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Myelodysplastic syndromes: the role of the immune system in pathogenesis

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Pages 2045-2049 | Received 14 Feb 2011, Accepted 20 Apr 2011, Published online: 12 Jun 2011

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Zheng Zhang, Chun-Kang Chang, Qi He, Juan Guo, Ying Tao, Ling-Yun Wu, Feng Xu, Dong Wu, Li-Yu Zhou, Ji-Ying Su, Lu-Xi Song, Chao Xiao & Xiao Li. (2017) Increased PD-1/STAT1 ratio may account for the survival benefit in decitabine therapy for lower risk myelodysplastic syndrome. Leukemia & Lymphoma 58:4, pages 969-978.
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Kelly Garner, Stephen Ten Eyck, Fiona E. Craig & Christine G. Roth. (2014) T-cell immunoglobulin mucin-3 is underexpressed on myeloblasts in untreated myelodysplastic syndrome. Leukemia & Lymphoma 55:3, pages 689-691.
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Eunkyoung You, Chan-Jeoung Park, Young-Uk Cho, Seongsoo Jang, Min Young Lee, Hery Kim, Kyung Nam Koh, Ho Joon Im, Eun-Ji Choi, Je-Hwan Lee & Kyoo-Hyung Lee. (2023) Increased PD-1 expression of bone marrow T-cells in acute myeloid leukaemia patients after stem cell transplantation, and its association with overall survival. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine.
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Zhaoyun Liu, Yixuan Guo, Lei Huang, Yue Jia, Hui Liu, Fengping Peng, Lixiang Duan, Hongkai Zhang & Rong Fu. (2022) Bone marrow mesenchymal stem cells regulate the dysfunction of NK cells via the T cell immunoglobulin and ITIM domain in patients with myelodysplastic syndromes. Cell Communication and Signaling 20:1.
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Suxia Geng, Ruohao Xu, Xin Huang, Minming Li, Chengxin Deng, Peilong Lai, Yulian Wang, Ping Wu, Xiaomei Chen, Jianyu Weng & Xin Du. (2022) Dynamics of PD-1 expression are associated with treatment efficacy and prognosis in patients with intermediate/high-risk myelodysplastic syndromes under hypomethylating treatment. Frontiers in Immunology 13.
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Clement Chung. (2021) Targeting the Myeloid Lineages and the Immune Microenvironment in Myelodysplastic Syndromes: Novel and Evolving Therapeutic Strategies. Annals of Pharmacotherapy 56:4, pages 475-487.
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Paul Lee, Rita Yim, Yammy Yung, Hiu-Tung Chu, Pui-Kwan Yip & Harinder Gill. (2021) Molecular Targeted Therapy and Immunotherapy for Myelodysplastic Syndrome. International Journal of Molecular Sciences 22:19, pages 10232.
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Dhifaf Sarhan, Jinhua Wang, Upasana Sunil Arvindam, Caroline Hallstrom, Michael R. Verneris, Bartosz Grzywacz, Erica Warlick, Bruce R. Blazar & Jeffrey S. Miller. (2020) Mesenchymal stromal cells shape the MDS microenvironment by inducing suppressive monocytes that dampen NK cell function. JCI Insight 5:5.
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Jesse A. Sharp, Alexander P Browning, Tarunendu Mapder, Kevin Burrage & Matthew J Simpson. (2019) Optimal control of acute myeloid leukaemia. Journal of Theoretical Biology 470, pages 30-42.
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Ota Fuchs. (2019) Treatment of Lymphoid and Myeloid Malignancies by Immunomodulatory Drugs. Cardiovascular & Hematological Disorders-Drug Targets 19:1, pages 51-78.
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Christopher J. Gibson, Benjamin L. Ebert & David P. Steensma. 2018. Hematology. Hematology 944 969.e13 .
