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Critical Reviews in Microbiology Volume 39, 2013 - Issue 4
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Review Article

Drug-resistant microorganisms with a higher fitness – can medicines boost pathogens?

Manu VanaerschotDepartment of Biomedical Sciences, Institute of Tropical Medicine Antwerp, Antwerpen, Belgium
,
Saskia DecuypereDepartment of Biomedical Sciences, Institute of Tropical Medicine Antwerp, Antwerpen, Belgium
,
Maya BergDepartment of Biomedical Sciences, Institute of Tropical Medicine Antwerp, Antwerpen, Belgium
,
Syamal RoyIndian Institute of Chemical Biology, Kolkata, India
&
Jean-Claude DujardinDepartment of Biomedical Sciences, Institute of Tropical Medicine Antwerp, Antwerpen, Belgium
Pages 384-394 | Received 25 Mar 2012, Accepted 26 Jul 2012, Published online: 06 Sep 2012

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Manu Vanaerschot, Franck Dumetz, Syamal Roy, Alicia Ponte-Sucre, Jorge Arevalo & Jean-Claude Dujardin. (2014) Treatment failure in leishmaniasis: drug-resistance or another (epi-) phenotype?. Expert Review of Anti-infective Therapy 12:8, pages 937-946.
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Articles from other publishers (27)

