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Growth Factors Volume 32, 2014 - Issue 1
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Research Article

Expression levels of insulin receptor substrate-1 modulate the osteoblastic differentiation of mesenchymal stem cells and osteosarcoma cells

Clara ContaldoLaboratory of Experimental Oncology, CRS Development of Molecular Therapies, Orthopaedic Rizzoli Institute BolognaItaly;Department of Pediatrics
,
Timothy J. MyersDepartment of Pediatrics
,
Cinzia ZucchiniDepartment of Experimental, Diagnostic and Specialty Medicine, University of BolognaItaly
,
Maria Cristina ManaraLaboratory of Experimental Oncology, CRS Development of Molecular Therapies, Orthopaedic Rizzoli Institute BolognaItaly
,
Claudia ChiodoniMolecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori MilanItaly
,
Mario P. ColomboMolecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori MilanItaly
,
Giordano NicolettiLaboratory of Experimental Oncology, CRS Development of Molecular Therapies, Orthopaedic Rizzoli Institute BolognaItaly
,
Pier Luigi LolliniDepartment of Experimental, Diagnostic and Specialty Medicine, University of BolognaItaly
,
Tieshi LiDepartment of Pediatrics
,
Lara LongobardiDepartment of Pediatrics
,
Katia ScotlandiLaboratory of Experimental Oncology, CRS Development of Molecular Therapies, Orthopaedic Rizzoli Institute BolognaItaly
&
Anna SpagnoliDepartment of Pediatrics;Department of Biomedical Engineering, University of North Carolina at Chapel Hill Chapel Hill, NCUSACorrespondence[email protected]
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Pages 41-52 | Received 10 Sep 2013, Accepted 24 Nov 2013, Published online: 20 Jan 2014

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Lingling Xu, Yinling Tan, Fengxia Xu & Yong Zhang. (2022) Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761. Bioengineered 13:2, pages 2028-2043.
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Xing Wang, Feng Qi, Helin Xing, Xiaoxuan Zhang, Chunxiang Lu, Jiajia Zheng & Xiuyun Ren. (2019) Uniform-sized insulin-loaded PLGA microspheres for improved early-stage peri-implant bone regeneration. Drug Delivery 26:1, pages 1178-1190.
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Xing Wang, Guilan Zhang, Feng Qi, Yongfeng Cheng, Xuguang Lu, Lu Wang, Jing Zhao & Bin Zhao. (2018) Enhanced bone regeneration using an insulin-loaded nano-hydroxyapatite/collagen/PLGA composite scaffold. International Journal of Nanomedicine 13, pages 117-127.
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Arathy S. Kumar, Suresh K. Rayala & Ganesh Venkatraman. (2018) Targeting IGF1R pathway in cancer with microRNAs: How close are we?. RNA Biology 15:3, pages 320-326.
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Zhan-Qing Yang, Hong-Liang Zhang, Cui-Cui Duan, Shuang Geng, Kai Wang, Hai-Fan Yu, Zhan-Peng Yue & Bin Guo. (2017) IGF1 regulates RUNX1 expression via IRS1/2: Implications for antler chondrocyte differentiation. Cell Cycle 16:6, pages 522-532.
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Articles from other publishers (9)

Nan Wei, Gong Chao-yang, Zhou Wen-ming, Lei Ze-yuan, Shi Yong-qiang, Zhang Shun-bai, Zhang Kai, Ma Yan-chao & Zhang Hai-hong. (2022) A ubiquitin-related gene signature for predicting prognosis and constructing molecular subtypes in osteosarcoma. Frontiers in Pharmacology 13.
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Gaohong Sheng, Yuan Gao, Yong Yang & Hua Wu. (2021) Osteosarcoma and Metastasis. Frontiers in Oncology 11.
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Peiran Wei, Yan Xu, Huikang Zhang & Liming Wang. (2021) Continued sustained insulin-releasing PLGA nanoparticles modified 3D-Printed PCL composite scaffolds for osteochondral repair. Chemical Engineering Journal 422, pages 130051.
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Xing Wang, Lu Wang, Feng Qi & Jing Zhao. (2018) The effect of a single injection of uniform-sized insulin-loaded PLGA microspheres on peri-implant bone formation. RSC Advances 8:70, pages 40417-40425.
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Xing Wang, Xia Wu, Helin Xing, Guilan Zhang, Quan Shi, Lingling E, Na Liu, Tingyuan Yang, Dongsheng Wang, Feng Qi, Lianyan Wang & Hongchen Liu. (2017) Porous Nanohydroxyapatite/Collagen Scaffolds Loading Insulin PLGA Particles for Restoration of Critical Size Bone Defect. ACS Applied Materials & Interfaces 9:13, pages 11380-11391.
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Nikolaos Armakolas, Athanasios Armakolas, Athanasios Antonopoulos, Andreas Dimakakos, Martha Stathaki & Michael Koutsilieris. (2016) The role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology. Critical Reviews in Oncology/Hematology 108, pages 137-145.
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Xiaoyun Wu, Huiyan Kang, Xuemin Liu, Jin Gao, Kuijun Zhao & Zhijie Ma. (2016) Serum and xeno-free, chemically defined, no-plate-coating-based culture system for mesenchymal stromal cells from the umbilical cord. Cell Proliferation 49:5, pages 579-588.
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Gang Xi, Xinchun Shen, Clifford J Rosen & David R Clemmons. (2016) IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation. Journal of Bone and Mineral Research 31:6, pages 1300-1314.
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Cecilia Garofalo, Mariantonietta Capristo, Caterina Mancarella, Hadas Reunevi, Piero Picci & Katia Scotlandi. (2015) Preclinical Effectiveness of Selective Inhibitor of IRS-1/2 NT157 in Osteosarcoma Cell Lines. Frontiers in Endocrinology 6.
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