Citations (58)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (6)
Can Tu, Ming Niu, Ai-Wu Wei, Jin-Fa Tang, Le Zhang, Jing Jing, Xiao-He Xiao & Jia-Bo Wang. (2021) Susceptibility-Related Cytokine Panel for Prediction of Polygonum multiflorum-Induced Hepatotoxicity in Humans. Journal of Inflammation Research 14, pages 645-655.
Read now
Read now
Reza Heidari, Fatemeh Ahmadi, Hamid Reza Rahimi, Negar Azarpira, Massood Hosseinzadeh, Asma Najibi & Hossein Niknahad. (2019) Exacerbated liver injury of antithyroid drugs in endotoxin-treated mice. Drug and Chemical Toxicology 42:6, pages 615-623.
Read now
Read now
Petar D. Petrov, M. Leonor Fernández-Murga, Mireia López-Riera, M. José Goméz-Lechón, Jose V. Castell & Ramiro Jover. (2018) Predicting drug-induced cholestasis: preclinical models. Expert Opinion on Drug Metabolism & Toxicology 14:7, pages 721-738.
Read now
Read now
Richard J. Weaver, Catherine Betts, Eric A.G. Blomme, Helga H.J. Gerets, Klaus Gjervig Jensen, Philip G. Hewitt, Satu Juhila, Gilles Labbe, Michael J. Liguori, Natalie Mesens, Monday O. Ogese, Mikael Persson, Jan Snoeys, James L. Stevens, Tracy Walker & B. Kevin Park. (2017) Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 13:7, pages 767-782.
Read now
Read now
J. Gerry Kenna. (2017) Human biology-based drug safety evaluation: scientific rationale, current status and future challenges. Expert Opinion on Drug Metabolism & Toxicology 13:5, pages 567-574.
Read now
Read now
Qiuping Guo, Wei Yang, Baiquan Xiao, Hong Zhang, Xialing Lei, Huiyu Ou, Renan Qin & Ruomin Jin. (2015) Study on early biomarkers of zebrafish liver injury induced by acetaminophen. Toxin Reviews 34:1, pages 28-36.
Read now
Read now
Articles from other publishers (52)
Yingying Li, Mengmeng Lin, Bo Cao, Jing Xu, Xiaohe Xiao, Guohui Li & Chunyu Li. (2023) Investigation of synergistic induction of idiosyncratic drug-induced liver injury by Bavachin and Icariin under immunological stress conditions using pseudotargeted metabonomics. Chinese Science Bulletin.
Crossref
Crossref
Hanghang Wu, Xiyuan Bao, Alejandro H. Gutierrez, Yulia A. Nevzorova & Francisco Javier Cubero. (2023) Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury. Exploration of Digestive Diseases, pages 83-99.
Crossref
Crossref
Tingting Liu, Guang Xu, Yurong Li, Wei Shi, Lutong Ren, Zhie Fang, Longxin Liang, Yan Wang, Yuan Gao, Xiaoyan Zhan, Qiang Li, Wenqing Mou, Li Lin, Ziying Wei, Zhiyong Li, Wenzhang Dai, Jia Zhao, Hui Li, Jiabo Wang, Yanling Zhao, Xiaohe Xiao & Zhaofang Bai. (2022) Discovery of bakuchiol as an AIM2 inflammasome activator and cause of hepatotoxicity. Journal of Ethnopharmacology 298, pages 115593.
Crossref
Crossref
Wenqing Mu, Guang Xu, Ziying Wei, Zhilei Wang, Qin Qin, Li Lin, Lutong Ren, Tingting Liu, Zhie Fang, Yan Yang, Jing Zhao, Junnan Wang, Xiaoyan Zhan, Xiaohe Xiao & Zhaofang Bai. (2022) The role of NLRP3 inflammasome in psychotropic drug-induced hepatotoxicity. Cell Death Discovery 8:1.
