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Original Article

Clinical Significance of Deletions of Chromosome Arm 6q in Childhood Acute Lymphoblastic Leukemia: A Report from the Children's Cancer Group

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Pages 467-478 | Published online: 01 Jul 2009

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Birgit Burkhardt, Anja Moericke, Wolfram Klapper, Franziska Greene, Janina Salzburg, Christine Damm-Welk, Martin Zimmermann, Konstantin Strauch, Wolf-Dieter Ludwig, Martin Schrappe & Alfred Reiter. (2008) Pediatric precursor T lymphoblastic leukemia and lymphoblastic lymphoma: Differences in the common regions with loss of heterozygosity at chromosome 6q and their prognostic impact. Leukemia & Lymphoma 49:3, pages 451-461.
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D. Yahya, V. Miteva, I. Micheva, T. Ruseva & L. Angelova. (2023) Cytogenetic Analysis of Patients with Hematological Malignancies. Cytology and Genetics 57:3, pages 272-281.
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Ryota Shirai, Tomoo Osumi, Aiko Sato‐Otsubo, Kazuhiko Nakabayashi, Takeshi Mori, Masanori Yoshida, Kaoru Yoshida, Mika Kohri, Takashi Ishihara, Shiho Yasue, Toshihiko Imamura, Mikiya Endo, Satoshi Miyamoto, Kentaro Ohki, Masashi Sanada, Nobutaka Kiyokawa, Seishi Ogawa, Takako Yoshioka, Kenichiro Hata, Masatoshi Takagi & Motohiro Kato. (2021) Genetic features of B‐cell lymphoblastic lymphoma with TCF3‐PBX1 . Cancer Reports 5:9.
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Kathryn A. F. Kline, Michael E. Kallen, Vu H. Duong & Jennie Y. Law. (2021) Acute Lymphoblastic Leukemia and Acute Lymphoblastic Lymphoma: Same Disease Spectrum but Two Distinct Diagnoses. Current Hematologic Malignancy Reports 16:5, pages 384-393.
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Emma Kroeze, Jan L. C. Loeffen, Vera M. Poort & Jules P. P. Meijerink. (2020) T-cell lymphoblastic lymphoma and leukemia: different diseases from a common premalignant progenitor?. Blood Advances 4:14, pages 3466-3473.
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Birgit Burkhardt, Stephanie Mueller, Tasneem Khanam & Sherrie L. Perkins. (2016) Current status and future directions of T-lymphoblastic lymphoma in children and adolescents. British Journal of Haematology 173:4, pages 545-559.
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Tadakal Mallana Goud, Kamla Khalfan Al Salmani, Salma Mohammed Al Harasi, Muhanna Al Musalhi, Shah Mohammed Wasifuddin & Anna Rajab. (2015) Importance of FISH combined with Morphology, Immunophenotype and Cytogenetic Analysis of Childhood/Adult Acute Lymphoblastic Leukemia in Omani Patients. Asian Pacific Journal of Cancer Prevention 16:16, pages 7343-7350.
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Joonhong Park, Myungshin Kim, Hae Kyung Lee, Yonggoo Kim, Kyungja Han, Jungok Son, Seok Lee, Nack-Gyun Chung & Bin Cho. (2014) Chromosome abnormalities in T-cell acute lymphoblastic leukemia in Korea. International Journal of Hematology 99:3, pages 279-287.
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Nyla A. Heerema & Susana Catalina Raimondi. 2013. Neoplastic Diseases of the Blood. Neoplastic Diseases of the Blood 285 303 .
William L. Carroll, Mignon Loh, Andrea Biondi & Cheryl Willman. 2011. Childhood Leukemia. Childhood Leukemia 29 61 .
Etienne De Braekeleer, Audrey Basinko, Nathalie Douet-Guilbert, Frédéric Morel, Marie-Josée Le Bris, Christian Berthou, Patrick Morice, Claude Férec & Marc De Braekeleer. (2010) Cytogenetics in pre-B and B-cell acute lymphoblastic leukemia: a study of 208 patients diagnosed between 1981 and 2008. Cancer Genetics and Cytogenetics 200:1, pages 8-15.
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Birgit Burkhardt. (2009) Paediatric lymphoblastic T-cell leukaemia and lymphoma: one or two diseases?. British Journal of Haematology 149:5, pages 653-668.
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Ron Yaar, Karen Rothman & Meera Mahalingam. (2010) When Dead Cells Tell Tales-Cutaneous Involvement by Precursor T-Cell Acute Lymphoblastic Lymphoma With an Uncommon Phenotype. The American Journal of Dermatopathology 32:2, pages 183-186.
