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Original Article

Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats

Pages 284-296 | Received 17 Jul 2009, Accepted 03 Sep 2009, Published online: 27 Jan 2010

Keep up to date with the latest research on this topic with citation updates for this article.

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Ruchi Jakhmola Mani, Nikita Sehgal, Nitu Dogra, Shikha Saxena & Deepshikha Pande Katare. (2022) Deciphering underlying mechanism of Sars-CoV-2 infection in humans and revealing the therapeutic potential of bioactive constituents from Nigella sativa to combat COVID19: in-silico study. Journal of Biomolecular Structure and Dynamics 40:6, pages 2417-2429.
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Heng Zhang, Hao Yan, Jianzi Ying, Liqing Du, Chunze Zhang, Yiling Yang, Huaqing Wang & Hui Wang. (2018) Resveratrol ameliorates ionizing irradiation-induced long-term immunosuppression in mice. International Journal of Radiation Biology 94:1, pages 28-36.
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Seyed Ali Malekhosseini, Behzad Alizadeh, Ahmad Hosseinzadeh, Reza Shahriarirad, Reyhaneh Naseri, Kourosh Kazemi, Alireza Shamsaeefar & Nader Tanideh. (2023) Comparison of the preventive effect of colchicine versus diphenhydramine, prednisolone, and a combination therapy on intraperitoneal adhesion bands: an experimental study in rats. BMC Surgery 23:1.
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Shagufta Khan, M. Ali, Mohammed M.A. Albratty, Asim Y. Najmi, Uzma Azeem, Shah A. Khan & Mashoque Ahmad Rather. 2022. Black Seeds (Nigella Sativa). Black Seeds (Nigella Sativa) 29 62 .
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Hany Salah Mahmoud, Amani A. Almallah, Heba Nageh Gad EL-Hak, Tahany Saleh Aldayel, Heba M. A. Abdelrazek & Howayda E. Khaled. (2021) The effect of dietary supplementation with Nigella sativa (black seeds) mediates immunological function in male Wistar rats. Scientific Reports 11:1.
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Ranga Rao Ambati & Mohamed Fawzy Ramadan. 2021. Black cumin (Nigella sativa) seeds: Chemistry, Technology, Functionality, and Applications. Black cumin (Nigella sativa) seeds: Chemistry, Technology, Functionality, and Applications 501 520 .
Samaneh Soleymani, Arman Zargaran, Mohammad Hosein Farzaei, Amin Iranpanah, Fatemeh Heydarpour, Fariba Najafi & Roja Rahimi. (2020) The effect of a hydrogel made by Nigella sativa L. on acne vulgaris: A randomized double‐blind clinical trial . Phytotherapy Research 34:11, pages 3052-3062.
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Sarfraz Ahmed, Adeela Zahoor, Muhammad Ibrahim, Muhammad Younus, Sadia Nawaz, Rahat Naseer, Qaiser Akram, Cun-Liang Deng & Suvash Chandra Ojha. (2020) Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants. Oxidative Medicine and Cellular Longevity 2020, pages 1-10.
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Amna Parveen, Muhammad Asim Farooq & Whang Wan Kyunn. (2020) A New Oleanane Type Saponin from the Aerial Parts of Nigella sativa with Anti-Oxidant and Anti-Diabetic Potential. Molecules 25:9, pages 2171.
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Reza Mohebbati & Abbasali Abbasnezhad. (2020) Effects of Nigella sativa on endothelial dysfunction in diabetes mellitus: A review. Journal of Ethnopharmacology 252, pages 112585.
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Mohsen Abdel-Tawwab, Eman Khalifa, Amany M. Diab, Mohamed A. Khallaf, Nashwa Abdel-Razek & Riad H. Khalil. (2019) Dietary garlic and chitosan alleviated zearalenone toxic effects on performance, immunity, and challenge of European sea bass, Dicentrarchus labrax, to Vibrio alginolyticus infection. Aquaculture International 28:2, pages 493-510.
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Krishnapura Srinivasan. (2018) Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: traditional uses, chemical constituents, and nutraceutical effects. Food Quality and Safety 2:1, pages 1-16.