Crossref
Crossref
Valon Llabjani, M. R. Siddique, Anaïs Macos, Afaf Abouzid, Valmira Hoti, Francis L. Martin, Imran I. Patel & Ahtasham Raza. (2022) Introducing CELLBLOKS®: a novel organ-on-a-chip platform allowing a plug-and-play approach towards building organotypic models. In vitro models 1:6, pages 423-435.
Crossref
Crossref
Le Zhang, Ming Niu, Ai-wu Wei, Jin-fa Tang, Peng-yan Li, Di Song, Zhao-fang Bai, You-ping Liu, Xiao-he Xiao & Jia-bo Wang. (2022)
Clinical correlation between serum cytokines and the susceptibility to
Polygonum multiflorum
-induced liver injury and an experimental study
. Food & Function 13:2, pages 825-833.
Crossref
Crossref
Yuan Gao, Guang Xu, Li Ma, Wei Shi, Zhilei Wang, Xiaoyan Zhan, Nan Qin, Tingting He, Yuming Guo, Ming Niu, Jiabo Wang, Zhaofang Bai & Xiaohe Xiao. (2021) Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Cell Communication and Signaling 19:1.
Crossref
Crossref
Yan Lin, Rong Xiao, Bo-hou Xia, Zhi-min Zhang, Chun Li, Ping Wu, Duan-fang Liao & Li-mei Lin. (2021) Investigation of the idiosyncratic hepatotoxicity of Polygonum multiflorum Thunb. through metabolomics using GC-MS. BMC Complementary Medicine and Therapies 21:1.
Crossref
Crossref
Xing-Ran Zhai, Zheng-Sheng Zou, Jia-Bo Wang & Xiao-He Xiao. (2021) Herb-Induced Liver Injury Related to Reynoutria multiflora (Thunb.) Moldenke: Risk Factors, Molecular and Mechanistic Specifics. Frontiers in Pharmacology 12.
Crossref
Crossref
Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao & Zhaofang Bai. (2021) Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity. Frontiers of Medicine 15:4, pages 594-607.
Crossref
Crossref
Florian Padberg, Tessa Höper, Sebastian Henkel, Dominik Driesch, Andreas Luch & Sebastian Zellmer. (2021) Novel indirect co-culture of immortalised hepatocytes with monocyte derived macrophages is characterised by pro-inflammatory cytokine networks. Toxicology in Vitro 73, pages 105134.
Crossref
Crossref
Sean Hammond, Paul Thomson, Xiaoli Meng & Dean Naisbitt. (2021) In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs. Frontiers in Immunology 12.
Crossref
Crossref
Zhilei Wang, Guang Xu, Hongbo Wang, Xiaoyan Zhan, Yuan Gao, Nian Chen, Ruisheng Li, Xueai Song, Yuming Guo, Ruichuang Yang, Ming Niu, Jiabo Wang, Youping Liu, Xiaohe Xiao & Zhaofang Bai. (2020) Icariside Ⅱ, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation. Acta Pharmaceutica Sinica B 10:9, pages 1619-1633.
Crossref
Crossref
Merrie Mosedale & Paul B. Watkins. (2020) Understanding Idiosyncratic Toxicity: Lessons Learned from Drug-Induced Liver Injury. Journal of Medicinal Chemistry 63:12, pages 6436-6461.
Crossref
Crossref
Nicola J. Stagg, Hanan N. Ghantous, Robert Roth & Kenneth L. Hastings. (2019) Predictivity/Translatability of Toxicities Observed in Nonclinical Toxicology Studies to Clinical Safety Outcomes in Drug Development: Case Examples. International Journal of Toxicology 39:2, pages 141-150.
Crossref
Crossref
Yuan Gao, Zhilei Wang, Jinfa Tang, Xiaoyi Liu, Wei Shi, Nan Qin, Xiaoyan Wang, Yu Pang, Ruisheng Li, Yaming Zhang, Jiabo Wang, Ming Niu, Zhaofang Bai & Xiaohe Xiao. (2019) New incompatible pair of TCM: Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions. Frontiers of Medicine 14:1, pages 68-80.
