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Shihao Hu, Amita Datta-Mannan & David Z. D’Argenio. (2022) Physiologically Based Modeling to Predict Monoclonal Antibody Pharmacokinetics in Humans from in vitro Physiochemical Properties. mAbs 14:1.
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Darren Michael Moss, Catia Marzolini, Rajith KR Rajoli & Marco Siccardi. (2015) Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies. Expert Opinion on Drug Metabolism & Toxicology 11:8, pages 1203-1217.
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Articles from other publishers (53)
Hannah Kinvig, Rajith K. R. Rajoli, Henry Pertinez, Lalitkumar K. Vora, Fabiana Volpe-Zanutto, Ryan F. Donnelly, Steve Rannard, Charles Flexner, Marco Siccardi & Andrew Owen. (2023) Physiologically Based Pharmacokinetic Modelling of Cabotegravir Microarray Patches in Rats and Humans. Pharmaceutics 15:12, pages 2709.
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Ashley R. Johnson, Jeanine E. Ballard, Andrew Leithead, Corin Miller, Fried Faassen, Xiaowei Zang, Rebecca Nofsinger & Angela M. Wagner. (2023) A Retrospective Analysis of Preclinical and Clinical Pharmacokinetics from Administration of Long-Acting Aqueous Suspensions. Pharmaceutical Research 40:7, pages 1641-1656.
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Sandra Grañana-Castillo, Maiara Camotti Montanha, Rachel Bearon, Saye Khoo & Marco Siccardi. (2022) Evaluation of drug-drug interaction between rilpivirine and rifapentine using PBPK modelling. Frontiers in Pharmacology 13.
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Hannah Kinvig, Nicolas Cottura, Andrew Lloyd, Collrane Frivold, Jessica Mistilis, Courtney Jarrahian & Marco Siccardi. (2022) Evaluating Islatravir Administered Via Microneedle Array Patch for Long-Acting HIV Pre-exposure Prophylaxis Using Physiologically Based Pharmacokinetic Modelling. European Journal of Drug Metabolism and Pharmacokinetics 47:6, pages 855-868.
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Maiara Camotti Montanha, Alice Howarth, Doaa Ahmed Mohamed, Estelle Loier, Lauren Main, Matthias Rösslein, Christiaan Delmaar, Adriele Prina-Mello & Marco Siccardi. (2022) A physiologically based pharmacokinetic model to predict pegylated liposomal doxorubicin disposition in rats and human. Drug Delivery and Translational Research 12:9, pages 2178-2186.
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Maiara Camotti Montanha, Francesc Fabrega, Alice Howarth, Nicolas Cottura, Hannah Kinvig, Fazila Bunglawala, Andrew Lloyd, Paolo Denti, Catriona Waitt & Marco Siccardi. (2021) Predicting Drug–Drug Interactions between Rifampicin and Ritonavir-Boosted Atazanavir Using PBPK Modelling. Clinical Pharmacokinetics 61:3, pages 375-386.
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Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Suelen S. G. Dias, Jairo R. Temerozo, Aline de Paula D. Da Silva, Carine S. da Silva, Camilla Blanco, André C. Ferreira, Mayara Mattos, Vinicius C. Soares, Filipe Pereira-Dutra, Milene Dias Miranda, Debora F. Barreto-Vieira, Marcos Alexandre N. da Silva, Suzana S. Santos, Mateo Torres, Otávio Augusto Chaves, Rajith K. R. Rajoli, Alberto Paccanaro, Andrew Owen, Dumith Chequer Bou-Habib, Patrícia T. Bozza & Thiago Moreno L. Souza. (2022) Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells. Viruses 14:2, pages 374.
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Maiara Camotti Montanha, Nicolas Cottura, Michael Booth, Daryl Hodge, Fazila Bunglawala, Hannah Kinvig, Sandra Grañana-Castillo, Andrew Lloyd, Saye Khoo & Marco Siccardi. (2022) PBPK Modelling of Dexamethasone in Patients With COVID-19 and Liver Disease. Frontiers in Pharmacology 13.
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Teerachat Sae‐heng, Rajith Kumar Reddy Rajoli, Marco Siccardi, Juntra Karbwang & Kesara Na‐Bangchang. (2021) Physiologically based pharmacokinetic modeling for dose optimization of quinine–phenobarbital coadministration in patients with cerebral malaria. CPT: Pharmacometrics & Systems Pharmacology 11:1, pages 104-115.
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Christopher D. Bruno, Ahmed Elmokadem, Conrad Housand, Eric Burroughs Jordie, Christina R. Chow, Thomas P. Laughren & David J. Greenblatt. (2021) Impact of Obesity on Brexpiprazole Pharmacokinetics: Proposal for Improved Initiation of Treatment. The Journal of Clinical Pharmacology 62:1, pages 55-65.
