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Ophthalmic Epidemiology Volume 21, 2014 - Issue 2
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Research Article

Central Retinal Enrichment Supplementation Trials (CREST): Design and Methodology of the CREST Randomized Controlled Trials

Kwadwo Owusu AkuffoMacular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology WaterfordIrelandCorrespondence[email protected]
,
Stephen BeattyMacular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology WaterfordIreland
,
Jim StackMacular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology WaterfordIreland
,
Jessica DennisonMacular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology WaterfordIreland
,
Sarah O’ReganMacular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology WaterfordIreland
,
Katherine A. MeagherMacular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology WaterfordIreland
,
Tunde PetoNIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology LondonUK
&
John NolanMacular Pigment Research Group, Department of Chemical and Life Sciences, Waterford Institute of Technology WaterfordIreland
 show all
Pages 111-123 | Received 14 Mar 2013, Accepted 03 Sep 2013, Published online: 12 Mar 2014

Citations (27)

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Pinakin Gunvant Davey, Silverio D Alvarez & Jessica Y Lee. (2016) Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance. Clinical Ophthalmology 10, pages 1671-1678.
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Michael John Tolentino, Abrahan Dennrick, Elizabeth John & Michael Steven Tolentino. (2015) Drugs in Phase II clinical trials for the treatment of age-related macular degeneration. Expert Opinion on Investigational Drugs 24:2, pages 183-199.
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Articles from other publishers (25)

