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Leukemia & Lymphoma Volume 52, 2011 - Issue sup1
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Chronic myeloid leukemia cells refractory/resistant to tyrosine kinase inhibitors are genetically unstable and may cause relapse and malignant progression to the terminal disease state

Tomasz SkorskiDepartment of Microbiology and Immunology, School of Medicine, Temple University, Philadelphia, Pennsylvania, USACorrespondence[email protected]
Pages 23-29 | Received 17 Aug 2010, Accepted 18 Aug 2010, Published online: 08 Feb 2011

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Lulu Wang, Li Li, Rongrong Chen, Xianbo Huang & Xiujin Ye. (2021) Understanding and Monitoring Chronic Myeloid Leukemia Blast Crisis: How to Better Manage Patients. Cancer Management and Research 13, pages 4987-5000.
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Sylwia Flis & Tomasz Chojnacki. (2019) Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities. Drug Design, Development and Therapy 13, pages 825-843.
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Melanie T. Rebechi & Keith W. Pratz. (2017) Genomic instability is a principle pathologic feature of FLT3 ITD kinase activity in acute myeloid leukemia leading to clonal evolution and disease progression. Leukemia & Lymphoma 58:9, pages 2040-2050.
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Runzhe Chen & Baoan Chen. (2015) The role of dasatinib in the management of chronic myeloid leukemia. Drug Design, Development and Therapy 9, pages 773-779.
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Krzysztof Flis, David Irvine, Mhairi Copland, Ravi Bhatia & Tomasz Skorski. (2012) Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation. Leukemia & Lymphoma 53:12, pages 2474-2478.
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Emanuela Andretta, Caterina Costa, Consiglia Longobardi, Sara Damiano, Antonio Giordano, Francesco Pagnini, Serena Montagnaro, Massimiliano Quintiliani, Chiara Lauritano & Roberto Ciarcia. (2021) Potential Approaches Versus Approved or Developing Chronic Myeloid Leukemia Therapy. Frontiers in Oncology 11.
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George Sgouros, Wesley E. Bolch, Arturo Chiti, Yuni K. Dewaraja, Dimitris Emfietzoglou, Robert F. Hobbs, Mark Konijnenberg, Katarina Sjögreen-Gleisner, Lidia Strigari, Tzu-Chen Yen & Roger W. Howell. (2022) ICRU REPORT 96, Dosimetry-Guided Radiopharmaceutical Therapy. Journal of the ICRU 21:1, pages 1-212.
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Bilal Abdulmawjood, Beatriz Costa, Catarina Roma-Rodrigues, Pedro V. Baptista & Alexandra R. Fernandes. (2021) Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?. International Journal of Molecular Sciences 22:22, pages 12516.
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Raquel Alves, Ana Cristina Gonçalves, Sergio Rutella, António M. Almeida, Javier De Las Rivas, Ioannis P. Trougakos & Ana Bela Sarmento Ribeiro. (2021) Resistance to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia—From Molecular Mechanisms to Clinical Relevance. Cancers 13:19, pages 4820.
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Christine J. Ye, Zachary Sharpe & Henry H. Heng. (2020) Origins and Consequences of Chromosomal Instability: From Cellular Adaptation to Genome Chaos-Mediated System Survival. Genes 11:10, pages 1162.
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Sylwia Flis, Ewelina Bratek, Tomasz Chojnacki, Marlena Piskorek & Tomasz Skorski. (2019) Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinase Exerts Synergistic Effect against Chronic Myeloid Leukemia Cells. Cancers 11:10, pages 1544.
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. 2019. Genome Chaos. Genome Chaos 489 533 .