Hai-Fang Zhang, Zhen-Dong Huang, Xue-Run Wu, Qian Li & Zhi-Feng Yu. (2017) Comparison of T lymphocyte subsets in aplastic anemia and hypoplastic myelodysplastic syndromes. Life Sciences 189, pages 71-75.
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Wen Dong, Tingting Ding, Lei Wu, Xiubao Ren, P.K. Epling-Burnette & Lili Yang. (2016) Effect of IL-7 and IL-15 on T cell phenotype in myelodysplastic syndromes. Oncotarget 7:19, pages 27479-27488.
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Borhane Guezguez, Mohammed Almakadi, Yannick D. Benoit, Zoya Shapovalova, Susann Rahmig, Aline Fiebig-Comyn, Fanny L. Casado, Borko Tanasijevic, Silvia Bresolin, Riccardo Masetti, Bradley W. Doble & Mickie Bhatia. (2016) GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia. Cancer Cell 29:1, pages 61-74.
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Jun Wu, Yifei Cheng & Leping Zhang. (2015) Comparison of immune manifestations between refractory cytopenia of childhood and aplastic anemia in children: A single-center retrospective study. Leukemia Research 39:12, pages 1347-1352.
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Miyoung Kim, Seungwoo Hwang, Kiejung Park, Seon Young Kim, Young Kyung Lee & Dong Soon Lee. (2015) Increased Expression of Interferon Signaling Genes in the Bone Marrow Microenvironment of Myelodysplastic Syndromes. PLOS ONE 10:3, pages e0120602.
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Qingtian Li, Jia Zou, Mingjun Wang, Xilai Ding, Iouri Chepelev, Xikun Zhou, Wei Zhao, Gang Wei, Jun Cui, Keji Zhao, Helen Y. Wang & Rong-Fu Wang. (2014) Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation. Nature Communications 5:1.
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H Yang, C Bueso-Ramos, C DiNardo, M R Estecio, M Davanlou, Q-R Geng, Z Fang, M Nguyen, S Pierce, Y Wei, S Parmar, J Cortes, H Kantarjian & G Garcia-Manero. (2013) Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents. Leukemia 28:6, pages 1280-1288.
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Esther Natalie Oliva, Maria Cuzzola, Maria Antonietta Aloe Spiriti, Antonella Poloni, Carmelo Laganà, Carmela Rigolino, Fortunato Morabito, Sara Galimberti, Riccardo Ghio, Agostino Cortelezzi, Giuseppe Alberto Palumbo, Grazia Sanpaolo, Carlo Finelli, Alessandra Ricco, Antonio Volpe, Filippo Rodà, Massimo Breccia, Giuliana Alimena, Francesco Nobile & Roberto Latagliata. (2012) Biological activity of lenalidomide in myelodysplastic syndromes with del5q: results of gene expression profiling from a multicenter phase II study. Annals of Hematology 92:1, pages 25-32.
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A Pardanani, C Finke, T L Lasho, A Al-Kali, K H Begna, C A Hanson & A Tefferi. (2011) IPSS-independent prognostic value of plasma CXCL10, IL-7 and IL-6 levels in myelodysplastic syndromes. Leukemia 26:4, pages 693-699.
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Elpiniki Kritikou-Griva, Maria Spyropoulou-Vlachou, Nikolaos J. Tsagarakis, Eleni Goumakou, Vasiliki Vrani, Athanasios Galanopoulos, Stefanos I. Papadhimitriou, George Androutsos, George Paterakis & Catherine Stavropoulos-Giokas. (2012) High frequency of human leukocyte antigen class II DRB1*1602 haplotype in Greek patients with myelodysplastic syndrome and of DRB1*1501 in the low-risk subgroup. Human Immunology 73:3, pages 278-281.
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Ayed A. Algarni, Mojtaba Akhtari & Kai Fu. (2012) Myelodysplastic Syndrome with Myelofibrosis Transformed to a Precursor B-Cell Acute Lymphoblastic Leukemia: A Case Report with Review of the Literature. Case Reports in Hematology 2012, pages 1-6.
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