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Original Article

A controlled study of the activity of hyaluronic acid in the treatment of venous leg ulcers

Pages 75-81 | Received 21 Jun 1995, Accepted 13 Nov 1995, Published online: 12 Jul 2009

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Gaia Pellegatta, Marco Spadaccini, Laura Lamonaca, Vincenzo Craviotto, Ferdinando D’Amico, Laura Ceriotti, Marisa Meloni & Alessandro Repici. (2020) Evaluation of Human Esophageal Epithelium Permeability in Presence of Different Formulations Containing Hyaluronic Acid and Chondroitin Sulphate. Medical Devices: Evidence and Research 13, pages 57-66.
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Sylvie Meaume, Zohra Ourabah, Marco Romanelli, Roberto Manopulo, Florent De Vathaire, Denis Salomon & Jean-Hilaire Saurat. (2008) Efficacy and tolerance of a hydrocolloid dressing containing hyaluronic acid for the treatment of leg ulcers of venous or mixed origin. Current Medical Research and Opinion 24:10, pages 2729-2739.
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Yong-Hong Liao, Stuart A. Jones, Ben Forbes, Gary P. Martin & Marc B. Brown. (2005) Hyaluronan: Pharmaceutical Characterization and Drug Delivery. Drug Delivery 12:6, pages 327-342.
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José Verdú-Soriano, Antonio Casado-Díaz, Marisol de Cristino-Espinar, Silvia Luna-Morales, Caridad Dios-Guerra, Paloma Moreno-Moreno, Gabriel Dorado, José Manuel Quesada-Gómez, Leocadio Rodríguez-Mañas & José Luis Lázaro-Martínez. (2023) Hard-to-Heal Wound Healing: Superiority of Hydrogel EHO-85 (Containing Olea europaea Leaf Extract) vs. a Standard Hydrogel. A Randomized Controlled Trial. Gels 9:12, pages 962.
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Mariah G. Bezold, Andrew R. Hanna, Bryan R. Dollinger, Prarthana Patil, Fang Yu, Craig L. Duvall & Mukesh K. Gupta. (2023) Hybrid Shear‐Thinning Hydrogel Integrating Hyaluronic Acid with ROS‐Responsive Nanoparticles. Advanced Functional Materials 33:31.
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Hellen Roehrs, Janislei GD Stocco, Franciele Pott, Gisely Blanc, Marineli J Meier & Fernando AL Dias. (2023) Dressings and topical agents containing hyaluronic acid for chronic wound healing. Cochrane Database of Systematic Reviews 2023:7.
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Boris Nikolaev, Ludmila Yakovleva, Viacheslav Fedorov, Hanmei Li, Huile Gao & Maxim Shevtsov. (2023) Nano- and Microemulsions in Biomedicine: From Theory to Practice. Pharmaceutics 15:7, pages 1989.
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Arnaud Fotso Kamdem, Anne-Laure Parmentier, Frédéric Mauny & Emilie Soriano. (2021) Assessment of care protocol using hyaluronic acid dressing in Second-Degree skin burns in children. Burns Open 5:3, pages 118-124.
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Ahmed S. Hashem, Rakhi Issrani, Tamer E. E. Elsayed & Namdeo Prabhu. (2018) Topical hyaluronic acid in the management of oral lichen planus: A comparative study. Journal of Investigative and Clinical Dentistry 10:2, pages e12385.
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Batoryna Olgierd, Aleksandra Sklarek, Paulina Siwek & Ewa Waluga. 2019. Stem Cells and Biomaterials for Regenerative Medicine. Stem Cells and Biomaterials for Regenerative Medicine 163 189 .
Gill Norman, Maggie J Westby, Amber D Rithalia, Nikki Stubbs, Marta O Soares & Jo C Dumville. (2018) Dressings and topical agents for treating venous leg ulcers. Cochrane Database of Systematic Reviews 2018:6.
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A. Shaharudin & Z. Aziz. (2016) Effectiveness of hyaluronic acid and its derivatives on chronic wounds: a systematic review. Journal of Wound Care 25:10, pages 585-592.
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Moses Lee, Seung Hwan Han, Woo Jin Choi, Kwang Ho Chung & Jin Woo Lee. (2016) Hyaluronic acid dressing (Healoderm) in the treatment of diabetic foot ulcer: A prospective, randomized, placebo-controlled, single-center study. Wound Repair and Regeneration 24:3, pages 581-588.