Jennifer R Evans & John G Lawrenson. (2023) Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database of Systematic Reviews 2023:9.
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Takeshi Yoshida, Yasutaka TakagiTae Igarashi-Yokoi & Kyoko Ohno-Matsui. (2023) Efficacy of lutein supplements on macular pigment optical density in highly myopic individuals: A randomized controlled trial. Medicine 102:12, pages e33280.
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Sandhya Sahye-Pudaruth & David W. L. Ma. (2023) Assessing the Highest Level of Evidence from Randomized Controlled Trials in Omega-3 Research. Nutrients 15:4, pages 1001.
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Drake W. Lem, Dennis L. Gierhart & Pinakin Gunvant Davey. (2022) Can Nutrition Play a Role in Ameliorating Digital Eye Strain?. Nutrients 14:19, pages 4005.
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Emmanuel Ankamah, Marina Green-Gomez, Warren Roche, Eugene Ng, Ulrich Welge-Lüßen, Thomas Kaercher & John M. Nolan. (2021) Dietary Intervention With a Targeted Micronutrient Formulation Reduces the Visual Discomfort Associated With Vitreous Degeneration. Translational Vision Science & Technology 10:12, pages 19.
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Drake W. Lem, Pinakin Gunvant Davey, Dennis L. Gierhart & Richard B. Rosen. (2021) A Systematic Review of Carotenoids in the Management of Age-Related Macular Degeneration. Antioxidants 10:8, pages 1255.
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Drake W. Lem, Dennis L. Gierhart & Pinakin Gunvant Davey. (2021) A Systematic Review of Carotenoids in the Management of Diabetic Retinopathy. Nutrients 13:7, pages 2441.
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Marina Green-Gomez, Rachel Moran, James Stringham, Cesar Hernández-Alcaraz, Kenny Mendoza-Herrera, J. Jans Fromow-Guerra, Alfonso Prado-Cabrero & John Nolan. (2021) Environmental and Nutritional Determinants of Macular Pigment in a Mexican Population. Investigative Opthalmology & Visual Science 62:9, pages 18.
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Pinakin Davey, Angeline Ngo, Jeneatte Cross & Dennis L. Gierhart. (2019) Macular pigment reflectometry: development and evaluation of a novel clinical device for rapid objective assessment of the macular carotenoids. Macular pigment reflectometry: development and evaluation of a novel clinical device for rapid objective assessment of the macular carotenoids.
Fábio B. Daga, Nara G. Ogata, Felipe A. Medeiros, Rachel Moran, Jeffrey Morris, Linda M. Zangwill, Robert N. Weinreb & John M. Nolan. (2018) Macular Pigment and Visual Function in Patients With Glaucoma: The San Diego Macular Pigment Study. Investigative Opthalmology & Visual Science 59:11, pages 4471.
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Rebecca Power, Robert F. Coen, Stephen Beatty, Riona Mulcahy, Rachel Moran, Jim Stack, Alan N. Howard & John M. Nolan. (2018) Supplemental Retinal Carotenoids Enhance Memory in Healthy Individuals with Low Levels of Macular Pigment in A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Journal of Alzheimer's Disease 61:3, pages 947-961.
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Jennifer R Evans & John G Lawrenson. (2017) Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database of Systematic Reviews 2017:9.
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Kwadwo Owusu Akuffo, John M Nolan, Tunde Peto, Jim Stack, Irene Leung, Laura Corcoran & Stephen Beatty. (2017) Relationship between macular pigment and visual function in subjects with early age-related macular degeneration. British Journal of Ophthalmology 101:2, pages 190-197.
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X Li, D Kelly, J M Nolan, J L Dennison & S Beatty. (2016) The evidence informing the surgeon’s selection of intraocular lens on the basis of light transmittance properties. Eye 31:2, pages 258-272.
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David Kelly, John M. Nolan, Alan N. Howard, Jim Stack, Kwadwo O. Akuffo, Rachel Moran, David I. Thurnham, Jessica Dennison, Katherine A. Meagher & Stephen Beatty. (2017) Serum and macular response to carotenoid-enriched egg supplementation in human subjects: the Egg Xanthophyll Intervention clinical Trial (EXIT). British Journal of Nutrition 117:1, pages 108-123.
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Wei Zhu, Yan Wu, Yi-Fang Meng, Qian Xing, Jian-Jun Tao & Jiong Lu. (2016) Fish Consumption and Age-Related Macular Degeneration Incidence: A Meta-Analysis and Systematic Review of Prospective Cohort Studies. Nutrients 8:11, pages 743.
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Le Ma, Rong Liu, Jun Du, Tao Liu, Shan Wu & Xiao Liu. (2016) Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density. Nutrients 8:7, pages 426.
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Paul S. Bernstein, Binxing Li, Preejith P. Vachali, Aruna Gorusupudi, Rajalekshmy Shyam, Bradley S. Henriksen & John M. Nolan. (2016) Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. Progress in Retinal and Eye Research 50, pages 34-66.
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David J. Valent & Emily Y. Chew. 2016. Anti-Angiogenic Therapy in Ophthalmology. Anti-Angiogenic Therapy in Ophthalmology 67 77 .
Melisa D. Marquioni-Ramella & Angela M. Suburo. (2015) Photo-damage, photo-protection and age-related macular degeneration. Photochemical & Photobiological Sciences 14:9, pages 1560-1577.
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David Kelly, Robert F. Coen, Kwadwo Owusu Akuffo, Stephen Beatty, Jessica Dennison, Rachel Moran, Jim Stack, Alan N. Howard, Riona Mulcahy & John M. Nolan. (2015) Cognitive Function and Its Relationship with Macular Pigment Optical Density and Serum Concentrations of its Constituent Carotenoids. Journal of Alzheimer's Disease 48:1, pages 261-277.
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Eric A. Saidi, Pinakin Gunvant Davey & D. Joshua Cameron. (2015) The Effect of Zeaxanthin on the Visual Acuity of Zebrafish. PLOS ONE 10:8, pages e0135211.
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K O Akuffo, J M Nolan, A N Howard, R Moran, J Stack, R Klein, B E Klein, S M Meuer, S Sabour-Pickett, D I Thurnham & S Beatty. (2015) Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular degeneration. Eye 29:7, pages 902-912.
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Ninel Z. Gregori & Raquel Goldhardt. (2015) Nutritional Supplements for Age-Related Macular Degeneration. Current Ophthalmology Reports 3:1, pages 34-39.
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Sarah Sabour-Pickett, Stephen Beatty, Eithne Connolly, James Loughman, Jim Stack, Alan Howard, Ronald Klein, Barbara E. Klein, Stacy M. Meuer, Chelsea E. Myers, Kwadwo O. Akuffo & John M. Nolan. (2014) SUPPLEMENTATION WITH THREE DIFFERENT MACULAR CAROTENOID FORMULATIONS IN PATIENTS WITH EARLY AGE-RELATED MACULAR DEGENERATION. Retina 34:9, pages 1757-1766.
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