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Pigmentation

Topical tranexamic acid as an adjuvant treatment in melasma: Side-by-side comparison clinical study

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Pages 373-377 | Received 07 May 2015, Accepted 27 Oct 2015, Published online: 04 Dec 2015

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Nicoleta Neagu, Claudio Conforti, Marina Agozzino, Giovanni Francesco Marangi, Silviu Horia Morariu, Giovanni Pellacani, Paolo Persichetti, Domenico Piccolo, Francesco Segreto, Iris Zalaudek & Caterina Dianzani. (2022) Melasma treatment: a systematic review. Journal of Dermatological Treatment 33:4, pages 1816-1837.
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Punyaphat Sirithanabadeekul & Rattima Srieakpanit. (2018) Intradermal tranexamic acid injections to prevent post-inflammatory hyperpigmentation after solar lentigo removal with a Q-switched 532-nm Nd:YAG laser. Journal of Cosmetic and Laser Therapy 20:7-8, pages 398-404.
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Variya Laothaworn & Premjit Juntongjin. (2018) Topical 3% tranexamic acid enhances the efficacy of 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser in the treatment of melasma. Journal of Cosmetic and Laser Therapy 20:6, pages 320-325.
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Articles from other publishers (27)

Rongzhou Liang, Haiyan Luo, Wanwan Pan, Sifen Yang, Xiaoyun Peng, Baizeng Kuang, Hongyin Huang & Chengjiang Liu. (2023) Comparative efficacy and safety of tranexamic acid for melasma by different administration methods: A systematic review and network meta‐analysis. Journal of Cosmetic Dermatology.
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Nader Pazyar, Maryam Raeispour, Reza Yaghoobi & Maryam Seyedtabib. (2023) Evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin C in the treatment of melasma: A prospective and single‐blind clinical trial. Health Science Reports 6:10.
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Hyun‐A Park, Hoonhee Seo, Sukyung Kim, Asad Ul Haq, Sung Hae Bae, Hyun‐Ji Lee, Se Hee Ju, Hanieh Tajdozian, Md Abdur Rahim, Fatemeh Ghorbanian, Indrajeet Barman, Youjin Yoon, Sujin Jo, Youngkyoung Lee, Gyutae Cho, Hyein Jo, Mijung Kim, Saebim Lee & Ho‐Yeon Song. (2023) Clinical effect of Pediococcus acidilactici PMC48 on hyperpigmented skin . Journal of Cosmetic Dermatology.
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Zou Jia, Kai Tian, Yuanyuan Zhong, Xiaoyun Wang, Suyue Gao, Wushuang Xu, Ke Li & Lijun Wu. (2023) Effectiveness of combination therapy of broadband light and intradermal injection of tranexamic acid in the treatment of chloasma. Journal of Cosmetic Dermatology 22:5, pages 1536-1544.
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Katelyn M. Kim & Henry W. Lim. (2022) The uses of tranexamic acid in dermatology: a review. International Journal of Dermatology 62:5, pages 589-598.
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Nazila Poostiyan, Maryam Alizadeh, Zabihollah Shahmoradi & Farahnaz Fatemi Naeini. (2023) Tranexamic acid microinjections versus tranexamic acid mesoneedling in the treatment of facial melasma: A randomized assessor‐blind split‐face controlled trial. Journal of Cosmetic Dermatology 22:4, pages 1238-1244.
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Dayoung Ko, Rebecca F. Wang, David Ozog, Henry W. Lim & Tasneem F. Mohammad. (2023) Disorders of hyperpigmentation. Part II. Review of management and treatment options for hyperpigmentation. Journal of the American Academy of Dermatology 88:2, pages 291-320.
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Shane Reynal, Elise Martin & Girish Munavalli. (2023) Energy‐based devices for melasma and postinflammatory hyperpigmentation. Dermatological Reviews 4:1, pages 58-66.
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Mohammadreza Sobhan, Elaheh Talebi-Ghane & Elnaz Poostiyan. (2023) A comparative study of 20% azelaic acid cream versus 5% tranexamic acid solution for the treatment of postinflammatory hyperpigmentation in patients with acne vulgaris: A single-blinded randomized clinical trial. Journal of Research in Medical Sciences 28:1, pages 18.
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Rashmi Sarkar, Evangeline B. Handog, Anupam Das, Anuva Bansal, Ma. Juliet Macarayo, Vinay Keshavmurthy, Vignesh Narayan, Soumya Jagadeesan, Eugenio Pipo, Grace Monica Ibaviosa, Indrashis Podder & Shivani Bansal. (2023) Topical and Systemic Therapies in Melasma: A Systematic Review. Indian Dermatology Online Journal 14:6, pages 769-781.
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Zuzanna Piętowska, Danuta Nowicka & Jacek C. Szepietowski. (2022) Understanding Melasma-How Can Pharmacology and Cosmetology Procedures and Prevention Help to Achieve Optimal Treatment Results? A Narrative Review. International Journal of Environmental Research and Public Health 19:19, pages 12084.
