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International Journal of Food Sciences and Nutrition Volume 61, 2010 - Issue 3
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Effects of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells

Eun-Sun Hwang Department of Home Education, Jeonju University, Jeonju, Jeonbuk, KoreaCorrespondence[email protected]
&
Hyong Joo Lee Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul, Korea
Pages 324-336 | Received 20 Sep 2009, Accepted 20 Jan 2010, Published online: 20 Apr 2010

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Jeong Hoon Pan, Breann Abernathy, Young Jun Kim, Jin Hyup Lee, Jun Ho Kim, Eui Cheol Shin & Jae Kyeom Kim. (2018) Cruciferous vegetables and colorectal cancer prevention through microRNA regulation: A review. Critical Reviews in Food Science and Nutrition 58:12, pages 2026-2038.
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Anna Minarini, Andrea Milelli, Carmela Fimognari, Elena Simoni, Eleonora Turrini & Vincenzo Tumiatti. (2014) Exploring the effects of isothiocyanates on chemotherapeutic drugs. Expert Opinion on Drug Metabolism & Toxicology 10:1, pages 25-38.
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Teodora-Cristiana Grădinaru, Marilena Gilca, Adelina Vlad & Dorin Dragoș. (2023) Relevance of Phytochemical Taste for Anti-Cancer Activity: A Statistical Inquiry. International Journal of Molecular Sciences 24:22, pages 16227.
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Saadullah Khattak, Mohd Ahmar Rauf, Nazeer Hussain Khan, Qian-Qian Zhang, Hao-Jie Chen, Pir Muhammad, Mohammad Azam Ansari, Mohammad N. Alomary, Muhammad Jahangir, Chun-Yang Zhang, Xin-Ying Ji & Dong-Dong Wu. (2022) Hydrogen Sulfide Biology and Its Role in Cancer. Molecules 27:11, pages 3389.
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Zhihui Qin, Siyu Ou, Liping Xu, Kathleen Sorensen, Yingxue Zhang, Dan‐Ping Hu, Zhe Yang, Wen‐Yang Hu, Fei Chen & Gail S. Prins. (2021) Design and synthesis of isothiocyanate‐containing hybrid androgen receptor (AR) antagonist to downregulate AR and induce ferroptosis in GSH–Deficient prostate cancer cells. Chemical Biology & Drug Design 97:5, pages 1059-1078.
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Akanksha Srivastava & Richa Raghuwanshi. 2021. Evolutionary Diversity as a Source for Anticancer Molecules. Evolutionary Diversity as a Source for Anticancer Molecules 233 254 .
Asvinidevi Arumugam, Muhammad Din Ibrahim, Saie Brindha Kntayya, Nooraini Mohd Ain, Renato Iori, Stefania Galletti, Costas Ioannides & Ahmad Faizal Abdull Razis. (2020) Induction of Apoptosis by Gluconasturtiin-Isothiocyanate (GNST-ITC) in Human Hepatocarcinoma HepG2 Cells and Human Breast Adenocarcinoma MCF-7 Cells. Molecules 25:5, pages 1240.
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Alma MartelliValentina CitiLara TestaiSimone BrogiVincenzo Calderone. (2020) Organic Isothiocyanates as Hydrogen Sulfide Donors. Antioxidants & Redox Signaling 32:2, pages 110-144.
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Pilar Flores, Virginia Hernández, José Fenoll & Pilar Hellín. (2019) Pre-harvest application of ozonated water on broccoli crops: Effect on head quality. Journal of Food Composition and Analysis 83, pages 103260.
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Mitsiogianni, Koutsidis, Mavroudis, Trafalis, Botaitis, Franco, Zoumpourlis, Amery, Galanis, Pappa & Panayiotidis. (2019) The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents. Antioxidants 8:4, pages 106.
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P. Hellín, E. Novo-Uzal, M.A. Pedreño, J. Cava, I. Garrido, M.V. Molina, J. Fenoll & P. Flores. (2018) Impact of plant biostimulants on the production of glucosinolates in broccoli. Acta Horticulturae:1194, pages 99-104.
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Huarong Huang, Yan He, Lanyue Zhang, Hongping Xiang, Dongli Li, Wenfeng Liu, Xue-Tao Xu, Susan Goodin, Kun Zhang & Xi Zheng. (2018) Phenethyl isothiocyanate in combination with dibenzoylmethane inhibits the androgen-independent growth of prostate cancer cells. Food & Function 9:4, pages 2398-2408.
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Kuang-Chi Lai, Yung-Ting Hsiao, Jiun-Long Yang, Yi-Shih Ma, Yi-Ping Huang, Tai-An Chiang & Jing-Gung Chung. (2017) Benzyl isothiocyanate and phenethyl isothiocyanate inhibit murine melanoma B16F10 cell migration and invasion in vitro. International Journal of Oncology 51:3, pages 832-840.
