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Leukemia & Lymphoma Volume 50, 2009 - Issue 12
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Original Articles: Clinical

A phase I/II dose escalation study of apolizumab (Hu1D10) using a stepped-up dosing schedule in patients with chronic lymphocytic leukemia and acute leukemia

Thomas S. LinDivision of Hematology and Oncology, The Ohio State University, Columbus, OH, USA
,
Wendy StockDivision of Hematology and Oncology, University of Chicago, Chicago, IL, USA
,
Huiping XuDivision of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA
,
Mitch A. PhelpsDivision of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA
,
Margaret S. LucasDivision of Hematology and Oncology, The Ohio State University, Columbus, OH, USA
,
Sara K. GusterDivision of Hematology and Oncology, The Ohio State University, Columbus, OH, USA
,
Bruce R. BriggsDepartment of Pathology, The Ohio State University, Columbus, OH, USA
,
Carolyn CheneyDivision of Hematology and Oncology, The Ohio State University, Columbus, OH, USA
,
Pierluigi PorcuDivision of Hematology and Oncology, The Ohio State University, Columbus, OH, USA
,
Ian W. FlinnSarah Cannon Research Institute, Nashville, TN, USA
,
Michael R. GreverDivision of Hematology and Oncology, The Ohio State University, Columbus, OH, USA
,
James T. DaltonDivision of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA
&
John C. ByrdDivision of Hematology and Oncology, The Ohio State University, Columbus, OH, USACorrespondence[email protected]
 show all
Pages 1958-1963 | Received 05 May 2009, Accepted 13 Jul 2009, Published online: 30 Sep 2009

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Rod Balhorn, Monique Cosman Balhorn, Karuppiah Balakrishnan & Robert B. Rebhun. (2020) The small molecule antibody mimic SH7139 targets a family of HLA-DRs expressed by B-cell lymphomas and other solid cancers. Journal of Drug Targeting 28:10, pages 1124-1136.
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Chadi Nabhan, Neil Dalal, Jayesh Mehta & Neil E. Kay. (2011) Biologic agent activity in chronic lymphocytic leukemia: a framework for future therapies. Leukemia & Lymphoma 52:3, pages 374-386.
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Jon E. Arnason & Jennifer R. Brown. (2015) Targeted Therapy for Chronic Lymphocytic Leukemia: Current Status and Future Directions. Drugs 75:2, pages 143-155.
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Deborah M. Stephens & John C. Byrd. (2013) Improving the Treatment Outcome of Patients with Chronic Lymphocytic Leukemia Through Targeted Antibody Therapy. Hematology/Oncology Clinics of North America 27:2, pages 303-327.
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Carmen D. Schweighofer, Armin Tuchscherer, Sabine Sperka, Thorsten Meyer, Benno Rattel, Sandra Stein, Semra Ismail, Thomas Elter, Peter Staib, Marcel Reiser & Michael Hallek. (2012) Clinical safety and pharmacological profile of the HLA-DR antibody 1D09C3 in patients with B cell chronic lymphocytic leukemia and lymphoma: results from a phase I study. Cancer Immunology, Immunotherapy 61:12, pages 2367-2373.
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Matthew Barth, Elizabeth Raetz & Mitchell S. Cairo. (2012) The future role of monoclonal antibody therapy in childhood acute leukaemias. British Journal of Haematology 159:1, pages 3-17.
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Felix Braun, Thomas Becker, Lutz Renders & Burckhardt Ringe. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
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Sarah E. M. Herman, Amber L. Gordon, Erin Hertlein, Asha Ramanunni, Xiaoli ZhangSamantha Jaglowski, Joseph Flynn, Jeffrey Jones, Kristie A. Blum, Joseph J. Buggy, Ahmed Hamdy, Amy J. Johnson & John C. Byrd. (2011) Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood 117:23, pages 6287-6296.
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