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Leukemia & Lymphoma Volume 36, 2000 - Issue 5-6
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Original Article

Induction of Apoptosis by 2-Chloro-2'deoxyadenosine (2-CdA) Alone and In Combination with other Cytotoxic Drugs: Synergistic Effects on Normal and Neoplastic Lymphocytes by Addition of Doxorubicin and Mitoxantrone

Kai U. Chow Johann Wolfgang Goethe-University Hospital, Department of Medicine III, Hematology/Oncology, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
,
Mathias J. Rummel Johann Wolfgang Goethe-University Hospital, Department of Medicine III, Hematology/Oncology, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
,
Eckhart Weidmann Johann Wolfgang Goethe-University Hospital, Department of Medicine III, Hematology/Oncology, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
,
Juergen Ries Department of Medicine II, Gastroenterology, Johann Wolfgang Goethe-University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
,
Petra Jantschke Johann Wolfgang Goethe-University Hospital, Department of Medicine III, Hematology/Oncology, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
,
Simone Boehrer Johann Wolfgang Goethe-University Hospital, Department of Medicine III, Hematology/Oncology, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
,
Farsad Pourebrahim Johann Wolfgang Goethe-University Hospital, Department of Medicine III, Hematology/Oncology, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
,
Simone Napieralski Johann Wolfgang Goethe-University Hospital, Department of Medicine III, Hematology/Oncology, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
,
Juergen Stein Department of Medicine II, Gastroenterology, Johann Wolfgang Goethe-University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
,
Hans Martin Johann Wolfgang Goethe-University Hospital, Department of Medicine III, Hematology/Oncology, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
,
Dieter Hoelzer Johann Wolfgang Goethe-University Hospital, Department of Medicine III, Hematology/Oncology, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany
&
Paris S. Mitrou Johann Wolfgang Goethe-University Hospital, Department of Medicine III, Hematology/Oncology, Theodor-Stern-Kai 7, 60590, Frankfurt, GermanyCorrespondence[email protected]
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Pages 559-567 | Received 12 Jul 1999, Published online: 01 Jul 2009

Citations (13)

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Piotr Smolewski, Zbigniew Darzynkiewicz & Tadeusz Robak. (2003) Caspase-mediated Cell Death in Hematological Malignancies: Theoretical Considerations, Methods of Assessment, and Clinical Implications. Leukemia & Lymphoma 44:7, pages 1089-1104.
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Articles from other publishers (12)

Ewelina Wawryk-Gawda, Patrycja Chylińska-Wrzos, Marta Lis-Sochocka, Kamila Bulak & Barbara Jodłowska-Jędrych. (2014) Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine. The Scientific World Journal 2014, pages 1-9.
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Marian Jędrych, Ewelina Wawryk-Gawda, Barbara Jodłowska-Jędrych, Patrycja Chylińska-Wrzos & Ludwik Jasiński. (2013) Immunohistochemical evaluation of cell proliferation and apoptosis markers in ovarian surface epithelial cells of cladribine-treated rats. Protoplasma 250:5, pages 1025-1034.
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James O. Armitage, Kensei Tobinai, Dieter Hoelzer & Mathias J. Rummel. (2004) Treatment of Indolent Non-Hodgkin's Lymphoma with Cladribine as Single-Agent Therapy and in Combination with Mitoxantrone. International Journal of Hematology 79:4, pages 311-321.
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Malgorzata Rogalińska, Jerzy Z. Błoński, Margaret Hanausek, Zbigniew Walaszek, Tadeusz Robak & Zofia M. Kiliańska. (2004) 2-Chlorodeoxyadenosine alone and in combination with cyclophosphamide and mitoxantrone induce apoptosis in B chronic lymphocytic leukemia cells in vivo. Cancer Detection and Prevention 28:6, pages 433-442.
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Michela Giannecchini, Barbara D'Innocenzo, Rossana Pesi, Francesco Sgarrella, Mariacarla Iorio, Paola Collecchi, Maria Grazia Tozzi & Marcella Camici. (2003) 2′‐Deoxyadenosine causes apoptotic cell death in a human colon carcinoma cell line. Journal of Biochemical and Molecular Toxicology 17:6, pages 329-337.
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Kai Uwe Chow, Daniel Nowak, Simone Boehrer, Martin Ruthardt, Andrea Knau, Dieter Hoelzer, Paris S. Mitrou & Eckhart Weidmann. (2003) Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation. Biochemical Pharmacology 66:5, pages 711-724.
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M.J Rummel, K.U Chow, T Karakas, E Jäger, J Mezger, U von Grünhagen, K.-P Schalk, O Burkhard, M.-L Hansmann, H Ritzel, L Bergmann, D Hoelzer & P.S Mitrou. (2002) Reduced-dose cladribine (2-CdA) plus mitoxantrone is effective in the treatment of mantle-cell and low-grade non-Hodgkin's lymphoma. European Journal of Cancer 38:13, pages 1739-1746.
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T Robak & M Kasznicki. (2002) Alkylating agents and nucleoside analogues in the treatment of B cell chronic lymphocytic leukemia. Leukemia 16:6, pages 1015-1027.
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Anna Szmigielska-Kaplon, Ewa Ciesielska, Leszek Szmigiero & Tadeusz Robak. (2002) Anthracyclines potentiate activity against murine leukemias L1210 and P388 in vivo and in vitro . European Journal of Haematology 68:6, pages 370-375.
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Paweł Grieb, Jerzy Kamienowski, Monika Janisz, Piotr Kuśnierczyk, Jerzy Kawiak, Grazyna Hoser & Stanisław J. Chrapusta. (2001) Hematological Effects of Intermittent 2-Hour Infusions of Cladribine in Multiple Sclerosis Patients: A Comparison of 2 Dosage Patterns. International Journal of Hematology 74:4, pages 421-427.
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JEROME SAMPOL, BERTRAND DUSSOL, EMMANUEL FENOUILLET, CHRISTIAN CAPO, JEAN-LOUIS MEGE, GILLES HALIMI, GUY BECHIS, PHILIPPE BRUNET, HERVE ROCHAT, YVON BERLAND & REGIS GUIEU. (2001) High Adenosine and Deoxyadenosine Concentrations in Mononuclear Cells of Hemodialyzed Patients. Journal of the American Society of Nephrology 12:8, pages 1721-1728.
Crossref
Kai U Chow, Bernd Schneider, Paris S Mitrou & Eckhart Weidmann. (2001) Influence of various cytokines on the expression of CD20 on the surface of CLL-cells in vitro. Leukemia Research 25:1, pages 99-100.
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