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Original Article

Rearrangements of Bcl-1, Bcl-2, Bcl-6, and C-Myc in Diffuse Large B-Cell Lymphomas

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Pages 1099-1106 | Published online: 01 Jul 2009

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Thu Dang Anh Phan, Tu Thanh Duong, Diem Thi Nhu Pham, Minh Hoang Dang, Thien Thanh Ly, Hanh Thi Tuyet Ngo, Dat Quoc Ngo, Nguyen Dinh The Trinh, Uyen Le Ly, Tu Anh Thai, Ha Thi Ngoc Hua & Thao Thi Phuong Doan. (2023) A Multicenter Study of Clinicopathology and Immunohistochemical Distinction between Adult and Pediatric Large B-Cell Lymphoma. Fetal and Pediatric Pathology 42:3, pages 355-366.
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Daniel Filip & Marek Mraz. (2020) The role of MYC in the transformation and aggressiveness of ‘indolent’ B-cell malignancies. Leukemia & Lymphoma 61:3, pages 510-524.
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S. Aref, M. Fouda, E. El-Dosoky, A. Menessy, M. Mabed, M. Saleeb & K. Zalata. (2003) Lymphoproliferative Disease. Hematology 8:3, pages 183-190.
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Dongfeng Zeng, Aakash Desai, Fangfang Yan, Tiejun Gong, Haige Ye, Makhdum Ahmed, Krystle Nomie, Jorge Romaguera, Richard Champlin, Shaoying Li & Michael Wang. (2019) Challenges and Opportunities for High-grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangement (Double-hit Lymphoma). American Journal of Clinical Oncology 42:3, pages 304-316.
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Jeffrey A. Barnes, Robert Redd, David C. Fisher, Ephraim P. Hochberg, Tak Takvorian, Donna Neuberg, Eric Jacobsen & Jeremy S. Abramson. (2018) Panobinostat in combination with rituximab in heavily pretreated diffuse large B-cell lymphoma: Results of a phase II study. Hematological Oncology 36:4, pages 633-637.
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Graham W. Slack & Eric D. Hsi. 2018. Hematopathology. Hematopathology 271 305.e5 .
Lynh Nguyen, Peter Papenhausen & Haipeng Shao. (2017) The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects. Genes 8:4, pages 116.
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Zhihe Liu, Siyun Li, Wei Guo, Yinping Wang, Ming Wang & Ou Bai. (2017) MYC Gene Rearrangements Are Closely Associated with Poor Survival of Diffuse Large B Cell Lymphoma with Hepatitis B Virus Infection . BioMed Research International 2017, pages 1-7.
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Kuangguo Zhou, Danmei Xu, Yang Cao, Jue Wang, Yunfan Yang & Mei Huang. (2014) C-MYC Aberrations as Prognostic Factors in Diffuse Large B-cell Lymphoma: A Meta-Analysis of Epidemiological Studies. PLoS ONE 9:4, pages e95020.
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Olga Meltem Akay, Beyhan Durak Aras, Serap Isiksoy, Cigdem Toprak, Fezan Sahin Mutlu, Sevilhan Artan, Ulku Oner & Zafer Gulbas. (2014) BCL2, BCL6, IGH, TP53, and MYC protein expression and gene rearrangements as prognostic markers in diffuse large B-cell lymphoma: a study of 44 Turkish patients. Cancer Genetics 207:3, pages 87-93.
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Deniz Peker, Jianguo Tao & Ling Zhang. 2014. Molecular Pathology and Diagnostics of Cancer. Molecular Pathology and Diagnostics of Cancer 521 555 .
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Rebecca C. Stacy, Frederick A. Jakobiec, Martina C. Herwig, Lynn Schoenfield, Arun Singh & Hans E. Grossniklaus. (2012) Diffuse Large B-Cell Lymphoma of the Orbit: Clinicopathologic, Immunohistochemical, and Prognostic Features of 20 Cases. American Journal of Ophthalmology 154:1, pages 87-98.e1.
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Graham W. Slack, Eric D. Hsi & Randy D. Gascoyne. 2012. Hematopathology. Hematopathology 261 292 .
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Michele Roullet & Adam Bagg. (2010) The Basis and Rational Use of Molecular Genetic Testing in Mature B-cell Lymphomas. Advances in Anatomic Pathology 17:5, pages 333-358.
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Pia Fernberg, Ellen T. Chang, Kristina Duvefelt, Henrik Hjalgrim, Sandra Eloranta, Karina Meden Sørensen, Anna Porwit, Keith Humphreys, Mads Melbye & Karin Ekström Smedby. (2010) Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma. Cancer Causes & Control 21:5, pages 759-769.
