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Platelets Volume 23, 2012 - Issue 8
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Research Article

High on-treatment platelet reactivity by ADP and increased risk of MACE in good clopidogrel metabolizers

Rossella MarcucciDepartment of Medical and Surgical Critical Care, Centre for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy;Department of Heart and Vessels, Azienda Ospedaliero, Universitaria Careggi, Florence, ItalyCorrespondence[email protected]
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Betti GiustiDepartment of Medical and Surgical Critical Care, Centre for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy;Department of Heart and Vessels, Azienda Ospedaliero, Universitaria Careggi, Florence, Italy
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Rita PanicciaDepartment of Medical and Surgical Critical Care, Centre for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy;Department of Heart and Vessels, Azienda Ospedaliero, Universitaria Careggi, Florence, Italy
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Anna Maria GoriDepartment of Medical and Surgical Critical Care, Centre for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy;Department of Heart and Vessels, Azienda Ospedaliero, Universitaria Careggi, Florence, Italy
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Claudia SaraciniDepartment of Medical and Surgical Critical Care, Centre for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
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Serafina ValenteDepartment of Heart and Vessels, Azienda Ospedaliero, Universitaria Careggi, Florence, Italy
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Cristina GiglioliDepartment of Heart and Vessels, Azienda Ospedaliero, Universitaria Careggi, Florence, Italy
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Guido ParodiDepartment of Heart and Vessels, Azienda Ospedaliero, Universitaria Careggi, Florence, Italy
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David AntoniucciDepartment of Heart and Vessels, Azienda Ospedaliero, Universitaria Careggi, Florence, Italy
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Gian Franco GensiniDepartment of Medical and Surgical Critical Care, Centre for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy;Department of Heart and Vessels, Azienda Ospedaliero, Universitaria Careggi, Florence, Italy;Centro S. Maria agli Ulivi, Fondazione Don Carlo Gnocchi Onlus IRCCS, Impruneta, Florence, Italy
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Rosanna AbbateDepartment of Medical and Surgical Critical Care, Centre for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy;Department of Heart and Vessels, Azienda Ospedaliero, Universitaria Careggi, Florence, Italy
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Pages 586-593 | Received 24 Oct 2011, Accepted 12 Jan 2012, Published online: 05 Mar 2012

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Hong-Zhe Zhang, Long Hao Yu & Moo Hyun Kim. (2013) Effect of different anticoagulants on multiple electrode platelet aggregometry after clopidogrel and aspirin administration in patients undergoing coronary stent implantation: A comparison between citrate and hirudin. Platelets 24:5, pages 339-347.
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Paul Harrison. (2012) Advances in the monitoring of anti-P2Y12 therapy. Platelets 23:7, pages 510-525.
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Articles from other publishers (17)

