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Tumor

Progesterone inhibits growth and induces apoptosis in cancer cells through modulation of reactive oxygen species

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Pages 830-836 | Received 17 Aug 2010, Accepted 25 Oct 2010, Published online: 21 Dec 2010

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Maha AH Sulaiman, Yahya M Al-Farsi, Maha M Al-Khaduri, Jumana Saleh & Mostafa I Waly. (2018) Polycystic ovarian syndrome is linked to increased oxidative stress in Omani women. International Journal of Women's Health 10, pages 763-771.
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Juberiya M Azeez, Hima Sithul, Indhu Hariharan, Sreeja Sreekumar, Jem Prabhakar, Sreeharshan Sreeja & Madhavan Radhakrishna Pillai. (2015) Progesterone regulates the proliferation of breast cancer cells – in vitro evidence. Drug Design, Development and Therapy 9, pages 5987-5999.
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Articles from other publishers (31)

Laura J Mauro, Angela Spartz, Julia R Austin & Carol A Lange. (2023) Reevaluating the Role of Progesterone in Ovarian Cancer: Is Progesterone Always Protective?. Endocrine Reviews 44:6, pages 1029-1046.
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Setareh Maleki, Sara Keshtgar, Bahareh Ebrahimi, Hedie Matavos-Aramyan, Narges Karbalaei & Fatemeh Masjedi. (2023) Effects of CatSper Stimulation and Inhibition by Progesterone and NNC on Human Sperm. Andrologia 2023, pages 1-8.
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Anuradha Sharma & Indu Sharma. (2023) In vitro chemo-preventive efficacy of synthetic progestin Norethindrone in human epithelial ovarian cancer. Medical Oncology 40:7.
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Ankita Ray, Tanu Bhati, Renu Arora, Suhel Parvez & Sangita Rastogi. (2023) Association of functional superoxide gene polymorphism with chlamydia trachomatis-associated recurrent spontaneous abortion. Molecular Biology Reports 50:6, pages 4907-4915.
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Luca F. Castelnovo & Peter Thomas. (2023) Progesterone exerts a neuroprotective action in a Parkinson’s disease human cell model through membrane progesterone receptor α (mPRα/PAQR7). Frontiers in Endocrinology 14.
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Rui Feng, Xue Qin, Qi Li, Samson Olugbenga Adeniran, Fushuo Huang, Yulong Li, Qian Zhao & Peng Zheng. (2022) Progesterone regulates inflammation and receptivity of cells via the NF-κB and LIF/STAT3 pathways. Theriogenology 186, pages 50-59.
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Deepshikha Ghosh, Priti Chatterjee, Tulika Mitra & Sib Sankar Roy. 2022. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 165 183 .
Hao Lin, Kuo-Chung Lan, Yu-Che Ou, Chen-Hsuan Wu, Hong-Yo Kang, I-Chieh Chuang & Hung-Chun Fu. (2021) Highly Expressed Progesterone Receptor B Isoform Increases Platinum Sensitivity and Survival of Ovarian High-Grade Serous Carcinoma. Cancers 13:21, pages 5578.
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Ying Li, Yaxu Jia, Yurong Xu & Kan Li. (2021) DMF Activates NRF2 to Inhibit the Pro-Invasion Ability of TAMs in Breast Cancer. Frontiers in Oncology 11.
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Hajar Ku Yasin, Anthony H. Taylor & Thangesweran Ayakannu. (2021) A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer. Cancers 13:9, pages 2149.
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Jia-Wei Shi, Hui-Li Yang, Zhen-Zhen Lai, Hui-Hui Shen, Lu-Yu Ruan, Yan Wang, Xue-Min Qiu, Feng Xie & Ming-Qing Li. (2021) Aspirin enhances the protective effect of progesterone on trophoblast cell from oxidative stress and apoptosis. Reproductive and Developmental Medicine 5:1, pages 1.
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Deepshikha Ghosh, Priti Chatterjee, Tulika Mitra & Sib Sankar Roy. 2020. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 1 19 .
Tomoka Matsuda, Hazuki Ogata, Moe Kanno, Akira Ishikawa, Mizuki Yamada & Mikako Sakamaki-Sunaga. (2020) Effects of the menstrual cycle on oxidative stress and antioxidant response to high-intensity intermittent exercise until exhaustion in healthy women. The Journal of Sports Medicine and Physical Fitness 60:10.
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H.R. Motamed, M. Shariati, R. Ahmadi, S. Khatamsaz & M. Mokhtari. (2020) The apoptotic effects of progesterone on breast cancer (MCF-7) and human osteosarcoma (MG-636) cells. Physiology International 107:3, pages 406-418.
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Laura Tatiana Pelegrina, María de los Ángeles Sanhueza, Antonella Rosario Ramona Cáceres, Dario Cuello-Carrión, Cristina Elisa Rodriguez & Myriam Raquel Laconi. (2020) Effect of progesterone and first evidence about allopregnanolone action on the progression of epithelial human ovarian cancer cell lines. The Journal of Steroid Biochemistry and Molecular Biology 196, pages 105492.
