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Research Article

Metabolism, Toxicity, and Carcinogenicity of Trichloroethylene

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Pages 31-50 | Published online: 26 Sep 2008

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Ping Cai, Paul J. Boor, M. Firoze Khan, Bhupendra S. Kaphalia, G. A. S. Ansari & Rolf König. (2007) Immuno- and Hepato-Toxicity of Dichloroacetic Acid in MRL and B6C3F1 Mice. Journal of Immunotoxicology 4:2, pages 107-115.
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Kathleen M. Gilbert, Neil R. Pumford & Sarah J. Blossom. (2006) Environmental Contaminant Trichloroethylene Promotes Autoimmune Disease and Inhibits T-cell Apoptosis in MRL+/+ Mice. Journal of Immunotoxicology 3:4, pages 263-267.
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Harvey J. Clewell & Melvin E. Andersen. (2004) Applying Mode-of-Action and Pharmacokinetic Considerations in Contemporary Cancer Risk Assessments: An Example with Trichloroethylene. Critical Reviews in Toxicology 34:5, pages 385-445.
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AmyL. Lavin, CatherineF. Jacobson & JohnM. DeSesso. (2000) An Assessment of the Carcinogenic Potential of Trichloroethylene in Humans. Human and Ecological Risk Assessment: An International Journal 6:4, pages 575-641.
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Neil R. Pumford, N. Christine Halmes & Jack A. Hinson. (1997) Covalent Binding of Xenobiotics to Specific Proteins in the Liver. Drug Metabolism Reviews 29:1-2, pages 39-57.
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Elizabeth A. Maull, V. James Cogliano, Cheryl Siegel Scott, Hugh A. Barton, Jeffrey W. Fisher, Marc Greenberg, Lorenz Rhomberg & Steven P. Sorgen. (1997) Trichloroethylene Health Risk Assessment: A New and Improved Process. Drug and Chemical Toxicology 20:4, pages 427-442.
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N. C. Halmes, V. M. Samokyszyn & N. R. Pumford. (1997) Covalent binding and inhibition of cytochrome P4502E1 by trichloroethylene. Xenobiotica 27:1, pages 101-110.
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RussellJ. Eyre, DouglasK. Stevens, JeanC. Parker & RichardJ. Bull. (1995) Acid‐labile adducts to protein can be used as indicators of the cysteine S‐conjugate pathway of trichloroethene metabolism. Journal of Toxicology and Environmental Health 46:4, pages 443-464.
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K. Hughes, M.E. Meek & W. Windle. (1994) Trichloroethylene: Evaluation of risks to health from environmental exposure in Canada. Journal of Environmental Science and Health, Part C 12:2, pages 527-543.
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Judy L Raucy, James C. Kraner & Jerome M. Lasker. (1993) Bioactivation of Halogenated Hydrocarbons by Cytochrome P4502E1. Critical Reviews in Toxicology 23:1, pages 1-20.
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Ivan W. F. Davidson & Robert P. Beliles. (1991) Consideration of the Target Organ Toxicity of Trichloroethylene in Terms of Metabolite Toxicity and Pharmacokinetics. Drug Metabolism Reviews 23:5-6, pages 493-599.
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Douglas J. Fort, James R. Rayburn, Donna J. Deyoung & John A. Bantle. (1991) Assessing the Efficacy of an Aroclor 1254–Induced Exogenous Metabolic Activation System for Fetax. Drug and Chemical Toxicology 14:1-2, pages 143-160.
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Kathleen M. Gilbert, Shasha Bai, Dustyn Barnette & Sarah J. Blossom. (2017) Exposure Cessation During Adulthood Did Not Prevent Immunotoxicity Caused by Developmental Exposure to Low-Level Trichloroethylene in Drinking Water. Toxicological Sciences 157:2, pages 429-437.
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Yufei Dai, Ying Chen, Hanlin Huang, Wei Zhou, Yong Niu, Mingrong Zhang, Ping Bin, Haiyan Dong, Qiang Jia, Jianxun Huang, Juan Yi, Qijun Liao, Haishan Li, Yanxia Teng, Dan Zang, Qingfeng Zhai, Huawei Duan, Juan Shen, Jiaxi He, Tao Meng, Yan Sha, Meili Shen, Meng Ye, Xiaowei Jia, Yingping Xiang, Huiping Huang, Qifeng Wu, Mingming Shi, Xianqing Huang, Huanming Yang, Longhai Luo, Sai Li, Lin Li, Jinyang Zhao, Laiyu Li, Jun Wang & Yuxin Zheng. (2015) Performance of genetic risk factors in prediction of trichloroethylene induced hypersensitivity syndrome. Scientific Reports 5:1.
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Shams Tabrez & Masood Ahmad. (2012) Cytochrome P450 system as potential biomarkers of certain toxicants: comparison between plant and animal models. Environmental Monitoring and Assessment 185:4, pages 2977-2987.
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