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Ahmed Elmokadem, Christopher D. Bruno, Conrad Housand, Eric Burroughs Jordie, Christina R. Chow, Lawrence J. Lesko & David J. Greenblatt. (2021) Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations. The Journal of Clinical Pharmacology 62:1, pages 66-75.
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Babajide Shenkoya, Shakir Atoyebi, Ibrahim Eniayewu, Abdulafeez Akinloye & Adeniyi Olagunju. (2021) Mechanistic Modeling of Maternal Lymphoid and Fetal Plasma Antiretroviral Exposure During the Third Trimester. Frontiers in Pediatrics 9.
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Rajith K. R. Rajoli, Henry Pertinez, Usman Arshad, Helen Box, Lee Tatham, Paul Curley, Megan Neary, Joanne Sharp, Neill J. Liptrott, Anthony Valentijn, Christopher David, Steven P. Rannard, Ghaith Aljayyoussi, Shaun H. Pennington, Andrew Hill, Marta Boffito, Steve A. Ward, Saye H. Khoo, Patrick G. Bray, Paul M. O'Neill, W. David Hong, Giancarlo A. Biagini & Andrew Owen. (2020) Dose prediction for repurposing nitazoxanide in SARS‐CoV‐2 treatment or chemoprophylaxis. British Journal of Clinical Pharmacology 87:4, pages 2078-2088.
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Frederico S. Martins, Peijuan Zhu, M. Tobias Heinrichs & Sherwin K. B. Sy. (2020) Physiologically based pharmacokinetic‐pharmacodynamic evaluation of meropenem plus fosfomycin in paediatrics. British Journal of Clinical Pharmacology 87:3, pages 1012-1023.
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Rajith K. R. Rajoli, Zach R. Demkovich, Charles Flexner, Andrew Owen & Marco Siccardi. (2020) Predicting Pharmacokinetics of a Tenofovir Alafenamide Subcutaneous Implant Using Physiologically Based Pharmacokinetic Modelling. Antimicrobial Agents and Chemotherapy 64:8.
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Ali A. Alhadab & Richard C. Brundage. (2020) Physiologically‐Based Pharmacokinetic Model of Sertraline in Human to Predict Clinical Relevance of Concentrations at Target Tissues. Clinical Pharmacology & Therapeutics 108:1, pages 136-144.
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Fazila Bunglawala, Rajith K R Rajoli, Mark Mirochnick, Andrew Owen & Marco Siccardi. (2020) Prediction of dolutegravir pharmacokinetics and dose optimization in neonates via physiologically based pharmacokinetic (PBPK) modelling. Journal of Antimicrobial Chemotherapy 75:3, pages 640-647.
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Dyah Ekashanti Octorina Dewi & Nurul Shafiqa Mohd Yusof. 2020. Cardiovascular Engineering. Cardiovascular Engineering
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Rajith K. R. Rajoli. 2020. Mucosal Delivery of Drugs and Biologics in Nanoparticles. Mucosal Delivery of Drugs and Biologics in Nanoparticles
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John F Wambaugh, Barbara A Wetmore, Caroline L Ring, Chantel I Nicolas, Robert G Pearce, Gregory S Honda, Roger Dinallo, Derek Angus, Jon Gilbert, Teresa Sierra, Akshay Badrinarayanan, Bradley Snodgrass, Adam Brockman, Chris Strock, R Woodrow Setzer & Russell S Thomas. (2019) Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization. Toxicological Sciences 172:2, pages 235-251.
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Shakir Adeyinka Atoyebi, Rajith K.R. Rajoli, Ebunoluwa Adejuyigbe, Andrew Owen, Oluseye Bolaji, Marco Siccardi & Adeniyi Olagunju. (2019) Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: Thalidomide versus efavirenz as case studies. European Journal of Pharmaceutical Sciences 140, pages 105068.
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Rajith K.R. Rajoli, Charles Flexner, Justin Chiong, Andrew Owen, Ryan F. Donnelly, Eneko Larrañeta & Marco Siccardi. (2019) Modelling the intradermal delivery of microneedle array patches for long-acting antiretrovirals using PBPK. European Journal of Pharmaceutics and Biopharmaceutics 144, pages 101-109.
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Xiaoxia Yang, Huali Wu, Darshan Mehta, Mary C. Sullivan, Jian Wang, Gilbert J. Burckart, John A. Troutman & Jeffrey W. Fisher. (2019) Ontogeny equations with probability distributions for anthropomorphic measurements in preterm and term neonates and infants for use in a PBPK model. Computational Toxicology 11, pages 101-117.