Crossref
Crossref
Emanuel Raschi & Fabrizio De Ponti. (2019) Strategies for Early Prediction and Timely Recognition of Drug-Induced Liver Injury: The Case of Cyclin-Dependent Kinase 4/6 Inhibitors. Frontiers in Pharmacology 10.
Crossref
Crossref
Can Tu, Qin He, Chun-Yu Li, Ming Niu, Zi-Xin Han, Fei-Lin Ge, Yuan-Yuan Zhou, Le Zhang, Xiao-Hui Wang, Jing-Xiao Zhu, Rui-Sheng Li, Hai-Bo Song, Xiao-He Xiao & Jia-Bo Wang. (2019) Susceptibility-Related Factor and Biomarkers of Dietary Supplement Polygonum multiflorum-Induced Liver Injury in Rats. Frontiers in Pharmacology 10.
Crossref
Crossref
J.P. Luyendyk, P.E. Ganey, A. Fullerton & R.A. Roth. 2018. Comprehensive Toxicology. Comprehensive Toxicology
324
345
.
Paul B. Watkins & Merrie Mosedale. 2017. Schiff's Diseases of the Liver. Schiff's Diseases of the Liver
774
798
.
Ashley R. Maiuri, Bronlyn Wassink, Jonathan D. Turkus, Anna B. Breier, Theresa Lansdell, Gurpreet Kaur, Sarah L. Hession, Patricia E. Ganey & Robert A. Roth. (2017) Synergistic Cytotoxicity from Drugs and Cytokines In Vitro as an Approach to Classify Drugs According to Their Potential to Cause Idiosyncratic Hepatotoxicity: A Proof-of-Concept Study. Journal of Pharmacology and Experimental Therapeutics 362:3, pages 459-473.
Crossref
Crossref
Helen Musther, Matthew D. Harwood, Jiansong Yang, David B. Turner, Amin Rostami-Hodjegan & Masoud Jamei. (2017) The Constraints, Construction, and Verification of a Strain-Specific Physiologically Based Pharmacokinetic Rat Model. Journal of Pharmaceutical Sciences 106:9, pages 2826-2838.
Crossref
Crossref
Monday O. Ogese, Lee Faulkner, Roz E. Jenkins, Neil S. French, Ian M. Copple, Daniel J. Antoine, Mohamed Elmasry, Hasan Malik, Christopher E. Goldring, Brian Kevin Park, Catherine J. Betts & Dean J. Naisbitt. (2017) Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells. Toxicological Sciences 158:1, pages 76-89.
Crossref
Crossref
Chunyu Li, Ming Niu, Zhaofang Bai, Congen Zhang, Yanling Zhao, Ruiyu Li, Can Tu, Huifang Li, Jing Jing, Yakun Meng, Zhijie Ma, Wuwen Feng, Jinfa Tang, Yun Zhu, Jinjie Li, Xiaoya Shang, Zhengsheng Zou, Xiaohe Xiao & Jiabo Wang. (2017) Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum. Frontiers of Medicine 11:2, pages 253-265.
Crossref
Crossref
Jinping Gan, Haiying Zhang & W. Griffith Humphreys. (2016) Drug–Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization. Chemical Research in Toxicology 29:12, pages 2040-2057.
Crossref
Crossref
Chun-Yu Li, Can Tu, Dan Gao, Rui-Lin Wang, Hai-Zhu Zhang, Ming Niu, Rui-Yu Li, Cong-En Zhang, Rui-Sheng Li, Xiao-He Xiao, Mei-Hua Yang & Jia-Bo Wang. (2016) Metabolomic Study on Idiosyncratic Liver Injury Induced by Different Extracts of Polygonum multiflorum in Rats Integrated with Pattern Recognition and Enriched Pathways Analysis. Frontiers in Pharmacology 07.
Crossref
Crossref
Dan Gao, Jing-Yao Pang, Cong-En Zhang, Chun-Yu Li, Can Tu, Hai-Zhu Zhang, Ming Niu, Yin Xiong, Xiao-He Xiao, Kui-Jun Zhao, Wei-Wei Gao & Jia-Bo Wang. (2016) Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata. Frontiers in Pharmacology 7.
