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Articles

Biology and significance of signalling pathways activated by IGF-II

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Pages 1-12 | Received 17 Oct 2011, Accepted 08 Nov 2011, Published online: 05 Dec 2011

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Articles from other publishers (57)

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Cristina Maxia, Michela Isola, Eleonora Grecu, Alberto Cuccu, Alessandra Scano, Germano Orrù, Nick Di Girolamo, Andrea Diana & Daniela Murtas. (2023) Synergic Action of Insulin-like Growth Factor-2 and miRNA-483 in Pterygium Pathogenesis. International Journal of Molecular Sciences 24:5, pages 4329.
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Rajani M. George, Beth A. Firulli, Ram Podicheti, Douglas B. Rusch, Brandon J. Mannion, Len A. Pennacchio, Marco Osterwalder & Anthony B. Firulli. (2023) Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis . Development 150:3.
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Antonino Belfiore, Rosaria Valentina Rapicavoli, Rosario Le Moli, Rosamaria Lappano, Andrea Morrione, Ernestina Marianna De Francesco & Veronica Vella. (2023) IGF2: A Role in Metastasis and Tumor Evasion from Immune Surveillance?. Biomedicines 11:1, pages 229.
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Suhee Chang, Diana Fulmer, Stella K Hur, Joanne L Thorvaldsen, Li Li, Yemin Lan, Eric A Rhon-Calderon, Nicolae Adrian Leu, Xiaowen Chen, Jonathan A Epstein & Marisa S Bartolomei. (2022) Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver-Russell syndrome-like mouse models. eLife 11.
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Shuang Yang, Linhao Lan, Mingda Gong, Ke Yang & Xiaoming Li. (2022) An asymmetric wettable PCL/chitosan composite scaffold loaded with IGF-2 for wound dressing. Journal of Biomaterials Applications 37:4, pages 577-587.
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Andrew J. Blyth, Nicholas S. Kirk & Briony E. Forbes. (2020) Understanding IGF-II Action through Insights into Receptor Binding and Activation. Cells 9:10, pages 2276.
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Ying Chen, Jiabing Shen, Chengxiao Ma, Maosheng Cao, Jianan Yan, Jingjing Liang, Kaifu Ke, Maohong Cao & Gu Xiaosu. (2020) Skin-derived precursor Schwann cells protect SH-SY5Y cells against 6-OHDA-induced neurotoxicity by PI3K/AKT/Bcl-2 pathway. Brain Research Bulletin 161, pages 84-93.
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Marchien G. Dallinga, Yasmin I. Habani, Richelle P. Kayser, Cornelis J. F. Van Noorden, Ingeborg Klaassen & Reinier O. Schlingemann. (2020) IGF-binding proteins 3 and 4 are regulators of sprouting angiogenesis. Molecular Biology Reports 47:4, pages 2561-2572.
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Asiamah Amponsah Collins, Kun Zou, Zhang Li & Su Ying. (2019) Mechanism and Functions of Identified miRNAs in Poultry Skeletal Muscle Development – A Review. Annals of Animal Science 19:4, pages 887-904.
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Lynda K Harris, Priyadarshini Pantham, Hannah E J Yong, Anita Pratt, Anthony J Borg, Ian Crocker, Melissa Westwood, John Aplin, Bill Kalionis & Padma Murthi. (2019) The role of insulin-like growth factor 2 receptor-mediated homeobox gene expression in human placental apoptosis, and its implications in idiopathic fetal growth restriction. Molecular Human Reproduction 25:9, pages 572-585.
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Frank H. de Jong & Johannes Hofland. 2019. Encyclopedia of Endocrine Diseases. Encyclopedia of Endocrine Diseases 43 50 .