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Rajith K R Rajoli, Paul Curley, Justin Chiong, David Back, Charles Flexner, Andrew Owen & Marco Siccardi. (2019) Predicting Drug–Drug Interactions Between Rifampicin and Long-Acting Cabotegravir and Rilpivirine Using Physiologically Based Pharmacokinetic Modeling. The Journal of Infectious Diseases 219:11, pages 1735-1742.
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John A. Troutman, Mary C. Sullivan, Gregory J. Carr & Jeffrey Fisher. (2018) Development of growth equations from longitudinal studies of body weight and height in the full term and preterm neonate: From birth to four years postnatal age. Birth Defects Research 110:11, pages 916-932.
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Marco Siccardi, Steve Rannard & Andrew Owen. (2018) The emerging role of physiologically based pharmacokinetic modelling in solid drug nanoparticle translation. Advanced Drug Delivery Reviews 131, pages 116-121.
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Owain Roberts, Rajith K R Rajoli, David J Back, Andrew Owen, Kristin M Darin, Courtney V Fletcher, Mohammed Lamorde, Kimberly K Scarsi & Marco Siccardi. (2018) Physiologically based pharmacokinetic modelling prediction of the effects of dose adjustment in drug–drug interactions between levonorgestrel contraceptive implants and efavirenz-based ART. Journal of Antimicrobial Chemotherapy 73:4, pages 1004-1012.
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Rajith K. R. Rajoli, David J. Back, Steve Rannard, Caren Freel Meyers, Charles Flexner, Andrew Owen & Marco Siccardi. (2017) In Silico Dose Prediction for Long-Acting Rilpivirine and Cabotegravir Administration to Children and Adolescents. Clinical Pharmacokinetics 57:2, pages 255-266.
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Adeniyi Olagunju, Rajith K. R. Rajoli, Shakir A. Atoyebi, Saye Khoo, Andrew Owen & Marco Siccardi. (2018) Physiologically-based pharmacokinetic modelling of infant exposure to efavirenz through breastfeeding. AAS Open Research 1, pages 16.
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Joanna H. Sier, Alfred E. Thumser & Nick J. Plant. (2017) Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology. BMC Systems Biology 11:1.
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Caroline L. Ring, Robert G. Pearce, R. Woodrow Setzer, Barbara A. Wetmore & John F. Wambaugh. (2017) Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability. Environment International 106, pages 105-118.
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Darren M. Moss, Paul Domanico, Melynda Watkins, Seonghee Park, Ryan Randolph, Steve Wring, Rajith Kumar Reddy Rajoli, James Hobson, Steve Rannard, Marco Siccardi & Andrew Owen. (2017) Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate. Antimicrobial Agents and Chemotherapy 61:7.
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Catia Marzolini, Rajith Rajoli, Manuel Battegay, Luigia Elzi, David Back & Marco Siccardi. (2016) Physiologically Based Pharmacokinetic Modeling to Predict Drug–Drug Interactions with Efavirenz Involving Simultaneous Inducing and Inhibitory Effects on Cytochromes. Clinical Pharmacokinetics 56:4, pages 409-420.
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Jean Cornier, Andrew Owen, Arno Kwade & Marcel Van de Voorde. 2017. Pharmaceutical Nanotechnology: Innovation and Production. Pharmaceutical Nanotechnology: Innovation and Production
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Adny Henrique Silva, Enio Lima Jr, Marcelo Vasquez Mansilla, Roberto Daniel Zysler, Mary Luz Mojica Pisciotti, Claudriana Locatelli, Rajith Kumar Reddy Rajoli, Andrew Owen, Tânia Beatriz Creczynski-Pasa & Marco Siccardi. (2017) A physiologically based pharmacokinetic model to predict the superparamagnetic iron oxide nanoparticles (SPIONs) accumulation in vivo. European Journal of Nanomedicine 9:2.
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Paul Curley, Rajith K. R. Rajoli, Darren M. Moss, Neill J. Liptrott, Scott Letendre, Andrew Owen & Marco Siccardi. (2017)
Efavirenz Is Predicted To Accumulate in Brain Tissue: an
In Silico
,
In Vitro
, and
In Vivo
Investigation
. Antimicrobial Agents and Chemotherapy 61:1.
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José Moltó, Rajith Rajoli, David Back, Marta Valle, Cristina Miranda, Andrew Owen, Bonaventura Clotet & Marco Siccardi. (2016) Use of a physiologically based pharmacokinetic model to simulate drug–drug interactions between antineoplastic and antiretroviral drugs. Journal of Antimicrobial Chemotherapy, pages dkw485.
