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Original Article

Extracorporeal Photochemotherapy in the Treatment of Severe Graft-Versus-Host Disease

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Pages 425-434 | Received 20 Aug 1999, Published online: 01 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Baheyeldin Salem, Jennifer Webb & David Alex Jacobsohn. (2017) An update on the clinical utility of extracorporeal photopheresis in the treatment of graft-versus-host disease. International Journal of Clinical Transfusion Medicine 5, pages 19-28.
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E. Steels, N. Meuleman, P. Vereecken, N. de Saint Aubain, G. De Dobbeleer, D. Bron & M. Heenen. (2004) GRAFT-VERSUS-HOST DISEASE : REVIEW OF 22 CASES. Acta Clinica Belgica 59:4, pages 182-188.
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David A Jacobsohn. (2003) Emerging therapies for graft-versus-host disease. Expert Opinion on Emerging Drugs 8:2, pages 323-338.
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Djavid Gaziev & Guido Lucarelli. (2001) Novel approaches to the treatment of chronic graft-versus-host disease. Expert Opinion on Investigational Drugs 10:5, pages 909-923.
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Articles from other publishers (42)

Anxin Wu, Jing Lu, Guofeng Zhong, Ling Lu, Yan Qu & Chen Zhang. (2022) Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity. Phytotherapy Research 36:10, pages 3805-3832.
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Jennifer Schneiderman, Longhui Qiu, Xin Yi Yeap, Xin Kang, Feibo Zheng, Junsheng Ye, Yan Xie, Jiao-Jing Wang, Yuvaraj Sambandam, James Mathew, Lin Li, Joseph Leventhal, Richard L. Edelson & Zheng Jenny Zhang. (2022) Pre-transplant infusion of donor leukocytes treated with extracorporeal photochemotherapy induces immune hypo-responsiveness and long-term allograft survival in murine models. Scientific Reports 12:1.
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R. Knobler, T. Valero & U. Just. (2021) Update zur Extrakorporalen PhotophereseUpdate on Extracorporeal Photopheresis. hautnah 20:4, pages 207-212.
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Sa Rang Kim & Michael Girardi. 2021. Comprehensive Dermatologic Drug Therapy. Comprehensive Dermatologic Drug Therapy 271 279.e4 .
Susan Schubach Slater. 2021. Blood and Marrow Transplant Handbook. Blood and Marrow Transplant Handbook 423 452 .
R. Knobler, P. Arenberger, A. Arun, C. Assaf, M. Bagot, G. Berlin, A. Bohbot, P. Calzavara‐Pinton, F. Child, A. Cho, L.E. French, A.R. Gennery, R. Gniadecki, H.P.M. Gollnick, E. Guenova, P. Jaksch, C. Jantschitsch, C. Klemke, J. Ludvigsson, E. Papadavid, J. Scarisbrick, T. Schwarz, R. Stadler, P. Wolf, J. Zic, C. Zouboulis, A. Zuckermann & H. Greinix. (2020) European dermatology forum – updated guidelines on the use of extracorporeal photopheresis 2020 – part 1. Journal of the European Academy of Dermatology and Venereology 34:12, pages 2693-2716.
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Anar Mikailov, Molly Plovanich & Arturo P. Saavedra. 2017. Atlas of Graft-versus-Host Disease. Atlas of Graft-versus-Host Disease 57 68 .
Susan Schubach Slater. 2015. Blood and Marrow Transplant Handbook. Blood and Marrow Transplant Handbook 223 244 .
A L Gonzalez, C L Berger, J Remington, M Girardi, R E Tigelaar & R L Edelson. (2014) Integrin-driven monocyte to dendritic cell conversion in modified extracorporeal photochemotherapy. Clinical and Experimental Immunology 175:3, pages 449-457.
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Jaehyuk Choi, Peter W. Heald & Michael Girardi. 2013. Comprehensive Dermatologic Drug Therapy. Comprehensive Dermatologic Drug Therapy 291 298.e2 .
Sonja Alexandra Grundmann & Stefan Beissert. (2012) Modern Aspects of Phototherapy for Atopic Dermatitis. Journal of Allergy 2012, pages 1-8.
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Miklós SimonJrJr. 2011. Autoimmune Diseases of the Skin. Autoimmune Diseases of the Skin 373 388 .
