Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 25, 2013 - Issue 9
360
Views
34
CrossRef citations to date
0
Altmetric
Research Article

In vitro and ex vivo toxicological testing of sildenafil-loaded solid lipid nanoparticles

, , , , , , , & show all
Pages 536-543 | Received 28 Mar 2013, Accepted 28 May 2013, Published online: 02 Aug 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Roberta Bartucci, Abhimata Paramanandana, Ykelien L. Boersma, Peter Olinga & Anna Salvati. (2020) Comparative study of nanoparticle uptake and impact in murine lung, liver and kidney tissue slices. Nanotoxicology 14:6, pages 847-865.
Read now
Angela Temann, Tatiana Golovina, Vanessa Neuhaus, Carolann Thompson, Jessica A. Chichester, Armin Braun & Vidadi Yusibov. (2017) Evaluation of inflammatory and immune responses in long-term cultured human precision-cut lung slices. Human Vaccines & Immunotherapeutics 13:2, pages 351-358.
Read now

Articles from other publishers (32)

Liza Józsa, Dániel Nemes, Ágota Pető, Dóra Kósa, Réka Révész, Ildikó Bácskay, Ádám Haimhoffer & Gábor Vasvári. (2023) Recent Options and Techniques to Assess Improved Bioavailability: In Vitro and Ex Vivo Methods. Pharmaceutics 15:4, pages 1146.
Crossref
Qinqin Fei, Ian Bentley, Samir N. Ghadiali & Joshua A. Englert. (2023) Pulmonary drug delivery for acute respiratory distress syndrome. Pulmonary Pharmacology & Therapeutics 79, pages 102196.
Crossref
Raul Edison Luna Lazo, Mariana Mengarda, Susana Leão Almeida, Aline Caldonazo, Joel Toribio Espinoza & Fábio Seigi Murakami. (2022) Advanced formulations and nanotechnology-based approaches for pulmonary delivery of sildenafil: A scoping review. Journal of Controlled Release 350, pages 308-323.
Crossref
Sarah Marie Nußbaum, Julia Krabbe, Svenja Böll, Aaron Babendreyer & Christian Martin. (2022) Functional changes in long-term incubated rat precision-cut lung slices. Respiratory Research 23:1.
Crossref
Aftab Ahmad. (2022) Pharmacological Strategies and Recent Advancement in Nano-Drug Delivery for Targeting Asthma. Life 12:4, pages 596.
Crossref
Abdelhakim Bouyahya, Nasreddine El Omari, Maryam Hakkour, Naoual El Menyiy, Taoufiq Benali, Dmitriy Kulikov, Mikhail Karpukhin, Mohammad Ali Shariati, Baskar Venkidasamy, Muthu Thiruvengadam & Imane Chamkhi. (2022) A review on transcriptomic and metabolomic responses of plants to nanopollution. Environmental Science and Pollution Research 29:16, pages 22913-22929.
Crossref
Anand Maurya, Anurag Kumar Singh, Bhuwanendra Singh, Nidhi Singh, Sachin Kumar Agrahari, Arati Rai & Gopal Kumar Rai. 2022. Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases. Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases 107 124 .
Shadabul Haque, Colin W. Pouton, Michelle P. McIntosh, David B Ascher, David W Keizer, Michael R. Whittaker & Lisa M. Kaminskas. (2020) The impact of size and charge on the pulmonary pharmacokinetics and immunological response of the lungs to PLGA nanoparticles after intratracheal administration to rats. Nanomedicine: Nanotechnology, Biology and Medicine 30, pages 102291.
Crossref
Aylin Cidem, Peta Bradbury, Daniela Traini & Hui Xin Ong. (2020) Modifying and Integrating in vitro and ex vivo Respiratory Models for Inhalation Drug Screening. Frontiers in Bioengineering and Biotechnology 8.
Crossref
Roberta Bartucci, Christoffer Åberg, Barbro N. Melgert, Ykelien L. Boersma, Peter Olinga & Anna Salvati. (2020) Time‐Resolved Quantification of Nanoparticle Uptake, Distribution, and Impact in Precision‐Cut Liver Slices. Small 16:21, pages 1906523.
Crossref
BARBÁRA A. ABRAHIM-VIEIRA, ALESSANDRA M.T. DE SOUZA, RITA C. BARROS, FLÁVIA A. DO CARMO, LETÍCIA C.L. DE ABREU, RONYSON S.S. MOREIRA, THIAGO S. HONÓRIO, CARLOS R. RODRIGUES, VALERIA P. DE SOUSA & LUCIO M. CABRAL. (2020) In Silico studies of novel Sildenafil self-emulsifying drug delivery system absorption improvement for pulmonary arterial hypertension. Anais da Academia Brasileira de Ciências 92:2.
Crossref
Manisha Lalan, Hemal Tandel, Rohan Lalani, Vivek Patel & Ambikanandan Misra. 2019. Novel Drug Delivery Technologies. Novel Drug Delivery Technologies 291 333 .
Noha Nafee, Shaimaa Makled & Nabila Boraie. (2018) Nanostructured lipid carriers versus solid lipid nanoparticles for the potential treatment of pulmonary hypertension via nebulization. European Journal of Pharmaceutical Sciences 125, pages 151-162.
Crossref
Shadabul Haque, Michael Whittaker, Michelle P. McIntosh, Colin W. Pouton, Simon Phipps & Lisa M. Kaminskas. (2018) A comparison of the lung clearance kinetics of solid lipid nanoparticles and liposomes by following the 3H-labelled structural lipids after pulmonary delivery in rats. European Journal of Pharmaceutics and Biopharmaceutics 125, pages 1-12.
