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Expression of pleiotrophin, an important regulator of cell migration, is inhibited in intestinal epithelial cells by treatment with non-steroidal anti-inflammatory drugs

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Pages 258-266 | Received 09 Feb 2012, Accepted 11 May 2012, Published online: 13 Jun 2012

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Di Shen, Nataly P. Podolnikova, Valentin P. Yakubenko, Christopher L. Ardell, Arnat Balabiyev, Tatiana P. Ugarova & Xu Wang. (2017) Pleiotrophin, a multifunctional cytokine and growth factor, induces leukocyte responses through the integrin Mac-1. Journal of Biological Chemistry 292:46, pages 18848-18861.
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Yuseok Moon. (2017) NSAID-activated gene 1 and its implications for mucosal integrity and intervention beyond NSAIDs. Pharmacological Research 121, pages 122-128.
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Kristopher Silver, A. Littlejohn, Laurel Thomas, Bhupinder Bawa & James D. Lillich. (2017) Suppression of calpain expression by NSAIDs is associated with inhibition of cell migration in rat duodenum. Toxicology 383, pages 1-12.
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Jiequn Ma, Ying Kong, Haocheng Nan, Shengyang Qu, Xiao Fu, Lili Jiang, Wenjuan Wang, Hui Guo, Shounian Zhao, Jianjun He & Kejun Nan. (2017) Pleiotrophin as a potential biomarker in breast cancer patients. Clinica Chimica Acta 466, pages 6-12.
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Hye Jin Choi, Kee Hun Do, Jae-Hong Park, Juil Kim, Mira Yu, Seong-Hwan Park & Yuseok Moon. (2016) Early Epithelial Restitution by Nonsteroidal Anti-Inflammatory Drug–Activated Gene 1 Counteracts Intestinal Ulcerative Injuries. The Journal of Immunology 197:4, pages 1415-1424.
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Kristopher Silver, Alaina Littlejohn, Laurel Thomas, Elizabeth Marsh & James D. Lillich. (2015) Inhibition of Kv channel expression by NSAIDs depolarizes membrane potential and inhibits cell migration by disrupting calpain signaling. Biochemical Pharmacology 98:4, pages 614-628.
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Daniela Palmieri, Marzia Mura, Simone Mambrini & Domenico Palombo. (2015) Effects of Pleiotrophin on endothelial and inflammatory cells: Pro-angiogenic and anti-inflammatory properties and potential role for vascular bio-prosthesis endothelialization. Advances in Medical Sciences 60:2, pages 287-293.
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Sotiria Tsirmoula, Margarita Lamprou, Maria Hatziapostolou, Nelly Kieffer & Evangelia Papadimitriou. (2015) Pleiotrophin-induced endothelial cell migration is regulated by xanthine oxidase-mediated generation of reactive oxygen species. Microvascular Research 98, pages 74-81.
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