Marchien G. Dallinga, Bahar Yetkin-Arik, Richelle P. Kayser, Ilse M. C. Vogels, Patrycja Nowak-Sliwinska, Arjan W. Griffioen, Cornelis J. F. van Noorden, Ingeborg Klaassen & Reinier O. Schlingemann. (2018) IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers. Angiogenesis 21:4, pages 823-836.
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Amanda Nancy Sferruzzi-Perri. (2018) Regulating needs: Exploring the role of insulin-like growth factor-2 signalling in materno-fetal resource allocation. Placenta 64, pages S16-S22.
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Quanwei Zhang, Qi Wang, Jishang Gong, Jiaxing Du, Yong Zhang & Xingxu Zhao. (2018) Yak IGF2 Promotes Fibroblast Proliferation Via Suppression of IGF1R and PI3KCG Expression. Genes 9:3, pages 169.
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Shou P. Guan, Alan T.L. Lam, Jennifer P. Newman, Kevin L.M. Chua, Catherine Y.L. Kok, Siao T. Chong, Melvin L.K. Chua & Paula Y.P. Lam. (2018) Matrix metalloproteinase-1 facilitates MSC migration via cleavage of IGF-2/IGFBP2 complex. FEBS Open Bio 8:1, pages 15-26.
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Adetunji T. Toriola, Mark Ziegler, Yize Li, Michael Pollak & Rachael Stolzenberg-Solomon. (2017) Prediagnosis Circulating Insulin-Like Growth Factors and Pancreatic Cancer Survival. Annals of Surgical Oncology 24:11, pages 3212-3219.
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E. Martín-Montañez, C. Millon, F. Boraldi, F. Garcia-Guirado, C. Pedraza, E. Lara, L.J. Santin, J. Pavia & M. Garcia-Fernandez. (2017) IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids. Redox Biology 13, pages 69-81.
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Kristin Mussar, Stephanie Pardike, Tobias M. Hohl, Gary Hardiman, Vincenzo Cirulli & Laura Crisa. (2017) A CCR2+ myeloid cell niche required for pancreatic β cell growth. JCI Insight 2:15.
Crossref
Amanda N. Sferruzzi-Perri, Ionel Sandovici, Miguel Constancia & Abigail L. Fowden. (2017) Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth. The Journal of Physiology 595:15, pages 5057-5093.
Crossref
O. Escribano, N. Beneit, C. Rubio-Longás, A. R. López-Pastor & A. Gómez-Hernández. (2017) The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications. Journal of Diabetes Research 2017, pages 1-12.
Crossref
Almas R Juma, Pauliina E Damdimopoulou, Sylvia V H Grommen, Wim J M Van de Ven & Bert De Groef. (2016) Emerging role of PLAG1 as a regulator of growth and reproduction. Journal of Endocrinology 228:2, pages R45-R56.
Crossref
Jayne C. Charnock, Mark R. Dilworth, John D. Aplin, Colin P. Sibley, Melissa Westwood & Ian P. Crocker. (2016) The impact of a human IGF-II analog ([Leu 27 ]IGF-II) on fetal growth in a mouse model of fetal growth restriction . American Journal of Physiology-Endocrinology and Metabolism 310:1, pages E24-E31.
Crossref
J. M. Cottam Jones, P. W. R. Harris, D. B. Scanlon, B. E. Forbes, M. A. Brimble & A. D. Abell. (2016) Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R. Organic & Biomolecular Chemistry 14:9, pages 2698-2705.
Crossref
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Crossref
Jurriaan Brouwer-Visser & Gloria S. Huang. (2015) IGF2 signaling and regulation in cancer. Cytokine & Growth Factor Reviews 26:3, pages 371-377.
Crossref
Kuan‐Ho Lin, Chia‐Hua Kuo, Wei‐Wen Kuo, Tsung‐Jung Ho, Peiying Pai, Wei‐Kung Chen, Lung‐Fa Pan, Chien‐Cheng Wang, V. Vijaya Padma & Chih‐Yang Huang. (2015) NFIL3 Suppresses Hypoxia‐induced Apoptotic Cell Death by Targeting the Insulin‐like Growth Factor 2 Receptor. Journal of Cellular Biochemistry 116:6, pages 1113-1120.
Crossref
Kimberley C. W. Wang, Darran N. Tosh, Song Zhang, I. Caroline McMillen, Jaime A. Duffield, Doug A. Brooks & Janna L. Morrison. (2015) IGF-2R-G αq signaling and cardiac hypertrophy in the low-birth-weight lamb . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308:7, pages R627-R635.