Crossref
Jean Cornier, Andrew Owen, Arno Kwade & Marcel Van de VoordeChristel C. Müller-Goymann & Mukta Paranjpe. 2017. Pharmaceutical Nanotechnology: Innovation and Production. Pharmaceutical Nanotechnology: Innovation and Production 633 648 .
Jaleh Varshosaz, Somayeh Taymouri, Hamed Hamishehkar, Razieh Vatankhah & Shadi Yaghubi. (2017) Development of dry powder inhaler containing tadalafil-loaded PLGA nanoparticles. Research in Pharmaceutical Sciences 12:3, pages 222.
Crossref
Shaimaa Makled, Noha Nafee & Nabila Boraie. (2017) Nebulized solid lipid nanoparticles for the potential treatment of pulmonary hypertension via targeted delivery of phosphodiesterase-5-inhibitor. International Journal of Pharmaceutics 517:1-2, pages 312-321.
Crossref
Slavomira Doktorovová, Andjelka B. Kovačević, Maria L. Garcia & Eliana B. Souto. (2016) Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics 108, pages 235-252.
Crossref
Shadabul Haque, Michael R. Whittaker, Michelle P. McIntosh, Colin W. Pouton & Lisa M. Kaminskas. (2016) Disposition and safety of inhaled biodegradable nanomedicines: Opportunities and challenges. Nanomedicine: Nanotechnology, Biology and Medicine 12:6, pages 1703-1724.
Crossref
Liqing Yan, Mingbao Feng, Jiaoqin Liu, Liansheng Wang & Zunyao Wang. (2016) Antioxidant defenses and histological changes in Carassius auratus after combined exposure to zinc and three multi-walled carbon nanotubes. Ecotoxicology and Environmental Safety 125, pages 61-71.
Crossref
H. Bunjes & C. C. Müller-Goymann. 2016. Microsystems for Pharmatechnology. Microsystems for Pharmatechnology 153 179 .
C. FANIZZA, S. CASCIARDI, F. INCORONATO, D. CAVALLO, C.L. URSINI, A. CIERVO, R. MAIELLO, A.M. FRESEGNA, A.M. MARCELLONI, D. LEGA, A. ALVINO & S. BAIGUERA. (2015) Human epithelial cells exposed to functionalized multiwalled carbon nanotubes: interactions and cell surface modifications. Journal of Microscopy 259:3, pages 173-184.
Crossref
Bhuvaneshwar Vaidya & Vivek Gupta. (2015) Novel therapeutic approaches for pulmonary arterial hypertension: Unique molecular targets to site-specific drug delivery. Journal of Controlled Release 211, pages 118-133.
Crossref
Sabine H. van Rijt, Deniz A. Bölükbas, Christian Argyo, Stefan Datz, Michael Lindner, Oliver Eickelberg, Melanie Königshoff, Thomas Bein & Silke Meiners. (2015) Protease-Mediated Release of Chemotherapeutics from Mesoporous Silica Nanoparticles to ex Vivo Human and Mouse Lung Tumors . ACS Nano 9:3, pages 2377-2389.
Crossref
Zofi McKenzie, Michaela Kendall, Rose-Marie Mackay, Teresa D. Tetley, Cliff Morgan, Mark Griffiths, Howard W. Clark & Jens Madsen. (2015) Nanoparticles modulate surfactant protein A and D mediated protection against influenza A infection in vitro . Philosophical Transactions of the Royal Society B: Biological Sciences 370:1661, pages 20140049.
Crossref
M. López-Heras, I. G. Theodorou, B. F. Leo, M. P. Ryan & A. E. Porter. (2015) Towards understanding the antibacterial activity of Ag nanoparticles: electron microscopy in the analysis of the materials-biology interface in the lung. Environmental Science: Nano 2:4, pages 312-326.
Crossref
Stephanie Hirn, Nadine Haberl, Kateryna Loza, Matthias Epple, Wolfgang G Kreyling, Barbara Rothen-Rutishauser, Markus Rehberg & Fritz Krombach. (2014) Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices. Beilstein Journal of Nanotechnology 5, pages 2440-2449.
Crossref
M. Paranjpe, J.H. Finke, C. Richter, T. Gothsch, A. Kwade, S. Büttgenbach & C.C. Müller-Goymann. (2014) Physicochemical characterization of sildenafil-loaded solid lipid nanoparticle dispersions (SLN) for pulmonary application. International Journal of Pharmaceutics 476:1-2, pages 41-49.
Crossref
Mukta Paranjpe, Vanessa Neuhaus, Armin Braun & Christel C. Mueller‐Goymann. (2014) Toxicity testing of sildenafil base‐loaded liposomes in in vitro and ex vivo models for pulmonary application. European Journal of Lipid Science and Technology 116:9, pages 1129-1136.
Crossref
Nathalie Wauthoz & Karim Amighi. (2014) Phospholipids in pulmonary drug delivery. European Journal of Lipid Science and Technology 116:9, pages 1114-1128.
Crossref
Mukta Paranjpe & Christel Müller-Goymann. (2014) Nanoparticle-Mediated Pulmonary Drug Delivery: A Review. International Journal of Molecular Sciences 15:4, pages 5852-5873.
Crossref
Ž. Vanić & N. Škalko-Basnet. (2014) Mucosal nanosystems for improved topical drug delivery: vaginal route of administration. Journal of Drug Delivery Science and Technology 24:5, pages 435-444.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.