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Endometriosis

Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis

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Pages 644-648 | Received 13 Feb 2014, Accepted 31 Mar 2014, Published online: 07 May 2014

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Read on this site (5)

Denis V. Krakhotkin, Maria N. Silkina, Volodymyr A. Chernylovskyi & Svetlana A. Gayvoronskaya. (2022) The dienogest-related cystitis in women with endometriosis: a prospective, controlled, comparative study. Journal of Obstetrics and Gynaecology 42:6, pages 2492-2497.
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Mohamed Mabrouk, Roberto Paradisi, Alessandro Arena, Simona Del Forno, Carlotta Matteucci, Letizia Zannoni, Giacomo Caprara & Renato Seracchioli. (2018) Short-term histopathological effects of dienogest therapy on ovarian endometriomas: in vivo, nonrandomized, controlled trial. Gynecological Endocrinology 34:5, pages 399-403.
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Antonio Simone Laganà, Salvatore Giovanni Vitale, Roberta Granese, Vittorio Palmara, Helena Ban Frangež, Eda Vrtačnik-Bokal, Benito Chiofalo & Onofrio Triolo. (2017) Clinical dynamics of Dienogest for the treatment of endometriosis: from bench to bedside. Expert Opinion on Drug Metabolism & Toxicology 13:6, pages 593-596.
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Antonio Simone Laganà, Valentina Giacobbe, Onofrio Triolo, Roberta Granese, Helena Ban Frangež, Eda Vrtačnik-Bokal, Chiara Ietto & Vittorio Italo Palmara. (2016) Dienogest as preoperative treatment of submucous myomas for hysteroscopic surgery: a prospective, randomized study. Gynecological Endocrinology 32:5, pages 408-411.
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Nicolò Bizzarri, Valentino Remorgida, Umberto Leone Roberti Maggiore, Carolina Scala, Emanuela Tafi, Valentina Ghirardi, Stefano Salvatore, Massimo Candiani, Pier Luigi Venturini & Simone Ferrero. (2014) Dienogest in the treatment of endometriosis. Expert Opinion on Pharmacotherapy 15:13, pages 1889-1902.
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Articles from other publishers (45)