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Weimin CiJose M. Polo, Leandro CerchiettiRita ShaknovichLing WangShao Ning YangKenny YePedro Farinha, Douglas E. Horsman, Randy D. Gascoyne, Olivier Elemento & Ari Melnick. (2009) The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. Blood 113:22, pages 5536-5548.
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Maria Grazia Tibiletti, Vittoria Martin, Barbara Bernasconi, Barbara Del Curto, Lorenza Pecciarini, Silvia Uccella, Giancarlo Pruneri, Maurillio Ponzoni, Luca Mazzucchelli, Giovanni Martinelli, Andrés J. Ferreri, Graziella Pinotti, Andrea Assanelli, Marta Scandurra, Claudio Doglioni, Emanuele Zucca, Carlo Capella & Francesco Bertoni. (2009) BCL2, BCL6, MYC, MALT 1, and BCL10 rearrangements in nodal diffuse large B-cell lymphomas: a multicenter evaluation of a new set of fluorescent in situ hybridization probes and correlation with clinical outcome. Human Pathology 40:5, pages 645-652.
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H A Poirel, M S Cairo, N A Heerema, J Swansbury, A Aupérin, E Launay, W G Sanger, P Talley, S L Perkins, M Raphaël, K McCarthy, R Sposto, M Gerrard, A Bernheim & C Patte. (2008) Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB/LMB 96 international study. Leukemia 23:2, pages 323-331.
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Rodney R. Miles, Martine Raphael, Keith McCarthy, Andrew Wotherspoon, Mark A. Lones, Marie J. Terrier‐Lacombe, Catherine Patte, Mary Gerrard, Anne Auperin, Richard Sposto, Virginia Davenport, Mitchell S. Cairo & Sherrie L. Perkins. (2008) Pediatric diffuse large B‐cell lymphoma demonstrates a high proliferation index, frequent c‐Myc protein expression, and a high incidence of germinal center subtype: Report of the French–American–British (FAB) international study group. Pediatric Blood & Cancer 51:3, pages 369-374.
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Yuko Nomura, Kennosuke Karube, Ritsuro Suzuki, Guo Ying, Morishige Takeshita, Shinichi Hirose, Shigeo Nakamura, Tadashi Yoshino, Masahiro Kikuchi & Koichi Ohshima. (2008) High-grade mature B-cell lymphoma with Burkitt-like morphology: Results of a clinicopathological study of 72 Japanese patients. Cancer Science 99:2, pages 246-252.
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Christian Hallermann, Christoph Niermann, Rudolf-Josef Fischer & Hans-Joachim Schulze. (2007) New prognostic relevant factors in primary cutaneous diffuse large B-cell lymphomas. Journal of the American Academy of Dermatology 56:4, pages 588-597.
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Huan-You Wang, Aaron D. Bossler, Andras Schaffer, Ewa Tomczak, Doris DiPatri, Dale M. Frank, Peter C. Nowell & Adam Bagg. (2007) A novel t(3;8)(q27;q24.1) simultaneously involving both the BCL6 and MYC genes in a diffuse large B-cell lymphoma. Cancer Genetics and Cytogenetics 172:1, pages 45-53.
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Young-Ha OhChan-Kum Park. (2006) Prognostic Evaluation of Nodal Diffuse Large B Cell Lymphoma by Immunohistochemical Profiles with Emphasis on CD138 Expression as a Poor Prognostic Factor. Journal of Korean Medical Science 21:3, pages 397.
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Megan L. Troxell, Charles D. Bangs, Athena M. Cherry, Yasodha Natkunam & Christina S. Kong. (2005) Cytologic diagnosis of Burkitt lymphoma. Cancer 105:5, pages 310-318.
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M Bai, N J Agnantis, A Skyrlas, E Tsanou, S Kamina, V Galani & P Kanavaros. (2003) Increased Expression of the bcl6 and CD10 Proteins Is Associated with Increased Apoptosis and Proliferation in Diffuse Large B-Cell Lymphomas. Modern Pathology 16:5, pages 471-480.
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Henry Y. Dong, Wojciech Gorczyca, Zach Liu, Patricia Tsang, C. Daniel Wu, Patti Cohen & James Weisberger. (2003) B-Cell Lymphomas With Coexpression of CD5 and CD10. American Journal of Clinical Pathology 119:2, pages 218-230.
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Henry Y. Dong, MD, PhD. (2003) B-Cell Lymphomas With Coexpression of CD5 and CD10. American Journal of Clinical Pathology 119:2, pages 218-230.
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Lluı́s ColomoArmando López-GuillermoMarı́a PeralesSusana RivesAntonio Martı́nezFrancesc BoschDolors ColomerBrunangelo FaliniEmili MontserratElı́as Campo. (2003) Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma. Blood 101:1, pages 78-84.
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