D Hoda, J Pidala, N Salgado-Vila, J Kim, J Perkins, R Bookout, T Field, L Perez, E Ayala, J L Ochoa-Bayona, J Raychaudhuri, M Alsina, J Greene, W Janssen, H F Fernandez, C Anasetti & M A Kharfan-Dabaja. (2009) Sirolimus for treatment of steroid-refractory acute graft-versus-host disease. Bone Marrow Transplantation 45:8, pages 1347-1351.
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P J Shaughnessy, B J Bolwell, K van Besien, M Mistrik, A Grigg, A Dodds, H M Prince, S Durrant, O Ilhan, D Parenti, J Gallo, F Foss, J Apperley, M-J Zhang, M M Horowitz & S Abhyankar. (2009) Extracorporeal photopheresis for the prevention of acute GVHD in patients undergoing standard myeloablative conditioning and allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplantation 45:6, pages 1068-1076.
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Susan Slater. 2011. Blood and Marrow Transplant Handbook. Blood and Marrow Transplant Handbook 167 187 .
Jennifer Schneiderman, David A. Jacobsohn, Jennifer Collins, Kimberly Thormann & Morris Kletzel. (2010) The use of fluid boluses to safely perform extracorporeal photopheresis (ECP) in low-weight children: A novel procedure. Journal of Clinical Apheresis, pages NA-NA.
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Kristin Baird & Alan S. Wayne. (2009) Extracorporeal photo-apheresis for the treatment of steroid-resistant graft versus host disease. Transfusion and Apheresis Science 41:3, pages 209-216.
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Madan H. Jagasia, Bipin N. Savani, George Stricklin, Brian Engelhardt, Adetola Kassim, Sheri Dixon, Heidi Chen, Wichai Chinratanalab, Stacey Goodman, John P. Greer & Friedrich Schuening. (2009) Classic and Overlap Chronic Graft-versus-Host Disease (cGVHD) Is Associated with Superior Outcome after Extracorporeal Photopheresis (ECP). Biology of Blood and Marrow Transplantation 15:10, pages 1288-1295.
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L. Pérez-Carmona, A. Harto-Castaño, E. Díez-Recio & P. Jaén-Olasolo. (2009) Fotoféresis extracorpórea en Dermatología. Actas Dermo-Sifiliográficas 100:6, pages 459-471.
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Mikaël Hivelin, Maria Siemionow, Philippe Grimbert & Laurent Lantieri. (2009) Extracorporeal photopheresis: From solid organs to face transplantation. Transplant Immunology 21:3, pages 117-128.
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L. Pérez-Carmona, A. Harto-Castaño, E. Díez-Recio & P. Jaén-Olasolo. (2009) Extracorporeal Photopheresis in Dermatology. Actas Dermo-Sifiliográficas (English Edition) 100:6, pages 459-471.
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Mary E. D. FlowersJane F. ApperleyKoen van BesienAhmet ElmaagacliAndrew GriggVijay ReddyAndrea BacigalupoHans-Jochem KolbLuis BouzasMauricette MichalletH. Miles PrinceRobert KnoblerDennis Parenti, Jose Gallo & Hildegard T. Greinix. (2008) A multicenter prospective phase 2 randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease. Blood 112:7, pages 2667-2674.
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Maria Rosaria Carcagnì, Giovambattista De Aloe, Giuseppina D'Ascenzo, Pietro Rubegni & Michele Fimiani. (2008) Extracorporeal photopheresis in graft-versus-host disease. JDDG 6:6, pages 451-457.
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Sonja A Grundmann & Stefan Beissert. 2008. Textbook of Atopic Dermatitis. Textbook of Atopic Dermatitis 187 196 .
Tomohide Hori, Kagemasa Kuribayashi, Shinji Uemoto, Kanako Saito, Linan Wang, Mie Torii, Shintaro Shibutani, Kentaro Taniguchi, Shintaro Yagi, Taku Iida, Chiduru Yamamoto & Takuma Kato. (2008) Alloantigen-specific prolongation of allograft survival in recipient mice treated by alloantigen immunization following ultraviolet-B irradiation. Transplant Immunology 19:1, pages 45-54.
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E. Motolese, P. Rubegni, S. Poggiali, P.A. Motolese, G. Marotta, L. Russo, G. D'ascenzo, M.R. Carcagnì, M. Fruschelli, I. Motolese & M. Fimiani. (2018) Ocular Manifestations of Chronic Graft-Versus-Host Disease in Patients Treated with Extracorporeal Photochemotherapy. European Journal of Ophthalmology 17:6, pages 961-969.
