65
Views
46
CrossRef citations to date
0
Altmetric
Original Article

Kinetics of the Enzymatic Resolution of Racemic Compounds in Bi-Bi Reactions

, &
Pages 13-27 | Received 17 Jul 1991, Accepted 27 Mar 1992, Published online: 11 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

A. J. J. Straathof & J. J. Heijnen. (1997) Derivation of Enzymatic Rate Equations Using Symbolic Software. Biocatalysis and Biotransformation 15:1, pages 29-37.
Read now
J. L. L. Rakels, A. G. M. Schneiders, A. J. J. Straatho & J. J. Heijnen. (1996) Improved Kinetic Resolution by Enzyme-Catalyzed Parallel Reactions. Biocatalysis and Biotransformation 13:3, pages 179-188.
Read now
J. Bert A. Van Tol, Diana E. Kraayveld, Jaap A. Jongejan & Johannis A. Duine. (1995) The Catalytic Performance of Pig Pancreas Lipase in Enantioselective Transesterification in Organic Solvents. Biocatalysis and Biotransformation 12:2, pages 119-136.
Read now
Niklas Öhrner, Mats Martinelle, Anders Mattson, Torbjörn Norin & Karl Hult. (1994) Thioethyl-, Vinyl-, Ethyl Octanoate Esters and Octanoic Acid as Acyl Donors in Lipase Catalysed Acyl Transfer Reactions. Biocatalysis 9:1-4, pages 105-114.
Read now
Kurt Faber, Gianluca Ottolina & Sergio Riva. (1993) Selectivity-Enhancement of Hydrolase Reactions. Biocatalysis 8:2, pages 91-132.
Read now

Articles from other publishers (39)