Crossref
Crossref
J. Gerry Kenna & Richard A. Thompson. 2016. Metabolite Safety in Drug Development. Metabolite Safety in Drug Development
111
139
.
M. José Gómez-Lechón, Laia Tolosa & M. Teresa Donato. (2016)
Metabolic activation and drug-induced liver injury:
in vitro
approaches for the safety risk assessment of new drugs
. Journal of Applied Toxicology 36:6, pages 752-768.
Crossref
Crossref
Sherry J. Morgan & Chandikumar S. Elangbam. 2016. Drug Discovery Toxicology. Drug Discovery Toxicology
261
297
.
Haoheng Yan, Yukinori Endo, Yi Shen, David Rotstein, Milos Dokmanovic, Nishant Mohan, Partha Mukhopadhyay, Bin Gao, Pal Pacher & Wen Jin Wu. (2016) Ado-Trastuzumab Emtansine Targets Hepatocytes Via Human Epidermal Growth Factor Receptor 2 to Induce Hepatotoxicity. Molecular Cancer Therapeutics 15:3, pages 480-490.
Crossref
Crossref
F S Wolenski & Y P Dragan. (2015) Understanding drug-cytokine synergistic toxicity. Cell Death & Disease 6:11, pages e1988-e1988.
Crossref
Crossref
Can Tu, Dan Gao, Xiao-Fei Li, Chun-Yu Li, Rui-Sheng Li, Yan-Ling Zhao, Na Li, Ge-Liu-Chang Jia, Jing-Yao Pang, He-Rong Cui, Zhi-Jie Ma, Xiao-He Xiao & Jia-Bo Wang. (2015) Inflammatory stress potentiates emodin-induced liver injury in rats. Frontiers in Pharmacology 6.
Crossref
Crossref
Ashley R. Maiuri, Anna B. Breier, Lukas F.J. Gora, Robert V. Parkins, Patricia E. Ganey & Robert A. Roth. (2015) Cytotoxic Synergy Between Cytokines and NSAIDs Associated With Idiosyncratic Hepatotoxicity Is Driven by Mitogen-Activated Protein Kinases. Toxicological Sciences 146:2, pages 265-280.
Crossref
Crossref
S. Ramm, B. Morissey, B. Hernandez, C. Rooney, S.R. Pennington & A. Mally. (2015) Application of a discovery to targeted LC–MS proteomics approach to identify deregulated proteins associated with idiosyncratic liver toxicity in a rat model of LPS/diclofenac co-administration. Toxicology 331, pages 100-111.
Crossref
Crossref
Kevin M. Beggs, Ashley R. Maiuri, Aaron M. Fullerton, Kyle L. Poulsen, Anna B. Breier, Patricia E. Ganey & Robert A. Roth. (2015) Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related. Toxicology 331, pages 35-46.
Crossref
Crossref
Gwilym J. Webb & David H. Adams. (2015) Modeling idiosyncrasy: A novel animal model of drug‐induced liver injury. Hepatology 61:4, pages 1124-1126.
Crossref
Crossref
Kyle L. Poulsen, Jesus Olivero-Verbel, Kevin M. Beggs, Patricia E. Ganey & Robert A. Roth. (2014)
Trovafloxacin Enhances Lipopolysaccharide-Stimulated Production of Tumor Necrosis Factor-
α
by Macrophages: Role of the DNA Damage Response
. Journal of Pharmacology and Experimental Therapeutics 350:1, pages 164-170.
Crossref
Crossref
Lisa Fredriksson, Steven Wink, Bram Herpers, Giulia Benedetti, Mackenzie Hadi, Hans de Bont, Geny Groothuis, Mirjam Luijten, Erik Danen, Marjo de Graauw, John Meerman & Bob van de Water. (2014) Drug-Induced Endoplasmic Reticulum and Oxidative Stress Responses Independently Sensitize Toward TNFα-Mediated Hepatotoxicity. Toxicological Sciences 140:1, pages 144-159.