Joowon Lee, Hyeon Ji Park & Kyong Wook Yi. (2023) Dienogest in endometriosis treatment: A narrative literature review. Clinical and Experimental Reproductive Medicine 50:4, pages 223-229.
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Antonio Maiorana, Marianna Maranto, Vincenzo Restivo, Daniele Lo Gerfo, Gabriella Minneci, Antonella Mercurio & Domenico Incandela. (2023) Evaluation of long-term efficacy and safety of dienogest in patients with chronic cyclic pelvic pain associated with endometriosis. Archives of Gynecology and Obstetrics.
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O. V. Yakushevskaya, M. V. IurovaE. A. Mezhevitinova. (2023) Dienogest therapy: a window of opportunity for endometriosis. Meditsinskiy sovet = Medical Council:15, pages 65-70.
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Hiroshi Honda, Norihisa Nishimichi, Mayumi Kaneko, Michinori Yamashita, Yumiko Akimoto, Hirotoshi Tanimoto, Mitsue Teramoto, Hideki Teramoto & Yasuyuki Yokosaki. (2023) Genome-Wide Gene Expression Profiling Reveals the Direct Effect of Dienogest on Ovarian Endometriotic Stromal Cells. Reproductive Sciences 30:8, pages 2457-2467.
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Kerem Doga Seckin & Pinar Kadirogullari. (2023) Is dienogest a convenient treatment option for cesarean scar endometriosis or should it be treated surgically?. European Journal of Obstetrics & Gynecology and Reproductive Biology 282, pages 110-115.
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I. A. Ivanov. (2022) The issues of endometriosis hormonal treatment in reproductive age women. Meditsinskiy sovet = Medical Council:6, pages 157-163.
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Siyuan Yang, Yuchen Liu, Jing Wen, Yi Sun & Fang Ren. (2022) Clinical Efficacy of Dienogest versus Levonorgestrel-Releasing Intrauterine System for Adenomyosis. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-6.
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Manuela Cristina Russu. 2022. Endometriosis - Recent Advances, New Perspectives and Treatments. Endometriosis - Recent Advances, New Perspectives and Treatments.
Natalie Marty. (2022) Dienogest (Monopräparat). pharma-kritik 44:1.
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Yanqing Ren, Xinru Wang, Jinyu Guo, Di Wang, Xinhua Li, Xiumei Cheng & Xinguo Wang. (2022) CHCHD2 Regulates Mitochondrial Function and Apoptosis of Ectopic Endometrial Stromal Cells in the Pathogenesis of Endometriosis. Reproductive Sciences.
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V.A. Burlev & N.A. Ilyasova. (2022) Inversion of angiogenesis with ethinyl estradiol/dienogest or estradiol valerate/dienogest. Problemy reproduktsii 28:4, pages 8.
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A.M. Grigorenko. (2021) Endometriosis, hormonal therapy and oncological risks. REPRODUCTIVE ENDOCRINOLOGY:59, pages 61-65.
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Michael Oettel, Hans Joachim Zentel & Klaus Nickisch. (2021) A progestin isn’t a progestin: dienogest for endometriosis as a blueprint for future research – Review as a contribution for discussion -. Hormone Molecular Biology and Clinical Investigation 42:2, pages 133-142.
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I. V. Kuznetsova. (2021) Empirical and long-term therapy for endometriosis-associated pelvic pain. Medical alphabet:8, pages 8-12.
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Andrew Zakhari, Darl Edwards, Michelle Ryu, John J. Matelski, Olga Bougie & Ally Murji. (2020) Dienogest and the Risk of Endometriosis Recurrence Following Surgery: A Systematic Review and Meta-analysis. Journal of Minimally Invasive Gynecology 27:7, pages 1503-1510.
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Michio Kitajima, Kanako Matsumoto, Naoko Murakami, Ayumi Harada, Yuriko Kitajima, Hideaki Masuzaki & Kiyonori Miura. (2020) Ovarian reserve after three‐step laparoscopic surgery for endometriomas utilizing dienogest: A pilot study. Reproductive Medicine and Biology 19:4, pages 425-431.
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V Arunadevi & S N S Minnalkodi. (2020) Dienogest treatment improves quality of life in women with endometriosis: A prospective cohort study. Indian Journal of Obstetrics and Gynecology Research 7:3, pages 348-351.
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Fernando M Reis, Larissa M Coutinho, Silvia Vannuccini, Frédéric Batteux, Charles Chapron & Felice Petraglia. (2020) Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure. Human Reproduction Update 26:4, pages 565-585.
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Kei Inaba, Osamu Wada-Hiraike, Miyuki Harada, Yasushi Hirota, Kaori Koga, Tomoyuki Fujii & Yutaka Osuga. (2020) Dienogest suppresses cellular proliferation status of endometrial polyps and acts differently depending on the morphological type. Women's Health 16, pages 174550652095200.