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Niclas Setterblad, Frédéric Garban, Roman Weigl, Eric Assier, Philippe Drillat, Dominique Charron, Anne Dickinson, Hildegard Greinix & Nuala Mooney. (2007) Extracorporeal photophoresis increases sensitivity of monocytes from patients with graft-versus-host disease to HLA-DR–mediated cell death. Transfusion 0:0, pages 071005074756006-???.
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Ernst Holler. (2007) Risk assessment in haematopoietic stem cell transplantation: GvHD prevention and treatment. Best Practice & Research Clinical Haematology 20:2, pages 281-294.
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Chelsea A. Sheppard & Christopher D. Hillyer. 2007. Consultative Hemostasis and Thrombosis. Consultative Hemostasis and Thrombosis 509 529 .
Ka Wah Chan. (2006) Extracorporeal photopheresis in children with graft‐versus‐host disease. Journal of Clinical Apheresis 21:1, pages 60-64.
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David Peritt. (2006) Potential Mechanisms of Photopheresis in Hematopoietic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 12:1, pages 7-12.
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Kouhei Yamashita, Mitchell E. Horwitz, Akua Kwatemaa, Effie Nomicos, Kathleen Castro, Robert Sokolic, Susan F. Foster, Mary Garofalo, Uimook Choi, Mark Ryherd, Margaret R. Brown, Susan F. Leitman, Alan S. Wayne, Daniel H. Fowler, Michael R. Bishop, Richard W. Childs, A. John Barrett, Steven Z. Pavletic & Harry L. Malech. (2006) Unique Abnormalities of CD4+ and CD8+ Central Memory Cells Associated with Chronic Graft-versus-Host Disease Improve after Extracorporeal Photopheresis. Biology of Blood and Marrow Transplantation 12:1, pages 22-30.
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Mohamed Mabed, Christian Coffe, Evelyne Racadot, Regis Angonin, Jean-Jaques Pavey, Pierre Tiberghien & Patrick Herve. (2005) Differential sensitivity of T lymphocytes and hematopoietic precursor cells to photochemotherapy with 8-methoxypsoralen and ultraviolet A light. Annals of Hematology 85:1, pages 17-24.
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Akira Maeda, Agatha Schwarz, Kerstin Kernebeck, Nicole Gross, Yoshinori Aragane, David Peritt & Thomas Schwarz. (2005) Intravenous Infusion of Syngeneic Apoptotic Cells by Photopheresis Induces Antigen-Specific Regulatory T Cells. The Journal of Immunology 174:10, pages 5968-5976.
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Mikló SimonJr.Jr.. 2005. Autoimmune Diseases of the Skin. Autoimmune Diseases of the Skin 333 348 .
M. Fimiani, M. DI Renzo & P. Rubegni. (2004) Mechanism of action of extracorporeal photochemotherapy in chronic graft-versus-host disease. British Journal of Dermatology 150:6, pages 1055-1060.
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K B Miller, T F Roberts, G Chan, D P Schenkein, D Lawrence, K Sprague, G Gorgun, V Relias, H Grodman, A Mahajan & F M Foss. (2004) A novel reduced intensity regimen for allogeneic hematopoietic stem cell transplantation associated with a reduced incidence of graft-versus-host disease. Bone Marrow Transplantation 33:9, pages 881-889.
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François Aubin & Christiane Mousson. (2004) Ultraviolet light-induced regulatory (suppressor) T cells: an approach for promoting induction of operational allograft tolerance?. Transplantation 77:Supplement, pages S29-S31.
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Walter Macheiner, Christian Jantschitsch, Winfried Graninger, Katalin Plczy, Gza Blint, Mrta Marschalk, Franz Kainberger, Friedrich Breier & Robert M. Knobler. (2003) S?zary syndrome and seronegative polyarthritis: Treatment with extracorporeal photochemotherapy. Journal of the American Academy of Dermatology 48:2, pages 220-226.
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N Worel, D Biener, P Kalhs, M Mitterbauer, F Keil, A Schulenburg, P Höcker, K Dieckmann, G Fischer, A Rosenmayr, W Linkesch, W Hinterberger, K Lechner & HT Greinix. (2002) Long-term outcome and quality of life of patients who are alive and in complete remission more than two years after allogeneic and syngeneic stem cell transplantation. Bone Marrow Transplantation 30:9, pages 619-626.
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A. Oliven & Y. Shechter. (2001) Extracorporeal photopheresis: a review. Blood Reviews 15:2, pages 103-108.
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Miklós SimonJr.Jr.. 2001. Autoimmune Diseases of the Skin. Autoimmune Diseases of the Skin 303 317 .

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