645
Views
62
CrossRef citations to date
0
Altmetric
Original Articles: Research

Involvement of neutrophils and natural killer cells in the anti-tumor activity of alemtuzumab in xenograft tumor models

, , , , , , , & show all
Pages 1293-1304 | Received 24 Nov 2009, Accepted 12 Mar 2010, Published online: 08 Apr 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Shiho Ito, Kyoko Miwa, Chiharu Hattori, Tetsuo Aida, Yoshimi Tsuchiya & Kazuhiko Mori. (2021) Highly sensitive in vitro cytokine release assay incorporating high-density preculture. Journal of Immunotoxicology 18:1, pages 136-143.
Read now
Nada S. Alakhras, Jiabin Qiu, Guilherme V. Rocha, Derrick R. Witcher, Anja Koester, Jinsam You, David A. Schaer, Rikke B. Holmgaard, Kyla Driscoll, Jeffrey A. Willy & Laurent P. Malherbe. (2018) FcγRIIIa-dependent IFN-γ release in whole blood assay is predictive of therapeutic IgG1 antibodies safety. mAbs 10:6, pages 913-921.
Read now
Stefanie Derer, Pia Glorius, Martin Schlaeth, Stefan Lohse, Katja Klausz, Umesh Muchhal, John R Desjarlais, Andreas Humpe, Thomas Valerius & Matthias Peipp. (2014) Increasing FcγRIIa affinity of an FcγRIII-optimized anti-EGFR antibody restores neutrophil-mediated cytotoxicity. mAbs 6:2, pages 409-421.
Read now
Clive S. Zent, Wenting Wu, Deborah A. Bowen, Curtis A. Hanson, Adam M. Pettinger, Tait D. Shanafelt, Neil E. Kay, Jose F. Leis & Timothy G. Call. (2013) Addition of granulocyte macrophage colony stimulating factor does not improve response to early treatment of high-risk chronic lymphocytic leukemia with alemtuzumab and rituximab. Leukemia & Lymphoma 54:3, pages 476-482.
Read now
Tri-Hung Nguyen, Evis Havari, Rajashree McLaren, Mindy Zhang, Yide Jiang, Stephen L. Madden, Bruce Roberts, Johanne Kaplan & Srinivas Shankara. (2012) Alemtuzumab induction of intracellular signaling and apoptosis in malignant B lymphocytes. Leukemia & Lymphoma 53:4, pages 699-709.
Read now
Yanping Hu, Matthew Gale, Jacqueline Shields, Carrie Garron, Mark Swistak, Tri-Hung Nguyen, Gary Jacques, Robert Fogle, William Siders & Johanne Kaplan. (2012) Enhancement of the anti-tumor activity of therapeutic monoclonal antibodies by CXCR4 antagonists. Leukemia & Lymphoma 53:1, pages 130-138.
Read now

Articles from other publishers (56)

Federica R. Achini-Gutzwiller, Marco W. Schilham, Erik G. J. von Asmuth, Anja M. Jansen-Hoogendijk, Cornelia M. Jol-van der Zijde, Maarten J. D. van Tol, Robbert G. M. Bredius, Tayfun Güngör, Arjan C. Lankester & Dirk Jan A. R. Moes. (2023) Exposure-response analysis of alemtuzumab in pediatric allogeneic HSCT for nonmalignant diseases: the ARTIC study. Blood Advances 7:16, pages 4462-4474.
Crossref
Wencheng Zhou, Xinran Cao, Qiang Xu, Jiao Qu & Yang Sun. (2023) The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers. MedComm 4:4.
Crossref
Leonie M. Behrens, Marjolein van Egmond & Timo K. van den Berg. (2022) Neutrophils as immune effector cells in antibody therapy in cancer. Immunological Reviews 314:1, pages 280-301.
Crossref
Sacha Zinn, Rodrigo Vazquez-Lombardi, Carsten Zimmermann, Puja Sapra, Lutz Jermutus & Daniel Christ. (2023) Advances in antibody-based therapy in oncology. Nature Cancer 4:2, pages 165-180.
