchewsky$suffix/text()$suffix/text(), Miriam Trevisan, Marcelo Lima Ribeiro, José Pedrazzoli$suffix/text()$suffix/text(), Nelci Fenalti Hoehr & Alessandra Gambero. (2007) Effects of a one-week treatment with acid gastric inhibitors on Helicobacter pylori-infected mice. Scandinavian Journal of Gastroenterology 42:12, pages 1404-1412.
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Angelo De Milito & Stefano Fais. (2005) Proton pump inhibitors may reduce tumour resistance. Expert Opinion on Pharmacotherapy 6:7, pages 1049-1054.
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Articles from other publishers (54)

Christopher D. Conrady, Tejus Pradeep, Yinxi Yu, Mark W. Johnson & Brian L. VanderBeek. (2023) Association of Proton Pump Inhibitor/Histamine-2 Blocker Use and Ocular Toxoplasmosis. Ophthalmology Retina 7:3, pages 261-265.
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Isabelle Goyer, Edouard Lacotte, Julien Montreuil, Pascal Thibon, Anaïs R. Briant, Claire Dupont, Jean-Jacques Parienti & David Brossier. (2022) Proton Pump Inhibitor Use and Associated Infectious Complications in the PICU: Propensity Score Matching Analysis. Pediatric Critical Care Medicine 23:12, pages e590-e594.
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Syeda Sahra, Mohammad Abureesh, Shivantha Amarnath, Motasem Alkhayyat, Rawan Badran, Abdullah Jahangir & Vivek Gumaste. (2021) Clostridioides difficile infection in liver cirrhosis patients: A population-based study in United States . World Journal of Hepatology 13:8, pages 926-938.
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Henning Sommermeyer & Jacek PiątekHenning Sommermeyer & Jacek Piątek. 2021. Clostridioides difficile. Clostridioides difficile 49 59 .
Andrea Corsonello & Fabrizia Lattanzio. (2019) Cardiovascular and non-cardiovascular concerns with proton pump inhibitors: Are they safe?. Trends in Cardiovascular Medicine 29:6, pages 353-360.
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Felicia D. Allard & Edward B. Stelow. (2019) Review of Drug-induced Injury in Mucosal Biopsies From the Tubular Gastrointestinal Tract. Advances in Anatomic Pathology 26:3, pages 151-170.
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Sophie Ribiere, Marie-Anne Guillaumot, Amélie Barré, Einas Abou Ali, Maximilien Barret, Stanislas Chaussade & Romain Coriat. (2019) Quel est le VRAI risque au long cours des inhibiteurs de la pompe à protons ?. La Presse Médicale 48:5, pages 503-510.
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Abdel-Naser Elzouki, Nadia Neffati, Fatma A. Rasoul, Ali Abdallah, Muftah Othman & Abdelkarim  Waness. (2019) Increased Risk of Spontaneous Bacterial Peritonitis in Cirrhotic Patients Using Proton Pump Inhibitors. GE - Portuguese Journal of Gastroenterology 26:2, pages 83-89.
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Wei-Te Hung, Ying-Hock Teng, Shun-Fa Yang, Han-Wei Yeh, Ying-Tung Yeh, Yu-Hsun Wang, Ming-Yung Chou, Ming-Chih Chou, Chi-Ho Chan & Chao-Bin Yeh. (2018) Association between Proton Pump Inhibitor Use and CNS Infection Risk: A Retrospective Cohort Study. Journal of Clinical Medicine 7:9, pages 252.
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Yohannes T. Ghebre. (2018) Proton Pump Inhibitors in IPF: A Call for Clinical Trials. Frontiers in Pharmacology 9.
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Carolin Maria Haas, Martina Maywald, Andreas Goetzenich, Christian Stoppe & Lothar Rink. (2018) Proton-pump inhibitors elevate infection rate in cardiothoracic surgery patients by influencing PMN function in vitro and in vivo. Journal of Leukocyte Biology 103:4, pages 777-788.
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D. Bettinger, D. Martin, S. Rieg, M. Schultheiss, N. Buettner, R. Thimme & T. Boettler. (2018) Treatment with proton pump inhibitors is associated with increased mortality in patients with pyogenic liver abscess. Alimentary Pharmacology & Therapeutics 47:6, pages 801-808.
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Maja Kostrzewska, Agnieszka Świdnicka-Siergiejko, Dorota Olszańska, Grażyna Jurkowska, Marzena Garley, Wioletta Ratajczak-Wrona, Ewa Jabłońska, Jacek Jamiołkowski & Andrzej Dabrowski. (2017) The effect of omeprazole treatment on the gut microflora and neutrophil function. Clinics and Research in Hepatology and Gastroenterology 41:5, pages 575-584.
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Leon Fisher & Alexander Fisher. (2017) Acid-Suppressive Therapy and Risk of Infections: Pros and Cons. Clinical Drug Investigation 37:7, pages 587-624.
