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Original Article

VLA-4 Mediated Adhesion to Bone Marrow Stromal Cells Confers Chemoresistance to Adherent Lymphoma Cells

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Pages 631-645 | Received 17 Sep 1999, Published online: 01 Jul 2009

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Takeharu Kawaguchi, Chikako Ohwada, Masahiro Takeuchi, Naomi Shimizu, Emiko Sakaida, Yusuke Takeda, Shio Sakai, Shokichi Tsukamoto, Atsuko Yamazaki, Yasumasa Sugita, Morihiro Higashi, Kazuhisa Fujikawa, Kosei Matsue, Koutaro Yokote, Jun-Ichi Tamaru, Hideaki Bujo & Chiaki Nakaseko. (2014) Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma. Leukemia & Lymphoma 55:10, pages 2391-2394.
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Edna Cukierman & Daniel E. Bassi. (2012) The mesenchymal tumor microenvironment. Cell Adhesion & Migration 6:3, pages 285-296.
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Nina Shah, Fernando Cabanillas, Bradley McIntyre, Lei Feng, Peter McLaughlin, Maria A. Rodriguez, Jorge Romaguera, Anas Younes, Fredrick B. Hagemeister, Larry Kwak & Luis Fayad. (2012) Prognostic value of serum CD44, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 levels in patients with indolent non-Hodgkin lymphomas. Leukemia & Lymphoma 53:1, pages 50-56.
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Kevin B. L. Lin, Spencer A. Freeman & Michael R. Gold. (2010) Rap GTPase-mediated adhesion and migration. Cell Adhesion & Migration 4:3, pages 327-332.
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Jefferson W Tilley. (2008) Very late antigen-4 integrin antagonists. Expert Opinion on Therapeutic Patents 18:8, pages 841-859.
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Jefferson W Tilley. (2002) VLA-4 antagonists. Expert Opinion on Therapeutic Patents 12:7, pages 991-1008.
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Shivem B. Shah, Christopher R. Carlson, Kristine Lai, Zhe Zhong, Grazia Marsico, Katherine M. Lee, Nicole E. Félix Vélez, Elisabeth B. Abeles, Mayar Allam, Thomas Hu, Lauren D. Walter, Karen E. Martin, Khanjan Gandhi, Scott D. Butler, Rishi Puri, Angela L. McCleary-Wheeler, Wayne Tam, Olivier Elemento, Katsuyoshi Takata, Christian Steidl, David W. Scott, Lorena Fontan, Hideki Ueno, Benjamin D. Cosgrove, Giorgio Inghirami, Andrés J. García, Ahmet F. Coskun, Jean L. Koff, Ari Melnick & Ankur Singh. (2023) Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas. Nature Materials 22:4, pages 511-523.
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Ryann E. Shor, Jinxiang Dai, Sun‐Young Lee, Laura Pisarsky, Irina Matei, Serena Lucotti, David Lyden, Mina J. Bissell & Cyrus M. Ghajar. (2021) The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings. Molecular Oncology 16:1, pages 130-147.
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Lauren M. Kreps & Christina L. Addison. (2021) Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth. International Journal of Molecular Sciences 22:6, pages 2911.
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James Brandon Reinecke & Ryan David Roberts. 2020. Current Advances in the Science of Osteosarcoma. Current Advances in the Science of Osteosarcoma 111 123 .
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Sonali P. Barwe, Anthony Quagliano & Anilkumar Gopalakrishnapillai. (2017) Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia. Seminars in Oncology 44:2, pages 101-112.
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Sujan Piya, Steven M. Kornblau, Vivian R. Ruvolo, Hong Mu, Peter P. Ruvolo, Teresa McQueen, R. Eric Davis, Numsen HailJrJrHagop KantarjianMichael Andreeff & Gautam Borthakur. (2016) Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia. Blood 128:9, pages 1260-1269.
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Martin Schlesinger & Gerd Bendas. (2015) Contribution of very late antigen-4 (VLA-4) integrin to cancer progression and metastasis. Cancer and Metastasis Reviews 34:4, pages 575-591.
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Takeharu Kawaguchi, Chikako Ohwada, Masahiro Takeuchi, Naomi Shimizu, Emiko Sakaida, Yusuke Takeda, Shio Sakai, Shokichi Tsukamoto, Atsuko Yamazaki, Yasumasa Sugita, Meizi Jiang, Morihiro Higashi, Koutaro Yokote, Jun‐ichi Tamaru, Hideaki Bujo & Chiaki Nakaseko. (2013) LR11: a novel biomarker identified in follicular lymphoma. British Journal of Haematology 163:2, pages 277-280.
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Abigail Hielscher, Timothy McGuire, Dennis Weisenburger & John Graham Sharp. (2013) Matrigel modulates a stem cell phenotype and promotes tumor formation in a mantle cell lymphoma cell line. Stem Cell Discovery 03:03, pages 167-179.
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Marek Mraz, Clive S. Zent, Amy K. Church, Diane F. Jelinek, Xiaosheng Wu, Sarka Pospisilova, Stephen M. Ansell, Anne J. Novak, Neil E. Kay, Thomas E. Witzig & Grzegorz S. Nowakowski. (2011) Bone marrow stromal cells protect lymphoma B-cells from rituximab-induced apoptosis and targeting integrin α-4-β-1 (VLA-4) with natalizumab can overcome this resistance. British Journal of Haematology 155:1, pages 53-64.
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Mark S. Duxbury, Hiromichi Ito, Eric Benoit, Talat Waseem, Stanley W. Ashley & Edward E. Whang. (2005) RNA Interference Demonstrates a Novel Role for Integrin-Linked Kinase as a Determinant of Pancreatic Adenocarcinoma Cell Gemcitabine Chemoresistance. Clinical Cancer Research 11:9, pages 3433-3438.
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Dian L. Olson, Linda C. Burkly, Diane R. Leone, Brian M. Dolinski & Roy R. Lobb. (2005) Anti-α4 integrin monoclonal antibody inhibits multiple myeloma growth in a murine model. Molecular Cancer Therapeutics 4:1, pages 91-99.
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A Demirkazik, A Kessinger, JO Armitage, PJ Bierman, J Lynch, J Vose, W Chan & JG Sharp. (2001) Progenitor and lymphoma cells in blood stem cell harvests: impact on survival following transplantation. Bone Marrow Transplantation 28:2, pages 207-212.
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