682
Views
69
CrossRef citations to date
0
Altmetric
Radiation-Induced Genomic Instability and Epigentics

Radiation-induced genomic instability: Are epigenetic mechanisms the missing link?

, &
Pages 179-191 | Received 01 Jul 2010, Accepted 07 Sep 2010, Published online: 02 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Daryna A. Sokolova, Taras V. Halych, Vladyslav V. Zhuk & Alexandra P. Kravets. (2023) Relationship of radiation-induced genomic instability and antioxidant production in the chamomile plant. International Journal of Radiation Biology 99:10, pages 1631-1638.
Read now
Janet E. Baulch. (2019) Radiation-induced genomic instability, epigenetic mechanisms and the mitochondria: a dysfunctional ménage a trois?. International Journal of Radiation Biology 95:4, pages 516-525.
Read now
Scott Bright & Munira Kadhim. (2018) The future impacts of non-targeted effects. International Journal of Radiation Biology 94:8, pages 727-736.
Read now
Paul N. Schofield & Monika Kondratowicz. (2018) Evolving paradigms for the biological response to low dose ionizing radiation; the role of epigenetics. International Journal of Radiation Biology 94:8, pages 769-781.
Read now
Nicholas Dainiak, Ludwig E. Feinendegen, Randall N. Hyer, Paul A. Locke & Alan E. Waltar. (2018) Synergies resulting from a systems biology approach: integrating radiation epidemiology and radiobiology to optimize protection of the public after exposure to low doses of ionizing radiation. International Journal of Radiation Biology 94:1, pages 2-7.
Read now
Suleyman Dasdag, Mehmet Zulkuf Akdag, Mehmet Emin Erdal, Nurten Erdal, Ozlem Izci Ay, Mustafa Ertan Ay, Senay Gorucu Yilmaz, Bahar Tasdelen & Korkut Yegin. (2015) Effects of 2.4 GHz radiofrequency radiation emitted from Wi-Fi equipment on microRNA expression in brain tissue. International Journal of Radiation Biology 91:7, pages 555-561.
Read now
Irena Szumiel. (2015) From radioresistance to radiosensitivity: In vitro evolution of L5178Y lymphoma. International Journal of Radiation Biology 91:6, pages 465-471.
Read now
Jae-Sung Kim, Sun Young Kim, Minyoung Lee, Sung Hyun Kim, Sang-Man Kim & Eun Ju Kim. (2015) Radioresistance in a human laryngeal squamous cell carcinoma cell line is associated with DNA methylation changes and topoisomerase II α. Cancer Biology & Therapy 16:4, pages 558-566.
Read now
Younghyun Lee, Yang Jee Kim, Young Joo Choi, Joong Won Lee, Sunyeong Lee, Yoon Hee Cho & Hai Won Chung. (2015) Radiation-induced changes in DNA methylation and their relationship to chromosome aberrations in nuclear power plant workers. International Journal of Radiation Biology 91:2, pages 142-149.
Read now
Shuang Ye, Dexiao Yuan, Yuexia Xie, Yan Pan & Chunlin Shao. (2013) Role of DNA methylation in long-term low-dose γ-rays induced adaptive response in human B lymphoblast cells. International Journal of Radiation Biology 89:11, pages 898-906.
Read now
Irena Szumiel. (2012) Radiation hormesis: Autophagy and other cellular mechanisms. International Journal of Radiation Biology 88:9, pages 619-628.
Read now

Articles from other publishers (57)

Mariyana Georgieva & Valya Vassileva. (2023) Stress Management in Plants: Examining Provisional and Unique Dose-Dependent Responses. International Journal of Molecular Sciences 24:6, pages 5105.
Crossref
D. O. Sokolova, T. V. Halych, V. V. Zhuk, O. P. Kravets & M. V. Kuchuk. (2022) Association of the Stimulation of Plant Antioxidant Protection with Traits of Genome Instability. Cytology and Genetics 56:5, pages 431-440.
Crossref
Elena Yushkova. (2022) Contribution of transposable elements to transgenerational effects of chronic radioactive exposure of natural populations of Drosophila melanogaster living for a long time in the zone of the Chernobyl nuclear disaster. Journal of Environmental Radioactivity 251-252, pages 106945.
