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Review Article

Human RECQL5: Guarding the crossroads of DNA replication and transcription and providing backup capability

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Pages 289-299 | Received 12 Mar 2013, Accepted 02 Apr 2013, Published online: 29 Apr 2013

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Read on this site (3)

Julia M Sidorova & Raymond J Monnat Jr. (2015) Human RECQ helicases: roles in cancer, aging, and inherited disease. Advances in Genomics and Genetics 5, pages 19-33.
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Guido Keijzers, Scott Maynard, Raghavendra A. Shamanna, Lene Juel Rasmussen, Deborah L. Croteau & Vilhelm A. Bohr. (2014) The role of RecQ helicases in non-homologous end-joining. Critical Reviews in Biochemistry and Molecular Biology 49:6, pages 463-472.
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Articles from other publishers (27)

Min Huang, Fuwen Yao, Litong Nie, Chao Wang, Dan Su, Huimin Zhang, Siting Li, Mengfan Tang, Xu Feng, Bin Yu, Zhen Chen, Shimin Wang, Ling Yin, Lisha Mou, Traver Hart & Junjie Chen. (2023) FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways. Molecular Cell 83:15, pages 2810-2828.e6.
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Yujun Hou, Jae-Hyeon Park, Xiuli Dan, Xixia Chu, Beimeng Yang, Mansoor Hussain, Deborah L. Croteau & Vilhelm A. Bohr. (2023) RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice. Neurobiology of Disease 180, pages 106092.
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远哲 荣. (2023) Research Progress on Reversing Oxaliplatin Resistance in Colon Cancer. Advances in Clinical Medicine 13:08, pages 12687-12695.
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Megha K. Thakkar, Jamie Lee, Stefan Meyer & Vivian Y. Chang. (2022) RecQ Helicase Somatic Alterations in Cancer. Frontiers in Molecular Biosciences 9.
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Tulika Das, Surasree Pal & Agneyo Ganguly. (2021) Human RecQ helicases in transcription-associated stress management: bridging the gap between DNA and RNA metabolism. Biological Chemistry 402:5, pages 617-636.
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Saikat Chakraborty, Kartik Dutta, Pooja Gupta, Anubrata Das, Amit Das, Sunil Kumar Ghosh & Birija Sankar Patro. (2021) Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitr o and in Vivo . Journal of Medicinal Chemistry 64:3, pages 1524-1544.
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Dongbo Ding, Xulun Sun, Matthew Y.H. Pang, Liwei An, Michael S.Y. Huen, Taobo Hu & Toyotaka Ishibashi. (2021) RECQL5 KIX domain splicing isoforms have distinct functions in transcription repression and DNA damage response. DNA Repair 97, pages 103007.
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Cody M. Rogers, Robert H. Simmons III, Gabriella E. Fluhler Thornburg, Nicholas J. Buehler & Matthew L. Bochman. (2020) Fanconi anemia-independent DNA inter-strand crosslink repair in eukaryotes. Progress in Biophysics and Molecular Biology 158, pages 33-46.
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Srijita Dhar, Arindam Datta & Robert M. BroshJr.Jr.. (2020) DNA helicases and their roles in cancer. DNA Repair 96, pages 102994.
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Sylwia K. Król, Agnieszka Kaczmarczyk, Kamil Wojnicki, Bartosz Wojtas, Bartłomiej Gielniewski, Wieslawa Grajkowska, Katarzyna Kotulska, Cezary Szczylik, Ryszard Czepko, Mariusz Banach, Wojciech Kaspera, Wojciech Szopa, Andrzej Marchel, Tomasz Czernicki & Bozena Kaminska. (2020) Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells. Cancers 12:10, pages 2919.
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Chetan K. Jain, Swagata Mukhopadhyay & Agneyo Ganguly. (2020) RecQ Family Helicases in Replication Fork Remodeling and Repair: Opening New Avenues towards the Identification of Potential Targets for Cancer Chemotherapy. Anti-Cancer Agents in Medicinal Chemistry 20:11, pages 1311-1326.
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Muhammad Idris, Nathan Harmston, Enrico Petretto, Babita Madan & David M. Virshup. (2019) Broad regulation of gene isoform expression by Wnt signaling in cancer. RNA 25:12, pages 1696-1713.
