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Platelets Volume 23, 2012 - Issue 4
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Original Article

A randomized clinical trial comparing point-of-care platelet function assays and bleeding time in healthy subjects treated with aspirin or clopidogrel

Fabian ChenMerck Research Laboratories, Rahway, NJ, USACorrespondence[email protected]
,
Victor MaridakisMerck Research Laboratories, Rahway, NJ, USA
,
Edward A. O’neillMerck Research Laboratories, Rahway, NJ, USA
,
Chan BealsMerck Research Laboratories, Rahway, NJ, USA
,
Waldemar RadziszewskiMerck Research Laboratories, Rahway, NJ, USA;Johnson & Johnson Pharmaceutical Research & Development, L.L.C., La Jolla, CA, USA
,
Inge de LepeleireMerck Sharp & Dohme, Brussels, Belgium
,
Kristien Van DyckMerck Sharp & Dohme, Brussels, Belgium
,
Marleen DepréCenter for Clinical Pharmacology, University Hospitals Leuven, Campus Gasthuisberg (Catholic University of Leuven), Leuven, Belgium
,
James A. BologneseCytel Inc., Cambridge, MA, USA
,
Jan de HoonCenter for Clinical Pharmacology, University Hospitals Leuven, Campus Gasthuisberg (Catholic University of Leuven), Leuven, Belgium
&
Marc JacqueminCenter for Molecular and Vascular Biology, University of Leuven, Leuven, BelgiumCorrespondence[email protected]
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Pages 249-258 | Received 23 May 2011, Accepted 09 Jul 2011, Published online: 15 Sep 2011

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Samira Merali, Zhaoqing Wang, Charles Frost, Stephanie Meadows-Shropshire, Dara Hawthorne, Jing Yang & Dietmar Seiffert. (2023) First-in-human study to assess the safety, pharmacokinetics, and pharmacodynamics of BMS-986141, a novel, reversible, small-molecule, PAR4 agonist in non-Japanese and Japanese healthy participants. Platelets 34:1.
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Samira Merali, Zhaoqing Wang, Charles Frost, Mario Callejo, Michael Hedrick, Lester Hui, Stephanie Meadows Shropshire, Ke Xu, Michel Bouvier, Mary M. DeSouza & Jing Yang. (2022) New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans. Platelets 33:7, pages 969-978.
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Articles from other publishers (10)

Weiwei Zeng, Tanya T. W. Chu, Elaine Y. K. Chow, Miao Hu, Benny S. P. Fok, Juliana C. N. Chan, Bryan P. Y. Yan & Brian Tomlinson. (2022) Factors Associated with Aspirin Resistance in Hong Kong Chinese Patients with Stable Coronary Heart Disease Using the Multiplate® Analyzer and Serum Thromboxane B2. Pharmaceutics 14:10, pages 2099.
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Tarun Tyagi, Kanika Jain, Sean X. Gu, Miaoyun Qiu, Vivian W. Gu, Hannah Melchinger, Henry Rinder, Kathleen A. Martin, Elizabeth E. Gardiner, Alfred I. Lee, Wai Ho Tang & John Hwa. (2022) A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 1:3, pages 223-237.
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Johnathan P. Mack, Jeffrey Miles & Moritz Stolla. (2020) Cold-Stored Platelets: Review of Studies in Humans. Transfusion Medicine Reviews 34:4, pages 221-226.
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Franziska Lieschke, Yi Zheng, Jan Hendrik Schaefer, Klaus van Leyen & Christian Foerch. (2020) Measurement of Platelet Function in an Experimental Stroke Model With Aspirin and Clopidogrel Treatment. Frontiers in Neurology 11.
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B.M.E. Tullemans, J.W.M. Heemskerk & M.J.E. Kuijpers. (2018) Acquired platelet antagonism: off‐target antiplatelet effects of malignancy treatment with tyrosine kinase inhibitors. Journal of Thrombosis and Haemostasis 16:9, pages 1686-1699.
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K. A. Roscher, K. Failing, I. Schenk & A. Moritz. (2017) Suspected aspirin resistance in individual healthy adult warmblood horses. Journal of Veterinary Pharmacology and Therapeutics 40:6, pages e16-e22.
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Kimberly K. Ho, Anthony C. G. Abrams-Ogg, R. Darren Wood, M. Lynne O’Sullivan, Gordon M. Kirby & Shauna L. Blois. (2015) Assessment of platelet function in healthy sedated cats using three whole blood platelet function tests. Journal of Veterinary Diagnostic Investigation 27:3, pages 352-360.
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Katja A. Roscher, Klaus Failing & Andreas Moritz. (2015) Inhibition of platelet function with clopidogrel, as measured with a novel whole blood impedance aggregometer in horses. The Veterinary Journal 203:3, pages 332-336.
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Simon Thalén, Ida Forsling, Jaak Eintrei, Lisbeth Söderblom & Jovan P. Antovic. (2013) Pneumatic tube transport affects platelet function measured by multiplate electrode aggregometry. Thrombosis Research 132:1, pages 77-80.
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Hans Gombotz & Gerhard Lanzer. 2013. Evidence-Based Practice of Anesthesiology. Evidence-Based Practice of Anesthesiology 164 173 .

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