906
Views
48
CrossRef citations to date
0
Altmetric
Review Article

The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis

&
Pages 881-895 | Received 21 Feb 2012, Accepted 18 Jun 2012, Published online: 13 Sep 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Hui Yang, Sulei Wang, Linjie Yu, Xiaolei Zhu & Yun Xu. (2015) Esculentoside A suppresses Aβ1–42-induced neuroinflammation by down-regulating MAPKs pathways in vivo . Neurological Research 37:10, pages 859-866.
Read now
Salman Aziz, Syed Shoaib Ahmed, Asad Ali, Faiza Akhter Khan, Gulraiz Zulfiqar, Javed Iqbal, Ayyaz Ali Khan & Muhammad Shoaib. (2015) Salivary Immunosuppressive Cytokines IL-10 and IL-13 Are Significantly Elevated in Oral Squamous Cell Carcinoma Patients. Cancer Investigation 33:7, pages 318-328.
Read now

Articles from other publishers (46)

Aisha Siddiqui, Syafiq Asnawi Zainal Abidin, Zahoor A. Shah, Iekhsan Othman & Yatinesh Kumari. (2023) Behavioural, genomics and proteomic approach to examine Alzheimer's disease in zebrafish. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 271, pages 109636.
Crossref
Jeremy R. Townsend, Trevor O. Kirby, Tess M. Marshall, David D. Church, Adam R. Jajtner & Ralph Esposito. (2023) Foundational Nutrition: Implications for Human Health. Nutrients 15:13, pages 2837.
Crossref
Maria del Carmen Domínguez-Horta, Anabel Serrano-Díaz, Mabel Hernández-Cedeño, Gillian Martínez-Donato & Gerardo Guillén-Nieto. (2023) A peptide derived from HSP60 reduces proinflammatory cytokines and soluble mediators: a therapeutic approach to inflammation. Frontiers in Immunology 14.
Crossref
Adolfo Toledano-Díaz, M Isabel Álvarez & Adolfo Toledano. (2022) The relationships between neuroglial alterations and neuronal changes in Alzheimer’s disease, and the related controversies I: Gliopathogenesis and glioprotection. Journal of Central Nervous System Disease 14, pages 117957352211287.
Crossref
Adolfo Toledano-Díaz, M Isabel Álvarez & Adolfo Toledano. (2022) The relationships between neuroglial and neuronal changes in Alzheimer’s disease, and the related controversies II: gliotherapies and multimodal therapy . Journal of Central Nervous System Disease 14, pages 117957352211238.
Crossref
Aisha Siddiqui, Zahoor Shah, Rao Nargis Jahan, Iekhsan Othman & Yatinesh Kumari. (2021) Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties. Biomedicine & Pharmacotherapy 144, pages 112250.
Crossref
Chanyuan Ye, Rui Xu, Zhongcheng Cao, Qing Song, Guangjun Yu, Yichun Shi, Zhuoling Liu, Xiuxiu Liu & Yong Deng. (2021) Design, synthesis, and in vitro evaluation of 4-aminoalkyl-1(2H)-phthalazinones as potential multifunctional anti-Alzheimer’s disease agents. Bioorganic Chemistry 111, pages 104895.
Crossref
Xiuling Wang, Xiulin Wu, Jin Huang, Haiyan Li, Qiujin Yan & Fan Zhu. (2021) Human endogenous retrovirus W family envelope protein (HERV-W env) facilitates the production of TNF-α and IL-10 by inhibiting MyD88s in glial cells. Archives of Virology 166:4, pages 1035-1045.
Crossref
Ricardo B. Maccioni, Leonardo P. Navarrete, Andrea González, Alejandra González-Canacer, Leonardo Guzmán-Martínez & Nicole Cortés. (2020) Inflammation: A Major Target for Compounds to Control Alzheimer’s Disease. Journal of Alzheimer's Disease 76:4, pages 1199-1213.
Crossref
Aaron Hilliard, Patricia Mendonca & Karam F.A. Soliman. (2020) Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS. Journal of Neuroimmunology 345, pages 577269.
Crossref
Sabine Hazan. (2020) Rapid improvement in Alzheimer’s disease symptoms following fecal microbiota transplantation: a case report. Journal of International Medical Research 48:6, pages 030006052092593.
Crossref
Naiara Silva Dourado, Cleide dos Santos Souza, Monique Marylin Alves de Almeida, Alessandra Bispo da Silva, Balbino Lino dos Santos, Victor Diogenes Amaral Silva, Adriano Martimbianco De Assis, Jussemara Souza da Silva, Diogo Onofre Souza, Maria de Fatima Dias Costa, Arthur Morgan Butt & Silvia Lima Costa. (2020) Neuroimmunomodulatory and Neuroprotective Effects of the Flavonoid Apigenin in in vitro Models of Neuroinflammation Associated With Alzheimer’s Disease. Frontiers in Aging Neuroscience 12.
Crossref
Qing Xie, Wei-Jiang Zhao, Guan-Yong Ou & Wei-Kang Xue. (2019) An Overview of Experimental and Clinical Spinal Cord Findings in Alzheimer’s Disease. Brain Sciences 9:7, pages 168.
