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Research Article

Romiplostim therapy in children with unresponsive chronic immune thrombocytopenia

, , MD &
Pages 264-273 | Received 17 Feb 2011, Accepted 19 Aug 2011, Published online: 03 Apr 2012

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David J. Rabbolini, Yenna Chun, Maya Latimer, Shinji Kunishima, Kathleen Fixter, Bhavia Valecha, Peter Tan, Lee Ping Chew, Benjamin T. Kile, Rachel Burt, Kottayam Radhakrishnan, Robert Bird, Paul Ockelford, Sara Gabrielli, Qiang Chen, William S. Stevenson, Christopher M. Ward & Marie-Christine Morel-Kopp. (2018) Diagnosis and treatment of MYH9-RD in an Australasian cohort with thrombocytopenia. Platelets 29:8, pages 793-800.
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David Buchbinder, Diane Nugent & Loan Hsieh. (2017) Spotlight on romiplostim in the treatment of children with chronic immune thrombocytopenia: design, development, and potential place in therapy. Drug Design, Development and Therapy 11, pages 1055-1063.
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Jiaxing Zhang, Yi Liang, Yuan Ai, Juan Xie, Youping Li & Wenyi Zheng. (2017) Thrombopoietin-receptor agonists for children with immune thrombocytopenia: a systematic review. Expert Opinion on Pharmacotherapy 18:15, pages 1543-1551.
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John D. Grainger & Sharon Thind. (2017) A practical guide to the use of eltrombopag in children with chronic immune thrombocytopenia. Pediatric Hematology and Oncology 34:2, pages 73-89.
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Articles from other publishers (25)