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John A. Arnott & Sonia Lobo. 2020. Hormonal Signaling in Biology and Medicine. Hormonal Signaling in Biology and Medicine 13 42 .
Abdul Wajid, Malik Shoaib Ahmad, Sammer Yousuf, Atia-tul-Wahab, Almas Jabeen, Atta-ur-Rahman & M. Iqbal Choudhary. (2019) Biotransformation of progestonic hormone dydrogesterone with Macrophomina phaseolina, and study of the effect of biotransformed products on phagocytes oxidative burst. Steroids 143, pages 67-72.
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M.O. Alese, M.A. Agbaje & O.O. Alese. (2018) Cadmium induced damage in Wistar rats, ameliorative potentials of progesterone. Journal of Trace Elements in Medicine and Biology 50, pages 276-282.
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A. O. Michurina, A. V. Polikarpova, I. S. Levina, L. E. Kulikova, I. V. Zavarzin, A. A. Guseva, I. A. Morozov, P. M. Rubtsov, O. V. Smirnova & T. A. Shchelkunova. (2018) Agonistic and Antagonistic Effects of Progesterone Derivatives on the Transcriptional Activity of Nuclear Progesterone Receptor B in Yeast Model System. Biochemistry (Moscow) 83:5, pages 574-585.
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Bao Yuan, Shuang Liang, Yong-Xun Jin, Jeong-Woo Kwon, Jia-Bao Zhang & Nam-Hyung Kim. (2016) Progesterone influences cytoplasmic maturation in porcine oocytes developing in vitro . PeerJ 4, pages e2454.
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Patricia G. Moorman, Anthony J. Alberg, Elisa V. Bandera, Jill Barnholtz-Sloan, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, Edward S. Peters, Ann G. Schwartz, Paul Terry, Sydnee Crankshaw, Frances Wang & Joellen M. Schildkraut. (2016) Reproductive factors and ovarian cancer risk in African-American women. Annals of Epidemiology 26:9, pages 654-662.
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Melissa E. HeardStepan B. MelnykFrank A. SimmenYanqing Yang, John Mark P. PabonaRosalia C. M. Simmen. (2016) High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status. Endocrinology 157:7, pages 2870-2882.
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ZHIYING HU, YANG YANG, KEQIANG GAO, JOHN A. RUDD & MARONG FANG. (2016) Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease. Experimental and Therapeutic Medicine 11:1, pages 89-97.
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Amber A. Bokhari, Laura R. Lee, Dewayne Raboteau, Chad A. Hamilton, George L. Maxwell, Gustavo C. Rodriguez & Viqar Syed. (2014) Progesterone Inhibits Endometrial Cancer Invasiveness by Inhibiting the TGFβ Pathway. Cancer Prevention Research 7:10, pages 1045-1055.
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Akiyoshi Yamanaka, Fuminori Kimura, Yohei Kishi, Kentaro Takahashi, Hiroshi Suginami, Yutaka Shimizu & Takashi Murakami. (2014) Progesterone and synthetic progestin, dienogest, induce apoptosis of human primary cultures of adenomyotic stromal cells. European Journal of Obstetrics & Gynecology and Reproductive Biology 179, pages 170-174.
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V A Nunes, E P Portioli-Sanches, M P Rosim, M S Araujo, P Praxedes-Garcia, M M R Valle, L P Roma, C Hahn, E Gurgul-Convey, S Lenzen & A K Azevedo-Martins. (2014) Progesterone induces apoptosis of insulin-secreting cells: insights into the molecular mechanism. Journal of Endocrinology 221:2, pages 273-284.
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Laura R. Lee, Pang-Ning Teng, Huyen Nguyen, Brian L. Hood, Leyla Kavandi, Guisong Wang, Jane M. Turbov, Larry G. Thaete, Chad A. Hamilton, George L. Maxwell, Gustavo C. Rodriguez, Thomas P. Conrads & Viqar Syed. (2013) Progesterone Enhances Calcitriol Antitumor Activity by Upregulating Vitamin D Receptor Expression and Promoting Apoptosis in Endometrial Cancer Cells. Cancer Prevention Research 6:7, pages 731-743.
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Kyung Hee Han, Mi-Kyung Kim, Hee Seung Kim, Hyun Hoon Chung & Yong Sang Song. (2013) Protective Effect of Progesterone during Pregnancy against Ovarian Cancer. Journal of Cancer Prevention 18:2, pages 113-122.
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Leyla Kavandi, Michael A. Collier, Huyen Nguyen & Viqar Syed. (2012) Progesterone and calcitriol attenuate inflammatory cytokines CXCL1 and CXCL2 in ovarian and endometrial cancer cells. Journal of Cellular Biochemistry 113:10, pages 3143-3152.
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Subash C. GuptaDavid HeviaSridevi PatchvaByoungduck ParkWonil KohBharat B. Aggarwal. (2012) Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy. Antioxidants & Redox Signaling 16:11, pages 1295-1322.
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Gye-Sik Min. (2011) Inhibitory Effects of High Concentrations of Estrogen, Progesterone and Tamoxifen on Proliferation of HeLa in Culture. Journal of Life Science 21:12, pages 1746-1751.
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