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Marco Giardiello, Neill J. Liptrott, Tom O. McDonald, Darren Moss, Marco Siccardi, Phil Martin, Darren Smith, Rohan Gurjar, Steve P. Rannard & Andrew Owen. (2016) Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies. Nature Communications 7:1.
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Marco Siccardi, Phillip Martin, Darren Smith, Paul Curley, Tom McDonald, Marco Giardiello, Neill Liptrott, Steve Rannard & Andrew Owen. (2016) Towards a rational design of solid drug nanoparticles with optimised pharmacological properties. Journal of Interdisciplinary Nanomedicine 1:3, pages 110-123.
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Elliot Offman, Colin Phipps & Andrea N. Edginton. (2016) Population physiologically-based pharmacokinetic model incorporating lymphatic uptake for a subcutaneously administered pegylated peptide. In Silico Pharmacology 4:1.
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Sieto Bosgra, Maria L. H. Vlaming & Wouter H. J. Vaes. (2015) To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics. Clinical Pharmacokinetics 55:1, pages 1-15.
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Jochem Louisse, Sieto Bosgra, Bas J. Blaauboer, Ivonne M. C. M. Rietjens & Miriam Verwei. (2014) Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling. Archives of Toxicology 89:7, pages 1135-1148.
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Kevin McNally, Richard Cotton, Alex Hogg & George Loizou. (2015) Reprint of PopGen: A virtual human population generator. Toxicology 332, pages 77-93.
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Rajith K. R. Rajoli, David J. Back, Steve Rannard, Caren L. Freel Meyers, Charles Flexner, Andrew Owen & Marco Siccardi. (2014) Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV. Clinical Pharmacokinetics 54:6, pages 639-650.
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Sieto Bosgra, Evita van de Steeg, Maria L. Vlaming, Kitty C. Verhoeckx, Maarten T. Huisman, Miriam Verwei & Heleen M. Wortelboer. (2014) Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling. European Journal of Pharmaceutical Sciences 65, pages 156-166.
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Guo Yu, Qing-Shan Zheng & Guo-Fu Li. (2014) Similarities and Differences in Gastrointestinal Physiology Between Neonates and Adults: a Physiologically Based Pharmacokinetic Modeling Perspective. The AAPS Journal 16:6, pages 1162-1166.
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B. Zimmer, G. Pallocca, N. Dreser, S. Foerster, T. Waldmann, J. Westerhout, S. Julien, K. H. Krause, C. van Thriel, J. G. Hengstler, A. Sachinidis, S. Bosgra & M. Leist. (2014) Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery. Archives of Toxicology.
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Tom O. McDonald, Marco Giardiello, Philip Martin, Marco Siccardi, Neill J. Liptrott, Darren Smith, Phill Roberts, Paul Curley, Alessandro Schipani, Saye H. Khoo, James Long, Alison J. Foster, Steven P. Rannard & Andrew Owen. (2013) Antiretroviral Solid Drug Nanoparticles with Enhanced Oral Bioavailability: Production, Characterization, and In Vitro–In Vivo Correlation. Advanced Healthcare Materials 3:3, pages 400-411.
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Guo-Fu Li, Guo Yu, Hong-Xia Liu & Qing-Shan Zheng. (2013) Ethnic-Specific In Vitro–In Vivo Extrapolation and Physiologically Based Pharmacokinetic Approaches to Predict Cytochrome P450-Mediated Pharmacokinetics in the Chinese Population: Opportunities and Challenges. Clinical Pharmacokinetics 53:2, pages 197-202.
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Kevin McNally, Richard Cotton, Alex Hogg & George Loizou. (2014) PopGen: A virtual human population generator. Toxicology 315, pages 70-85.
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Nadia Quignot, Jérémy Hamon & Frederic Y. Bois. 2014. In Vitro Toxicology Systems. In Vitro Toxicology Systems
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Marco SiccardiRajith Kumar Reddy Rajoli, Paul Curley, Adeniyi Olagunju, Darren Moss & Andrew Owen. (2013) Physiologically based pharmacokinetic models for the optimization of antiretroviral therapy: recent progress and future perspective. Future Virology 8:9, pages 871-890.
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Marco Siccardi, Adeniyi Olagunju, Kay Seden, Farid Ebrahimjee, Steve Rannard, David Back & Andrew Owen. (2013) Use of a physiologically-based pharmacokinetic model to simulate artemether dose adjustment for overcoming the drug-drug interaction with efavirenz. In Silico Pharmacology 1:1.
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