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International Journal of Radiation Biology Volume 89, 2013 - Issue 9
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SORANFENIB ENHANCES RADIOSENSITIVITY IN LIVER CANCER CELLS

Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway

Xiao-Fang DaiCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
,
Jie DingCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
,
Rui-Guang ZhangCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
,
Jing-Hua RenCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
,
C.-M. Charlie MaDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
&
Gang WuCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaCorrespondence[email protected]
Pages 724-731 | Received 23 Jun 2012, Accepted 26 Mar 2013, Published online: 31 May 2013

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Jen-Yang Tang, Chih-Wen Shu, Chun-Lin Wang, Sheng-Chieh Wang, Meng-Yang Chang, Li-Ching Lin & Hsueh-Wei Chang. (2019) Sulfonyl chromen-4-ones (CHW09) shows an additive effect to inhibit cell growth of X-ray irradiated oral cancer cells, involving apoptosis and ROS generation. International Journal of Radiation Biology 95:9, pages 1226-1235.
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John E. Moulder. (2019) Chemical radiosensitizers: the Journal history. International Journal of Radiation Biology 95:7, pages 940-944.
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Ehsan Salari, Jan Unkelbach & Thomas Bortfeld. (2015) A mathematical programming approach to the fractionation problem in chemoradiotherapy. IIE Transactions on Healthcare Systems Engineering 5:2, pages 55-73.
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Luis A. Pérez-Romasanta, Elisabet González-Del Portillo, Ana Rodríguez-Gutiérrez & Ángela Matías-Pérez. (2021) Stereotactic Radiotherapy for Hepatocellular Carcinoma, Radiosensitization Strategies and Radiation-Immunotherapy Combination. Cancers 13:2, pages 192.
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Chen-Hsi Hsieh, Yu-Jen Chen, Tung-Hu Tsai, Li-Ying Wang, Hung-Chi Tai, Hsiang-Ling Huang & Yu-Chuen Huang. (2020) Robust combination of liver stereotactic body radiotherapy modulates pharmacokinetics of sorafenib toward preferable parameters. Scientific Reports 10:1.
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Michel M. Ouellette & Ying Yan. (2019) Radiation‐activated prosurvival signaling pathways in cancer cells. Precision Radiation Oncology 3:3, pages 111-120.
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Hamidreza Badri, Ehsan Salari, Yoichi Watanabe & Kevin Leder. (2018) Optimizing Chemoradiotherapy to Target Metastatic Disease and Tumor Growth. INFORMS Journal on Computing 30:2, pages 259-277.
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Ji-wei Ma, Yong Zhang, Ji-cheng Ye, Ru Li, Yu-Lin Wen, Jian-xian Huang & Xue-yun Zhong. (2017) Tetrandrine Exerts a Radiosensitization Effect on Human Glioma through Inhibiting Proliferation by Attenuating ERK Phosphorylation. Biomolecules & Therapeutics 25:2, pages 186-193.
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Matthias Riedel, Nina Struve, Justus Müller-Goebel, Sabrina Köcher, Cordula Petersen, Ekkehard Dikomey, Kai Rothkamm & Malte Kriegs. (2016) Sorafenib inhibits cell growth but fails to enhance radio- and chemosensitivity of glioblastoma cell lines. Oncotarget 7:38, pages 61988-61995.
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Kuo-Hsin Chen, Meng-Tzu Weng, Yueh-Hung Chou, Yueh-Feng Lu & Chen-Hsi Hsieh. (2016) Epigastric Distress Caused by Esophageal Candidiasis in 2 Patients Who Received Sorafenib Plus Radiotherapy for Hepatocellular Carcinoma. Medicine 95:11, pages e3133.
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WEI-LU WU, WEI-YA WANG, WEN-QING YAO & GAN-DI LI. (2015) Suppressive effects of microRNA-16 on the proliferation, invasion and metastasis of hepatocellular carcinoma cells. International Journal of Molecular Medicine 36:6, pages 1713-1719.
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Sunil J. Advani, Maria Fernanda Camargo, Laetitia Seguin, Ainhoa Mielgo, Sudarshan Anand, Angel M. Hicks, Joseph Aguilera, Aleksandra Franovic, Sara M. Weis & David A. Cheresh. (2015) Kinase-independent role for CRAF-driving tumour radioresistance via CHK2. Nature Communications 6:1.
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Qi Liu, Meng Wang, Ashley M. Kern, Saman Khaled, Jing Han, Beow Y. Yeap, Theodore S. Hong, Jeff Settleman, Cyril H. Benes, Kathryn D. Held, Jason A. Efstathiou & Henning Willers. (2015) Adapting a Drug Screening Platform to Discover Associations of Molecular Targeted Radiosensitizers with Genomic Biomarkers. Molecular Cancer Research 13:4, pages 713-720.
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Jennifer W. Harris, Tianyan Gao & B. Mark Evers. 2015. Intestinal Tumorigenesis. Intestinal Tumorigenesis 101 135 .
ASHLEY L. HEIN, MICHEL M. OUELLETTE & YING YAN. (2014) Radiation-induced signaling pathways that promote cancer cell survival (Review). International Journal of Oncology 45:5, pages 1813-1819.
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E. Gabriela Chiorean, Bryan P. Schneider, Fatih M. Akisik, Susan M. Perkins, Stephen Anderson, Cynthia S. Johnson, John DeWitt, Paul Helft, Romnee Clark, Erica L. Johnston, A. John Spittler, Jill Deluca, Guixue Bu, Safi Shahda, Patrick J. Loehrer, Kumar Sandrasegaran & Higinia R. Cardenes. (2014) Phase 1 Pharmacogenetic and Pharmacodynamic Study of Sorafenib With Concurrent Radiation Therapy and Gemcitabine in Locally Advanced Unresectable Pancreatic Cancer. International Journal of Radiation Oncology*Biology*Physics 89:2, pages 284-291.
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