Crossref
Leonie M. Behrens, Timo K. van den Berg & Marjolein van Egmond. (2022) Targeting the CD47-SIRPα Innate Immune Checkpoint to Potentiate Antibody Therapy in Cancer by Neutrophils. Cancers 14:14, pages 3366.
Crossref
Nima Rezaei, Mona Sadeghalvad & Hamid-Reza Mohammadi-Motlagh. 2022. Encyclopedia of Infection and Immunity. Encyclopedia of Infection and Immunity 1 13 .
Yanchao Wang, Chen Zheng, Chao Zhuang, Qiang Fu, Jinyan Qin, Baohong Zhang, Yanling Bian, Nianmin Qi & Jianwei Zhu. (2021) Preclinical pharmacology and toxicology evaluation of an anti-CD52 monoclonal antibody produced by perfusion fermentation process. Journal of Industrial Microbiology and Biotechnology.
Crossref
Mandy Gruijs, Celine A.N. Sewnath & Marjolein van Egmond. (2021) Therapeutic exploitation of neutrophils to fight cancer. Seminars in Immunology 57, pages 101581.
Crossref
Marie Siwicki & Mikael J. Pittet. (2021) Versatile neutrophil functions in cancer. Seminars in Immunology 57, pages 101538.
Crossref
Kaixin Du, Yulu Li, Juan Liu, Wei Chen, Zhizhong Wei, Yong Luo, Huisi Liu, Yonghe Qi, Fengchao Wang & Jianhua Sui. (2021) A bispecific antibody targeting GPC3 and CD47 induced enhanced antitumor efficacy against dual antigen-expressing HCC. Molecular Therapy 29:4, pages 1572-1584.
Crossref
Natasha Ustyanovska Avtenyuk, Nienke Visser, Edwin Bremer & Valerie R. Wiersma. (2020) The Neutrophil: The Underdog That Packs a Punch in the Fight against Cancer. International Journal of Molecular Sciences 21:21, pages 7820.
Crossref
Charita Furumaya, Paula Martinez-Sanz, Panagiota Bouti, Taco W. Kuijpers & Hanke L. Matlung. (2020) Plasticity in Pro- and Anti-tumor Activity of Neutrophils: Shifting the Balance. Frontiers in Immunology 11.
Crossref
Yohannes Haile, Adeolu Adegoke, Bahareh Laribi, Jiaxin Lin & Colin C. Anderson. (2020) Anti‐CD52 blocks EAE independent of PD‐1 signals and promotes repopulation dominated by double‐negative T cells and newly generated T and B cells. European Journal of Immunology 50:9, pages 1362-1373.
Crossref
Belén P. Solans, Robert Chiesa, Bilyana Doncheva, Helen Prunty, Paul Veys, Iñaki F. Trocóniz & Joseph F. Standing. (2020) Modelling of neutrophil dynamics in children receiving busulfan or treosulfan for haematopoietic stem cell transplant conditioning. British Journal of Clinical Pharmacology 86:8, pages 1537-1549.
Crossref
Louise W. Treffers, Toine ten Broeke, Thies Rösner, J.H. Marco Jansen, Michel van Houdt, Steffen Kahle, Karin Schornagel, Paul J.J.H. Verkuijlen, Jan M. Prins, Katka Franke, Taco W. Kuijpers, Timo K. van den Berg, Thomas Valerius, Jeanette H.W. Leusen & Hanke L. Matlung. (2020) IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47–SIRPα Checkpoint Inhibition. Cancer Immunology Research 8:1, pages 120-130.
Crossref
Maryam Ebadi, Mohammad Amin Sadeghi, Nishitha M. Reddy & Nima Rezaei. 2020. Cancer Immunology. Cancer Immunology 159 212 .
A. Brú, R. Bosch, M. V. Céspedes, S. Carmona-Güedes, E. Pascual, I. Brú & J. C. Souto. (2019) Antitumoral effect of maintained neutrophilia induced by rhG-CSF in a murine model of pancreatic cancer. Scientific Reports 9:1.