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Maja KostrzewskaMarzena GarleyWioletta Ratajczak-WronaEwa JabłońskaJacek JamiołkowskiAndrzej Dabrowski. (2017) The effect of short-term oral treatment with omeprazole or pantoprazole on the function of polymorphonuclear neutrophils. Canadian Journal of Physiology and Pharmacology 95:6, pages 675-680.
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Carlos Carvajal, Carlos Pacheco & Fabián Jaimes. (2017) Clinical and demographic profile and risk factors for Clostridium difficile infection. Biomédica 37:1, pages 53.
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Sarah Larcombe, Melanie L. Hutton & Dena Lyras. (2016) Involvement of Bacteria Other Than Clostridium difficile in Antibiotic-Associated Diarrhoea. Trends in Microbiology 24:6, pages 463-476.
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Lukas Buendgens. (2016) Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis. World Journal of Critical Care Medicine 5:1, pages 57.
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Chalermrat Bunchorntavakul, Naichaya Chamroonkul & Disaya Chavalitdhamrong. (2016) Bacterial infections in cirrhosis: A critical review and practical guidance. World Journal of Hepatology 8:6, pages 307.
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Natasha Singh, Aparna Dhayade, Abdel-Latif Mohamed & Tejasvi Vasant Chaudhari. (2016) Morbidity and Mortality in Preterm Infants following Antacid Use: A Retrospective Audit. International Journal of Pediatrics 2016, pages 1-6.
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Priscilla Johanesen, Kate Mackin, Melanie Hutton, Milena Awad, Sarah Larcombe, Jacob Amy & Dena Lyras. (2015) Disruption of the Gut Microbiome: Clostridium difficile Infection and the Threat of Antibiotic Resistance. Genes 6:4, pages 1347-1360.
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Yohannes T Ghebremariam, John P Cooke, William Gerhart, Carol Griego, Jeremy B Brower, Melanie Doyle-Eisele, Benjamin C Moeller, Qingtao Zhou, Lawrence Ho, Joao de Andrade, Ganesh Raghu, Leif Peterson, Andreana Rivera & Glenn D Rosen. (2015) Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosis. Journal of Translational Medicine 13:1.
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Cade M. Nylund, Matilda Eide & Gregory H. Gorman. (2014) Association of Clostridium difficile Infections with Acid Suppression Medications in Children. The Journal of Pediatrics 165:5, pages 979-984.e1.
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Edaire Cheng, Rhonda F. Souza & Stuart Jon Spechler. (2014) Eosinophilic Esophagitis. Gastroenterology Clinics of North America 43:2, pages 243-256.
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Daryl D. DePestel & David M. Aronoff. (2013) Epidemiology of Clostridium difficile Infection . Journal of Pharmacy Practice 26:5, pages 464-475.
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Marie de Vos, Bénédicte De Vroey, Béatrice Garcia Garcia, Clothilde Roy, François Kidd, Jean Henrion & Pierre Deltenre. (2013) Role of proton pump inhibitors in the occurrence and the prognosis of spontaneous bacterial peritonitis in cirrhotic patients with ascites. Liver International 33:9, pages 1316-1323.
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Ethan A. Mezoff & Mitchell B. Cohen. (2013) Acid Suppression and the Risk of Clostridium difficile Infection. The Journal of Pediatrics 163:3, pages 627-630.
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Edaire Cheng. (2013) Proton pump inhibitors for eosinophilic oesophagitis. Current Opinion in Gastroenterology 29:4, pages 416-420.
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Béatrice Jans, Didier Schoevaerdts, Te-Din Huang, Catherine Berhin, Katrien Latour, Pierre Bogaerts, Claire Nonhoff, Olivier Denis, Boudewijn Catry & Youri Glupczynski. (2013) Epidemiology of Multidrug-Resistant Microorganisms among Nursing Home Residents in Belgium. PLoS ONE 8:5, pages e64908.
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Yong Gil Kim & Byung Ik Jang. (2013) Significance of Proton Pump Inhibitor Types for Clostridium difficile Infection. Journal of Clinical Gastroenterology 47:3, pages 292.
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Luigi Corvaglia, Caterina Monari, Silvia Martini, Arianna Aceti & Giacomo Faldella. (2013) Pharmacological Therapy of Gastroesophageal Reflux in Preterm Infants. Gastroenterology Research and Practice 2013, pages 1-12.
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Ryan T. Hurt, Thomas H. Frazier, Stephen A. McClave, Neil E. Crittenden, Christopher Kulisek, Mohamed Saad & Glen A. Franklin. (2012) Stress Prophylaxis in Intensive Care Unit Patients and the Role of Enteral Nutrition. Journal of Parenteral and Enteral Nutrition 36:6, pages 721-731.
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C. P. C. de Jager, P. C. Wever, E. F. A. Gemen, M. G. H. van Oijen, A. B. van Gageldonk‐Lafeber, P. D. Siersema, G. C. M. Kusters & R. J. F. Laheij. (2012) Proton pump inhibitor therapy predisposes to community‐acquired S treptococcus pneumoniae pneumonia . Alimentary Pharmacology & Therapeutics 36:10, pages 941-949.