Crossref
Abdulnaser Alkhalil, John Clifford, Stacyann M. Miller, Aarti Gautam, Marti Jett, Rasha Hammamieh, Lauren T. Moffatt & Jeffrey W. Shupp. (2022) Transcriptomes of Wet Skin Biopsies Predict Outcomes after Ionizing Radiation Exposure with Potential Dosimetric Applications in a Mouse Model. Current Issues in Molecular Biology 44:8, pages 3711-3734.
Crossref
Anna Fiselier, Richelle Mychasiuk, Arif Muhammad, Shakhawat Hossain, Abhijit Ghose, Charles Kirkby, Esmaeel Ghasroddashti, Olga Kovalchuk & Bryan Kolb. (2022) Complex housing partially mitigates low dose radiation-induced changes in brain and behavior in rats. Restorative Neurology and Neuroscience 40:2, pages 109-124.
Crossref
Yiqing Xu, Yulong Ge, Xuming Chen, Yingzi Zhang, Huanliang Chen, Dongli Liu, Yue Lu, Yong Liu & Wenzhi Tu. (2022) Hypoxic Cell-Derived Extracellular Vesicles Aggravate Rectal Injury Following Radiotherapy via MiR-122-5p. Frontiers in Cell and Developmental Biology 10.
Crossref
Navyateja Korimerla & Daniel R. Wahl. (2022) Interactions between Radiation and One-Carbon Metabolism. International Journal of Molecular Sciences 23:3, pages 1919.
Crossref
Elena Yushkova. (2022) Radiobiological features in offspring of natural populations of Drosophila melanogaster after Chernobyl accident . Environmental and Molecular Mutagenesis 63:2, pages 84-97.
Crossref
N. S. Kuzmina. (2022) Radiation-Induced DNA Methylation Disorders: In Vitro and In Vivo Studies. Biology Bulletin 48:11, pages 2015-2037.
Crossref
Yeh Siang Lau, Ming Tsuey Chew, Amal Alqahtani, Bleddyn Jones, Mark A. Hill, Andrew Nisbet & David A. Bradley. (2021) Low Dose Ionising Radiation-Induced Hormesis: Therapeutic Implications to Human Health. Applied Sciences 11:19, pages 8909.
Crossref
Guadalupe M. Vedoya, Marcela M. López Nigro & Gabriela A. Martín. (2021) The secretome of non-tumorigenic mammary cells MCF-10A elicits DNA damage in MCF-7 and MDA-MB-231 breast cancer cells. Toxicology in Vitro 70, pages 105018.
Crossref
Metin Budak. 2020. DNA Methylation Mechanism. DNA Methylation Mechanism.
Alexandra Sexton-Oates, Alexei Novoloaca, Akram Ghantous & Zdenko Herceg. 2020. Environmental Epigenetics in Toxicology and Public Health. Environmental Epigenetics in Toxicology and Public Health 171 189 .
Dajana Blagojevic, YeonKyeong Lee, Dag A. Brede, Ole Christian Lind, Igor Yakovlev, Knut Asbjørn Solhaug, Carl Gunnar Fossdal, Brit Salbu & Jorunn E. Olsen. (2019) Comparative sensitivity to gamma radiation at the organismal, cell and DNA level in young plants of Norway spruce, Scots pine and Arabidopsis thaliana. Planta 250:5, pages 1567-1590.
Crossref
Dajana Blagojevic, YeonKyeong Lee, Li Xie, Dag A. Brede, Line Nybakken, Ole Christian Lind, Knut Erik Tollefsen, Brit Salbu, Knut Asbjørn Solhaug & Jorunn E. Olsen. (2020) No evidence of a protective or cumulative negative effect of UV-B on growth inhibition induced by gamma radiation in Scots pine (Pinus sylvestris) seedlings. Photochemical & Photobiological Sciences 18:8, pages 1945-1962.
Crossref
R. A. Yakymchuk. (2019) Distant genetic consequences of radiation impact on organisms. Vìsnik Harkìvsʹkogo nacìonalʹnogo agrarnogo unìversitetu. Serìâ Bìologiâ 2019:2, pages 6-22.