Yao Yao, Xiaoye Li, Zi Wang, Shikun Xu & Qianzhou Lv. (2023) The impact of high on-treatment platelet reactivity and fibrinogen levels on ischemic events in patients with ST elevation myocardial infarction: a prospective observational study. International Journal of Clinical Pharmacy 45:2, pages 461-472.
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M. Berteotti, A. M. Gori, B. Giusti, A. Fortini, G. Grossi, N. Ciardetti, A. Migliorini, E. Lotti, R. Valenti, C. Di Mario, N. Marchionni & R. Marcucci. (2023) Clinical impact of high platelet reactivity in patients with atrial fibrillation and concomitant percutaneous coronary intervention on dual or triple antithrombotic therapy. Journal of Thrombosis and Thrombolysis 55:4, pages 667-679.
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Masahiro Tsuji, Yusuke Kawai, Toru Miyoshi, Eisuke Saito, Kohei Kawamura, Tamaki Ono, Koji Tokioka, Tohru Ohe, Kazufumi Nakamura & Hiroshi Ito. (2022) High platelet reactivity is a predictor of left ventricular remodelling in patients with acute myocardial infarction. ESC Heart Failure.
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Mohitosh Biswas, Chonlaphat Sukasem, Most Sumaiya Khatun Kali & Baharudin Ibrahim. (2022) Effects of the CYP2C19 LoF allele on major adverse cardiovascular events associated with clopidogrel in acute coronary syndrome patients undergoing percutaneous coronary intervention: a meta-analysis . Pharmacogenomics 23:3, pages 207-220.
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Matej Samoš, Ingrid Škorňová, Tomáš Bolek, Lucia Stančiaková, Barbora Korpallová, Peter Galajda, Ján Staško, Peter Kubisz & Marián Mokáň. (2021) Viscoelastic Hemostatic Assays and Platelet Function Testing in Patients with Atherosclerotic Vascular Diseases. Diagnostics 11:1, pages 143.
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Gregory F. Guzauskas, Anirban Basu, Josh J. Carlson & David L. Veenstra. (2019) Are There Different Evidence Thresholds for Genomic Versus Clinical Precision Medicine? A Value of Information-Based Framework Applied to Antiplatelet Drug Therapy. Value in Health 22:9, pages 988-994.
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Phillip A. Bonney, Benjamin Yim, Waleed Brinjikji & Brian P. Walcott. (2019) Pharmacogenomic considerations for antiplatelet agents: the era of precision medicine in stroke prevention and neurointerventional practice. Molecular Case Studies 5:2, pages a003731.
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Anna Maria Gori, Elisa Grifoni, Renato Valenti, Betti Giusti, Rita Paniccia, Guido Parodi, Angela Migliorini, David Antoniucci, Rosanna Abbate, Gian Franco Gensini & Rossella Marcucci. (2016) High on-aspirin platelet reactivity predicts cardiac death in acute coronary syndrome patients undergoing PCI. European Journal of Internal Medicine 30, pages 49-54.
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T Raymond Foley, Stephen W Waldo & Ehrin J Armstrong. (2016) Antithrombotic therapy in peripheral artery disease. Vascular Medicine 21:2, pages 156-169.
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Rossella Marcucci, Elisa Grifoni & Betti Giusti. (2016) On-treatment platelet reactivity: State of the art and perspectives. Vascular Pharmacology 77, pages 8-18.
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Rossella Marcucci. (2015) Resistance to antiplatelet drugs. Can it be assessed?. IJC Metabolic & Endocrine 8, pages 31-33.
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Michael J. SorichAndrew RowlandRoss A. McKinnonMichael D. Wiese. (2014) CYP2C19 Genotype Has a Greater Effect on Adverse Cardiovascular Outcomes Following Percutaneous Coronary Intervention and in Asian Populations Treated With Clopidogrel . Circulation: Cardiovascular Genetics 7:6, pages 895-902.
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Alfi Yasmina, Anthonius de Boer, Olaf H Klungel & Vera HM Deneer. (2014) Pharmacogenomics of oral antiplatelet drugs. Pharmacogenomics 15:4, pages 509-528.
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Rossella Marcucci, Gabriele Cioni, Betti Giusti, Cinzia Fatini, Lorenza Rossi, Maddalena Pazzi & Rosanna Abbate. (2014) Gender and Anti-thrombotic Therapy: from Biology to Clinical Implications. Journal of Cardiovascular Translational Research 7:1, pages 72-81.
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Fabrizio D’Ascenzo, Umberto Barbero, Marta Bisi, Claudio Moretti, Pierluigi Omedè, Enrico Cerrato, Giorgio Quadri, Federico Conrotto, Giuseppe Biondi Zoccai, James J. DiNicolantonio, Mauro Gasparini, Sripal Bangalore & Fiorenzo Gaita. (2014) The Prognostic Impact of High On-Treatment Platelet Reactivity with Aspirin or ADP Receptor Antagonists: Systematic Review and Meta-Analysis. BioMed Research International 2014, pages 1-13.
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Betti Giusti, Claudia Saracini, Silvia Galora & Rossella Marcucci. 2014. Handbook of Pharmacogenomics and Stratified Medicine. Handbook of Pharmacogenomics and Stratified Medicine 509 541 .
Rossella Marcucci, Betti Giusti & Rosanna Abbate. (2013) Personalized antiplatelet therapy in acute coronary syndromes: a dead-end street or a future scenario?. Interventional Cardiology 5:6, pages 601-604.
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