Crossref
Ming Yu, Demei Zang, Yuhao Xu, Jie Meng & Shengnan Qian. (2019) Protective effect of ISO‑1 against advanced glycation end product aggravation of PC12 cell injury induced by Aβ1‑40. Molecular Medicine Reports.
Crossref
Domenico Nuzzo, Sara Baldassano, Antonella Amato, Pasquale Picone, Giacoma Galizzi, Gaetano Felice Caldara, Marta Di Carlo & Flavia Mulè. (2019) Glucagon-like peptide-2 reduces the obesity-associated inflammation in the brain. Neurobiology of Disease 121, pages 296-304.
Crossref
Xu-Dong Yang, Li-Kuan Wang, Hai-Yin Wu & Liang Jiao. (2018) Effects of prebiotic galacto-oligosaccharide on postoperative cognitive dysfunction and neuroinflammation through targeting of the gut-brain axis. BMC Anesthesiology 18:1.
Crossref
Antero Salminen, Kai Kaarniranta & Anu Kauppinen. (2018) The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer’s disease. Cellular and Molecular Life Sciences 75:17, pages 3099-3120.
Crossref
Makini K. Cobourne-Duval, Equar Taka, Patricia Mendonca & Karam F.A. Soliman. (2018) Thymoquinone increases the expression of neuroprotective proteins while decreasing the expression of pro-inflammatory cytokines and the gene expression NFκB pathway signaling targets in LPS/IFNγ -activated BV-2 microglia cells. Journal of Neuroimmunology 320, pages 87-97.
Crossref
T. N. C. Magalhães, M. Weiler, C. V. L. Teixeira, T. Hayata, A. S. Moraes, V. O. Boldrini, L. M. dos Santos, B. M. de Campos, T. J. R. de Rezende, H. P. G. Joaquim, L. L. Talib, O. V. Forlenza, F. Cendes & Marcio L. F. Balthazar. (2017) Systemic Inflammation and Multimodal Biomarkers in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease. Molecular Neurobiology 55:7, pages 5689-5697.
Crossref
Bo Li, Yun Gao, Wei Zhang & Jian-rong Xu. (2018) Regulation and effects of neurotrophic factors after neural stem cell transplantation in a transgenic mouse model of Alzheimer disease. Journal of Neuroscience Research 96:5, pages 828-840.
Crossref
José-Enrique O’Connor, Guadalupe Herrera, Beatriz Jávega & Alicia Martínez-Romero. 2018. Conn's Handbook of Models for Human Aging. Conn's Handbook of Models for Human Aging 783 802 .
Tung Thanh Bui & Hai Thanh Nguyen. (2017) Ethanolic extract of Sophora japonica flower buds alleviates cognitive deficits induced by scopolamine in mice. Oriental Pharmacy and Experimental Medicine 17:4, pages 337-344.
Crossref
Iván Patraca, Nohora Martínez, Oriol Busquets, Aleix Martí, Ignacio Pedrós, Carlos Beas-Zarate, Miguel Marin, Miren Ettcheto, Francesc Sureda, Carme Auladell, Antoni Camins & Jaume Folch. (2017) Anti-inflammatory role of Leptin in glial cells through p38 MAPK pathway inhibition. Pharmacological Reports 69:3, pages 409-418.
Crossref
Dayana Sazereen Mohd Hasni, Siong Meng Lim, Ai Vyrn Chin, Maw Pin Tan, Philip Jun Hua Poi, Shahrul Bahyah Kamaruzzaman, Abu Bakar Abdul Majeed & Kalavathy Ramasamy. (2017) Peripheral cytokines, C-X-C motif ligand10 and interleukin-13, are associated with Malaysian Alzheimer's disease. Geriatrics & Gerontology International 17:5, pages 839-846.
Crossref
Anna Mietelska-Porowska & Urszula Wojda. (2017) T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers. Journal of Immunology Research 2017, pages 1-17.
Crossref
Stephen Beesley, James Olcese, Charles Saunders & Ewa A. Bienkiewicz. (2016) Combinatorial Treatment Effects in a Cell Culture Model of Alzheimer’s Disease. Journal of Alzheimer's Disease 55:3, pages 1155-1166.
Crossref
Do-Geun Kim, Antje Krenz, Leon E. Toussaint, Kirk J. Maurer, Sudie-Ann Robinson, Angela Yan, Luisa Torres & Margaret S. Bynoe. (2016) Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model. Journal of Neuroinflammation 13:1.
Crossref
Reza Nosratabadi, Maryam Rastin, Mojtaba Sankian, Dariush Haghmorad & Mahmoud Mahmoudi. (2016) Hyperforin-loaded gold nanoparticle alleviates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells and upregulating regulatory T cells. Nanomedicine: Nanotechnology, Biology and Medicine 12:7, pages 1961-1971.
Crossref
Ji-Young Na, Kibbeum Song, Ju-Woon Lee, Sokho Kim & Jungkee Kwon. (2016) 6-Shogaol has anti-amyloidogenic activity and ameliorates Alzheimer’s disease via CysLT1R-mediated inhibition of cathepsin B. Biochemical and Biophysical Research Communications 477:1, pages 96-102.