Crossref
Yoon Hee Cho, Yoonhee Jang, Hae Dong Woo, Yang Jee Kim, Su Young Kim, Sonja Christensen, Elizabeth Cole, Soo Yong Choi & Hai Won Chung. (2018) LINE‐1 hypomethylation is associated with radiation‐induced genomic instability in industrial radiographers. Environmental and Molecular Mutagenesis 60:2, pages 174-184.
Crossref
Maria Rita Fabbrizi, Kacie E. Warshowsky, Cheri L. Zobel, Dennis E. Hallahan & Girdhar G. Sharma. (2018) Molecular and epigenetic regulatory mechanisms of normal stem cell radiosensitivity. Cell Death Discovery 4:1.
Crossref
Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai & Kwang-Huei Lin. (2018) Impact of DNA and RNA Methylation on Radiobiology and Cancer Progression. International Journal of Molecular Sciences 19:2, pages 555.
Crossref
Jie Shen, Renduo Song, Jie Wan, Chad Huff, Shenying Fang, Jeffrey E. Lee & Hua Zhao. (2017) Global methylation of blood leukocyte DNA and risk of melanoma. International Journal of Cancer 140:7, pages 1503-1509.
Crossref
Yoshikazu Kuwahara, Mehryar Habibi Roudkenar, Yusuke Urushihara, Yohei Saito, Kazuo Tomita, Amaneh Mohammadi Roushandeh, Tomoaki Sato, Akihiro Kurimasa & Manabu Fukumoto. (2017) X-Ray Induced Mutation Frequency at the <i>Hypoxanthine Phosphoribosyltransferase</i> Locus in Clinically Relevant Radioresistant Cells. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 06:04, pages 377-391.
Crossref
Carsten Herskind, Christopher J. Talbot, Sarah L. Kerns, Marlon R. Veldwijk, Barry S. Rosenstein & Catharine M.L. West. (2016) Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?. Cancer Letters 382:1, pages 95-109.
Crossref
Won Hee Lee, Patricia K. Nguyen, Dominik Fleischmann & Joseph C. Wu. (2016) DNA damage-associated biomarkers in studying individual sensitivity to low-dose radiation from cardiovascular imaging. European Heart Journal 37:40, pages 3075-3080.
Crossref
Dong Pan, Yarong Du, Zhenxin Ren, Yaxiong Chen, Xiaoman Li, Jufang Wang & Burong Hu. (2016) Radiation induces premature chromatid separation via the miR-142-3p/Bod1 pathway in carcinoma cells. Oncotarget 7:37, pages 60432-60445.
Crossref
Julie J Burtt, Patsy A Thompson & Robert M Lafrenie. (2016) Non-targeted effects and radiation-induced carcinogenesis: a review. Journal of Radiological Protection 36:1, pages R23-R35.
Crossref
Benjamin M. Haley, Tatjana Paunesku, David J. Grdina & Gayle E. Woloschak. (2015) The Increase in Animal Mortality Risk following Exposure to Sparsely Ionizing Radiation Is Not Linear Quadratic with Dose. PLOS ONE 10:12, pages e0140989.
Crossref
Kanokporn Noy Rithidech, Louise M. Honikel, Paiboon Reungpathanaphong, Montree Tungjai, Witawat Jangiam & Elbert B. Whorton. (2015) Late-occurring chromosome aberrations and global DNA methylation in hematopoietic stem/progenitor cells of CBA/CaJ mice exposed to silicon (28Si) ions. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 781, pages 22-31.
Crossref
Eitan Fibach & Eliezer A. Rachmilewitz. (2015) The Effect of Fermented Papaya Preparation on Radioactive Exposure. Radiation Research 184:3, pages 304-313.
Crossref
V.W.Y. Choi & K.N. Yu. (2015) Embryos of the zebrafish Danio rerio in studies of non-targeted effects of ionizing radiation. Cancer Letters 356:1, pages 91-104.
Crossref
William F. Morgan & Marianne B. Sowa. (2015) Non-targeted effects induced by ionizing radiation: Mechanisms and potential impact on radiation induced health effects. Cancer Letters 356:1, pages 17-21.