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Kanika Kamal, Kerry Heitmiller & Mitalee Christman. (2022) Lasers, lights, and compounds for melasma in aesthetics. Clinics in Dermatology 40:3, pages 249-255.
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Joseph N. Mehrabi, Efrat Bar‐Ilan, Shehadeh Wasim, Amir Koren, Lior Zusmanovitch, Fares Salameh, Gila Isman Nelkenbaum, Tamir Horovitz, Eyal Zur, Ting Song Lim, Jacob Mashiah & Ofir Artzi. (2021) A review of combined treatments for melasma involving energy‐based devices and proposed pathogenesis‐oriented combinations. Journal of Cosmetic Dermatology 21:2, pages 461-472.
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Diana I. S. P. Resende, Marta S. Ferreira, José M. S. Lobo, Emília Sousa & Isabel F. Almeida. (2022) Skin Depigmenting Agents in Anti-Aging Cosmetics: A Medicinal Perspective on Emerging Ingredients. Applied Sciences 12:2, pages 775.
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Xiaowei Feng, Hong Su & Jinwei Xie. (2021) Efficacy and safety of tranexamic acid in the treatment of adult melasma: An updated meta‐analysis of randomized controlled trials. Journal of Clinical Pharmacy and Therapeutics 46:5, pages 1263-1273.
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Aya Y. Badran, Ahmed U. Ali & Ahmed S. Gomaa. (2021) Efficacy of topical versus intradermal injection of Tranexamic Acid In Egyptian melasma Patients: A randomised clinical trial. Australasian Journal of Dermatology 62:3.
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Saleh Rachidi & David J. Goldberg. (2021) Intense pulsed light for pigmented and vascular lesions and skin rejuvenation: Two decades of clinical trials. Dermatological Reviews 2:2, pages 99-105.
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Khadiga S. Sayed, Samar Tuqan & Rana F. Hilal. (2020) Q‐Switched Nd:YAG (532 nm) Laser Versus Intra‐Dermal Tranexamic Acid for Treatment of Facial Ephelides: A Split Face, Randomized, Comparative Trial. Lasers in Surgery and Medicine 53:3, pages 324-332.
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Simin Shamsi Meymandi, Amirhossein Mozayyeni, Manzumeh Shamsi Meymandi & Mahin Aflatoonian. (2020) Efficacy of microneedling plus topical 4% tranexamic acid solution vs 4% hydroquinone in the treatment of melasma: A single‐blind randomized clinical trial. Journal of Cosmetic Dermatology 19:11, pages 2906-2911.
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Bhavana Tetali, Fatima M. Fahs & Darius Mehregan. (2019) Popular over‐the‐counter cosmeceutical ingredients and their clinical efficacy. International Journal of Dermatology 59:4, pages 393-405.
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Giovanni Cannarozzo, Steven Paul Nisticò, Keyvan Nouri & Mario SanninoGiovanni Cannarozzo, Steven Paul Nisticò, Keyvan Nouri & Mario Sannino. 2020. Atlas of Lasers and Lights in Dermatology. Atlas of Lasers and Lights in Dermatology 43 48 .
Anis I. Anwar, Siswanto Wahab, Widya Widita, Airin R. Nurdin, Suci Budhiani & Arifin Seweng. (2019) Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals. Dermatologic Therapy 32:6.
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Fotini Bageorgou, Varvara Vasalou, Vasiliki Tzanetakou & George Kontochristopoulos. (2018) The new therapeutic choice of tranexamic acid solution in treatment of erythematotelangiectatic rosacea. Journal of Cosmetic Dermatology 18:2, pages 563-567.
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Bridget P. Kaufman & Andrew F. Alexis. 2019. Evidence-Based Procedural Dermatology. Evidence-Based Procedural Dermatology 933 962 .
Lei Zhang, Wei-Qiang Tan, Qing-Qing Fang, Wan-Yi Zhao, Qi-Ming Zhao, Jie Gao & Xiao-Wei Wang. (2018) Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis. BioMed Research International 2018, pages 1-13.
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Arwa M. Hassan, Ghada F.R. Hassan, Mayada A.F. Ismail & Gamal M. El-Maghraby. (2018) A comparative study between two topical treatments (tranexamic acid and flutamide) in the treatment of patients with melasma. Journal of the Egyptian Womenʼs Dermatologic Society 15:3, pages 144-150.
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Vahideh Lajevardi, Afsaneh Ghayoumi, Robabeh Abedini, Hamed Hosseini, Azadeh Goodarzi, Zahra Akbari & Kosar Hedayat. (2017) Comparison of the therapeutic efficacy and safety of combined oral tranexamic acid and topical hydroquinone 4% treatment vs. topical hydroquinone 4% alone in melasma: a parallel-group, assessor- and analyst-blinded, randomized controlled trial with a shor. Journal of Cosmetic Dermatology 16:2, pages 235-242.
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