Crossref
Claudia Pivonello, Maria Cristina De Martino, Mariarosaria Negri, Gaia Cuomo, Federica Cariati, Francesco Izzo, Annamaria Colao & Rosario Pivonello. (2014) The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets. Infectious Agents and Cancer 9:1.
Crossref
Ling Lin, Lynn Chamberlain, Magnolia L. Pak, Arvindhan Nagarajan, Romi Gupta, Lihua J. Zhu, Casey M. Wright, Kwun M. Fong, Narendra Wajapeyee & Michael R. Green. (2014) A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling. Cancer Discovery 4:10, pages 1168-1181.
Crossref
J.-M. OU, W.-S. LIAN, M.-K. QIU, Y.-X. DAI, Q. DONG, J. SHEN, P. DONG, X.-F. WANG, Y.-B. LIU, Z.-W. QUAN & Z.-W. FEI. (2014) Knockdown of IGF2R suppresses proliferation and induces apoptosis in hemangioma cells in vitro and in vivo. International Journal of Oncology 45:3, pages 1241-1249.
Crossref
Marine Guillaud-Bataille, Bruno Ragazzon, Aurélien de Reyniès, Claire Chevalier, Isabelle Francillard, Olivia Barreau, Virginie Steunou, Johann Guillemot, Frédérique Tissier, Marthe Rizk-Rabin, Fernande René-Corail, Abir Al Ghuzlan, Guillaume Assié, Xavier Bertagna, Eric Baudin, Yves Le Bouc, Jérôme Bertherat & Eric Clauser. (2014) IGF2 Promotes Growth of Adrenocortical Carcinoma Cells, but Its Overexpression Does Not Modify Phenotypic and Molecular Features of Adrenocortical Carcinoma. PLoS ONE 9:8, pages e103744.
Crossref
Elisa Martin-Montañez, José Pavia, Luis J. Santin, Federica Boraldi, Guillermo Estivill-Torrus, José A. Aguirre & Maria Garcia-Fernandez. (2014) Involvement of IGF-II receptors in the antioxidant and neuroprotective effects of IGF-II on adult cortical neuronal cultures. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842:7, pages 1041-1051.
Crossref
Xiao-Rui Geng, Gui Yang, Meng Li, Jiang-Ping Song, Zhi-Qiang Liu, Shuqi Qiu, Zhigang Liu & Ping-Chang Yang. (2014) Insulin-like Growth Factor-2 Enhances Functions of Antigen (Ag)-specific Regulatory B Cells. Journal of Biological Chemistry 289:25, pages 17941-17950.
Crossref
Jakob H. Mikkelsen, Zachary T. Resch, Bhanu Kalra, Gopal Savjani, Ajay Kumar, Cheryl A. Conover & Claus Oxvig. (2014) Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity . Oncotarget 5:4, pages 1014-1025.
Crossref
Rikke Hjortebjerg & Jan Frystyk. (2013) Determination of IGFs and their binding proteins. Best Practice & Research Clinical Endocrinology & Metabolism 27:6, pages 771-781.
Crossref
Daniel PortalHufeng ZhouBo ZhaoPeter V. KharchenkoElizabeth LowryLimsoon WongJohn Quackenbush, Dustin Holloway, Sizun JiangYong Lu & Elliott Kieff. (2013) Epstein–Barr virus nuclear antigen leader protein localizes to promoters and enhancers with cell transcription factors and EBNA2. Proceedings of the National Academy of Sciences 110:46, pages 18537-18542.
Crossref
Nataly L. Magner, Yunjoon Jung, Jian Wu, Jan A. Nolta, Mark A. Zern & Ping Zhou. (2013) Insulin and igfs enhance hepatocyte differentiation from human embryonic stem cells via the PI3K/AKT pathway. Stem Cells 31:10, pages 2095-2103.
Crossref
LJ Hale, GI Welsh, CM Perks, JA Hurcombe, S Moore, I Hers, MA Saleem, PW Mathieson, AJ Murphy, M Jeansson, JM Holly, SN Hardouin & RJ Coward. (2013) Insulin‐like growth factor‐ II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse . The Journal of Pathology 230:1, pages 95-106.
Crossref
Jade M. Cottam, Denis B. Scanlon, John A. Karas, Antonio N. Calabrese, Tara L. Pukala, Briony E. Forbes, John C. Wallace & Andrew D. Abell. (2012) Chemical Synthesis of a Fluorescent IGF-II Analogue. International Journal of Peptide Research and Therapeutics 19:1, pages 61-69.
Crossref

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