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Krzysztof Mrózek, David P. Harper & Peter D. Aplan. (2009) Cytogenetics and Molecular Genetics of Acute Lymphoblastic Leukemia. Hematology/Oncology Clinics of North America 23:5, pages 991-1010.
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Kristina Karrman, Erik Forestier, Mats Heyman, Mette K. Andersen, Kirsi Autio, Elisabeth Blennow, Georg Borgström, Hans Ehrencrona, Irina Golovleva, Sverre Heim, Kristiina Heinonen, Randi Hovland, Johann H. Johannsson, Gitte Kerndrup, Ann Nordgren, Lars Palmqvist & Bertil Johansson. (2009) Clinical and cytogenetic features of a population‐based consecutive series of 285 pediatric T‐cell acute lymphoblastic leukemias: Rare T‐cell receptor gene rearrangements are associated with poor outcome. Genes, Chromosomes and Cancer 48:9, pages 795-805.
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Achandira Muthappa Udayakumar, Wafa Ahmed Bashir, Anil Vasant Pathare, Yasser Ahmed Wali, Mathew Zacharia, Ashfaq Ahmed Khan, Heba Soliman, Zakia Al-Lamki & John Alexander Raeburn. (2007) Cytogenetic Profile of Childhood Acute Lymphoblastic Leukemia in Oman. Archives of Medical Research 38:3, pages 305-312.
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B Burkhardt, J Bruch, M Zimmermann, K Strauch, R Parwaresch, W-D Ludwig, L Harder, B Schlegelberger, F Mueller, J Harbott & A Reiter. (2006) Loss of heterozygosity on chromosome 6q14–q24 is associated with poor outcome in children and adolescents with T-cell lymphoblastic lymphoma. Leukemia 20:8, pages 1422-1429.
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Zuzana Zemanova, Kyra Michalova, Lenka Sindelarova, Petr Smisek, Jana Brezinova, Sarka Ransdorfova, Vladimir Vavra, Alena Dohnalova & Jan Stary. (2005) Prognostic value of structural chromosomal rearrangements and small cell clones with high hyperdiploidy in children with acute lymphoblastic leukemia. Leukemia Research 29:3, pages 273-281.
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Paul B. Sinclair, Amani Sorour, Mary Martineau, Christine J. Harrison, Wayne A. Mitchell, Elena O’Neill & Letizia Foroni. (2004) A Fluorescence in Situ Hybridization Map of 6q Deletions in Acute Lymphocytic Leukemia . Cancer Research 64:12, pages 4089-4098.
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Krzysztof Mrózek, Nyla A Heerema & Clara D Bloomfield. (2004) Cytogenetics in acute leukemia. Blood Reviews 18:2, pages 115-136.
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Tim D. Kristensen, Finn Wesenberg, Olafur G. Jonsson, Niels T. Carlsen, Erik Forestier, Maria Kirchhoff, Claes Lundsteen & Kjeld Schmiegelow. (2003) High-resolution comparative genomic hybridisation yields a high detection rate of chromosomal aberrations in childhood acute lymphoblastic leukaemia. European Journal of Haematology 70:6, pages 363-372.
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S Takeuchi, K Tsukasaki, C R Bartram, T Seriu, M Zimmermann, M Schrappe, N Takeuchi, S Park, H Taguchi & H P Koeffler. (2003) Long-term study of the clinical significance of loss of heterozygosity in childhood acute lymphoblastic leukemia. Leukemia 17:1, pages 149-154.
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Partow Kebriaei, John Anastasi & Richard A. Larson. (2002) Acute lymphoblastic leukaemia: diagnosis and classification. Best Practice & Research Clinical Haematology 15:4, pages 597-621.
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M Mancini, ML Vegna, GL Castoldi, C Mecucci, F Spirito, L Elia, A Tafuri, L Annino, F Pane, G Rege-Cambrin, M Gottardi, P Leoni, E Gallo, A Camera, L Luciano, G Specchia, G Torelli, M Sborgia, A Gabbas, A Tedeschi, I Della Starza, N Cascavilla, F Di Raimondo, F Mandelli & R Foà. (2002) Partial deletions of long arm of chromosome 6: biologic and clinical implications in adult acute lymphoblastic leukemia. Leukemia 16:10, pages 2055-2061.
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Christine J. Harrison & Letizia Foroni. (2002) Cytogenetics and molecular genetics of acute lymphoblastic leukemia. Reviews in Clinical and Experimental Hematology 6:2, pages 91-113.
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