Crossref
Shuang Ye, Dexiao Yuan, Yuexia Xie, Yan Pan & Chunlin Shao. (2014) Role of DNA methylation in the adaptive responses induced in a human B lymphoblast cell line by long-term low-dose exposures to γ-rays and cadmium. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 773, pages 34-38.
Crossref
Janet E. Baulch, Umut Aypar, Katrina M. Waters, Austin J. Yang & William F. Morgan. (2014) Genetic and Epigenetic Changes in Chromosomally Stable and Unstable Progeny of Irradiated Cells. PLoS ONE 9:9, pages e107722.
Crossref
Katriina Huumonen, Merja Korkalainen, Matti Viluksela, Tapani Lahtinen, Jonne Naarala & Jukka Juutilainen. (2014) Role of microRNAs and DNA Methyltransferases in Transmitting Induced Genomic Instability between Cell Generations. Frontiers in Public Health 2.
Crossref
Michael Abend, Tamara Azizova, Kerstin Müller, Harald Dörr, Sven Senf, Helmut Kreppel, Galina Rusinova, Irina Glazkova, Natalia Vyazovskaya, Kristian Unger & Viktor Meineke. (2014) Independent Validation of Candidate Genes Identified after a Whole Genome Screening on Mayak Workers Exposed to Prolonged Occupational Radiation. Radiation Research 182:3, pages 299.
Crossref
Florence Lima, Dacheng Ding, Wilfried Goetz, Austin J. Yang & Janet E. Baulch. (2014) High LET 56 Fe ion irradiation induces tissue-specific changes in DNA methylation in the mouse . Environmental and Molecular Mutagenesis 55:3, pages 266-277.
Crossref
Jingzi Wang, Youwei Zhang, Kai Xu, Xiaobei Mao, Lijun Xue, Xiaobei Liu, Hongjun Yu, Longbang Chen & Xiaoyuan Chu. (2014) Genome-Wide Screen of DNA Methylation Changes Induced by Low Dose X-Ray Radiation in Mice. PLoS ONE 9:3, pages e90804.
Crossref
Kuei-Fang Lee, Yi-Cheng Chen, Paul Wei-Che Hsu, Ingrid Y. Liu & Lawrence Shih-Hsin Wu. (2014) MicroRNA Expression Profiling Altered by Variant Dosage of Radiation Exposure. BioMed Research International 2014, pages 1-10.
Crossref
Winnie Wai-Ying Kam & Richard B. Banati. (2013) Effects of ionizing radiation on mitochondria. Free Radical Biology and Medicine 65, pages 607-619.
Crossref
M Abend, R M Pfeiffer, C Ruf, M Hatch, T I Bogdanova, M D Tronko, J Hartmann, V Meineke, K Mabuchi & A V Brenner. (2013) Iodine-131 dose-dependent gene expression: alterations in both normal and tumour thyroid tissues of post-Chernobyl thyroid cancers. British Journal of Cancer 109:8, pages 2286-2294.
Crossref
S. G. Andreev, Ya. A. Eidelman, I. V. Salnikov & S. V. Slanina. (2013) Modeling study of dose-response relationships for radiation-induced chromosomal instability. Doklady Biochemistry and Biophysics 451:1, pages 171-175.
Crossref
William F. Morgan & William J. Bair. (2013) Issues in Low Dose Radiation Biology: The Controversy Continues. A Perspective. Radiation Research 179:5, pages 501-510.
Crossref
J Bensimon, S Altmeyer-Morel, H Benjelloun, S Chevillard & J Lebeau. (2012) CD24−/low stem-like breast cancer marker defines the radiation-resistant cells involved in memorization and transmission of radiation-induced genomic instability. Oncogene 32:2, pages 251-258.
Crossref
Carmel Mothersill & Colin Seymour. 2013. Stress-Induced Mutagenesis. Stress-Induced Mutagenesis 199 222 .
Edouard I. Azzam, Jean-Paul Jay-Gerin & Debkumar Pain. (2012) Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Letters 327:1-2, pages 48-60.
