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Acne

Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: a randomized controlled trial

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Pages 21-25 | Received 22 Mar 2010, Accepted 01 Apr 2010, Published online: 22 Oct 2010

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Carol Sanchez & Jonette Keri. (2022) Androgen Receptor Inhibitors in the Treatment of Acne Vulgaris: Efficacy and Safety Profiles of Clascoterone 1% Cream. Clinical, Cosmetic and Investigational Dermatology 15, pages 1357-1366.
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Dusan Ilic, Maja Cvetkovic & Marija Tasic-Kostov. (2021) Emulsions with alkyl polyglucosides as carriers for off-label topical spironolactone – safety and stability evaluation. Pharmaceutical Development and Technology 26:3, pages 373-379.
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Rofida Albash, Abdurrahman M. Fahmy, Mohammed I.A. Hamed, Khaled M. Darwish & Rania Moataz El-Dahmy. (2021) Spironolactone hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism: in silico studies, statistical optimization, ex vivo, and in vivo studies . Drug Delivery 28:1, pages 2289-2300.
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Leena Chularojanamontri, Papapit Tuchinda, Kanokvalai Kulthanan, Supenya Varothai & Waranaree Winayanuwattikun. (2016) A double-blinded, randomized, vehicle-controlled study to access skin tolerability and efficacy of an anti-inflammatory moisturizer in treatment of acne with 0.1% adapalene gel. Journal of Dermatological Treatment 27:2, pages 140-145.
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Zohreh Hajheydari, Majid Saeedi, Katayoun Morteza-Semnani & Aida Soltani. (2014) Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. Journal of Dermatological Treatment 25:2, pages 123-129.
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Laura F Sandoval, Jennifer K Hartel & Steven R Feldman. (2014) Current and future evidence-based acne treatment: a review. Expert Opinion on Pharmacotherapy 15:2, pages 173-192.
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Syeda Tayyaba Rehan, Zayeema Khan, Samina Abbas, Laiba Imran, Saqib Munir, Muhammad Junaid Tahir, Aqib Zaman Kheljee, Mohammed Mahmmoud Fadelallah Eljack & Ali Ahmed. (2022) Role of topical spironolactone in the treatment of acne: A systematic review of clinical trials—Does this therapy open a path towards favorable outcomes?. The Journal of Dermatology 50:2, pages 166-174.
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Ricardo Ferreira-Nunes, Edson Aliel Teixeira de Almeida, Marcilio Cunha-Filho, Tais Gratieri & Guilherme Martins Gelfuso. (2023) Liquid chromatography-mass spectrometry for simultaneous determination of spironolactone and canrenone in plasma samples. Brazilian Journal of Pharmaceutical Sciences 59.
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Sophia Ly, John Miller, Lauren Tong, Lindsay Blake, Arash Mostaghimi & John S. Barbieri. (2022) Use of Patient-Reported Outcomes in Acne Vulgaris and Rosacea Clinical Trials From 2011 to 2021. JAMA Dermatology 158:12, pages 1419.
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Hudson Polonini, Bruna Marianni, Sarah Taylor & Clark Zander. (2022) Compatibility of Personalized Formulations in Cleoderm™, A Skin Rebalancing Cream Base for Oily and Sensitive Skin. Cosmetics 9:5, pages 92.
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Kasiani Papadimitriou, Panagiotis Anagnostis & Dimitrios G. Goulis. 2022. Polycystic Ovary Syndrome. Polycystic Ovary Syndrome 297 314 .
Azin Ayatollahi, Ansieh Samadi, Ayda Bahmanjahromi & Reza M. Robati. (2021) Efficacy and safety of topical spironolactone 5% cream in the treatment of acne: A pilot study. Health Science Reports 4:3.
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Adil Noaimi & Shatha R Al-Saadi. (2021) Treatment of Acne Vulgaris by Topical Spironolactone Solution Compared With Clindamycin Solution. Cureus.