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Jin Peng, Lichun Tang, Mengjiao Cai, Huan Chen, Jiemin Wong & Pumin Zhang. (2019) RECQL5 plays an essential role in maintaining genome stability and viability of triple‐negative breast cancer cells. Cancer Medicine 8:10, pages 4743-4752.
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Alejandra Tavera-Tapia, Miguel de la Hoya, Oriol Calvete, Paloma Martin-Gimeno, Victoria Fernández, José Antonio Macías, Beatriz Alonso, Luz Pombo, Carles de Diego, Rosario Alonso, Guillermo Pita, Alicia Barroso, Miguel Urioste, Trinidad Caldés, Joseph A. Newman, Javier Benítez & Ana Osorio. (2019) RECQL5 : Another DNA helicase potentially involved in hereditary breast cancer susceptibility . Human Mutation 40:5, pages 566-577.
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Wezley C. Griffin & Michael A. Trakselis. (2019) The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance. DNA Repair 76, pages 1-10.
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Cody M. Rogers, Joseph Che-Yen Wang, Hiroki Noguchi, Tsuyoshi Imasaki, Yuichiro Takagi & Matthew L. Bochman. (2017) Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase. Nucleic Acids Research 45:9, pages 5217-5230.
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Jing You, Ya-Nan Xu, Hui Li, Xi-Ming Lu, Wei Li, Peng-Ye Wang, Shuo-Xing Dou & Xu-Guang Xi. (2017) Helicase activity and substrate specificity of RecQ5 β . Chinese Physics B 26:6, pages 068701.
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Joseph A. Newman, Hazel Aitkenhead, Pavel Savitsky & Opher Gileadi. (2017) Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5. Nucleic Acids Research, pages gkw1362.
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Tatiana García-Muse & Andrés Aguilera. (2016) Transcription–replication conflicts: how they occur and how they are resolved. Nature Reviews Molecular Cell Biology 17:9, pages 553-563.
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Arvind Arora, Tarek M.A. Abdel-Fatah, Devika Agarwal, Rachel Doherty, Deborah L. Croteau, Paul M. Moseley, Khalid Hameed, Andrew Green, Mohammed A. Aleskandarany, Emad A. Rakha, Karl Patterson, Graham Ball, Stephen Y.T. Chan, Ian O. Ellis, Vilhelm A. Bohr, Helen E. Bryant & Srinivasan Madhusudan. (2016) Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers. Carcinogenesis 37:1, pages 63-71.
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Prabhat Khadka, Deborah L. Croteau & Vilhelm A. Bohr. (2016) RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins. DNA Repair 37, pages 53-66.
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Junlong Wu, Liqiang Zhi, Xin Dai, Qingchun Cai & Wei Ma. (2015) Decreased RECQL5 correlated with disease progression of osteosarcoma. Biochemical and Biophysical Research Communications 467:4, pages 617-622.
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Sebastian Veith & Aswin Mangerich. (2015) RecQ helicases and PARP1 team up in maintaining genome integrity. Ageing Research Reviews 23, pages 12-28.
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Zhubing Hu, Toon Cools, Pooneh Kalhorzadeh, Jefri Heyman & Lieven De Veylder. (2015) Deficiency of the Arabidopsis Helicase RTEL1 Triggers a SOG1-Dependent Replication Checkpoint in Response to DNA Cross-Links . The Plant Cell 27:1, pages 149-161.
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Wan-Qin Liao. (2015) Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice. World Journal of Gastroenterology 21:36, pages 10375.
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Deborah L. CroteauVenkateswarlu PopuriPatricia L. Opresko & Vilhelm A. Bohr. (2014) Human RecQ Helicases in DNA Repair, Recombination, and Replication. Annual Review of Biochemistry 83:1, pages 519-552.
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H Lu, E F Fang, P Sykora, T Kulikowicz, Y Zhang, K G Becker, D L Croteau & V A Bohr. (2014) Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice. Cell Death & Disease 5:5, pages e1226-e1226.
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