Crossref
David S. Bouvier, Emma V. Jones, Gaël Quesseveur, Maria Antonietta Davoli, Tiago A. Ferreira, Rémi Quirion, Naguib Mechawar & Keith K. Murai. (2016) High Resolution Dissection of Reactive Glial Nets in Alzheimer’s Disease. Scientific Reports 6:1.
Crossref
Francesco Bonetti, Gloria Brombo & Giovanni Zuliani. (2016) The relationship between hyperhomocysteinemia and neurodegeneration. Neurodegenerative Disease Management 6:2, pages 133-145.
Crossref
Changrun Guo, Jinyang Shen, Zhaoqing Meng, Xiaolin Yang & Fei Li. (2016) Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice. Phytomedicine 23:2, pages 149-155.
Crossref
Gholamreza Azizi & Abbas Mirshafiey. 2016. Compendium of Inflammatory Diseases. Compendium of Inflammatory Diseases 34 43 .
Gholamreza Azizi & Abbas Mirshafiey. 2016. Encyclopedia of Inflammatory Diseases. Encyclopedia of Inflammatory Diseases 1 10 .
Gholamreza Azizi & Abbas Mirshafiey. 2016. Encyclopedia of Inflammatory Diseases. Encyclopedia of Inflammatory Diseases 1 10 .
Jaume Folch, Iván Patraca, Nohora Martínez, Ignacio Pedrós, Dmitry Petrov, Miren Ettcheto, Sonia Abad, Miguel Marin, Carlos Beas-Zarate & Antoni Camins. (2015) The role of leptin in the sporadic form of Alzheimer's disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin. Life Sciences 140, pages 19-28.
Crossref
LUSHUANG XIE, YU LAI, FANG LEI, SUJUAN LIU, RAN LIU & TINGHUA WANG. (2015) Exploring the association between interleukin-1β and its interacting proteins in Alzheimer’s disease. Molecular Medicine Reports 11:5, pages 3219-3228.
Crossref
Xian-hui Dong, Jiang-tao Bai, Wei-na Kong, Xiao-ping He, Peng Yan, Tie-mei Shao, Wen-guo Yu, Xi-qing Chai, Yan-hua Wu & Cong LIu. (2015) Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload. Neural Regeneration Research 10:5, pages 778.
Crossref
Isabelle St-Amour, Isabelle Paré, Cyntia Tremblay, Katherine Coulombe, Renée Bazin & Frédéric Calon. (2014) IVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathology. Journal of Neuroinflammation 11:1.
Crossref
Simon Holmgren, Erik Hjorth, Marianne Schultzberg, Marie Lärksäter, Dan Frenkel, Ann Christine Tysen-Bäckström, Dag Aarsland & Yvonne Freund-Levi. (2014) Neuropsychiatric symptoms in dementia—A role for neuroinflammation?. Brain Research Bulletin 108, pages 88-93.
Crossref
Guo-Long Mo, Ying Li, Rong-hui Du, De-Zai Dai, Xiao-Dong Cong & Yin Dai. (2014) Isoproterenol Induced Stressful Reactions in the Brain Are Characterized by Inflammation due to Activation of NADPH Oxidase and ER Stress: Attenuated by Apocynin, Rehmannia Complex and Triterpene Acids. Neurochemical Research 39:4, pages 719-730.
Crossref
Yong Shen, Libang Yang & Rena Li. (2013) What does complement do in Alzheimer’s disease? Old molecules with new insights. Translational Neurodegeneration 2:1.
Crossref
Ke-Wu Zeng, Jun Li, Xin Dong, Ying-Hong Wang, Zhi-Zhong Ma, Yong Jiang, Hong-Wei Jin & Peng-Fei Tu. (2013) Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-κB and MAPK pathways. Toxicology and Applied Pharmacology 273:1, pages 159-171.
Crossref
Silvia Caioli, Massimo Pieri, Alessia Antonini, Angelo Guglielmotti, Cinzia Severini & Cristina Zona. (2013) Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: Evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis. Neuropharmacology 73, pages 247-260.
Crossref
Ki-Choon ChoiJung-Min HwangSung-Jun BangBeom-Tae KimDong-Hern KimMinseon ChaeSeung-Ah LeeGi Jun ChoiDa Hye KimJeong-Chae Lee. (2013) Chloroform Extract of Alfalfa ( Medicago sativa ) Inhibits Lipopolysaccharide-Induced Inflammation by Downregulating ERK/NF-κB Signaling and Cytokine Production . Journal of Medicinal Food 16:5, pages 410-420.
Crossref
Hui Zhao, Su‐Lei Wang, Lai Qian, Jia‐Li Jin, Hui Li, Yun Xu & Xiao‐Lei Zhu. (2012) Diammonium Glycyrrhizinate Attenuates Aβ 1–42 ‐Induced Neuroinflammation and Regulates MAPK and NF‐κB Pathways In Vitro and In Vivo . CNS Neuroscience & Therapeutics 19:2, pages 117-124.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.