Tatiana Ziemniczak Pereira de Figueiredo, Fernando Augusto Pedersen Voll, Nadia Krieger & David Alexander Mitchell. (2023) Lipase-catalyzed two-step transesterification of diols: Estimation of selectivities. Biochemical Engineering Journal 195, pages 108911.
Crossref
David Alexander Mitchell & Nadia Krieger. (2022) Kinetics of lipase-catalyzed kinetic resolutions of racemic compounds: Reparameterization in terms of specificity constants. Biochemical Engineering Journal 181, pages 108397.
Crossref
Dominicky Cristina Serrano, David Alexander Mitchell & Nadia Krieger. (2022) Rate equations for two enzyme-catalyzed Ping Pong bi bi reactions in series: General formulation for two reaction loops joined by a common vertex and deduction of a reaction loop selectivity factor. Biochemical Engineering Journal 177, pages 108234.
Crossref
Tao Zhang, Gaia Scalabrino, Neil Frankish & Helen Sheridan. (2018) Bioactive Indanes: Proof of Concept Study for Enantioselective Synthetic Routes to PH46A, a New Potential Anti-Inflammatory Agent. Molecules 23:7, pages 1503.
Crossref
Kurt FaberKurt Faber. 2018. Biotransformations in Organic Chemistry. Biotransformations in Organic Chemistry 31 313 .
Ingvild T. Lund, Pål L. Bøckmann & Elisabeth E. Jacobsen. (2016) Highly enantioselective CALB-catalyzed kinetic resolution of building blocks for β-blocker atenolol. Tetrahedron 72:46, pages 7288-7292.
Crossref
Shau-Wei Tsai. (2016) Enantiopreference of Candida antarctica lipase B toward carboxylic acids: Substrate models and enantioselectivity thereof. Journal of Molecular Catalysis B: Enzymatic 127, pages 98-116.
Crossref
Vivian Rotuno Moure, Cristiane Fabrício, Gustavo Frensch, Francisco A. Marques, David Alexander Mitchell & Nadia Krieger. (2014) Enhancing the enantioselectivity of the lipase from Burkholderia cepacia LTEB11 towards the resolution of secondary allylic alcohols. Biocatalysis and Agricultural Biotechnology 3:2, pages 146-153.
Crossref
Naweed Al-Haque, Paloma A. Santacoloma, Watson Neto, Pär Tufvesson, Rafiqul Gani & John M. Woodley. (2012) A robust methodology for kinetic model parameter estimation for biocatalytic reactions. Biotechnology Progress 28:5, pages 1186-1196.
Crossref
Kurt FaberKurt Faber. 2011. Biotransformations in Organic Chemistry. Biotransformations in Organic Chemistry 31 313 .
David Alexander Mitchell, Vivian Rotuno Moure, Francisco de Assis Marques & Nadia Krieger. (2010) A new mathematical method for determining the enantiomeric ratio in lipase-catalyzed reactions. Journal of Molecular Catalysis B: Enzymatic 64:1-2, pages 23-28.
Crossref
Lucia Gardossi, Poul B. Poulsen, Antonio Ballesteros, Karl Hult, Vytas K. Švedas, Đurđa Vasić-Rački, Giacomo Carrea, Anders Magnusson, Andreas Schmid, Roland Wohlgemuth & Peter J. Halling. (2010) Guidelines for reporting of biocatalytic reactions. Trends in Biotechnology 28:4, pages 171-180.
Crossref
Jaap A. Jongejan. 2008. Organic Synthesis with Enzymes in Non‐Aqueous Media. Organic Synthesis with Enzymes in Non‐Aqueous Media 25 46 .
Xiang-Guo Li, Maria Lähitie, Mari Päiviö & Liisa T. Kanerva. (2007) Enantioselective acylation of alcohols with fluorinated β-phenyl-β-lactams in the presence of Burkholderia cepacia lipase. Tetrahedron: Asymmetry 18:13, pages 1567-1573.
Crossref
Lee Suan Chua & Mohamad Roji Sarmidi. (2004) Immobilised lipase-catalysed resolution of (R,S)-1-phenylethanol in recirculated packed bed reactor. Journal of Molecular Catalysis B: Enzymatic 28:2-3, pages 111-119.
Crossref
Kurt FaberKurt Faber. 2004. Biotransformations in Organic Chemistry. Biotransformations in Organic Chemistry 29 333 .
Hans Joachim Gais & Fritz Theil. 2002. Enzyme Catalysis in Organic Synthesis. Enzyme Catalysis in Organic Synthesis 335 578 .
Guo‐Hua Xiu, Lei Jiang & Ping Li. (2001) Mass‐transfer limitations for immobilized enzyme‐catalyzed kinetic resolution of racemate in a fixed‐bed reactor. Biotechnology and Bioengineering 74:1, pages 29-39.
Crossref
S.W. Tsai, I.C. Cheng & C.M. Huang. (2000) Effects of hydrolysis and esterification side-reactions on the kinetic resolution of enzyme-catalyzed irreversible transesterification in organic solvents. Chemical Engineering Science 55:20, pages 4571-4582.
Crossref
Mateja Pogorevc & Kurt Faber. (2000) Biocatalytic resolution of sterically hindered alcohols, carboxylic acids and esters containing fully substituted chiral centers by hydrolytic enzymes. Journal of Molecular Catalysis B: Enzymatic 10:4, pages 357-376.
Crossref
Aldo Jongejan, Sonia S Machado & Jaap A Jongejan. (2000) The enantioselectivity of quinohaemoprotein alcohol dehydrogenases: mechanistic and structural aspects. Journal of Molecular Catalysis B: Enzymatic 8:1-3, pages 121-163.
Crossref
Kurt FaberKurt Faber. 2000. Biotransformations in Organic Chemistry. Biotransformations in Organic Chemistry 29 333 .
Jong-Shik Shin & Byung-Gee Kim. (1998) Kinetic modeling of ω-transamination for enzymatic kinetic resolution of α-methylbenzylamine. Biotechnology and Bioengineering 60:5, pages 534-540.
Crossref
P.L.Antoine Overbeeke, S.Christian Orrenius, Jaap A Jongejan & Johannis A Duine. (1998) Enthalpic and entropic contributions to lipase enantioselectivity. Chemistry and Physics of Lipids 93:1-2, pages 81-93.
Crossref
A.J.J. Straathof & J.A. Jongejan. (1997) The enantiomeric ratio: origin, determination and prediction. Enzyme and Microbial Technology 21:8, pages 559-571.
Crossref
Francesco Secundo, Gianluca Ottolina, Sergio Riva & Giacomo Carrea. (1997) The enantioselectivity of lipase PS in chlorinated solvents increases as a function of substrate conversion. Tetrahedron: Asymmetry 8:13, pages 2167-2173.
Crossref
Eero Vänttinen & Liisa T Kanerva. (1997) Optimized double kinetic resolution for the preparation of (S)-solketal. Tetrahedron: Asymmetry 8:6, pages 923-933.
Crossref
Thorleif Anthonsen & Jaap A. Jongejan. 1997. Lipases Part B: Enzyme Characterization and Utilization. Lipases Part B: Enzyme Characterization and Utilization 473 495 .
Karl Hult & Mats Holmquist. 1997. Lipases Part B: Enzyme Characterization and Utilization. Lipases Part B: Enzyme Characterization and Utilization 386 405 .
Kurt FaberKurt Faber. 1997. Biotransformations in Organic Chemistry. Biotransformations in Organic Chemistry 27 299 .
Henrik Walbye Anthonsen, Bård Helge Hoff & Thorleif Anthonsen. (1996) Calculation of enantiomer ratio and equilibrium constants in biocatalytic ping-pong bi-bi resolutions. Tetrahedron: Asymmetry 7:9, pages 2633-2638.
Crossref
A.J.J. Straathof, J.L.L. Rakels, J.B.A. van Tol & J.J. Heijnen. (1995) Improvement of lipase-catalyzed kinetic resolution by tandem transesterification. Enzyme and Microbial Technology 17:7, pages 623-628.
Crossref
Per Berglund, Mats Holmquist, Karl Hult & Hans-Erik H�gberg. (1995) Alcohols as enantioselective inhibitors in a lipase catalysed esterification of a chiral acyl donor. Biotechnology Letters 17:1, pages 55-60.
Crossref
Kurt FaberKurt Faber. 1995. Biotransformations in Organic Chemistry — A Textbook. Biotransformations in Organic Chemistry — A Textbook 24 269 .
J. L. L. Rakels, P. Caillat, A. J. J. Straathof & J. J. Heijnen. (2008) Modification of the Enzyme Enantioselectivity by Product Inhibition. Biotechnology Progress 10:4, pages 403-409.
Crossref
J. L. L. Rakels, B. Romein, A. J. J. Straathof & J. J. Heijnen. (2004) Kinetic analysis of enzymatic chiral resolution by progress curve evaluation. Biotechnology and Bioengineering 43:5, pages 411-422.
Crossref
Gaétan Caron, George W.-M. Tseng & Romas J. Kazlauskas. (1994) Kinetic resolutions concentrate the minor enantiomer and aid measurement of high enantiomeric purity.. Tetrahedron: Asymmetry 5:1, pages 83-92.
Crossref
J. L. L. Rakels, A. J. J. Straathof & J. J. Heijnen. 1994. Advances in Bioprocess Engineering. Advances in Bioprocess Engineering 473 480 .
J.L.L. Rakels, A.J.J. Straathof & J.J. Heijnen. (1993) A simple method to determine the enantiomeric ratio in enantioselective biocatalysis. Enzyme and Microbial Technology 15:12, pages 1051-1056.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.