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N.S. Abou Khalil, M. Abd-Elkareem & A.H. Sayed. (2017) Nigella sativa seed protects against 4-nonylphenol-induced haematotoxicity in Clarias gariepinus (Burchell, 1822): Oxidant/antioxidant rebalance . Aquaculture Nutrition 23:6, pages 1467-1474.
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Ravindra M Samarth, Meenakshi Samarth & Yoshihisa Matsumoto. (2017) Medicinally important aromatic plants with radioprotective activity. Future Science OA 3:4, pages FSO247.
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Mahbubur Rahman, Dong Kwon Yang, Gi-Beum Kim, Sei-Jin Lee & Shang-Jin Kim. (2017) Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats. Biomedical Reports 6:4, pages 468-474.
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Nashwa H. Zaher, Asmaa A.M. Salem & Amel F.M. Ismail. (2016) Novel amino acid derivatives bearing thieno[2,3-d]pyrimidine moiety down regulate NF-κB in γ-irradiation mediated rat liver injury. Journal of Photochemistry and Photobiology B: Biology 165, pages 328-339.
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Hilal Irmak Sapmaz, Mustafa Sarsılmaz, Ahmet Gödekmerdan, Murat Ögetürk, Ufuk Taş & Evren Köse. (2016) Effects of formaldehyde inhalation on humoral immunity and protective effect of Nigella sativa oil . Toxicology and Industrial Health 32:9, pages 1564-1569.
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Mona Abd El-Fattah Ahmad Mahmoud, Heba AbdelKader Aminou & Hanan Ahmed Hashem. (2014) Are the fatty acids responsible for the higher effect of oil and alcoholic extract of Nigella sativa over its aqueous extract on Trichomonas vaginalis trophozoites?. Journal of Parasitic Diseases 40:1, pages 22-31.
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Amin F. Majdalawieh & Muneera W. Fayyad. (2015) Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review. International Immunopharmacology 28:1, pages 295-304.
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Heba Shawky, Amany S. Maghraby, Mohei El-Din Solliman, Mehreshan T. El-Mokadem, Mohamed M. Sherif, Azza Arafa & Mahmoud M. Bahgat. (2015) Expression, immunogenicity and diagnostic value of envelope proteins from an Egyptian hepatitis C virus isolate. Archives of Virology 160:4, pages 945-958.
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A. Elkhateeb, I. El Khishin, O. Megahed & F. Mazen. (2015) Effect of Nigella sativa Linn oil on tramadol-induced hepato- and nephrotoxicity in adult male albino rats. Toxicology Reports 2, pages 512-519.
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Monira M. Rageh, Reem H. EL-Gebaly, H. Abou-Shady & Doaa G. Amin. (2014) Melanin Nanoparticles (MNPs) provide protection against whole-body ɣ-irradiation in mice via restoration of hematopoietic tissues. Molecular and Cellular Biochemistry 399:1-2, pages 59-69.
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K Üstün, S Taysı, U Sezer, E Demir, E Baysal, T Demir, E Sarıçiçek, H Alkış, SZ Şenyurt, M Tarakçıoğlu & N Aksoy. (2014) Radio-protective effects of Nigella sativa oil on oxidative stress in tongue tissue of rats . Oral Diseases 20:1, pages 109-113.
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Mamdooh Ghoneum, Heba Allah M. Elbaghdady, Abdallah A. El-Shebly, Deyu Pan, Edward Assanah & Greg Lawson. (2013) Protective effect of hydroferrate fluid, MRN-100, against lethality and hematopoietic tissue damage in γ-radiated Nile tilapia, Oreochromis niloticus. Journal of Radiation Research 54:5, pages 852-862.
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Esam S. Kamel & Nashwa Mostafa. (2013) Effect of aluminum chloride on the hippocampus of adult rats and the possible protective role of Nigella sativa. The Egyptian Journal of Histology 36:2, pages 505-513.
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M. Ghoneum, N. K. Badr El-Din, S. M. Abdel Fattah & L. Tolentino. (2013) Arabinoxylan rice bran (MGN-3/Biobran) provides protection against whole-body  -irradiation in mice via restoration of hematopoietic tissues. Journal of Radiation Research 54:3, pages 419-429.
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