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Inhalation Toxicology
International Forum for Respiratory Research
Volume 27, 2015 - Issue 1
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Research Article

Acrolein inhalation alters arterial blood gases and triggers carotid body-mediated cardiovascular responses in hypertensive rats

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Pages 54-63 | Received 12 Jul 2014, Accepted 30 Oct 2014, Published online: 20 Jan 2015

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Yue Zhou, Wendy Jin, Qingli Wu & Qian Zhou. (2023) Acrolein: formation, health hazards and its controlling by dietary polyphenols. Critical Reviews in Food Science and Nutrition 0:0, pages 1-14.
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Samuel A. Vance, Yong Ho Kim, Ingrid J. George, Janice A. Dye, Wanda C. Williams, Mette J. Schladweiler, M. Ian Gilmour, Ilona Jaspers & Stephen H. Gavett. (2023) Contributions of particulate and gas phases of simulated burn pit smoke exposures to impairment of respiratory function. Inhalation Toxicology 35:5-6, pages 129-138.
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Brandi L. Martin, Leslie C. Thompson, Yong Ho Kim, Charly King, Samantha Snow, Mette Schladweiler, Najwa Haykal-Coates, Ingrid George, M. Ian Gilmour, Urmila P Kodavanti, Mehdi S. Hazari & Aimen K. Farraj. (2020) Peat smoke inhalation alters blood pressure, baroreflex sensitivity, and cardiac arrhythmia risk in rats. Journal of Toxicology and Environmental Health, Part A 83:23-24, pages 748-763.
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Leslie C. Thompson, Yong Ho Kim, Brandi L. Martin, Allen D. Ledbetter, Janice A. Dye, Mehdi S. Hazari, M. Ian Gilmour & Aimen K. Farraj. (2018) Pulmonary exposure to peat smoke extracts in rats decreases expiratory time and increases left heart end systolic volume. Inhalation Toxicology 30:11-12, pages 439-447.
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C.B.M. Tulen, P.A. Leermakers, S.E. Schrieder, F.J. van Schooten, A. Opperhuizen & A.H.V. Remels. (2023) Impact of sub-acute acrolein inhalation on the molecular regulation of mitochondrial metabolism in rat lung. Toxicology Letters 378, pages 19-30.
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Katlyn E. McGraw, Stacey L. Konkle, Daniel W. Riggs, Shesh N. Rai, Natasha DeJarnett, Zhengzhi Xie, Rachel J. Keith, Adebamike Oshunbade, Michael E. Hall, Daichi Shimbo & Aruni Bhatnagar. (2023) Exposure to Volatile Organic Compounds Is Associated with Hypertension in Black Adults: The Jackson Heart Study. Environmental Research 223, pages 115384.
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Qinghong Liu, Hongwei Lou, Xiaofang Zhang & Qin Yang. (2023) Association between acrolein exposure and respiratory hazards: A systematic review and meta-analysis. Atmospheric Pollution Research 14:1, pages 101633.
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Alex P. Carll, Claudia Arab, Renata Salatini, Meredith D. Miles, Matthew A. Nystoriak, Kyle L. Fulghum, Daniel W. Riggs, Gregg A. Shirk, Whitney S. Theis, Nima Talebi, Aruni Bhatnagar & Daniel J. Conklin. (2022) E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice. Nature Communications 13:1.
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Pablo Scharf, Felipe Rizzetto, Luana Filippi Xavier & Sandra Helena Poliselli Farsky. (2022) Xenobiotics Delivered by Electronic Nicotine Delivery Systems: Potential Cellular and Molecular Mechanisms on the Pathogenesis of Chronic Kidney Disease. International Journal of Molecular Sciences 23:18, pages 10293.
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Urvish Patel, Neel Patel, Mahika Khurana, Akshada Parulekar, Amrapali Patel, Juan Fernando Ortiz, Rutul Patel, Eseosa Urhoghide, Anuja Mistry, Arpita Bhriguvanshi, Mohammed Abdulqader, Neev Mehta, Kogulavadanan Arumaithurai & Shamik Shah. (2022) Effect Comparison of E-Cigarette and Traditional Smoking and Association with Stroke—A Cross-Sectional Study of NHANES. Neurology International 14:2, pages 441-452.
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C.B.M. Tulen, S.J. Snow, P.A. Leermakers, U.P. Kodavanti, F.J. van Schooten, A. Opperhuizen & A.H.V. Remels. (2022) Acrolein inhalation acutely affects the regulation of mitochondrial metabolism in rat lung. Toxicology 469, pages 153129.
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Katlyn E. McGraw, Daniel W. Riggs, Shesh Rai, Ana Navas-Acien, Zhengzhi Xie, Pawel Lorkiewicz, Jordan Lynch, Nagma Zafar, Sathya Krishnasamy, Kira C. Taylor, Daniel J. Conklin, Andrew P. DeFilippis, Sanjay Srivastava & Aruni Bhatnagar. (2021) Exposure to volatile organic compounds – acrolein, 1,3-butadiene, and crotonaldehyde – is associated with vascular dysfunction. Environmental Research 196, pages 110903.
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Saroj Khadka, Manul Awasthi, Rabindra Raj Lamichhane, Chandra Ojha, Hadii M. Mamudu, Carl J. Lavie, Ramesh Daggubati & Timir K. Paul. (2021) The Cardiovascular Effects of Electronic Cigarettes. Current Cardiology Reports 23:5.
