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Review

Significance of the anti-aging protein Klotho

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Pages 369-385 | Received 03 May 2013, Accepted 16 Aug 2013, Published online: 14 Oct 2013

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Young Soon Yoon, Minhee Jin & Don D. Sin. (2019) Accelerated lung aging and chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 13:4, pages 369-380.
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Sergej M. Ostojic, Elisabet R. Hillesund, Nina C. Øverby, Frøydis N. Vik & Anine C. Medin. (2023) Individual nutrients and serum klotho levels in adults aged 40–79 years. Food Science & Nutrition 11:6, pages 3279-3286.
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Guoyu Guan, Jiasheng Cai, Songbai Zheng, Yanzhen Xiang, Shijin Xia, Yixuan Zhang, Jiaqiang Shi & Jun Wang. (2023) Association between serum manganese and serum klotho in a 40–80-year-old American population from NHANES 2011–2016. Frontiers in Aging 4.
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Li-Xia Yu, Sha-Sha Li, Min-Yue Sha, Jia-Wei Kong, Jian-Ming Ye & Qi-Feng Liu. (2022) The controversy of klotho as a potential biomarker in chronic kidney disease. Frontiers in Pharmacology 13.
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Tsz Fung, Ashok Iyaswamy, Sravan Sreenivasmurthy, Senthilkumar Krishnamoorthi, Xin-Jie Guan, Zhou Zhu, Cheng-Fu Su, Jia Liu, Yuxuan Kan, Yuan Zhang, Hoi Wong & Min Li. (2022) Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer’s Disease: A Review. Biomedicines 10:3, pages 705.
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Kelsey HansonKate FisherNigel M. Hooper. (2021) Exploiting the neuroprotective effects of α-klotho to tackle ageing- and neurodegeneration-related cognitive dysfunction. Neuronal Signaling 5:2.
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Amin Cheikhi, Aaron Barchowsky, Amrita Sahu, Sunita N Shinde, Abish Pius, Zachary J Clemens, Hua Li, Charles A Kennedy, Joerg D Hoeck, Michael Franti & Fabrisia Ambrosio. (2019) Klotho: An Elephant in Aging Research. The Journals of Gerontology: Series A 74:7, pages 1031-1042.
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John E. Morley. (2019) Senolytics: The Modern Snake Oil?. The journal of nutrition, health & aging 23:6, pages 490-493.
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Furong Fan, Yufei Li, Yi Liu, Li Shao, Juehua Yu & Ziwei Li. (2018) Overexpression of klotho in adipose-derived stem cells protects against UVB-induced photoaging in co-cultured human fibroblasts. Molecular Medicine Reports.
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Lu‐Hong Cong, Shi‐Yu Du, Yi‐Na Wu, Ying Liu, Tao Li, Hui Wang, Gang Li & Jun Duan. (2018) Retracted : Upregulation of Klotho potentially inhibits pulmonary vascular remodeling by blocking the activation of the Wnt signaling pathway in rats with PM2.5‐induced pulmonary arterial hypertension . Journal of Cellular Biochemistry 119:7, pages 5581-5597.
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A. A. Moskalev, E. N. Proshkina, A. A. Belyi & I. A. Solovyev. (2017) Genetics of aging and longevity. Russian Journal of Genetics: Applied Research 7:4, pages 369-384.
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Youliang Yan, Yifeng Wang, Yi Xiong, Xiufeng Lin, Ping Zhou & Zhiying Chen. (2017) Reduced Klotho expression contributes to poor survival rates in human patients with ovarian cancer, and overexpression of Klotho inhibits the progression of ovarian cancer partly via the inhibition of systemic inflammation in nude mice. Molecular Medicine Reports.
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Elizabeth A. Grunz-Borgmann, LaNita A. Nichols, Charles E. Wiedmeyer, Sean Spagnoli, Jerome P. Trzeciakowski & Alan R. Parrish. (2016) Structural equation modeling identifies markers of damage and function in the aging male Fischer 344 rat. Mechanisms of Ageing and Development 156, pages 55-62.
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Erica P.A. Rutten, Poornima Gopal, Emiel F.M. Wouters, Frits M.E. Franssen, Geja J. Hageman, Lowie E. Vanfleteren, Martijn A. Spruit & Niki L. Reynaert. (2016) Various Mechanistic Pathways Representing the Aging Process Are Altered in COPD. Chest 149:1, pages 53-61.
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Huidong Sun, Yanchao Gao, Kemei Lu, Guimei Zhao, Xuehua Li, Zhu Li & Hong Chang. (2015) Overexpression of Klotho suppresses liver cancer progression and induces cell apoptosis by negatively regulating wnt/β-catenin signaling pathway. World Journal of Surgical Oncology 13:1.
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Peter J. Barnes. (2015) Mechanisms of development of multimorbidity in the elderly. European Respiratory Journal 45:3, pages 790-806.
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Xuanxuan Zhou, Qian Yang, Yanhua Xie, Jiyuan Sun, Jing Hu, Pengcheng Qiu, Wei Cao & Siwang Wang. (2015) Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1. Neurobiology of Aging 36:3, pages 1462-1470.
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Paul D. Miller, Sophie Jamal & Stuart M. Sprague. 2015. The Parathyroids. The Parathyroids 653 669 .
XIN-XIANG LI, LI-YONG HUANG, JUN-JIE PENG, LEI LIANG, DE-BING SHI, HONG-TU ZHENG & SAN-JUN CAI. (2014) Klotho suppresses growth and invasion of colon cancer cells through inhibition of IGF1R-mediated PI3K/AKT pathway. International Journal of Oncology 45:2, pages 611-618.
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M. Dermaku-Sopjani, S. Abazi, C. Faggio, J. Kolgeci & M. Sopjani. (2014) AMPK-sensitive cellular transport. Journal of Biochemistry 155:3, pages 147-158.
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