Crossref
Crossref
Xiaoyan Zhang, Caixia Li & Zhiyuan Gong. (2014) Development of a Convenient In Vivo Hepatotoxin Assay Using a Transgenic Zebrafish Line with Liver-Specific DsRed Expression. PLoS ONE 9:3, pages e91874.
Crossref
Crossref
Minjun Chen, Halil Bisgin, Lillian Tong, Huixiao Hong, Hong Fang, Jürgen Borlak & Weida Tong. (2014) Toward predictive models for drug-induced liver injury in humans: are we there yet?. Biomarkers in Medicine 8:2, pages 201-213.
Crossref
Crossref
Frida Gustafsson, Alison J. Foster, Sunil Sarda, Matthew H. Bridgland-Taylor & J. Gerry Kenna. (2014) A Correlation Between the In Vitro Drug Toxicity of Drugs to Cell Lines That Express Human P450s and Their Propensity to Cause Liver Injury in Humans. Toxicological Sciences 137:1, pages 189-211.
Crossref
Crossref
J.E. Kester. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology
96
106
.
Jingtao Lu, Robert A. Roth, Ernst Malle & Patricia E. Ganey. (2013) Roles of the Hemostatic System and Neutrophils in Liver Injury From Co-exposure to Amiodarone and Lipopolysaccharide. Toxicological Sciences 136:1, pages 51-62.
Crossref
Crossref
Rachel P.L. van Swelm, Coby M.M. Laarakkers, Jeanne C.L.M. Pertijs, Vivienne Verweij, Rosalinde Masereeuw & Frans G.M. Russel. (2013) Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice. Toxicology and Applied Pharmacology 269:2, pages 141-149.
Crossref
Crossref
Mackenzie Hadi, Inge M. Westra, Viktoriia Starokozhko, Sanja Dragovic, Marjolijn T. Merema & Geny M. M. Groothuis. (2013)
Human Precision-Cut Liver Slices as an
ex Vivo
Model to Study Idiosyncratic Drug-Induced Liver Injury
. Chemical Research in Toxicology 26:5, pages 710-720.
Crossref
Crossref
Frank A Barile. 2013. Principles of Toxicology Testing. Principles of Toxicology Testing
118
127
.
Robert A. Roth & Patricia E. Ganey. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease
157
173
.
Mackenzie Hadi, Yixi Chen, Viktoriia Starokozhko, Marjolijn T. Merema & Geny M.M. Groothuis. (2012) Mouse Precision-Cut Liver Slices as an ex Vivo Model To Study Idiosyncratic Drug-Induced Liver Injury. Chemical Research in Toxicology 25:9, pages 1938-1947.
Crossref
Crossref
C. David Williams & Hartmut Jaeschke. (2012) Role of innate and adaptive immunity during drug-induced liver injury. Toxicology Research 1:3, pages 161.
Crossref
Crossref
Kevin J. Wells-Knecht, Gregory R. Ott, Mangeng Cheng, Gregory J. Wells, Henry J. Breslin, Diane E. Gingrich, Linda Weinberg, Eugen F. Mesaros, Zeqi Huang, Mehran Yazdanian, Mark A. Ator, Lisa D. Aimone, Kelli Zeigler & Bruce D. Dorsey. (2011) 2,7-Disubstituted-Pyrrolotriazine Kinase Inhibitors with an Unusually High Degree of Reactive Metabolite Formation. Chemical Research in Toxicology 24:11, pages 1994-2003.
Crossref
Crossref
Tingting Liu, Xu Guang, Li Yurong, Shi Wei, Ren Lutong, Fang Zhie, Liang Longxin, Wang Yan, Gao Yuan, Zhan Xiaoyan, Li Qiang, Mou Wenqing, Lin Li, Wei Ziying, Li Zhiyong, Dai Wenzhang, Zhao Jia, Li Hui, Wang Jiabo, Zhao Yanling, Xiao Xiaohe & Bai Zhaofang. (2022) Discovery of Bakuchiol as Aim2 Inflammasome Activator and Cause Hepatotoxicity. SSRN Electronic Journal.
Crossref
Crossref