Crossref
Cristina Vieira, Marie Fablet, Emmanuelle Lerat, Matthieu Boulesteix, Rita Rebollo, Nelly Burlet, Abdou Akkouche, Benjamin Hubert, Hussein Mortada & Christian Biémont. (2012) A comparative analysis of the amounts and dynamics of transposable elements in natural populations of Drosophila melanogaster and Drosophila simulans. Journal of Environmental Radioactivity 113, pages 83-86.
Crossref
Eileen Pernot, Janet Hall, Sarah Baatout, Mohammed Abderrafi Benotmane, Eric Blanchardon, Simon Bouffler, Houssein El Saghire, Maria Gomolka, Anne Guertler, Mats Harms-Ringdahl, Penny Jeggo, Michaela Kreuzer, Dominique Laurier, Carita Lindholm, Radhia Mkacher, Roel Quintens, Kai Rothkamm, Laure Sabatier, Soile Tapio, Florent de Vathaire & Elisabeth Cardis. (2012) Ionizing radiation biomarkers for potential use in epidemiological studies. Mutation Research/Reviews in Mutation Research 751:2, pages 258-286.
Crossref
Katriina Huumonen, Hanna-Kaisa Immonen, Keith Baverstock, Mikko Hiltunen, Merja Korkalainen, Tapani Lahtinen, Juha Parviainen, Matti Viluksela, Garry Wong, Jonne Naarala & Jukka Juutilainen. (2012) Radiation-induced genomic instability in Caenorhabditis elegans. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 748:1-2, pages 36-41.
Crossref
Andrei V. Karotki & Keith Baverstock. (2012) What mechanisms/processes underlie radiation-induced genomic instability?. Cellular and Molecular Life Sciences 69:20, pages 3351-3360.
Crossref
Stefani N. Thomas, Katrina M. Waters, William F. Morgan, Austin J. Yang & Janet E. Baulch. (2012) Quantitative proteomic analysis of mitochondrial proteins reveals prosurvival mechanisms in the perpetuation of radiation-induced genomic instability. Free Radical Biology and Medicine 53:3, pages 618-628.
Crossref
Michael Abend, Ruth M. Pfeiffer, Christian Ruf, Maureen Hatch, Tetiana I. Bogdanova, Mykola D. Tronko, Armin Riecke, Julia Hartmann, Viktor Meineke, Houda Boukheris, Alice J. Sigurdson, Kiyohiko Mabuchi & Alina V. Brenner. (2012) Iodine-131 Dose Dependent Gene Expression in Thyroid Cancers and Corresponding Normal Tissues Following the Chernobyl Accident. PLoS ONE 7:7, pages e39103.
Crossref
Merja Korkalainen, Katriina Huumonen, Jonne Naarala, Matti Viluksela & Jukka Juutilainen. (2012) Dioxin Induces Genomic Instability in Mouse Embryonic Fibroblasts. PLoS ONE 7:5, pages e37895.
Crossref
Hamdy E. Abouzeid Ali, Ruth C. Barber & Yuri E. Dubrova. (2012) The effects of maternal irradiation during adulthood on mutation induction and transgenerational instability in mice. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 732:1-2, pages 21-25.
Crossref
Anita Krisko, Magali LeroyMiroslav Radman & Matthew Meselson. (2012) Extreme anti-oxidant protection against ionizing radiation in bdelloid rotifers. Proceedings of the National Academy of Sciences 109:7, pages 2354-2357.
Crossref
Christelle Adam-Guillermin, Sandrine Pereira, Claire Della-Vedova, Tom Hinton & Jacqueline Garnier-Laplace. 2012. Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology 67 103 .
V. Krutovskikh & C. Partensky. (2011) Nouvelles perspectives en oncologie : épigénétique et cellules souches cancéreuses. Cancer/Radiothérapie 15:8, pages 716-722.
Crossref
A. Fueyo-Casado & J. Pedraz-Muñoz. (2011) Fukushima: What a Dermatologist Should Know. Actas Dermo-Sifiliográficas (English Edition) 102:8, pages 631-633.
Crossref
A. Fueyo-Casado & J. Pedraz-Muñoz. (2011) Fukushima: lo que el dermatólogo debe saber. Actas Dermo-Sifiliográficas 102:8, pages 631-633.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.