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Research Article

Mechanism of Action of Amphotericin B at the Cellular Level. Its Modulation by Delivery Systems

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Pages 409-427 | Published online: 28 Sep 2008

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Rafaela de Oliveira Nóbrega, Anna Paula de Castro Teixeira, Wylly Araújo de Oliveira, Edeltrudes de Oliveira Lima & Igara Oliveira Lima. (2016) Investigation of the antifungal activity of carvacrol against strains of Cryptococcus neoformans. Pharmaceutical Biology 54:11, pages 2591-2596.
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P.J. Sperry, D.J. Cua, S.A. Wetzel & J.P. Adler-Moore. (1998) Antimicrobial activity of AmBisome and non-liposomal amphotericin B following uptake of Candida glabrata by murine epidermal Langerhans cells. Medical Mycology 36:3, pages 135-141.
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Articles from other publishers (27)

Neha Farid, Khair Bux, Kashif Ali, Asma Bashir & Rahima Tahir. (2023) Repurposing Amphotericin B: anti-microbial, molecular docking and molecular dynamics simulation studies suggest inhibition potential of Amphotericin B against MRSA. BMC Chemistry 17:1.
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Giuseppe Pezzotti, Miyuki Kobara, Tamaki Nakaya, Hayata Imamura, Tenma Asai, Nao Miyamoto, Tetsuya Adachi, Toshiro Yamamoto, Narisato Kanamura, Eriko Ohgitani, Elia Marin, Wenliang Zhu, Ichiro Nishimura, Osam Mazda, Tetsuo Nakata & Koichi Makimura. (2022) Raman Study of Pathogenic Candida auris: Imaging Metabolic Machineries in Reaction to Antifungal Drugs. Frontiers in Microbiology 13.
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Nishat Tabassum, Shoeb Ahmed & M. Azam Ali. 2022. Chitooligosaccharides. Chitooligosaccharides 309 332 .
Sayaka Sawada, Chika Miyagi‐Shiohira, Kazuho Kuwae, Yoshihito Tamaki, Kai Nishime, Mayuko Sakai‐Yonaha, Tasuku Yonaha, Issei Saitoh, Masami Watanabe & Hirofumi Noguchi. (2021) Pancreas preservation with amphotericin B deteriorates islet yield for porcine islet isolation. Xenotransplantation 28:4.
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Aleksandra S. Chikina, Francesca Nadalin, Mathieu Maurin, Mabel San-Roman, Thibault Thomas-Bonafos, Xin V. Li, Sonia Lameiras, Sylvain Baulande, Sandrine Henri, Bernard Malissen, Livia Lacerda Mariano, Jorge Barbazan, J. Magarian Blander, Iliyan D. Iliev, Danijela Matic Vignjevic & Ana-Maria Lennon-Duménil. (2020) Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption. Cell 183:2, pages 411-428.e16.
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Zhimei Song, Yi Wen, Peizong Deng, Fangfang Teng, Feilong Zhou, Hongmei Xu, Sijia Feng, Li Zhu & Runliang Feng. (2019) Linolenic acid-modified methoxy poly (ethylene glycol)-oligochitosan conjugate micelles for encapsulation of amphotericin B. Carbohydrate Polymers 205, pages 571-580.
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Md Yousuf Ansari, Manas Ranjan Dikhit, Ganesh Chandra Sahoo, Vahab Ali & Pradeep Das. (2017) Recent advancement and treatment of leishmaniasis based on pharmacoinformatics approach: Current and future outlook. Gene Reports 9, pages 86-97.
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Ying Wang, Xiyu Ke, Zhi Xiang Voo, Serene Si Ling Yap, Chuan Yang, Shujun Gao, Shaoqiong Liu, Shrinivas Venkataraman, Sybil Akua Okyerewa Obuobi, Jasmeet Singh Khara, Yi Yan Yang & Pui Lai Rachel Ee. (2016) Biodegradable functional polycarbonate micelles for controlled release of amphotericin B. Acta Biomaterialia 46, pages 211-220.
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Camila Arruda Saldanha, Mônica Pereira Garcia, Diego Cesar Iocca, Luciana Guilherme Rebelo, Ana Camila Oliveira Souza, Anamélia Lorenzetti Bocca, Maria de Fátima Menezes Almeida Santos, Paulo Cesar Morais & Ricardo Bentes Azevedo. (2016) Antifungal Activity of Amphotericin B Conjugated to Nanosized Magnetite in the Treatment of Paracoccidioidomycosis. PLOS Neglected Tropical Diseases 10:6, pages e0004754.
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Rishikesh Kumar, Ganesh Chandra Sahoo, Krishna Pandey, V.N.R. Das, Roshan K. Topno, Md Yousuf Ansari, Sindhuprava Rana & Pradeep Das. (2016) Development of PLGA–PEG encapsulated miltefosine based drug delivery system against visceral leishmaniasis. Materials Science and Engineering: C 59, pages 748-753.
