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Gynecological Endocrinology Volume 26, 2010 - Issue 3
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Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: A randomized, double-blind, and placebo control trial

Carolina Fux OttaDepartamento de Endocrinología, Centro Médico de Córdoba, Hospital Privado, Córdoba Capital, ArgentinaCorrespondence[email protected]
,
Myriam WiorDepartamento de Endocrinología, Centro Médico de Córdoba, Hospital Privado, Córdoba Capital, Argentina
,
Gabriel S. IraciFacultad de Ciencias Médicas, Cátedra de Farmacología, Hospital Nacional de Clínicas, Universidad Nacional de Córdoba, Córdoba Capital, Argentina
,
Raquel KaplanFundación para el Progreso de la Medicina, Córdoba Capital, Argentina
,
Diana TorresFundación para el Progreso de la Medicina, Córdoba Capital, Argentina
,
María Isabel GaidoLaboratorio de Bioquímica Clínica, Centro Médico de Córdoba, Hospital Privado, Córdoba Capital, Argentina
&
Eduardo P. WyseDepartamento de Endocrinología, Centro Médico de Córdoba, Hospital Privado, Córdoba Capital, Argentina
 show all
Pages 173-178 | Received 19 Jul 2009, Accepted 20 Jul 2009, Published online: 12 Feb 2010

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Samantha Celeste Garcia-Hernandez, Leonardo M. Porchia, Blanca T. Pacheco-Soto, Esther López-Bayghen & M. Elba Gonzalez-Mejia. (2021) Metformin does not improve insulin sensitivity over hypocaloric diets in women with polycystic ovary syndrome: a systematic review of 12 studies. Gynecological Endocrinology 37:11, pages 968-976.
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Fatimah AlHussain, Yazed AlRuthia, Hazem Al-Mandeel, Arwa Bellahwal, Fadia Alharbi, Yasser Almogbel, Oriana Awwad, Roua Dala'een & Fawaz Abdullah Alharbi. (2020) Metformin Improves the Depression Symptoms of Women with Polycystic Ovary Syndrome in a Lifestyle Modification Program. Patient Preference and Adherence 14, pages 737-746.
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Petya Kamenova. (2020) Therapeutic potential of metformin in normal glucose tolerant persons with metabolic syndrome. Biotechnology & Biotechnological Equipment 34:1, pages 30-37.
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Articles from other publishers (38)

