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Leukemia & Lymphoma Volume 51, 2010 - Issue 2
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Original Articles: Clinical

Kinase domain mutations of BCR-ABL identified at diagnosis before imatinib-based therapy are associated with progression in patients with high Sokal risk chronic phase chronic myeloid leukemia

Angelo M. CarellaDepartment of Hematology, Azienda Ospedaliera Universitaria San Martino, L.go R. Benzi 10, 16132 Genova, ItalyCorrespondence[email protected]
,
Anna GarutiDepartment of Hematology, Azienda Ospedaliera Universitaria San Martino, L.go R. Benzi 10, 16132 Genova, Italy
,
Gabriella CirmenaDepartment of Hematology, Azienda Ospedaliera Universitaria San Martino, L.go R. Benzi 10, 16132 Genova, Italy
,
Gioacchino CataniaDepartment of Hematology, Azienda Ospedaliera Universitaria San Martino, L.go R. Benzi 10, 16132 Genova, Italy
,
Ilaria RoccoDepartment of Hematology, Azienda Ospedaliera Universitaria San Martino, L.go R. Benzi 10, 16132 Genova, Italy
,
Claudia PalermoDepartment of Hematology, Azienda Ospedaliera Universitaria San Martino, L.go R. Benzi 10, 16132 Genova, Italy
,
Gianmatteo PicaDepartment of Hematology, Azienda Ospedaliera Universitaria San Martino, L.go R. Benzi 10, 16132 Genova, Italy
,
Ivana PierriDepartment of Hematology, Azienda Ospedaliera Universitaria San Martino, L.go R. Benzi 10, 16132 Genova, Italy
,
Maurizio MiglinoDepartment of Hematology, Azienda Ospedaliera Universitaria San Martino, L.go R. Benzi 10, 16132 Genova, Italy
,
Alberto BallestreroDepartment of Hematology, Azienda Ospedaliera Universitaria San Martino, L.go R. Benzi 10, 16132 Genova, Italy
,
Marco GobbiDepartment of Hematology, Azienda Ospedaliera Universitaria San Martino, L.go R. Benzi 10, 16132 Genova, Italy
&
Franco PatroneDepartment of Hematology, Azienda Ospedaliera Universitaria San Martino, L.go R. Benzi 10, 16132 Genova, Italy
 show all
Pages 275-278 | Received 22 Sep 2009, Accepted 21 Nov 2009, Published online: 28 Dec 2009

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Lingyun Geng & Xin Wang. (2015) New insight into hedgehog signaling in hematological malignancies. Leukemia & Lymphoma 56:4, pages 858-865.
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Nicholas J. Short, Jayastu Senapati & Elias Jabbour. (2023) An Update on the Management of Advanced Phase Chronic Myeloid Leukemia. Current Hematologic Malignancy Reports 18:6, pages 234-242.
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Stephen E. Langabeer, Stuart Macleod, Úna Bhreathnach & Kamal Fadalla. (2023) Imatinib Resistance in Chronic Myeloid Leukemia Associated with a D363G BCR::ABL1 Kinase Domain Mutation. Case Reports in Hematology 2023, pages 1-2.
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Jayastu Senapati, Elias Jabbour, Hagop Kantarjian & Nicholas J. Short. (2022) Pathogenesis and management of accelerated and blast phases of chronic myeloid leukemia. Leukemia 37:1, pages 5-17.
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Federico Lussana, Tamara Intermesoli, Paola Stefanoni & Alessandro Rambaldi. 2018. Mechanisms of Drug Resistance in Cancer Therapy. Mechanisms of Drug Resistance in Cancer Therapy 231 250 .
TaeHyung Kim, Marc S. TyndelHyeoung Joon Kim, Jae-Sook Ahn, Seung Hyun ChoiHee Jeong ParkYeo-kyeoung KimSoo Young KimJeffrey H. Lipton, Zhaolei Zhang & Dennis (Dong Hwan) Kim. (2017) Spectrum of somatic mutation dynamics in chronic myeloid leukemia following tyrosine kinase inhibitor therapy. Blood 129:1, pages 38-47.
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D W Woessner, A M Eiring, B J Bruno, M S Zabriskie, K R Reynolds, G D Miller, T O'Hare, M W Deininger & C S Lim. (2015) A coiled-coil mimetic intercepts BCR-ABL1 dimerization in native and kinase-mutant chronic myeloid leukemia. Leukemia 29:8, pages 1668-1675.
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Naval Daver, Jorge Cortes, Farhad Ravandi, Keyur P. Patel, Jan A. Burger, Marina Konopleva & Hagop Kantarjian. (2015) Secondary mutations as mediators of resistance to targeted therapy in leukemia. Blood 125:21, pages 3236-3245.
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Eran Eyal, Tali Tohami, Amnon Amir, Karen Cesarkas, Jasmine Jacob‐Hirsch, Yuliya Volchek, Arnon Nagler, Gideon Rechavi & Ninette Amariglio. (2012) Detection of BCR ‐ ABL 1 mutations in chronic myeloid leukaemia by massive parallel sequencing . British Journal of Haematology 160:4, pages 477-486.
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Stefania Aliano, Gabriella Cirmena, Giuseppina Fugazza, Roberto Bruzzone, Claudia Palermo & Mario Sessarego. (2013) Standard and variant Philadelphia translocation in a CML patient with different sensitivity to imatinib therapy. Leukemia Research Reports 2:2, pages 75-78.
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Wanwisa Wongboonma, Wanna Thongnoppakhun & Chirayu U. Auewarakul. (2012) BCR-ABL kinase domain mutations in tyrosine kinase inhibitors-naïve and -exposed Southeast Asian chronic myeloid leukemia patients. Experimental and Molecular Pathology 92:2, pages 259-265.
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Marie P. ShiehMasato MitsuhashiMichael Lilly. (2011) Moving on up: Second-Line Agents as Initial Treatment for Newly-Diagnosed Patients with Chronic Phase CML. Clinical Medicine Insights: Oncology 5, pages CMO.S6416.
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A. M. Carella. (2010) Hypothesis: upfront use of ABL kinase inhibitor combination, either simultaneously or sequentially, in high-risk Ph+ leukemias?. Annals of Hematology 89:6, pages 531-533.
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