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Original Article

Inhibition of platelet activation by peptide analogs of the β₃-intracellular domain of platelet integrin α_IIbβ₃ conjugated to the cell-penetrating peptide Tat(48–60)

Andromaxi A. Dimitriou Laboratories of Biochemistry

Panagiotis Stathopoulos Laboratories of Organic Chemistry, Department of Chemistry

John V. Mitsios Laboratories of Biochemistry

Maria Sakarellos-Daitsiotis Laboratories of Organic Chemistry, Department of Chemistry

John Goudevenos Department of Cardiology, Medical School, University of Ioannina, Ioannina, Greece

Vassilios Tsikaris Laboratories of Organic Chemistry, Department of Chemistry

Alexandros D. Tselepis Laboratories of BiochemistryCorrespondence[email protected]

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Citations (8)

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Despoina Pantazi, Nikoleta Ntemou, Alexios Brentas, Dimitrios Alivertis, Konstantinos Skobridis & Alexandros D Tselepis. (2019) Molecular Requirements for the Expression of Antiplatelet Effects by Synthetic Structural Optimized Analogues of the Anticancer Drugs Imatinib and Nilotinib. Drug Design, Development and Therapy 13, pages 4225-4238.
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Articles from other publishers (7)

Anna Kosma, Despoina Pantazi, Pinelopi Voulgari, Nikoleta Ntemou, Alexios Brentas, Dimitrios Alivertis, Michael G. Siskos, Alexandros D. Tselepis & Konstantinos Skobridis. (2023) Expressing Enhanced Inhibitory Effects toward Arachidonic Acid Induced Platelet Activation: Design, Synthesis, DFT Calculations and in vitro Evaluation of Imatinib Analogues . ChemistrySelect 8:11.
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Zeliang Wei, Guang Xin, Haibo Wang, Huajie Zheng, Chengjie Ji, Jun Gu, Limei Ma, Chaoyi Qin, Zhihua Xing, Hai Niu & Wen Huang. (2018) The diosgenin prodrug nanoparticles with pH-responsive as a drug delivery system uniquely prevents thrombosis without increased bleeding risk. Nanomedicine: Nanotechnology, Biology and Medicine 14:3, pages 673-684.
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Vasileios G. Chantzichristos, Fani Gkrozou, Konstantinos Stellos, Minas E. Paschopoulos & Alexandros D. Tselepis. (2018) Comparative Anti-Platelet Profiling Reveals a Potent Anti-Aggregatory Effect of CD34+ Progenitor Cell-Derived Late-Outgrowth Endothelial Cells in vitro. Journal of Vascular Research 55:1, pages 13-25.
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Wen Su, Yahui Chen, Caihui Wang, Xue Ding, Gamariel Rwibasira & Yi Kong. (2016) Human cathelicidin LL-37 inhibits platelet aggregation and thrombosis via Src/PI3K/Akt signaling. Biochemical and Biophysical Research Communications 473:1, pages 283-289.
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Lucia Cardo, Steve G. Thomas, Alexandra Mazharian, Zoe Pikramenou, Joshua Z. Rappoport, Michael J. Hannon & Stephen P. Watson. (2015) Accessible Synthetic Probes for Staining Actin inside Platelets and Megakaryocytes by Employing Lifeact Peptide. ChemBioChem 16:11, pages 1680-1688.
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Andreas G. Tzakos, Vassiliki G. Kontogianni, Maria Tsoumani, Eleni Kyriakou, John Hwa, Francisco A. Rodrigues & Alexandros D. Tselepis. (2012) Exploration of the Antiplatelet Activity Profile of Betulinic Acid on Human Platelets. Journal of Agricultural and Food Chemistry 60:28, pages 6977-6983.
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Kamila Bledzka, Jianmin Liu, Zhen Xu, H. Dhanuja Perera, Satya P. Yadav, Katarzyna Bialkowska, Jun Qin, Yan-Qing Ma & Edward F. Plow. (2012) Spatial Coordination of Kindlin-2 with Talin Head Domain in Interaction with Integrin β Cytoplasmic Tails. Journal of Biological Chemistry 287:29, pages 24585-24594.
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Inhibition of platelet activation by peptide analogs of the β₃-intracellular domain of platelet integrin α_IIbβ₃ conjugated to the cell-penetrating peptide Tat(48–60)

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Inhibition of platelet activation by peptide analogs of the β3-intracellular domain of platelet integrin αIIbβ3 conjugated to the cell-penetrating peptide Tat(48–60)

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Inhibition of platelet activation by peptide analogs of the β₃-intracellular domain of platelet integrin α_IIbβ₃ conjugated to the cell-penetrating peptide Tat(48–60)