Crossref
Louise W. Treffers, Michel van Houdt, Christine W. Bruggeman, Marieke H. Heineke, Xi Wen Zhao, Joris van der Heijden, Sietse Q. Nagelkerke, Paul J. J. H. Verkuijlen, Judy Geissler, Suzanne Lissenberg-Thunnissen, Thomas Valerius, Matthias Peipp, Katka Franke, Robin van Bruggen, Taco W. Kuijpers, Marjolein van Egmond, Gestur Vidarsson, Hanke L. Matlung & Timo K. van den Berg. (2019) FcγRIIIb Restricts Antibody-Dependent Destruction of Cancer Cells by Human Neutrophils. Frontiers in Immunology 9.
Crossref
Xiaomo Wu, Zhongkai Gu, Yang Chen, Borui Chen, Wei Chen, Liqiang Weng & Xiaolong Liu. (2019) Application of PD-1 Blockade in Cancer Immunotherapy. Computational and Structural Biotechnology Journal 17, pages 661-674.
Crossref
Antonio Brú, David Gómez-Castro, Luis Vila, Isabel Brú & Juan Carlos Souto. (2018) Study of tumor growth indicates the existence of an “immunological threshold” separating states of pro- and antitumoral peritumoral inflammation. PLOS ONE 13:11, pages e0202823.
Crossref
Niels Heemskerk & Marjolein van Egmond. (2018) Monoclonal antibody-mediated killing of tumour cells by neutrophils. European Journal of Clinical Investigation 48, pages e12962.
Crossref
Emre Bilgin, Abdulsamet Erden & Ömer Dizdar. (2018) Familial Mediterranean Fever: New Insights Into Cancer Immunoprevention? Comment on the Article by Brenner et al. Arthritis & Rheumatology 70:7, pages 1167-1167.
Crossref
Hanke L. Matlung, Liane Babes, Xi Wen Zhao, Michel van Houdt, Louise W. Treffers, Dieke J. van Rees, Katka Franke, Karin Schornagel, Paul Verkuijlen, Hans Janssen, Pasi Halonen, Cor Lieftink, Roderick L. Beijersbergen, Jeanette H.W. Leusen, Jaap J. Boelens, Ingrid Kuhnle, Jutte van der Werff Ten Bosch, Karl Seeger, Sergio Rutella, Daria Pagliara, Takashi Matozaki, Eiji Suzuki, Catharina Willemien Menke-van der Houven van Oordt, Robin van Bruggen, Dirk Roos, Rene A.W. van Lier, Taco W. Kuijpers, Paul Kubes & Timo K. van den Berg. (2018) Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis. Cell Reports 23:13, pages 3946-3959.e6.
Crossref
Kelly D. Moynihan & Darrell J. Irvine. (2017) Roles for Innate Immunity in Combination Immunotherapies. Cancer Research 77:19, pages 5215-5221.
Crossref
Dan Li, Wenhui He, Ximing Liu, Sanduo Zheng, Yonghe Qi, Huiyu Li, Fengfeng Mao, Juan Liu, Yinyan Sun, Lijing Pan, Kaixin Du, Keqiong Ye, Wenhui Li & Jianhua Sui. (2017) A potent human neutralizing antibody Fc-dependently reduces established HBV infections. eLife 6.
Crossref
Thomas A. Rasmussen, James McMahon, J. Judy Chang, Jori Symons, Michael Roche, Ashanti Dantanarayana, Afam Okoye, Bonnie Hiener, Sarah Palmer, Wen Shi Lee, Stephen J. Kent, Carrie Van Der Weyden, H. Miles Prince, Paul U. Cameron & Sharon R. Lewin. (2017) Impact of alemtuzumab on HIV persistence in an HIV-infected individual on antiretroviral therapy with Sezary syndrome. AIDS 31:13, pages 1839-1845.
Crossref
Yang Zhao, Huiting Su, Xiaofei Shen, Junfeng Du, Xiaodong Zhang & Yong Zhao. (2017) The immunological function of CD52 and its targeting in organ transplantation. Inflammation Research 66:7, pages 571-578.