Christophe Desterke, Maud Voldoire, Marie-Laure Bonnet, Nathalie Sorel, Sarah Pagliaro, Hind Rahban, Annelise Bennaceur-Griscelli, Emilie Cayssials, Jean-Claude Chomel & Ali G. Turhan. (2018) Experimental and integrative analyses identify an ETS1 network downstream of BCR-ABL in chronic myeloid leukemia (CML). Experimental Hematology 64, pages 71-83.e8.
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George Sgouros & David M. Goldenberg. (2014) Radiopharmaceutical therapy in the era of precision medicine. European Journal of Cancer 50:13, pages 2360-2363.
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Hongjie Shen, Zixing Chen, Xin Ding, Xiaofei Qi, Jiannong Cen, Yuanyuan Wang, Li Yao & Yan Chen. (2014) BMI1 reprogrammes histone acetylation and enhances c‐fos pathway via directly binding to Zmym3 in malignant myeloid progression . Journal of Cellular and Molecular Medicine 18:6, pages 1004-1017.
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George SgourosRobert F. HobbsDiane S. Abou. (2014) The Role of Preclinical Models in Radiopharmaceutical Therapy. American Society of Clinical Oncology Educational Book:34, pages e121-e125.
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George Sgouros & Robert F. Hobbs. (2014) Dosimetry for Radiopharmaceutical Therapy. Seminars in Nuclear Medicine 44:3, pages 172-178.
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Hans-Peter Kantner, Wolfgang Warsch, Alessio Delogu, Eva Bauer, Harald Esterbauer, Emilio Casanova, Veronika Sexl & Dagmar Stoiber. (2013) ETV6/RUNX1 Induces Reactive Oxygen Species and Drives the Accumulation of DNA Damage in B Cells. Neoplasia 15:11, pages 1292-IN28.
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Tomasz Stoklosa, Eliza Glodkowska-Mrowka, Grazyna Hoser, Magdalena Kielak, Ilona Seferynska & Pawel Wlodarski. (2013) Diverse mechanisms of mTOR activation in chronic and blastic phase of chronic myelogenous leukemia. Experimental Hematology 41:5, pages 462-469.
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Steven D. Horne, Joshua B. Stevens, Batoul Y. Abdallah, Guo Liu, Steven W. Bremer, Christine J. Ye & Henry H.Q. Heng. (2012) Why imatinib remains an exception of cancer research. Journal of Cellular Physiology 228:4, pages 665-670.
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A Slupianek, R Falinski, P Znojek, T Stoklosa, S Flis, V Doneddu, D Pytel, E Synowiec, J Blasiak, A Bellacosa & T Skorski. (2012) BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability. Leukemia 27:3, pages 629-634.
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Felix Nwajei & Marina Konopleva. (2013) The Bone Marrow Microenvironment as Niche Retreats for Hematopoietic and Leukemic Stem Cells. Advances in Hematology 2013, pages 1-8.
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Teresa de Souza Fernandez, Cecilia de Souza Fernandez & André Luiz Mencalha. (2013) Human Induced Pluripotent Stem Cells from Basic Research to Potential Clinical Applications in Cancer. BioMed Research International 2013, pages 1-11.
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Seonyang Park, Youngil Koh, Seung-Hyun Jung & Yeun-Jun Chung. 2013. Array Comparative Genomic Hybridization. Array Comparative Genomic Hybridization 55 68 .
Wen Chun Juan & S. Tiong Ong. 2012. Protein Phosphorylation in Health and Disease. Protein Phosphorylation in Health and Disease 107 142 .
Tariq I. Mughal, Jerald P. Radich, Richard A. Van Etten, Alfonso Quintás‐Cardama, Tomasz Skorski, Farhad Ravandi, Daniel J. DeAngelo, Carlo Gambacorti‐Passerini, Giovanni Martinelli & Ayalew Tefferi. (2011) Chronic myeloid leukemia 2011: Successes, challenges, and strategies—Proceedings of the 5th annual BCR‐ABL1 positive and BCR‐ABL1 negative myeloproliferative neoplasms workshop. American Journal of Hematology 86:9, pages 811-819.
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Mark D. Vincent. 2011. 283 350 .

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