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Lo Lai & Hongyu Qiu. (2020) Biological Toxicity of the Compositions in Electronic-Cigarette on Cardiovascular System. Journal of Cardiovascular Translational Research 14:2, pages 371-376.
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Thomas E. Taylor-Clark. (2020) Air Pollution-Induced Autonomic Modulation. Physiology 35:6, pages 363-374.
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Michael Petroni, Dustin Hill, Lylla Younes, Liesl Barkman, Sarah Howard, I Brielle Howell, Jaime Mirowsky & Mary B Collins. (2020) Hazardous air pollutant exposure as a contributing factor to COVID-19 mortality in the United States. Environmental Research Letters 15:9, pages 0940a9.
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Edmond D. Shenassa & Andrew D. Williams. (2020) Concomitant exposure to area-level poverty, ambient air volatile organic compounds, and cardiometabolic dysfunction: a cross-sectional study of U.S. adolescents. Annals of Epidemiology 48, pages 15-22.
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Sezgi Arman & Sema İşisağ Üçüncü. (2020) Cardiac toxicity of acrolein exposure in embryonic zebrafish (Danio rerio). Environmental Science and Pollution Research 27:18, pages 22423-22433.
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Nebahat Yildizbayrak, Banu Orta-Yilmaz, Yasemin Aydin & Melike Erkan. (2020) Acrolein exerts a genotoxic effect in the Leydig cells by stimulating DNA damage-induced apoptosis. Environmental Science and Pollution Research 27:13, pages 15869-15877.
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Daniel J. Conklin, Suzaynn Schick, Michael J. Blaha, Alex Carll, Andrew DeFilippis, Peter Ganz, Michael E. Hall, Naomi Hamburg, Tim O’Toole, Lindsay Reynolds, Sanjay Srivastava & Aruni Bhatnagar. (2019) Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation. American Journal of Physiology-Heart and Circulatory Physiology 316:4, pages H801-H827.
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Leslie C Thompson, Leon Walsh, Brandi L Martin, John McGee, Charles Wood, Kasey Kovalcik, Joseph Patrick Pancras, Najwa Haykal-Coates, Allen D Ledbetter, David Davies, Wayne E Cascio, Mark Higuchi, Mehdi S Hazari & Aimen K Farraj. (2019) Ambient Particulate Matter and Acrolein Co-Exposure Increases Myocardial Dyssynchrony in Mice via TRPA1. Toxicological Sciences 167:2, pages 559-572.
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D.J. Conklin & A. Bhatnagar. 2018. Comprehensive Toxicology. Comprehensive Toxicology 514 537 .
Hanan Qasim, Zubair A. Karim, Jose O. Rivera, Fadi T. Khasawneh & Fatima Z. Alshbool. (2017) Impact of Electronic Cigarettes on the Cardiovascular System. Journal of the American Heart Association 6:9.
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Samantha J. Snow, Marie A. McGeeAndres Henriquez, Judy E. Richards, Mette C. Schladweiler, Allen D. Ledbetter & Urmila P. Kodavanti. (2017) Respiratory Effects and Systemic Stress Response Following Acute Acrolein Inhalation in Rats. Toxicological Sciences 158:2, pages 454-464.
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Robert J. Henning, Giffe T. Johnson, Jayme P. Coyle & Raymond D. Harbison. (2017) Acrolein Can Cause Cardiovascular Disease: A Review. Cardiovascular Toxicology 17:3, pages 227-236.
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Leslie C. Thompson, Allen D. Ledbetter, Najwa Haykal-Coates, Wayne E. Cascio, Mehdi S. Hazari & Aimen K. Farraj. (2016) Acrolein Inhalation Alters Myocardial Synchrony and Performance at and Below Exposure Concentrations that Cause Ventilatory Responses. Cardiovascular Toxicology 17:2, pages 97-108.
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Kai-Lee Wang, Wen-Ching Huang, Jou-Chun Chou, Ting-Chun Weng, Sindy Hu, Fu-Kong Lieu, Wei-Ho Lai, Galina Idova, Paulus S. Wang & Shyi-Wu Wang. (2016) Effects of acrolein on aldosterone release from zona glomerulosa cells in male rats. Steroids 111, pages 89-94.
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Aruni Bhatnagar. (2016) E-Cigarettes and Cardiovascular Disease Risk: Evaluation of Evidence, Policy Implications, and Recommendations. Current Cardiovascular Risk Reports 10:7.
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Daniel J. Conklin. (2016) Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1. Annals of the New York Academy of Sciences 1374:1, pages 59-67.
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Katlyn E. McGraw, Stacey L. Konkle, Daniel W. Riggs, Shesh N. Rai, Natasha K. DeJarnett, Zhengzhi Xie, Rachel J. Keith, Adebamike A. Oshunbade, Michael E. Hall, Daichi Shimbo & Aruni Bhatnagar. (2022) Exposure to Volatile Organic Compounds is Associated with Hypertension in Black Adults: The Jackson Heart Study. SSRN Electronic Journal.
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