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CHARACTERIZATION OF RADIATION-INDUCED CELL SENESCENCE

Characterization of DNA damage-induced cellular senescence by ionizing radiation in endothelial cells

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Pages 71-80 | Received 12 Mar 2013, Accepted 27 Aug 2013, Published online: 29 Oct 2013

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Kushal Sharma, Hyun-Ho Lee, Dal-Seong Gong, Sin-Hee Park, Eunyoung Yi, Valérie Schini-Kerth & Min-Ho Oak. (2019) Fine air pollution particles induce endothelial senescence via redox-sensitive activation of local angiotensin system. Environmental Pollution 252, pages 317-329.
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Alireza Mohammadkarim, Manijhe Mokhtari-Dizaji, Ali Kazemian, Hazhir Saberi, Mohammad Mehdi Khani & Mohsen Bakhshandeh. (2018) Dose-dependent 60Co γ-radiation Effects on Human Endothelial Cell Mechanical Properties. Cell Biochemistry and Biophysics 77:2, pages 179-186.
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Jieqiong You, Rong Dong, Meidan Ying, Qiaojun He, Ji Cao & Bo Yang. (2019) Cellular Senescence and Anti-Cancer Therapy. Current Drug Targets 20:7, pages 705-715.
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Alfredo Rodríguez, J. Jesús Naveja, Leda Torres, Benilde García de Teresa, Ulises Juárez-Figueroa, Cecilia Ayala-Zambrano, Eugenio Azpeitia, Luis Mendoza & Sara Frías. (2019) WIP1 Contributes to the Adaptation of Fanconi Anemia Cells to DNA Damage as Determined by the Regulatory Network of the Fanconi Anemia and Checkpoint Recovery Pathways. Frontiers in Genetics 10.
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Kshama Gupta & Terry C. Burns. (2018) Radiation-Induced Alterations in the Recurrent Glioblastoma Microenvironment: Therapeutic Implications. Frontiers in Oncology 8.
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Bjorn Baselet, Raghda Ramadan, Abderrafi Mohammed Benotmane, Pierre Sonveaux, Sarah Baatout & An Aerts. 2018. Endothelial Dysfunction - Old Concepts and New Challenges. Endothelial Dysfunction - Old Concepts and New Challenges.
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Christiane Ott, Tobias Jung, Tilman Grune & Annika Höhn. (2018) SIPS as a model to study age-related changes in proteolysis and aggregate formation. Mechanisms of Ageing and Development 170, pages 72-81.
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Anja Moncsek, Mohammed S. Al‐Suraih, Christy E. Trussoni, Steven P. O'Hara, Patrick L. Splinter, Camille Zuber, Eleonora Patsenker, Piero V. Valli, Christian D. Fingas, Achim Weber, Yi Zhu, Tamar Tchkonia, James L. Kirkland, Gregory J. Gores, Beat Müllhaupt, Nicholas F. LaRusso & Joachim C. Mertens. (2017) Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice. Hepatology 67:1, pages 247-259.
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Wheemoon Cho, E Ske Kim, Chang Mo Kang, Young-Hoon Ji, Jong-Il Kim, Sang Jun Park, Youngsook Son & Chun-Ho Kim. (2017) Low-Dose Ionizing γ-Radiation Promotes Proliferation of Human Mesenchymal Stem Cells and Maintains Their Stem Cell Characteristics. Tissue Engineering and Regenerative Medicine 14:4, pages 421-432.
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Audrey Lafargue, Charlotte Degorre, Isabelle Corre, Marie-Clotilde Alves-Guerra, Marie-Hélène Gaugler, François Vallette, Claire Pecqueur & François Paris. (2017) Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation. Free Radical Biology and Medicine 108, pages 750-759.
Crossref
Lucinda S. McRobb, Matthew J. McKay, Jennifer R. Gamble, Michael Grace, Vaughan Moutrie, Estevam D. Santos, Vivienne S. Lee, Zhenjun Zhao, Mark P. Molloy & Marcus A. Stoodley. (2017) Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence. Aging 9:4, pages 1248-1268.
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Bjorn Baselet, Charlotte Rombouts, Abderrafi Mohammed Benotmane, Sarah Baatout & An Aerts. (2016) Cardiovascular diseases related to ionizing radiation: The risk of low-dose exposure (Review). International Journal of Molecular Medicine 38:6, pages 1623-1641.
Crossref
Fumihiro Sanada, Yoshiaki Taniyama, Jun Muratsu, Rei Otsu, Masaaki Iwabayashi, Miguel Carracedo, Hiromi Rakugi & Ryuichi Morishita. (2016) Activated Factor X Induces Endothelial Cell Senescence Through IGFBP-5. Scientific Reports 6:1.
Crossref
Yingying Wang, Marjan Boerma & Daohong Zhou. (2016) Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases. Radiation Research 186:2, pages 153-161.
Crossref
Ia Pantsulaia, Wojciech Michal Ciszewski & Jolanta Niewiarowska. (2016) Senescent endothelial cells: Potential modulators of immunosenescence and ageing. Ageing Research Reviews 29, pages 13-25.
Crossref
Hyejin Park, Chun-Ho Kim, Jae-Hoon Jeong, Myungjin Park & Kwang Seok Kim. (2016) GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells. Oncotarget 7:9, pages 9634-9644.
Crossref
Alexander Helm, Ryonfa Lee, Marco Durante & Sylvia Ritter. (2016) The Influence of C-Ions and X-rays on Human Umbilical Vein Endothelial Cells. Frontiers in Oncology 6.
Crossref
Florence Debacq-Chainiaux, Randa Ben Ameur, Emilie Bauwens, Elise Dumortier, Marie Toutfaire & Olivier Toussaint. 2016. Cellular Ageing and Replicative Senescence. Cellular Ageing and Replicative Senescence 243 262 .
N. V. Petrova, A. K. Velichko, N. V. Petrova, S. V. Razin & O. L. Kantidze. (2015) Stress factor – dependent differences in molecular mechanisms of premature cell senescence. Biopolymers and Cell 31:5, pages 323-337.
Crossref
Kimberly Loesch, Stacy Galaviz, Zaher Hamoui, Ryan Clanton, Gamal Akabani, Michael Deveau, Michael DeJesus, Thomas Ioerger, James C. Sacchettini & Deeann Wallis. (2015) Functional Genomics Screening Utilizing Mutant Mouse Embryonic Stem Cells Identifies Novel Radiation-Response Genes. PLOS ONE 10:4, pages e0120534.
Crossref
T. Ebrahimian, C. Le Gallic, J. Stefani, I. Dublineau, R. Yentrapalli, M. Harms-Ringdahl & S. Haghdoost. (2015) Chronic Gamma-Irradiation Induces a Dose-Rate-Dependent Pro-inflammatory Response and Associated Loss of Function in Human Umbilical Vein Endothelial Cells. Radiation Research 183:4, pages 447-454.
Crossref
Leon A Bach. (2015) Endothelial cells and the IGF system. Journal of Molecular Endocrinology 54:1, pages R1-R13.
Crossref
Siddharth Manvati, Kailash Chandra Mangalhara, P. Kalaiarasan, Niloo Srivastava, Bhupender Kumar & R. N. K. Bamezai. (2014) MiR-101 Induces Senescence and Prevents Apoptosis in the Background of DNA Damage in MCF7 Cells. PLoS ONE 9:10, pages e111177.
Crossref

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