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Naoual Dahmana, Thibault Mugnier, Doris Gabriel, Tatiana Favez, Laura Kowalczuk, Francine Behar-Cohen, Robert Gurny & Yogeshvar N. Kalia. (2021) Polymeric micelle mediated follicular delivery of spironolactone: Targeting the mineralocorticoid receptor to prevent glucocorticoid-induced activation and delayed cutaneous wound healing. International Journal of Pharmaceutics 604, pages 120773.
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Najwa Somani & Marty E. Sawaya. 2021. Comprehensive Dermatologic Drug Therapy. Comprehensive Dermatologic Drug Therapy 366 381.e5 .
Mahboobeh Salmanian, Laila Shirbeigi, Fataneh Hashem-Dabaghian, Parvin Mansouri, Mohammad Azizkhani, Shiva Alavi & Ali Ghobadi. (2020) The Effects of Myrtle ( Myrtus communis ) and Clindamycin Topical Solution in the Treatment of Mild to Moderate Acne Vulgaris: A Comparative Split-Face Study . Journal of Pharmacopuncture 23:4, pages 220-229.
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Qingyang Shi, Lizi Tan, Zhe Chen, Long Ge, Xiaoyan Zhang, Fengwen Yang, Chunxiang Liu & Junhua Zhang. (2020) Comparative Efficacy of Pharmacological and Nonpharmacological Interventions for Acne Vulgaris: A Network Meta-Analysis. Frontiers in Pharmacology 11.
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Ryan D. Gabbard, Robert R. Hoopes & Michael G. Kemp. (2020) Spironolactone and XPB: An Old Drug with a New Molecular Target. Biomolecules 10:5, pages 756.
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Ayman Salama, Mohamed Badran, Mohammed Elmowafy & Ghareb M. Soliman. (2019) Spironolactone-Loaded LeciPlexes as Potential Topical Delivery Systems for Female Acne: In Vitro Appraisal and Ex Vivo Skin Permeability Studies. Pharmaceutics 12:1, pages 25.
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J.W. Charny, J.K. Choi & W.D. James. (2017) Spironolactone for the treatment of acne in women, a retrospective study of 110 patients. International Journal of Women's Dermatology 3:2, pages 111-115.
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M.K. Trivedi, K. Shinkai & J.E. Murase. (2017) A Review of hormone-based therapies to treat adult acne vulgaris in women. International Journal of Women's Dermatology 3:1, pages 44-52.
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Claudia Marcela Arenas Soto & Mar?a Victoria Sabogal G?mez. (2017) Espironolactona. Uso en dermatolog?a. Piel 32:2, pages 108-113.
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Theresa N. Canavan, Edward Chen & Boni E. Elewski. (2016) Optimizing Non-Antibiotic Treatments for Patients with Acne: A Review. Dermatology and Therapy 6:4, pages 555-578.
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Hamid Reza Kelidari, Majid Saeedi, Zohreh Hajheydari, Jafar Akbari, Katayoun Morteza-Semnani, Javad Akhtari, Hadi Valizadeh, Kofi Asare-Addo & Ali Nokhodchi. (2016) Spironolactone loaded nanostructured lipid carrier gel for effective treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trial. Colloids and Surfaces B: Biointerfaces 146, pages 47-53.
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Porntip Pan-In, Atthakorn Wongsomboon, Chayada Kokpol, Nuntaree Chaichanawongsaroj & Supason Wanichwecharungruang. (2015) Depositing ?-mangostin nanoparticles to sebaceous gland area for?acne treatment. Journal of Pharmacological Sciences 129:4, pages 226-232.
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Vivian Y. Shi, Michael Leo, Lauren Hassoun, Dev S. Chahal, Howard I. Maibach & Raja K. Sivamani. (2015) Role of sebaceous glands in inflammatory dermatoses. Journal of the American Academy of Dermatology 73:5, pages 856-863.
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Nooshin Bagherani. (2015) Efficacy of topical spironolactone in treatment of acne. Dermatologic Therapy 28:3, pages 176-176.
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F. William Danby. 2014. Acne. Acne 109 170 .
Takashi Nagase, Tomoko Akase, Hiromi Sanada, Takeo Minematsu, Ai Ibuki, Lijuan Huang, Mayumi Asada, Kotaro Yoshimura, Miki Nagase, Tsutomu Shimada, Masaki Aburada, Gojiro Nakagami & Junko Sugama. (2012) Aging‐like skin changes in metabolic syndrome model mice are mediated by mineralocorticoid receptor signaling. Aging Cell 12:1, pages 50-57.
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