Crossref
Hanke L. Matlung, Katka Szilagyi, Neil A. Barclay & Timo K. van den Berg. (2017) The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer. Immunological Reviews 276:1, pages 145-164.
Crossref
Courtney S. Casserly, Julia C. Nantes, Ryder F. Whittaker Hawkins & Luc Vallières. (2017) Neutrophil perversion in demyelinating autoimmune diseases: Mechanisms to medicine. Autoimmunity Reviews 16:3, pages 294-307.
Crossref
Dieke J. van Rees, Katka Szilagyi, Taco W. Kuijpers, Hanke L. Matlung & Timo K. van den Berg. (2016) Immunoreceptors on neutrophils. Seminars in Immunology 28:2, pages 94-108.
Crossref
Grzegorz Stasiłojć, Anders Österborg, Anna M. Blom & Marcin Okrój. (2016) New perspectives on complement mediated immunotherapy. Cancer Treatment Reviews 45, pages 68-75.
Crossref
Agnieszka Swierczak, Kellie A. Mouchemore, John A. Hamilton & Robin L. Anderson. (2015) Neutrophils: important contributors to tumor progression and metastasis. Cancer and Metastasis Reviews 34:4, pages 735-751.
Crossref
S. Vessillier, D. Eastwood, B. Fox, J. Sathish, S. Sethu, T. Dougall, S.J. Thorpe, R. Thorpe & R. Stebbings. (2015) Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials — Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm. Journal of Immunological Methods 424, pages 43-52.
Crossref
Eric?F. Zhu, Shuning?A. Gai, Cary?F. Opel, Byron?H. Kwan, Rishi Surana, Martin?C. Mihm, Monique?J. Kauke, Kelly?D. Moynihan, Alessandro Angelini, Robert?T. Williams, Matthias?T. Stephan, Jacob?S. Kim, Michael?B. Yaffe, Darrell?J. Irvine, Louis?M. Weiner, Glenn Dranoff & K.?Dane Wittrup. (2015) Synergistic Innate and Adaptive Immune Response to Combination Immunotherapy with Anti-Tumor Antigen Antibodies and Extended Serum Half-Life IL-2. Cancer Cell 27:4, pages 489-501.
Crossref
Rei WatanabeAhmed GehadChao YangLaura L. ScottJessica E. TeagueChristoph SchlapbachChristopher P. ElcoVictor HuangTiago R. MatosThomas S. KupperRachael A. Clark. (2015) Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells. Science Translational Medicine 7:279.
Crossref
Andrew C. Cannon & Fausto R. LoberizaJr.Jr.. (2015) Review of Antibody-Based Immunotherapy in the Treatment of Non-Hodgkin Lymphoma and Patterns of Use. Clinical Lymphoma Myeloma and Leukemia 15:3, pages 129-138.
Crossref
Maryam Ebadi, Nishitha M. Reddy & Nima Rezaei. 2015. Cancer Immunology. Cancer Immunology 135 183 .
Gregor Hoermann, Katharina Blatt, Georg Greiner, Eva Maria Putz, Angelika Berger, Harald Herrmann, Sabine Cerny‐Reiterer, Karoline V. Gleixner, Christoph Walz, Konrad Hoetzenecker, Leonhard Müllauer, Andreas Reiter, Karl Sotlar, Veronika Sexl, Peter Valent & Matthias Mayerhofer. (2014) CD52 is a molecular target in advanced systemic mastocytosis. The FASEB Journal 28:8, pages 3540-3551.
Crossref
Sarah I. Jawed, Patricia L. Myskowski, Steven Horwitz, Alison Moskowitz & Christiane Querfeld. (2014) Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome). Journal of the American Academy of Dermatology 70:2, pages 223.e1-223.e17.
Crossref
Rens Braster, Tom O’Toole & Marjolein van Egmond. (2014) Myeloid cells as effector cells for monoclonal antibody therapy of cancer. Methods 65:1, pages 28-37.