Nuno M. M. Moura, Xavier Moreira, Eliana Sousa Da Silva, Joaquim Luís Faria, Maria G. P. M. S. Neves, Adelaide Almeida, Maria A. F. Faustino & Ana T. P. C. Gomes. (2023) Efficient Strategies to Use β-Cationic Porphyrin-Imidazolium Derivatives in the Photoinactivation of Methicillin-Resistant Staphylococcus aureus. International Journal of Molecular Sciences 24:21, pages 15970.
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Silvie Huijben. (2022) The importance of understanding fitness costs associated with drug resistance throughout the life cycle of malaria parasites. Peer Community In Evolutionary Biology.
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Mary Elízabeth Salazar-Villamizar & Patricia Escobar. (2022) In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains. Experimental Parasitology 233, pages 108206.
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Maryam Fekri Soofi Abadi, Alireza Moradabadi, Reza Vahidi, Saeedeh Shojaeepour, Sara Rostami, Iman Rad & Shahriar Dabiri. (2021) High resolution melting analysis and detection of Leishmania resistance: the role of multi drug resistance 1 gene. Genes and Environment 43:1.
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Lieselotte Van Bockstal, Sarah Hendrickx, Louis Maes & Guy Caljon. (2020) Sand Fly Studies Predict Transmission Potential of Drug-resistant Leishmania. Trends in Parasitology 36:9, pages 785-795.
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Lieselotte Van Bockstal, Dimitri Bulté, Sarah Hendrickx, Jovana Sadlova, Petr Volf, Louis Maes & Guy Caljon. (2020) Impact of clinically acquired miltefosine resistance by Leishmania infantum on mouse and sand fly infection. International Journal for Parasitology: Drugs and Drug Resistance 13, pages 16-21.
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Noélie Douanne, Victoria Wagner, Gaetan Roy, Philippe Leprohon, Marc Ouellette & Christopher Fernandez-Prada. (2020) MRPA-independent mechanisms of antimony resistance in Leishmania infantum. International Journal for Parasitology: Drugs and Drug Resistance 13, pages 28-37.
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Laísa Vilar Cordeiro, Pedro Thiago Ramalho de Figueiredo, Thamara Rodrigues de Melo, Giulian César da Silva Sá & Aleson Pereira de Sousa. (2020) A RESISTÊNCIA AOS ANTIMONIAIS PODE LEVAR AO AUMENTO DA VIRULÊNCIA EM LEISHMANIA SPP.?. Revista interdisciplinar em saúde 7:Único, pages 577-593.
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Jeronimo N. Rugani, Patrícia F. Quaresma, Célia F. Gontijo, Rodrigo P. Soares & Rubens L. Monte-Neto. (2018) Intraspecies susceptibility of Leishmania (Viannia) braziliensis to antileishmanial drugs: Antimony resistance in human isolates from atypical lesions. Biomedicine & Pharmacotherapy 108, pages 1170-1180.
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Krishn Pratap Singh, Shadab Anwar, Amir Zaidi, Kuljit Singh, Pradeep Das, Samudrala Gourinath & Vahab Ali. (2018) LdIscU is a [2Fe-2S] scaffold protein which interacts with LdIscS and its expression is modulated by Fe-S proteins in Leishmania donovani. International Journal of Biological Macromolecules 116, pages 1128-1145.
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S HENDRICKX, PJ GUERIN, G CALJON, SL CROFT & L MAES. (2016) Evaluating drug resistance in visceral leishmaniasis: the challenges. Parasitology 145:4, pages 453-463.
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Eddaikra Naouel, Kherachi Djenad Ihcene, Bensegheir Sofiane, Ait Oudhia Khatima, Benikhlef Razika, Oury Bruno, Harrat Zoubir & Sereno Denis. (2018) Antimonial susceptibility and in vivo behaviour of Leishmania major isolates collected in Algeria before and after treatment. Acta Tropica 180, pages 7-11.
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Jean-Claude Dujardin. 2018. Drug Resistance in Leishmania Parasites. Drug Resistance in Leishmania Parasites 85 107 .
Luis Rivas, Montserrat Nácher-Vázquez & David Andreu. 2017. Drug Discovery for Leishmaniasis. Drug Discovery for Leishmaniasis 248 281 .
Aya Hefnawy, Maya Berg, Jean-Claude Dujardin & Géraldine De Muylder. (2017) Exploiting Knowledge on Leishmania Drug Resistance to Support the Quest for New Drugs. Trends in Parasitology 33:3, pages 162-174.
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Guy Caljon, Géraldine De Muylder, Lies Durnez, Wim Jennes, Manu Vanaerschot & Jean-Claude Dujardin. (2016) Alice in microbes' land: adaptations and counter-adaptations of vector-borne parasitic protozoa and their hosts. FEMS Microbiology Reviews 40:5, pages 664-685.
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Verónica Gómez Pérez, Raquel García-Hernandez, Victoriano Corpas-López, Ana M. Tomás, Joaquina Martín-Sanchez, Santiago Castanys & Francisco Gamarro. (2016) Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum. International Journal for Parasitology: Drugs and Drug Resistance 6:2, pages 133-139.
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S. Hendrickx, J. Beyers, A. Mondelaers, E. Eberhardt, L. Lachaud, P. Delputte, P. Cos & L. Maes. (2016) Evidence of a drug-specific impact of experimentally selected paromomycin and miltefosine resistance on parasite fitness in Leishmania infantum . Journal of Antimicrobial Chemotherapy 71:7, pages 1914-1921.
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Hideo Imamura, Tim Downing, Frederik Van den Broeck, Mandy J Sanders, Suman Rijal, Shyam Sundar, An Mannaert, Manu Vanaerschot, Maya Berg, Géraldine De Muylder, Franck Dumetz, Bart Cuypers, Ilse Maes, Malgorzata Domagalska, Saskia Decuypere, Keshav Rai, Surendra Uranw, Narayan Raj Bhattarai, Basudha Khanal, Vijay Kumar Prajapati, Smriti Sharma, Olivia Stark, Gabriele Schönian, Harry P De Koning, Luca Settimo, Benoit Vanhollebeke, Syamal Roy, Bart Ostyn, Marleen Boelaert, Louis Maes, Matthew Berriman, Jean-Claude Dujardin & James A Cotton. (2016) Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent. eLife 5.
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Neil A. Brown, Martin Urban & Kim E. Hammond-Kosack. (2016) The trans-kingdom identification of negative regulators of pathogen hypervirulence. FEMS Microbiology Reviews 40:1, pages 19-40.
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Sarah Hendrickx, Annelies Leemans, Annelies Mondelaers, Suman Rijal, Basudha Khanal, Jean-Claude Dujardin, Peter Delputte, Paul Cos & Louis Maes. (2015) Comparative Fitness of a Parent Leishmania donovani Clinical Isolate and Its Experimentally Derived Paromomycin-Resistant Strain. PLOS ONE 10:10, pages e0140139.
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Kimbra G. Turner, Paola Vacchina, Maricela Robles-Murguia, Mariha Wadsworth, Mary Ann McDowell & Miguel A. Morales. (2015) Fitness and Phenotypic Characterization of Miltefosine-Resistant Leishmania major. PLOS Neglected Tropical Diseases 9:7, pages e0003948.
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Raquel García-Hernández, Verónica Gómez-Pérez, Santiago Castanys & Francisco Gamarro. (2015) Fitness of Leishmania donovani Parasites Resistant to Drug Combinations. PLOS Neglected Tropical Diseases 9:4, pages e0003704.
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Veronika Seblova, Bruno Oury, Naouel Eddaikra, Khatima Aït-Oudhia, Francine Pratlong, Elodie Gazanion, Carla Maia, Petr Volf & Denis Sereno. (2014) Transmission Potential of Antimony-Resistant Leishmania Field Isolates. Antimicrobial Agents and Chemotherapy 58:10, pages 6273-6276.
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Maritza Padrón-Nieves, Claudia Machuca, Emilia Díaz, Paulo Cotrim, Noris Rodriguez & Alicia Ponte-Sucre. (2014) Correlation between glucose uptake and membrane potential in Leishmania parasites isolated from DCL patients with therapeutic failure: a proof of concept. Parasitology Research 113:6, pages 2121-2128.
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Keshav Rai, Bart Cuypers, Narayan Raj Bhattarai, Surendra Uranw, Maya Berg, Bart Ostyn, Jean-Claude Dujardin, Suman Rijal & Manu Vanaerschot. (2013) Relapse after Treatment with Miltefosine for Visceral Leishmaniasis Is Associated with Increased Infectivity of the Infecting Leishmania donovani Strain. mBio 4:5.
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Maya Berg, Manu Vanaerschot, Andris Jankevics, Bart Cuypers, Ilse Maes, Sandip Mukherjee, Basudha Khanal, Suman Rijal, Syamal Roy, Fred Opperdoes, Rainer Breitling & Jean-Claude Dujardin. (2013) Metabolic adaptations of Leishmania donovani in relation to differentiation, drug resistance, and drug pressure . Molecular Microbiology, pages n/a-n/a.
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