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Research Article

Engineering Antibiotic Producers to Overcome the Limitations of Classical Strain Improvement Programs

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Pages 201-255 | Published online: 25 Sep 2008

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Ashish Paradkar, Axel Trefzer, Rekha Chakraburtty & Diane Stassi. (2003) Streptomyces Genetics: A Genomic Perspective. Critical Reviews in Biotechnology 23:1, pages 1-27.
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T.M. Ndlovu, A.C. Ward, J. Glassey, J. Eskildsen & G. Akay. (2015) Bioprocess intensification of antibiotic production by Streptomyces coelicolor A3(2) in micro-porous culture. Materials Science and Engineering: C 49, pages 799-806.
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Aeshna Nigam, Khaled H. Almabruk, Anjali Saxena, Jongtae Yang, Udita Mukherjee, Hardeep Kaur, Puneet Kohli, Rashmi Kumari, Priya Singh, Lev N. Zakharov, Yogendra Singh, Taifo Mahmud & Rup Lal. (2014) Modification of Rifamycin Polyketide Backbone Leads to Improved Drug Activity against Rifampicin-resistant Mycobacterium tuberculosis. Journal of Biological Chemistry 289:30, pages 21142-21152.
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Carlos Soccol, Ashok Pandey & Christian LarrocheSyed Dastager. 2013. Fermentation Processes Engineering in the Food Industry. Fermentation Processes Engineering in the Food Industry 21 46 .
Leqian Liu, Ben Reed & Hal Alper. (2011) From Pathways to Genomes and Beyond: The Metabolic Engineering Toolbox and Its Place in Biofuels Production. Green 1:1.
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Ian S. Dunn. 2009. Searching for Molecular Solutions. Searching for Molecular Solutions 374 439 .
MinJin Kang, Brian D. Jones, Alexander L. Mandel, Justin C. Hammons, Antonio G. DiPasquale, Arnold L. Rheingold, James J. La Clair & Michael D. Burkart. (2009) Isolation, Structure Elucidation, and Antitumor Activity of Spirohexenolides A and B. The Journal of Organic Chemistry 74:23, pages 9054-9061.
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Chinping Chng, Amy M. Lum, Jonathan A. Vroom & Camilla M. Kao. (2008) A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea . Proceedings of the National Academy of Sciences 105:32, pages 11346-11351.
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Jian-Ting Zheng, Sheng-Lan Wang & Ke-Qian Yang. (2007) Engineering a regulatory region of jadomycin gene cluster to improve jadomycin B production in Streptomyces venezuelae. Applied Microbiology and Biotechnology 76:4, pages 883-888.
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Taek Soon Lee, Chaitan Khosla & Yi Tang. (2005) Orthogonal Protein Interactions in Spore Pigment Producing and Antibiotic Producing Polyketide Synthases. The Journal of Antibiotics 58:10, pages 663-666.
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Amy M Lum, Jianqiang Huang, C.Richard Hutchinson & Camilla M Kao. (2004) Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays. Metabolic Engineering 6:3, pages 186-196.
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Kozo Ochi, Susumu Okamoto, Yuzuru Tozawa, Takashi Inaoka, Takeshi Hosaka, Jun Xu & Kazuhiko Kurosawa. 2004. 155 184 .
Norimasa Tamehiro, Takeshi Hosaka, Jun Xu, Haifeng Hu, Noboru Otake & Kozo Ochi. (2003) Innovative Approach for Improvement of an Antibiotic-Overproducing Industrial Strain of Streptomyces albus . Applied and Environmental Microbiology 69:11, pages 6412-6417.
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Oreste A. Mascaretti. 2003. Bacteria versus Antibacterial Agents. Bacteria versus Antibacterial Agents 97 105 .
Haifeng Hu & Kozo Ochi. (2001) Novel Approach for Improving the Productivity of Antibiotic-Producing Strains by Inducing Combined Resistant Mutations. Applied and Environmental Microbiology 67:4, pages 1885-1892.
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Hardeep Kaur, Jesus Cortes, Peter Leadlay & Rup Lal. (2001) Cloning and partial characterization of the putative rifamycin biosynthetic gene cluster from the actinomycete Amycolatopsis mediterranei DSM 46095. Microbiological Research 156:3, pages 239-246.
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Rup Lal, Rekha Kumari, Hardeep Kaur, Richie Khanna, Nidhi Dhingra & Dipika Tuteja. (2000) Regulation and manipulation of the gene clusters encoding type-I PKSs. Trends in Biotechnology 18:6, pages 264-274.
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Paxton Loke, Chee Pang Ng & Tiow-Suan Sim. (2000) PCR cloning, heterologous expression, and characterization of isopenicillin N synthase from Streptomyces lipmanii NRRL 3584 . Canadian Journal of Microbiology 46:2, pages 166-170.
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Ben Shen. 2000. Biosynthesis. Biosynthesis 1 51 .
M. Khanna, M. Dua & R. Lal. (1998) Selection of suitable marker genes for the development of cloning vectors and electroporation in different strains of Amycolatopsis mediterranei. Microbiological Research 153:3, pages 205-211.
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