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JongYeob Choi, MinWha Jo, EunYoung Lee, Dong-Yun Lee & DooSeok Choi. (2020) Dienogest regulates apoptosis, proliferation, and invasiveness of endometriotic cyst stromal cells via endoplasmic reticulum stress induction. Molecular Human Reproduction 26:1, pages 30-39.
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Yingying Huang, Yong Huang, Jian He, Huiling Wang, Yiqun Luo, Yanmei Li, Junjie Liu, Liping Zhong & Yongxiang Zhao. (2019) PEGylated immunoliposome-loaded endoglin single-chain antibody enhances anti-tumor capacity of porcine α1,3GT gene. Biomaterials 217, pages 119231.
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Simona Del Forno, Mohamed Mabrouk, Alessandro Arena, Giulia Mattioli, Ilaria Giaquinto, Roberto Paradisi & Renato Seracchioli. (2019) Dienogest or Norethindrone acetate for the treatment of ovarian endometriomas: Can we avoid surgery?. European Journal of Obstetrics & Gynecology and Reproductive Biology 238, pages 120-124.
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О. V. Kachalina & A. A. Korenkova. (2019) Cervical endometriosis – solubility. Medical Council:21, pages 174-177.
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Weilin Zheng, Lixing Cao, Zheng Xu, Yuanyuan Ma & Xuefang Liang. (2018) Anti-Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms. Evidence-Based Complementary and Alternative Medicine 2018, pages 1-28.
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Thomas Römer. (2018) Long-term treatment of endometriosis with dienogest: retrospective analysis of efficacy and safety in clinical practice. Archives of Gynecology and Obstetrics 298:4, pages 747-753.
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Attila Bokor, Peter Lukovich, Noemi Csibi, Thomas D'Hooghe, Dan Lebovic, Reka Brubel & Janos Rigo. (2018) Natural Orifice Specimen Extraction during Laparoscopic Bowel Resection for Colorectal Endometriosis: Technique and Outcome. Journal of Minimally Invasive Gynecology 25:6, pages 1065-1074.
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András Gyovai, Renáta Minorics, Anita Kiss, Erzsébet Mernyák, Gyula Schneider, András Szekeres, Erika Kerekes, Imre Ocsovszki & István Zupkó. (2018) Antiproliferative Properties of Newly Synthesized 19-Nortestosterone Analogs Without Substantial Androgenic Activity. Frontiers in Pharmacology 9.
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K. N. Arslanyan, E. I. Kharchenko & O. N. Loginova. (2018) What do we know about endometrioid cysts today?. Problemy reproduktsii 24:6, pages 103.
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M. B. Okhapkin, V. S. Zabolotnov & K. V. Sheрeleva. (2017) A combined approach to treating patients with severe forms of endometriosis-associated infertility. Rossiiskii vestnik akushera-ginekologa 17:3, pages 90.
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Arisa Takeuchi, Kaori Koga, Mariko Miyashita, Tomoko Makabe, Fusako Sue, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Tomoyuki Fujii & Yutaka Osuga. (2016) Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis. European Journal of Obstetrics & Gynecology and Reproductive Biology 207, pages 157-161.
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S. Caruso, M. Iraci, S. Cianci, V. Fava, E. Casella & A. Cianci. (2016) Comparative, open-label prospective study on the quality of life and sexual function of women affected by endometriosis-associated pelvic pain on 2 mg dienogest/30 µg ethinyl estradiol continuous or 21/7 regimen oral contraceptive. Journal of Endocrinological Investigation 39:8, pages 923-931.
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Katiuscia Menni, Luca Facchetti & Paolo Cabassa. (2016) Extragenital endometriosis: assessment with MR imaging. A pictorial review. The British Journal of Radiology 89:1060, pages 20150672.
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Giovanni Grandi, Michael Mueller, Nick A. Bersinger, Angelo Cagnacci, Annibale Volpe & Brett McKinnon. (2015) Does dienogest influence the inflammatory response of endometriotic cells? A systematic review. Inflammation Research 65:3, pages 183-192.
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Thuy Thi NGUYEN, Toru HACHISUGA, Rie URABE, Taeko UEDA, Tomoko KURITA, Seiji KAGAMI, Toshinori KAWAGOE & Masanori HISAOKA. (2016) Immunohistochemical Analysis of the Effect of Dienogest on Ovarian Endometriotic Cysts. Journal of UOEH 38:4, pages 271-278.
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Milena Kralickova & Vaclav Vetvicka. (2016) Role of angiogenesis in endometriosis. Pathology Discovery 4:1, pages 1.
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Matteo Morotti, Fausta Sozzi, Valentino Remorgida, Pier Luigi Venturini & Simone Ferrero. (2014) Dienogest in women with persistent endometriosis-related pelvic pain during norethisterone acetate treatment. European Journal of Obstetrics & Gynecology and Reproductive Biology 183, pages 188-192.
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