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Laurel M. Morton, Laura L. Bolton, Lisa Q. Corbett, Susan Girolami & Tania J. Phillips. (2013) An Evaluation of the Association for the Advancement of Wound Care Venous Ulcer Guideline and Recommendations for Further Research. Advances in Skin & Wound Care 26:12, pages 553-561.
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Philippe Humbert, Jacek Mikosinki, Hakima Benchikhi & François‐André Allaert. (2012) Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double‐blind, randomised, controlled trial. International Wound Journal 10:2, pages 159-166.
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O. Dereure, J. Mikosinki, Z. Zegota & F.A. Allaert. (2012) RCT to evaluate a hyaluronic acid containing gauze pad in leg ulcers of venous or mixed aetiology. Journal of Wound Care 21:11, pages 539-547.
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Jeffrey Voigt & Vickie R. Driver. (2012) Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: A systematic review and meta-analysis of randomized controlled trials. Wound Repair and Regeneration 20:3, pages 317-331.
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O. Dereure, M. Czubek & P. Combemale. (2012) Efficacy and safety of hyaluronic acid in treatment of leg ulcers: a double-blind RCT. Journal of Wound Care 21:3, pages 131-139.
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Yan Xie, Zee Upton, Sean Richards, Simone C. Rizzi & David I. Leavesley. (2011) Hyaluronic acid: Evaluation as a potential delivery vehicle for vitronectin:growth factor complexes in wound healing applications. Journal of Controlled Release 153:3, pages 225-232.
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V??ronique Voinchet, Pascal Vasseur & J??r??me Kern. (2006) Efficacy and Safety of Hyaluronic Acid in the Management of Acute Wounds. American Journal of Clinical Dermatology 7:6, pages 353-357.
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P. Taddeucci, E. Pianigiani, V. Colletta, F. Torasso, L. Andreassi & A. Andreass. (2004) An evaluation of Hyalofill-F plus compression bandaging in the treatment of chronic venous ulcers. Journal of Wound Care 13:5, pages 202-204.
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V. Colletta, D. Dioguardi, A. Di Lonardo, G. Maggio & F. Torasso. (2003) A trial to assess the efficacy and tolerability of Hyalofill-F in non-healing venous leg ulcers. Journal of Wound Care 12:9, pages 357-361.
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R. Moseley, M. Walker, R.J. Waddington & W.Y.J. Chen. (2003) Comparison of the antioxidant properties of wound dressing materials–carboxymethylcellulose, hyaluronan benzyl ester and hyaluronan, towards polymorphonuclear leukocyte-derived reactive oxygen species. Biomaterials 24:9, pages 1549-1557.
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P. Stephens & D.W. Thomas. (2002) The cellular proliferative phase of the wound repair process. Journal of Wound Care 11:7, pages 253-261.
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R Moseley, M Leaver, M Walker, R.J Waddington, D Parsons, W.Y.J Chen & G Embery. (2002) Comparison of the antioxidant properties of HYAFF®-11p75, AQUACEL® and hyaluronan towards reactive oxygen species in vitro. Biomaterials 23:10, pages 2255-2264.
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Uwe Wollina. (2002) Clinical Management of Pyoderma Gangrenosum. American Journal of Clinical Dermatology 3:3, pages 149-158.
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Uwe Wollina & Theodor Karamfilov. (2002) Treatment of recalcitrant ulcers in pyoderma gangrenosum with mycophenolate mofetil and autologous keratinocyte transplantation on a hyaluronic acid matrix. Journal of the European Academy of Dermatology and Venereology 14:3, pages 187-190.
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