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Chun Shing Kwok, Aaron Kobina Arthur, Chukwudubem Ifeanyichukwu Anibueze, Sonal Singh, Rodrigo Cavallazzi & Yoon Kong Loke. (2012) Risk of Clostridium difficile Infection With Acid Suppressing Drugs and Antibiotics: Meta-Analysis. American Journal of Gastroenterology 107:7, pages 1011-1019.
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Valerie A Potter & Aloysious Aravinthan. (2012) Identifying patients at risk of severe Clostridium difficile –associated disease . British Journal of Hospital Medicine 73:5, pages 265-270.
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C. Bavishi & H. L. DuPont. (2011) Systematic review: the use of proton pump inhibitors and increased susceptibility to enteric infection. Alimentary Pharmacology & Therapeutics 34:11-12, pages 1269-1281.
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Halis Suleyman, Abdulmecit Albayrak, Mehmet Bilici, Elif Cadirci & Zekai Halici. (2010) Different Mechanisms in Formation and Prevention of Indomethacin-induced Gastric Ulcers. Inflammation 33:4, pages 224-234.
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Jasmohan S Bajaj, Ashwin N Ananthakrishnan, Muhammad Hafeezullah, Yelena Zadvornova, Alexis Dye, Emily L McGinley, Kia Saeian, Douglas Heuman, Arun J Sanyal & Raymond G Hoffmann. (2010) Clostridium difficile Is Associated With Poor Outcomes in Patients With Cirrhosis: A National and Tertiary Center Perspective. American Journal of Gastroenterology 105:1, pages 106-113.
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Ramalinga R. Kedika, Rhonda F. Souza & Stuart Jon Spechler. (2009) Potential Anti-inflammatory Effects of Proton Pump Inhibitors: A Review and Discussion of the Clinical Implications. Digestive Diseases and Sciences 54:11, pages 2312-2317.
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Sunghee Choi, Hyun Jung Min, Miyoung Kim, Eun Sook Hwang & Kyunglim Lee. (2009) Proton Pump Inhibitors Exert Anti-Allergic Effects by Reducing TCTP Secretion. PLoS ONE 4:6, pages e5732.
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R. Colucci, M. Fornai, L. Antonioli, N. Ghisu, M. Tuccori, C. Blandizzi & M. Del Tacca. (2009) Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment. Digestive and Liver Disease 41:6, pages 395-405.
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M Sandra Dial. (2009) Proton Pump Inhibitor Use and Enteric Infections. The American Journal of Gastroenterology 104:S2, pages S10-S16.
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Matteo Fornai, Rocchina Colucci, Luca Antonioli, Narcisa Ghisu, Marco Tuccori, Corrado Blandizzi & Mario Del Tacca. (2008) Effects of pantoprazole on ulcer healing delay associated with NSAID treatment. Naunyn-Schmiedeberg's Archives of Pharmacology 379:3, pages 305-313.
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O. Pastoris, M. Verri, F. Boschi, O. Kastsiuchenka, B. Balestra, F. Pace, M. Tonini & G. Natale. (2008) Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacin. Naunyn-Schmiedeberg's Archives of Pharmacology 378:4, pages 421-429.
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Corrado Blandizzi, Marco Tuccori, Rocchina Colucci, Giovanni Gori, Matteo Fornai, Luca Antonioli, Narcisa Ghisu & Mario Del Tacca. (2008) Clinical Efficacy of Esomeprazole in the Prevention and Healing of Gastrointestinal Toxicity Associated with NSAIDs in Elderly Patients. Drugs & Aging 25:3, pages 197-208.
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E. Capodicasa, P. Cornacchione, B. Natalini, A. Bartoli, S. Coaccioli, P. Marconi & L. Scaringi. (2008) Omeprazole Induces Apoptosis in Normal Human Polymorphonuclear Leucocytes. International Journal of Immunopathology and Pharmacology 21:1, pages 73-85.
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Cristina Pozzoli, Alessandro Menozzi, Daniela Grandi, Elvira Solenghi, Maria C. Ossiprandi, Chiara Zullian, Simone Bertini, Giulia M. Cavestro & Gabriella Coruzzi. (2006) Protective effects of proton pump inhibitors against indomethacin-induced lesions in the rat small intestine. Naunyn-Schmiedeberg's Archives of Pharmacology 374:4, pages 283-291.
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Angelo De MilitoStefano Fais. (2005) Tumor acidity, chemoresistance and proton pump inhibitors. Future Oncology 1:6, pages 779-786.
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M. Fornai, G. Natale, R. Colucci, M. Tuccori, G. Carazzina, L. Antonioli, S. Baldi, V. Lubrano, A. Abramo, C. Blandizzi & M. Del Tacca. (2005) Mechanisms of protection by pantoprazole against NSAID-induced gastric mucosal damage. Naunyn-Schmiedeberg's Archives of Pharmacology 372:1, pages 79-87.
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