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B. F. Sanches, P. Nunes, H. Almeida & M. Rebelo. (2014) Atrioventricular block related to liposomal amphotericin B. Case Reports 2014:jun06 1, pages bcr2013202688-bcr2013202688.
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T.T.H. Pham, G. Barratt, J.P. Michel, P.M. Loiseau & M. Saint-Pierre-Chazalet. (2013) Interactions of antileishmanial drugs with monolayers of lipids used in the development of amphotericin B–miltefosine-loaded nanocochleates. Colloids and Surfaces B: Biointerfaces 106, pages 224-233.
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Andreas Zumbuehl, Pasquale Stano, Marc Sohrmann, Mathias Peter, Peter Walde & Erick M. Carreira. (2007) A novel strategy for bioconjugation: synthesis and preliminary evaluation with amphotericin B. Organic & Biomolecular Chemistry 5:9, pages 1339.
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Andreas Zumbuehl, Damien Jeannerat, Scott E. Martin, Marc Sohrmann, Pasquale Stano, Tamas Vigassy, Daniel D. Clark, Stephen L. Hussey, Mathias Peter, Blake R. Peterson, Ernö Pretsch, Peter Walde & Erick M. Carreira. (2004) An Amphotericin B–Fluorescein Conjugate as a Powerful Probe for Biochemical Studies of the Membrane. Angewandte Chemie 116:39, pages 5293-5297.
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Andreas Zumbuehl, Pasquale Stano, Dominik Heer, Peter Walde & Erick M. Carreira. (2004) Amphotericin B as a Potential Probe of the Physical State of Vesicle Membranes. Organic Letters 6:21, pages 3683-3686.
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R Stoodley, J Shepherd, K.M Wasan & D Bizzotto. (2002) Amphotericin B interactions with a DOPC monolayer. Electrochemical investigations. Biochimica et Biophysica Acta (BBA) - Biomembranes 1564:1, pages 289-297.
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M. A. Campanero, M. S. Espuelas, J. R. Azanza & J. M. Irache. (2000) Rapid determination of intramacrophagic amphotericin B by direct injection HPLC. Chromatographia 52:11-12, pages 827-830.
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Mohamed Younsi, Elise Ramanandraibe, Roger Bonaly, Mireille Donner & Joël Coulon. (2000) Amphotericin B Resistance and Membrane Fluidity in Kluyveromyces lactis Strains . Antimicrobial Agents and Chemotherapy 44:7, pages 1911-1916.
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Ihor Bekersky, Robert M Fielding, Donald Buell & Ira Lawrence. (1999) Lipid-based amphotericin B formulations: from animals to man. Pharmaceutical Science & Technology Today 2:6, pages 230-236.
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F Gaboriau, M Chéron, C Petit & J Bolard. (1997) Heat-induced superaggregation of amphotericin B reduces its in vitro toxicity: a new way to improve its therapeutic index. Antimicrobial Agents and Chemotherapy 41:11, pages 2345-2351.
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Robert P Rapp, Paul O Gubbins & Martin E Evans. (2016) Amphotericin B Lipid Complex. Annals of Pharmacotherapy 31:10, pages 1174-1186.
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François Gaboriau, Monique Chéron, Liliane Leroy & Jacques Bolard. (1997) Physico-chemical properties of the heat-induced ‘superaggregates’ of amphotericin B. Biophysical Chemistry 66:1, pages 1-12.
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Anya M. Hillery. (1997) Supramolecular lipidic drug delivery systems: From laboratory to clinic A review of the recently introduced commercial liposomal and lipid-based formulations of amphotericin B. Advanced Drug Delivery Reviews 24:2-3, pages 345-363.
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Richard M. Eglen, Mont R. Juchau, Gillian Edwards, Arthur H. Weston, Helen Wise, M. D. Murray, D. Craig Brater, Olivier Valdenaire, Philippe Vernier & Annemarie PolakAnnemarie Polak. 1997. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques 219 318 .
Scott Hartsel & Jacques Bolard. (1996) Amphotericin B: new life for an old drug. Trends in Pharmacological Sciences 17:12, pages 445-449.
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J BrajtburgJ Bolard. (1996) Carrier effects on biological activity of amphotericin B. Clinical Microbiology Reviews 9:4, pages 512-531.
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Brian D. Wolf & Scott C. Hartsel. (1995) Osmotic stress sensitizes sterol-free phospholipid bilayers to the action of Amphotericin B. Biochimica et Biophysica Acta (BBA) - Biomembranes 1238:2, pages 156-162.
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