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Vivek Kumar Gupta, Reetika Singh & Bechan Sharma. (2017) Phytochemicals mediated signalling pathways and their implications in cancer chemotherapy: Challenges and opportunities in phytochemicals based drug development: A review. Biochemical Compounds 5:1, pages 2.
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Hae-Nim Lee, Seong-Ah Shin, Gang-Sik Choo, Hyeong-Jin Kim, Young-Seok Park, Sang-Ki Kim & Ji-Youn Jung. (2016) Inhibitory Effects of Spinach, Cabbage, and Onion Extracts on Growth of Cancer Cells. Journal of the Korean Society of Food Science and Nutrition 45:5, pages 671-679.
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Silvia Novío, María Cartea, Pilar Soengas, Manuel Freire-Garabal & María Núñez-Iglesias. (2016) Effects of Brassicaceae Isothiocyanates on Prostate Cancer. Molecules 21:5, pages 626.
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Chong-Zhen Qin, Xue Zhang, Lan-Xiang Wu, Chun-Jie Wen, Lei Hu, Qiao-Li Lv, Dong-Ya Shen & Hong-Hao Zhou. (2015) Advances in Molecular Signaling Mechanisms of β-Phenethyl Isothiocyanate Antitumor Effects. Journal of Agricultural and Food Chemistry 63:13, pages 3311-3322.
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Jae Kyeom Kim, Dong-Hoon Shin, Hui Gyu Park & Eui-Cheol Shin. (2014) Cruciferous vegetables, glutathione S-transferases, and implications of their interaction to colorectal cancer risk: A review. Journal of the Korean Society for Applied Biological Chemistry 57:4, pages 511-517.
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So-Eun Park, Yeon-Ju Bong, Hee-Young Kim & Kun-Young Park. (2013) Quality characteristics and functionalities of Korean and Japanese spring Baechu cabbages and the kimchi prepared with such cabbages. Korean Journal of Food Preservation 20:6, pages 854-862.
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Brinda Gupta, Linda Chiang, KyungMin Chae & Dae-Hee Lee. (2013) Phenethyl isothiocyanate inhibits hypoxia-induced accumulation of HIF-1α and VEGF expression in human glioma cells. Food Chemistry 141:3, pages 1841-1846.
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HUI-JYE CHEN, CHUNG-MING LIN, CHAO-YING LEE, NAI-CHEN SHIH, SAKAE AMAGAYA, YUNG-CHANG LIN & JAI-SING YANG. (2013) Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling. International Journal of Oncology 43:2, pages 629-637.
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Mei‐Fen Tsou, Ni Tien, Chi‐Cheng Lu, Jo‐Hua Chiang, Jai‐Sing Yang, Jing‐Pin Lin, Ming‐Jen Fan, Jang‐Jih Lu, Su‐Peng Yeh & Jing‐Gung Chung. (2011) Phenethyl isothiocyanate promotes immune responses in normal BALB/c mice, inhibits murine leukemia WEHI‐3 cells, and stimulates immunomodulations in vivo . Environmental Toxicology 28:3, pages 127-136.
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Melissa A. Crampsie, Manoj K. Pandey, Dhimant Desai, Julian Spallholz, Shantu Amin & Arun K. Sharma. (2012) Phenylalkyl isoselenocyanates vs phenylalkyl isothiocyanates: Thiol reactivity and its implications. Chemico-Biological Interactions 200:1, pages 28-37.
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Eun-Sun Hwang, Eun-Young Hong & Gun-Hee Kim. (2012) Determination of Bioactive Compounds and Anti-cancer Effect from Extracts of Korean Cabbage and Cabbage. The Korean Journal of Food And Nutrition 25:2, pages 259-265.
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C. Gonzales, J. Leiva-Revilla, J. Rubio, M. Gasco & G. F. Gonzales. (2012) Effect of red maca (Lepidium meyenii) on prostate zinc levels in rats with testosterone-induced prostatic hyperplasia. Andrologia 44, pages 362-369.
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Ben Liu, Qiqi Mao, Min Cao & Liping Xie. (2012) Cruciferous vegetables intake and risk of prostate cancer: A meta-analysis. International Journal of Urology 19:2, pages 134-141.
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Anna A. Powolny, Ajay Bommareddy & Shivendra V. Singh. 2012. Nutraceuticals and Cancer. Nutraceuticals and Cancer 231 258 .
Luksana Chaiswing, Weixiong Zhong & Terry D. Oberley. (2011) Distinct Redox Profiles of Selected Human Prostate Carcinoma Cell Lines: Implications for Rational Design of Redox Therapy. Cancers 3:3, pages 3557-3584.
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