Crossref
Marije B. Overdijk, Sandra Verploegen, Wim K. Bleeker & Paul W.H.I. Parren. 2014. Antibody Fc. Antibody Fc 239 255 .
Jantine E. Bakema & Marjolein van Egmond. 2014. Fc Receptors. Fc Receptors 373 392 .
Norbert-Claude Gorin, Françoise Isnard, Laurent Garderet, Souhila Ikhlef, Selim Corm, Bruno Quesnel, Ollivier Legrand, Marine Cachanado, Alexandra Rousseau & Jean-Philippe Laporte. (2013) Administration of alemtuzumab and G-CSF to adults with relapsed or refractory acute lymphoblastic leukemia: results of a phase II study. European Journal of Haematology, pages n/a-n/a.
Crossref
Marjolein van Egmond & Jantine E. Bakema. (2013) Neutrophils as effector cells for antibody-based immunotherapy of cancer. Seminars in Cancer Biology 23:3, pages 190-199.
Crossref
Hua Zhang & A.S. Verkman. (2013) Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica. Journal of Clinical Investigation 123:5, pages 2306-2316.
Crossref
Xuewen Deng, Hiroshi Terunuma, Mie Nieda, Weihua Xiao & Andrew Nicol. (2012) Synergistic cytotoxicity of ex vivo expanded natural killer cells in combination with monoclonal antibody drugs against cancer cells. International Immunopharmacology 14:4, pages 593-605.
Crossref
Peter J Bugelski & Pauline L Martin. (2012) Concordance of preclinical and clinical pharmacology and toxicology of therapeutic monoclonal antibodies and fusion proteins: cell surface targets. British Journal of Pharmacology 166:3, pages 823-846.
Crossref
Julien Ratelade, Hua Zhang, Samira Saadoun, Jeffrey L. Bennett, Marios C. Papadopoulos & A. S. Verkman. (2012) Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss. Acta Neuropathologica 123:6, pages 861-872.
Crossref
Amr Ahmed Nassar. (2012) Haploidentical Stem Cell Transplantation. Hematology/Oncology and Stem Cell Therapy 5:2, pages 73-83.
Crossref
Rachael A. ClarkRei WatanabeJessica E. TeagueChristoph SchlapbachMarianne C. TawaNatalie AdamsAndrew A. DorosarioKeri S. ChaneyCorey S. CutlerNicole R. LeBoeufJoi B. CarterDavid C. FisherThomas S. Kupper. (2012) Skin Effector Memory T Cells Do Not Recirculate and Provide Immune Protection in Alemtuzumab-Treated CTCL Patients. Science Translational Medicine 4:117.
Crossref
Douglas Côbo MicheliPaulo Cesar FernandesJrJrJoão Celso Garcia CruvinelIsabela Destro NomeliniEddie Fernando Candido MurtaBeatriz Martins Tavares-Murta. (2012) Circulating Cytokines and Nitric Oxide are Involved in the Inhibition of Neutrophil Migration in Patients with Uterine Cervical Neoplasia. Clinical Medicine Insights: Oncology 6, pages CMO.S9518.
Crossref
. 2012. Therapeutic Antibody Engineering. Therapeutic Antibody Engineering 405 595 .
. 2012. Therapeutic Antibody Engineering. Therapeutic Antibody Engineering 459 595 .
Raoul Tibes & Pierre Noel. (2011) Activity of Alemtuzumab in Acute Myelogenous Leukemia and Myelodysplastic Syndrome With Chromosome 7 Aberrations. Journal of Clinical Oncology 29:36, pages 4841-4842.
Crossref
Kathleen S. Neff, Susan M. Richards, John M. Williams, Richard D. Garman & Melanie C. Ruzek. (2011) Murine Antithymocyte Globulin T-Cell Depletion Is Mediated Predominantly by Macrophages, but the Fas/FasL Pathway Selectively Targets Regulatory T Cells. Transplantation 92:5, pages 523-528.
Crossref
Robert O. Dillman. (2011) Cancer Immunotherapy. Cancer Biotherapy and Radiopharmaceuticals 26:1, pages 1-64.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.