Fernanda Lubiana de Oliveira, Fernanda Silva Sequeira & Marlene Pereira Garanito. (2023) Safety and efficacy of romiplostim in children and adolescents with Immune thrombocytopenia: A systematic review. Hematology, Transfusion and Cell Therapy 45:1, pages 83-89.
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Xin He, Ningyuan Ran, Ting Wang & Zonghong Shao. (2022) Efficacy and quality of life of Romiplostim in adults and children with immune thrombocytopenia: A review. Medicine 101:50, pages e32345.
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Mohsen Saleh Elalfy, Khadiga Yehia Elsayed Mousa Eltonbary, Islam R. El Ghamry, Omar Elalfy, Marwa Wahid, Mohamed Badr, Tamer Hassan, Ahmed Mansour, Mohamed Meabed, Mahmoud El-Hawy, Ilham Youssry, Marwa Abd Elhady, Mohamed Elshanshory, Khalid Elsayh & Hoda M. Hassab. (2021) Intracranial hemorrhage in primary immune thrombocytopenia (ITP): 20 years’ experience in pediatrics. European Journal of Pediatrics 180:5, pages 1545-1552.
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Giuseppe Lassandro, Valentina Palladino, Giovanni C.D. Vecchio, Viviana V. Palmieri, Paola C. Corallo, Maria F. Faienza & Paola Giordano. (2021) Thrombopoietin Receptor Agonists in Children with Immune Thrombocytopenia: A New Therapeutic Era. Endocrine, Metabolic & Immune Disorders - Drug Targets 21:3, pages 397-406.
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Izabella Kelemen, Zsuzsanna Erzsébet Papp & Mária Adrienne Horváth. (2019) Immune Thrombocytopenia in an Adolescent with Hashimoto’s Thyroiditis – Case Report. Journal of Interdisciplinary Medicine 4:3, pages 145-149.
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Jiaxing Zhang, Yi Liang, Yuan Ai, Xiaosi Li, Juan Xie, Youping Li, Wenyi Zheng & Rui He. (2018) Eltrombopag versus romiplostim in treatment of children with persistent or chronic immune thrombocytopenia: a systematic review incorporating an indirect-comparison meta-analysis. Scientific Reports 8:1.
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Francesco Rodeghiero & Giuseppe Carli. (2017) Beyond immune thrombocytopenia: the evolving role of thrombopoietin receptor agonists. Annals of Hematology 96:9, pages 1421-1434.
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Rita Consolini, Giorgio Costagliola & Davide Spatafora. (2017) The Centenary of Immune Thrombocytopenia—Part 2: Revising Diagnostic and Therapeutic Approach. Frontiers in Pediatrics 5.
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Elena V. Suntsova, Irina M. Demina, Anastasia A. Ignatova, Nikolay M. Ershov, Natalia M. Trubina, Juliya Dobrynina, Irina V. Serkova, Zhanna S. Supik, Ekaterina V. Orekhova, Lili A. Hachatryan, Natalia N. Kotskaya, Aleksey V. Pshonkin, Aleksey A. Maschan, Galina A. Novichkova & Mikhail A. Panteleev. (2017) Bleeding tendency and platelet function during treatment with romiplostim in children with severe immune thrombocytopenic purpura. International Journal of Hematology 105:6, pages 841-848.
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Usha Gutti, Satya Ratan Pasupuleti, Itishri Sahu, Aneesh Kotipalli, Ram Babu Undi, Ravinder Kandi, Raja Gopal Venakata Saladi & Ravi Kumar Gutti. (2016) Erythropoietin and thrombopoietin mimetics: Natural alternatives to erythrocyte and platelet disorders. Critical Reviews in Oncology/Hematology 108, pages 175-186.
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Cindy Neunert, Jenny Despotovic, Kristina Haley, Michele P. Lambert, Kerri Nottage, Kristin Shimano, Carolyn Bennett, Robert Klaassen, Kimo Stine, Alexis Thompson, Yves Pastore, Travis Brown, Peter W. Forbes & Rachael F. Grace. (2016) Thrombopoietin Receptor Agonist Use in Children: Data From the Pediatric ITP Consortium of North America ICON2 Study. Pediatric Blood & Cancer 63:8, pages 1407-1413.
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Angelica Maria Garzon & William Beau Mitchell. (2015) Use of Thrombopoietin Receptor Agonists in Childhood Immune Thrombocytopenia. Frontiers in Pediatrics 3.
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M. Pasquet, N. Aladjidi, C. Guitton, T. Leblanc, Y. Pérel & G. Leverger. (2015) Recommandations d’utilisation des agonistes du récepteur de la thrombopoïétine dans le purpura thrombopénique immunologique de l’enfant et de l’adolescent. Revue d'Oncologie Hématologie Pédiatrique 3:1, pages 4-12.
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James B. Bussel, Loan Hsieh, George R. Buchanan, Kimo Stine, Ram Kalpatthi, David J. Gnarra, Richard H. Ho, Kun Nie & Melissa Eisen. (2014) Long‐term use of the thrombopoietin‐mimetic romiplostim in children with severe chronic immune thrombocytopenia (ITP). Pediatric Blood & Cancer 62:2, pages 208-213.
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Thomas Kühne. (2015) Treatment of Pediatric Primary Immune Thrombocytopenia With Thrombopoietin Receptor Agonists. Seminars in Hematology 52:1, pages 25-30.
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Kei Minowa, Katsuhiro Arai, Mureo Kasahara, Seisuke Sakamoto, Hirotaka Shimizu, Natsuko Nakano, Reiko Ito, Naho Obayashi, Atsuko Nakazawa & Akira Ishiguro. (2014) Romiplostim treatment allows for platelet transfusion‐free liver transplantation in pediatric thrombocytopenic patient with primary sclerosing cholangitis. Pediatric Transplantation 18:6.
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George R. Buchanan. (2014) Immune Thrombocytopenia during Childhood: New Approaches to Classification and Management. The Journal of Pediatrics 165:3, pages 437-439.
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Kavitha Ramaswamy, Loan Hsieh, Emily Leven, Michaela V. Thompson, Diane Nugent & James B. Bussel. (2014) Thrombopoietic Agents for the Treatment of Persistent and Chronic Immune Thrombocytopenia in Children. The Journal of Pediatrics 165:3, pages 600-605.e4.
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I. Marquínez-Alonso, V. Escudero-Vilaplana, S. Pernía, C. Beléndez Bieler, C. M. Fernández-Llamazares & M. Sanjurjo-Sáez. (2014) The treatment for primary immune thrombocytopenia with romiplostim in adult and paediatric patients: use experience at a Spanish university hospital. Journal of Clinical Pharmacy and Therapeutics 39:4, pages 376-382.
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Markus G. Seidel, Christian Urban, Johanna Sipurzynski, Christine Beham-Schmid, Herwig Lackner & Martin Benesch. (2014) High response rate but short-term effect of romiplostim in paediatric refractory chronic immune thrombocytopenia. British Journal of Haematology 165:3, pages 419-421.
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Marlène Pasquet, Nathalie Aladjidi, Corinne Guiton, Mary-France Courcoux, Martine Munzer, Anne Auvrignon, Patrick Lutz, Stéphane Ducassou, Gwennaelle LeRoy, Caroline Munzer & Guy Leverger. (2014) Romiplostim in children with chronic immune thrombocytopenia (ITP): the French Experience. British Journal of Haematology 164:2, pages 266-271.
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Giuseppe TridenteGiuseppe Tridente. 2014. Adverse Events with Biomedicines. Adverse Events with Biomedicines 503 512 .
Mohsen Saleh Elalfy. (2013) Three Decades of Experience in Managing Immune Thrombocytopenia in Children in Arab Countries. Seminars in Hematology 50, pages S22-S25.
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Alexandra Schifferli & Thomas Kühne. (2013) Chronic Immune Thrombocytopenia in Children: Who Needs Splenectomy?. Seminars in Hematology 50, pages S58-S62.
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Janna M. Journeycake. (2012) Childhood immune thrombocytopenia: role of rituximab, recombinant thrombopoietin, and other new therapeutics. Hematology 2012:1, pages 444-449.
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