Johanna Melin, Maria Forslund, Simon Alesi, Terhi Piltonen, Daniela Romualdi, Poli Mara Spritzer, Chau Thien Tay, Alexia Pena, Selma Feldman Witchel, Aya Mousa & Helena Teede. (2023) The impact of metformin with or without lifestyle modification versus placebo on polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. European Journal of Endocrinology 189:2, pages S37-S63.
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I. Rivas Vázquez & M. Soto González. (2022) Eficacia del ejercicio terapéutico en el síndrome del ovario poliquístico. Una revisión sistemática. Clínica e Investigación en Ginecología y Obstetricia 49:3, pages 100751.
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Rok Herman, Nika Aleksandra Kravos, Mojca Jensterle, Andrej Janež & Vita Dolžan. (2022) Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport. International Journal of Molecular Sciences 23:3, pages 1264.
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Yu Song, Huimin Wang, Zhengyan Zhu & Hongli Huang. (2021) Effects of Metformin and Exercise in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis. Hormone and Metabolic Research 53:11, pages 738-745.
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Haigang Ding, Juan Zhang, Feng Zhang, Songou Zhang, Xiaozhen Chen, Wenqing Liang & Qiong Xie. (2021) Resistance to the Insulin and Elevated Level of Androgen: A Major Cause of Polycystic Ovary Syndrome. Frontiers in Endocrinology 12.
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Mohamed Abdel-Maboud, Amr Menshawy, Elfatih A. Hasabo, Mohamed Ibrahim Abdelraoof, Mohamed Alshandidy, Muhammad Eid, Esraa Menshawy, Oumaima Outani & Ahmed Menshawy. (2021) The comparative effectiveness of 55 interventions in obese patients with polycystic ovary syndrome: A network meta-analysis of 101 randomized trials. PLOS ONE 16:7, pages e0254412.
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Hsuan Yen, Yu-Tung Chang, Fui-Jun Yee & Yu-Chen Huang. (2020) Metformin Therapy for Acne in Patients with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis. American Journal of Clinical Dermatology 22:1, pages 11-23.
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Yuanyuan Guan, Dongjun Wang, Huaien Bu, Tieniu Zhao & Hongwu Wang. (2020) The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology 2020, pages 1-12.
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Josef van Helden, Osman Evliyaoglu, Andreas Küberl & Ralf Weiskirchen. (2020) Disorders of the glucose metabolism correlate with the phenotype and the severity in women with polycystic ovary syndrome. Clinical Endocrinology 93:1, pages 44-51.
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Leonardo M. Porchia, Samantha Celeste Hernandez-Garcia, M. Elba Gonzalez-Mejia & Esther López-Bayghen. (2020) Diets with lower carbohydrate concentrations improve insulin sensitivity in women with polycystic ovary syndrome: A meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology 248, pages 110-117.
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Madison Parker, Anna Warren, Sonam Nair & Marie Barnard. (2020) Adherence to treatment for polycystic ovarian syndrome: A systematic review. PLOS ONE 15:2, pages e0228586.
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Shuwei Weng, Yonghong Luo, Ziyu Zhang, Xin Su & Daoquan Peng. (2020) Effects of metformin on blood lipid profiles in nondiabetic adults: a meta-analysis of randomized controlled trials. Endocrine 67:2, pages 305-317.
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Mostafa Metwally. 2020. Obesity and Gynecology. Obesity and Gynecology 77 82 .
Chris Kite, Ian M. Lahart, Islam Afzal, David R. Broom, Harpal Randeva, Ioannis Kyrou & James E. Brown. (2019) Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis. Systematic Reviews 8:1.
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Anran Wang, Tingting Mo, Qiao Li, Chuangpeng Shen & Min Liu. (2019) The effectiveness of metformin, oral contraceptives, and lifestyle modification in improving the metabolism of overweight women with polycystic ovary syndrome: a network meta-analysis. Endocrine 64:2, pages 220-232.
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Siew S Lim, Samantha K Hutchison, Emer Van Ryswyk, Robert J Norman, Helena J Teede & Lisa J Moran. (2019) Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews 2019:3.
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Elisabet Stener-Victorin, Haolin Zhang, Rong Li, Cecilia Friden, Dong Li, Wei Wang, Haining Wang, Cuiqing Chang, Shi Li, ZeJun Huo, Hua Zhang, Xiaolan Ji, Angelica Linden-Hirschberg & Jie Qiao. (2019) Acupuncture or metformin to improve insulin resistance in women with polycystic ovary syndrome: study protocol of a combined multinational cross sectional case-control study and a randomised controlled trial. BMJ Open 9:1, pages e024733.
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Lara C Morley, Thomas Tang, Ephia Yasmin, Robert J Norman & Adam H Balen. (2017) Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database of Systematic Reviews 2018:2.
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Yazed Sulaiman Al-Ruthia, Hazem Al-Mandeel, Hisham AlSanawi, Wael Mansy, Reem AlGasem & Lama AlMutairi. (2017) Ovulation induction by metformin among obese versus non-obese women with polycystic ovary syndrome. Saudi Pharmaceutical Journal 25:5, pages 795-800.
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Huang-tz Ou, Pei-Chi Chen & Meng-Hsing Wu. (2017) Effect of metformin by employing 2-hour postload insulin for measuring insulin resistance in Taiwanese women with polycystic ovary syndrome. Journal of the Formosan Medical Association 116:2, pages 80-89.
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Brittany Y Jarrett & Marla E Lujan. (2017) Impact of hypocaloric dietary intervention on ovulation in obese women with PCOS. Reproduction 153:1, pages R15-R27.
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Long Zhou, Huanhuan Liu, Xiaoxiao Wen, Yaguang Peng, Yu Tian & Liancheng Zhao. (2017) Effects of metformin on blood pressure in nondiabetic patients. Journal of Hypertension 35:1, pages 18-26.
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E.J. Zuuren & Z. Fedorowicz. (2016) Interventions for hirsutism excluding laser and photoepilation therapy alone: abridged Cochrane systematic review including GRADE assessments . British Journal of Dermatology 175:1, pages 45-61.
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Chung-Ying Lin, Huang-tz Ou, Meng-Hsing Wu & Pei-Chi Chen. (2016) Validation of Chinese Version of Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (Chi-PCOSQ). PLOS ONE 11:4, pages e0154343.
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Negar Naderpoor, Soulmaz Shorakae, Barbora de Courten, Marie L. Misso, Lisa J Moran & Helena J. Teede. (2015) Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis. Human Reproduction Update 21:5, pages 560-574.
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Volkan Turan, Ebru Kaya Mutlu, Ulas Solmaz, Atalay Ekin, Ozge Tosun, Gokhan Tosun, Emre Mat, Cenk Gezer & Mehtap Malkoc. (2015) Benefits of short-term structured exercise in non-overweight women with polycystic ovary syndrome: a prospective randomized controlled study. Journal of Physical Therapy Science 27:7, pages 2293-2297.
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Elizabeth Buzney, Johanna Sheu, Catherine Buzney & Rachel V. Reynolds. (2014) Polycystic ovary syndrome: A review for dermatologists. Journal of the American Academy of Dermatology 71:5, pages 859.e1-859.e15.
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Izhar Ben-Shlomo & Johnny S. Younis. (2014) Basic research in PCOS: are we reaching new frontiers?. Reproductive BioMedicine Online 28:6, pages 669-683.
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S. Palomba, A. Falbo & G.B. La Sala. 2014. Handbook of diet and nutrition in the menstrual cycle, periconception and fertility. Handbook of diet and nutrition in the menstrual cycle, periconception and fertility 533 552 .
Hatem Abu Hashim. (2012) Clomiphene citrate alternatives for the initial management of polycystic ovary syndrome: an evidence-based approach. Archives of Gynecology and Obstetrics 285:6, pages 1737-1745.
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Thomas Tang, Jonathan M Lord, Robert J Norman, Ephia Yasmin & Adam H Balen. (2012) Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database of Systematic Reviews.
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Michael F Costello & William L Ledger. (2012) Evidence-Based Lifestyle and Pharmacological Management of Infertility in Women with Polycystic Ovary Syndrome. Women's Health 8:3, pages 277-290.
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David H Geller, Danièle Pacaud, Catherine M Gordon & Madhusmita Misra. (2011) State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS). International Journal of Pediatric Endocrinology 2011:1.
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Michelle Greiver, Babak Aliarzadeh, Rahim Moineddin, Christopher Meaney & Noah Ivers. (2011) Diabetes screening with hemoglobin A1c prior to a change in guideline recommendations: prevalence and patient characteristics. BMC Family Practice 12:1.
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