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Inhalation Toxicology
International Forum for Respiratory Research
Volume 25, 2013 - Issue 10
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Research Article

Thrombin promotes airway remodeling via protease-activated receptor-1 and transforming growth factor-β1 in ovalbumin-allergic rats

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Pages 577-586 | Received 04 Mar 2013, Accepted 07 Jun 2013, Published online: 13 Aug 2013

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Meirong Bi, Aili Guo, Hongyang Zhao, Xuewu Sun, Qiang Chen, Li Yu, Wei Shi, Yan Wang, Guohong Shen, Xueying Wang, Yingchun Zhao, Nan Zhang, Mi Xu, Mingming Qin & Weiwei Zhu. (2015) Role of the extracellular signal-regulated kinase 1/2 signaling pathway in the process of thrombin-promoting airway remodeling in ovalbumin-allergic rats. Immunopharmacology and Immunotoxicology 37:1, pages 26-34.
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Xin Zhuo, Yue Wu, Xiujuan Fu, Xiaoyu Liang, Yuxin Xiang, Jianbin Li, Canquan Mao & Yuhong Jiang. (2022) The Yin‐Yang roles of protease‐activated receptors in inflammatory signalling and diseases. The FEBS Journal 289:14, pages 4000-4020.
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Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Chih-Kai Hsu, Chia-Yu Hu & Chuen-Mao Yang. (2022) Thrombin Induces COX-2 and PGE2 Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells. Mediators of Inflammation 2022, pages 1-18.
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Ming Yue, Mengjiao Hu, Fangda Fu, Hongfeng Ruan & Chengliang Wu. (2022) Emerging Roles of Platelets in Allergic Asthma. Frontiers in Immunology 13.
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Hendrik Ungefroren, Frank Gieseler, Roland Kaufmann, Utz Settmacher, Hendrik Lehnert & Bernhard Rauch. (2018) Signaling Crosstalk of TGF-β/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer. International Journal of Molecular Sciences 19:6, pages 1568.
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Michael Schuliga, Christopher Grainge, Glen Westall & Darryl Knight. (2018) The fibrogenic actions of the coagulant and plasminogen activation systems in pulmonary fibrosis. The International Journal of Biochemistry & Cell Biology 97, pages 108-117.
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Michael Schuliga, Jade JaffarAsres BerhanShenna LangenbachTrudi HarrisDavid WatersPeter V. S. LeeChristopher Grainge, Glen WestallDarryl Knight & Alastair G. Stewart. (2017) Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity. American Journal of Physiology-Lung Cellular and Molecular Physiology 312:5, pages L772-L782.
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Michael Schuliga, Jade Jaffar, Trudi Harris, Darryl A Knight, Glen Westall & Alastair G Stewart. (2017) The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF. Scientific Reports 7:1.
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Shuqing Ge, Tao Li, Qijian Yao, Hongling Yan, Zhang Huiyun, Yanshan Zheng, Bin Zhang & Shaoheng He. (2016) Expression of proteinase-activated receptor (PAR)-2 in monocytes from allergic patients and potential molecular mechanism. Cell Biology and Toxicology 32:6, pages 529-542.
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Sanjay Saw & Naveen Arora. (2016) PI3K and ERK1/2 kinase inhibition potentiate protease inhibitor to attenuate allergen induced Th2 immune response in mouse. European Journal of Pharmacology 776, pages 176-184.
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Michael Schuliga, Simon G. Royce, Shenna Langenbach, Asres Berhan, Trudi Harris, Christine R. Keenan & Alastair G. Stewart. (2016) The Coagulant Factor Xa Induces Protease-Activated Receptor-1 and Annexin A2–Dependent Airway Smooth Muscle Cytokine Production and Cell Proliferation. American Journal of Respiratory Cell and Molecular Biology 54:2, pages 200-209.
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Michael Schuliga. (2015) The Inflammatory Actions of Coagulant and Fibrinolytic Proteases in Disease. Mediators of Inflammation 2015, pages 1-9.
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C.E. Boorsma, B.G.J. Dekkers, E.M. van Dijk, K. Kumawat, J. Richardson, J.K. Burgess & A.E. John. (2014) Beyond TGFβ – Novel ways to target airway and parenchymal fibrosis. Pulmonary Pharmacology & Therapeutics 29:2, pages 166-180.
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Hatem Alkhouri, Wilfred Jelco Poppinga, Navessa Padma Tania, Alaina Ammit & Michael Schuliga. (2014) Regulation of pulmonary inflammation by mesenchymal cells. Pulmonary Pharmacology & Therapeutics 29:2, pages 156-165.
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Huiyun Zhang, Xiaoning Zeng & Shaoheng He. (2014) Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation. Mediators of Inflammation 2014, pages 1-20.
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Deborah L Clarke, Alan M Carruthers, Tomas Mustelin & Lynne A Murray. (2013) Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymes. Fibrogenesis & Tissue Repair 6:1.
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